Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.124 0.247 -9999.0 0.0 -0.643 17.0 17.0 IHH -0.041 0.107 -9999.0 0.0 -0.261 15.0 15.0 SHH Np/Cholesterol/GAS1 -0.038 0.12 -9999.0 0.0 -0.352 12.0 12.0 LRPAP1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.038 0.119 0.349 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 -0.112 0.196 -9999.0 0.0 -0.571 8.0 8.0 SMO -0.114 0.195 -9999.0 0.0 -0.545 11.0 11.0 AKT1 -0.062 0.15 -9999.0 0.0 -0.582 6.0 6.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.12 -9999.0 0.0 -0.377 9.0 9.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.192 -9999.0 0.0 -0.536 11.0 11.0 STIL -0.077 0.153 -9999.0 0.0 -0.45 8.0 8.0 DHH N/PTCH2 0.01 0.106 -9999.0 0.0 -0.418 6.0 6.0 DHH N/PTCH1 -0.071 0.154 -9999.0 0.0 -0.385 14.0 14.0 PIK3CA 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.005 0.099 -9999.0 0.0 -0.481 4.0 4.0 PTHLH -0.194 0.373 -9999.0 0.0 -0.928 21.0 21.0 determination of left/right symmetry -0.113 0.192 -9999.0 0.0 -0.536 11.0 11.0 PIK3R1 0.01 0.085 -9999.0 0.0 -0.395 4.0 4.0 skeletal system development -0.191 0.367 -9999.0 0.0 -0.915 21.0 21.0 IHH N/Hhip -0.031 0.094 -9999.0 0.0 -0.25 7.0 7.0 DHH N/Hhip -0.001 0.101 -9999.0 0.0 -0.412 4.0 4.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.192 -9999.0 0.0 -0.536 11.0 11.0 pancreas development -0.016 0.079 -9999.0 0.0 -0.225 13.0 13.0 HHAT 0.01 0.096 -9999.0 0.0 -0.566 3.0 3.0 PI3K 0.015 0.064 -9999.0 0.0 -0.418 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.018 0.136 -9999.0 0.0 -0.356 13.0 13.0 somite specification -0.113 0.192 -9999.0 0.0 -0.536 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.086 0.156 -9999.0 0.0 -0.455 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.023 0.103 -9999.0 0.0 -0.317 10.0 10.0 SHH Np/Cholesterol/Megalin -0.028 0.099 -9999.0 0.0 -0.295 10.0 10.0 SHH -0.04 0.108 -9999.0 0.0 -0.419 7.0 7.0 catabolic process -0.077 0.154 -9999.0 0.0 -0.424 11.0 11.0 SMO/Vitamin D3 -0.101 0.179 -9999.0 0.0 -0.529 10.0 10.0 SHH Np/Cholesterol/Hhip -0.035 0.101 -9999.0 0.0 -0.275 13.0 13.0 LRP2 -0.008 0.077 -9999.0 0.0 -0.225 12.0 12.0 receptor-mediated endocytosis -0.105 0.173 -9999.0 0.0 -0.506 11.0 11.0 SHH Np/Cholesterol/BOC -0.035 0.115 -9999.0 0.0 -0.357 10.0 10.0 SHH Np/Cholesterol/CDO -0.025 0.103 -9999.0 0.0 -0.339 9.0 9.0 mesenchymal cell differentiation 0.035 0.1 0.273 13.0 -9999.0 0.0 13.0 mol:Vitamin D3 -0.076 0.164 -9999.0 0.0 -0.456 9.0 9.0 IHH N/PTCH2 -0.019 0.103 -9999.0 0.0 -0.428 4.0 4.0 CDON 0.01 0.082 -9999.0 0.0 -0.452 3.0 3.0 IHH N/PTCH1 -0.061 0.163 -9999.0 0.0 -0.427 11.0 11.0 Megalin/LRPAP1 0.015 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.008 0.099 -9999.0 0.0 -0.481 4.0 4.0 SHH Np/Cholesterol -0.021 0.088 -9999.0 0.0 -0.326 7.0 7.0 PTCH1 -0.077 0.155 -9999.0 0.0 -0.425 11.0 11.0 HHIP -0.016 0.079 -9999.0 0.0 -0.225 13.0 13.0