Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.016 0.05 -9999.0 0.0 -0.333 2.0 2.0 epithelial cell differentiation 0.046 0.04 -9999.0 0.0 -0.307 1.0 1.0 CYFIP2 0.008 0.099 -9999.0 0.0 -0.481 4.0 4.0 ENAH 0.018 0.09 0.284 4.0 -0.371 1.0 5.0 EGFR -0.005 0.134 -9999.0 0.0 -0.566 6.0 6.0 EPHA2 0.01 0.096 -9999.0 0.0 -0.566 3.0 3.0 MYO6 0.01 0.029 -9999.0 0.0 -0.296 1.0 1.0 CTNNB1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.035 0.072 -9999.0 0.0 -0.359 3.0 3.0 AQP5 -0.135 0.22 -9999.0 0.0 -0.478 31.0 31.0 CTNND1 0.021 0.056 -9999.0 0.0 -0.566 1.0 1.0 mol:PI-4-5-P2 0.012 0.033 -9999.0 0.0 -0.292 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.074 -9999.0 0.0 -0.289 5.0 5.0 EGF -0.069 0.191 -9999.0 0.0 -0.389 25.0 25.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.039 0.161 -9999.0 0.0 -0.488 12.0 12.0 cortical microtubule organization 0.046 0.04 -9999.0 0.0 -0.307 1.0 1.0 GO:0000145 -0.006 0.032 0.177 1.0 -0.279 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.051 0.042 -9999.0 0.0 -0.31 1.0 1.0 MLLT4 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.016 0.054 -9999.0 0.0 -0.389 2.0 2.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.041 0.062 -9999.0 0.0 -0.329 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.003 0.026 -9999.0 0.0 -0.27 1.0 1.0 PVRL2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.011 0.034 -9999.0 0.0 -0.296 1.0 1.0 ARF6/GTP 0.045 0.062 -9999.0 0.0 -0.308 2.0 2.0 CDH1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.028 0.139 -9999.0 0.0 -0.326 17.0 17.0 RhoA/GDP 0.047 0.04 -9999.0 0.0 -0.294 1.0 1.0 actin cytoskeleton organization -0.009 0.027 -9999.0 0.0 -0.289 1.0 1.0 IGF-1R heterotetramer 0.021 0.056 -9999.0 0.0 -0.565 1.0 1.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.021 0.056 -9999.0 0.0 -0.566 1.0 1.0 IGF1 -0.079 0.216 -9999.0 0.0 -0.467 24.0 24.0 DIAPH1 -0.035 0.194 -9999.0 0.0 -0.573 7.0 7.0 Wnt receptor signaling pathway -0.046 0.04 0.307 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.016 0.054 -9999.0 0.0 -0.389 2.0 2.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.009 0.028 -9999.0 0.0 -0.295 1.0 1.0 EFNA1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.006 0.028 -9999.0 0.0 -0.285 1.0 1.0 Ephrin A1/EPHA2 0.029 0.075 -9999.0 0.0 -0.381 3.0 3.0 SEC6/SEC8 0.007 0.028 -9999.0 0.0 -0.277 1.0 1.0 MGAT3 -0.015 0.075 -9999.0 0.0 -0.293 5.0 5.0 HGF/MET 0.018 0.093 -9999.0 0.0 -0.334 6.0 6.0 HGF 0.005 0.101 -9999.0 0.0 -0.43 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.016 0.05 -9999.0 0.0 -0.336 2.0 2.0 actin cable formation 0.059 0.134 0.265 24.0 -0.29 1.0 25.0 KIAA1543 -0.015 0.053 -9999.0 0.0 -0.286 4.0 4.0 KIFC3 0.006 0.053 -9999.0 0.0 -0.299 3.0 3.0 NCK1 0.021 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.012 0.034 -9999.0 0.0 -0.296 1.0 1.0 NCK1/GIT1 0.031 0.017 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.046 0.04 -9999.0 0.0 -0.307 1.0 1.0 EXOC4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.012 0.034 -9999.0 0.0 -0.296 1.0 1.0 PIP5K1C 0.012 0.034 -9999.0 0.0 -0.296 1.0 1.0 LIMA1 0.022 0.056 -9999.0 0.0 -0.566 1.0 1.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.106 0.301 7.0 -0.442 1.0 8.0 adherens junction assembly -0.022 0.112 -9999.0 0.0 -0.467 5.0 5.0 IGF-1R heterotetramer/IGF1 -0.022 0.133 -9999.0 0.0 -0.304 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.009 0.096 -9999.0 0.0 -0.566 3.0 3.0 PLEKHA7 0.002 0.058 -9999.0 0.0 -0.299 4.0 4.0 mol:GTP 0.04 0.061 -9999.0 0.0 -0.327 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.037 0.093 0.324 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization 0.016 0.05 -9999.0 0.0 -0.333 2.0 2.0 regulation of cell-cell adhesion -0.009 0.027 -9999.0 0.0 -0.289 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.016 0.05 -9999.0 0.0 -0.336 2.0 2.0