Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	103 (66%)	52	0.17058	1	0.018696	1	0.1013	1	0.70016	1	0.38769	1	1	1	1	1
PIK3CA	26 (17%)	129	0.33079	1	0.33586	1	0.01783	1	0.21774	1	0.33202	1	1	1	0.59239	1
BRAF	20 (13%)	135	3.2907e-07	3.26e-05	4.3712e-08	4.37e-06	8.4985e-05	0.00833	0.734	1	0.92618	1	0.14533	1	1	1
KRAS	58 (37%)	97	0.024121	1	0.0006382	0.0619	0.14993	1	0.77217	1	0.75196	1	1	1	0.61348	1
TP53	75 (48%)	80	0.0022626	0.215	0.012952	1	1.0799e-09	1.09e-07	0.40329	1	0.37976	1	0.36629	1	0.80713	1
FBXW7	29 (19%)	126	0.22671	1	0.089159	1	0.00082466	0.0792	0.0053263	0.501	0.23259	1	0.58342	1	0.65747	1
NRAS	15 (10%)	140	0.077327	1	0.40857	1	0.531	1	0.065894	1	0.33213	1	1	1	1	1
SMAD4	18 (12%)	137	0.30352	1	0.57961	1	0.010006	0.921	0.40031	1	0.49482	1	1	1	1	1
FAM123B	19 (12%)	136	0.20808	1	0.0062163	0.578	0.019023	1	0.57949	1	0.42194	1	0.49751	1	0.49751	1
SOX9	9 (6%)	146	0.23526	1	0.21364	1	0.5849	1	0.14012	1	0.46084	1	1	1	1	1
ACVR2A	8 (5%)	147	0.044979	1	0.2961	1	0.098006	1	0.16743	1	0.66829	1	1	1	0.2549	1
TNFRSF10C	6 (4%)	149	0.38104	1	0.67607	1	0.081139	1	0.61775	1	0.16933	1	1	1	1	1
SMAD2	10 (6%)	145	0.099491	1	0.19002	1	0.033333	1	0.94337	1	0.37729	1	0.2827	1	1	1
ACOT4	3 (2%)	152	0.66496	1	0.39097	1	0.73592	1	NA	NA	NA	NA	1	1	1	1
PCBP1	4 (3%)	151	0.32974	1	0.55218	1	0.48567	1	NA	NA	NA	NA	1	1	1	1