rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL3(3)	661548	11	11	10	2	5	1	0	3	0	2	0.00166	0.520
2	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	CDH1(4), CREBBP(21), EP300(13), MAP2K1(3), MAP3K7(2), MAPK3(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7)	4534604	64	37	63	17	24	20	3	7	10	0	0.00262	0.520
3	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	AXIN1(1), CREBBP(21), CTNNB1(8), EP300(13), GSK3B(7), HDAC1(2), LDB1(3), LEF1(4), PITX2(2), TRRAP(17), WNT1(1)	6009423	79	46	78	21	33	25	1	8	12	0	0.00281	0.520
4	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	231	ADCYAP1R1(1), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), C5AR1(2), CALCR(3), CALCRL(5), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM3(4), CHRM5(1), CNR1(3), CRHR1(1), CRHR2(4), CTSG(2), CYSLTR1(3), CYSLTR2(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2(2), F2RL2(2), FPR1(2), FSHB(1), FSHR(6), GABBR1(4), GABBR2(3), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA6(4), GABRB1(6), GABRB2(4), GABRB3(5), GABRE(5), GABRG1(7), GABRG2(8), GABRG3(5), GABRP(2), GABRQ(7), GABRR1(2), GABRR2(3), GALR1(1), GH1(1), GH2(1), GHR(6), GHRHR(2), GHSR(5), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(7), GLRB(6), GNRHR(4), GPR156(6), GPR50(5), GPR63(2), GPR83(1), GRIA2(10), GRIA3(5), GRIA4(12), GRID1(15), GRID2(10), GRIK1(5), GRIK2(10), GRIK4(11), GRIK5(5), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM6(9), GRM7(8), GRM8(7), GRPR(3), GZMA(2), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LEP(1), LEPR(5), LHB(1), LHCGR(4), MAS1(1), MC2R(2), MC3R(1), MC4R(3), MC5R(4), MCHR1(6), MCHR2(2), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPBWR1(3), NPFFR2(3), NPY1R(4), NPY2R(5), NPY5R(1), NR3C1(3), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(6), P2RY13(2), P2RY14(4), P2RY2(2), P2RY4(6), PARD3(5), PPYR1(1), PRL(2), PRLR(2), PRSS1(3), PRSS2(1), PRSS3(4), PTAFR(1), PTGER2(1), PTGER3(6), PTGFR(6), PTGIR(1), PTH2R(6), RXFP1(2), RXFP2(8), SCTR(3), SSTR1(4), SSTR2(2), SSTR4(2), TAAR1(3), TAAR2(2), TAAR5(5), TAAR6(2), TAAR8(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(4), THRA(2), THRB(4), TRHR(6), TRPV1(3), TSHR(6), VIPR1(3), VIPR2(3)	47949907	701	117	698	266	270	150	15	208	58	0	0.00337	0.520
5	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(2), CTLA4(1), GRB2(2), HLA-DRA(4), HLA-DRB1(1), ICOS(1), IL2(3), ITK(8), LCK(2), PIK3R1(5), PTPN11(2)	2385350	33	23	32	7	7	9	2	8	5	2	0.00436	0.526
6	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6)	1229065	19	16	19	5	3	4	1	11	0	0	0.00737	0.526
7	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA6(4), GPX1(1), PRKCE(4)	1520965	27	19	27	5	9	5	0	10	3	0	0.00750	0.526
8	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(3), CFL1(1), GNAQ(3), GNAS(6), GNB1(1), LIMK1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), NOX1(1), PIK3C2G(7), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2(5), RAF1(4), ROCK2(2)	5505383	60	39	58	11	24	8	2	17	9	0	0.00785	0.526
9	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(3), AXIN1(1), BMP10(2), BMP4(1), BMP5(4), BMP7(5), BMPR1A(4), BMPR2(7), CHRD(5), CTNNB1(8), GATA4(1), GSK3B(7), MAP3K7(2), MEF2C(7), MYL2(1), NKX2-5(1), NPPA(1), RFC1(10), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), WNT1(1)	6681664	95	45	94	27	32	17	1	26	19	0	0.00832	0.526
10	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CCRL1(2), CHML(4), CHRM1(3), CHRM3(4), CHRM5(1), CMKLR1(2), CNR1(3), CX3CR1(1), CXCR4(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2RL2(2), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(2), GPR37(6), GPR37L1(3), GPR4(1), GPR50(5), GPR6(5), GPR63(2), GPR77(1), GPR83(1), GPR85(1), GPR87(4), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LHCGR(4), MAS1(1), MC3R(1), MC4R(3), MC5R(4), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR2H1(3), OR5V1(2), OR7A5(3), OR8B8(2), OXTR(2), P2RY1(3), P2RY10(6), P2RY12(3), P2RY13(2), P2RY14(4), P2RY2(2), PPYR1(1), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1), RGR(2), RHO(2), RRH(2), SSTR1(4), SSTR2(2), SSTR4(2), TRHR(6)	26088640	342	93	343	123	142	81	5	88	26	0	0.00894	0.526
11	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(6), AGT(4), AGTR1(3), AGTR2(4), COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), REN(3)	5623215	78	38	77	14	17	23	2	22	14	0	0.0103	0.526
12	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	79	ABL1(4), ABL2(5), AKT1(2), AKT2(5), ARAF(3), BAD(1), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(6), CDKN1A(1), CDKN1B(1), CRKL(2), EGF(3), EGFR(10), ERBB2(6), ERBB3(11), EREG(1), GAB1(6), GRB2(2), GSK3B(7), HBEGF(1), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), NRG1(9), NRG2(4), NRG3(3), NRG4(1), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), RAF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SRC(3), STAT5B(2)	21422571	222	77	216	71	77	54	9	52	30	0	0.0131	0.526
13	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), AXIN1(1), CD14(1), CTNNB1(8), GJA1(3), GNAI1(3), GSK3B(7), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(1), NFKB1(3), PDPK1(1), PIK3R1(5), PPP2CA(1), RELA(2), TIRAP(1), TLR4(7), TOLLIP(1), WNT1(1)	4870085	56	36	56	19	22	11	2	10	11	0	0.0144	0.526
14	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRB1(2), CSNK1D(3), DRD1(1), DRD2(3), EGF(3), EGFR(10), GJA1(3), GNA11(1), GNAI1(3), GNAQ(3), GNAS(6), GRB2(2), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HTR2A(2), HTR2B(1), HTR2C(6), ITPR1(11), ITPR2(12), ITPR3(11), MAP2K1(3), MAP2K5(2), MAP3K2(2), MAPK1(2), MAPK3(2), MAPK7(3), NPR1(6), NPR2(9), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(5), SOS2(9), SRC(3), TJP1(5), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2)	28303583	347	92	345	135	149	69	11	91	26	1	0.0149	0.526
15	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(4), CREM(4), FHL5(1), FSHB(1), FSHR(6), GNAS(6), XPO1(1)	2121753	23	20	23	8	9	5	2	5	2	0	0.0151	0.526
16	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3(2), CREB3L1(3), CREB3L2(3), CREB3L3(1), CREB3L4(1), CREBBP(21), CTNNB1(8), DCT(9), DVL2(8), DVL3(2), EDN1(1), EDNRB(7), EP300(13), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GSK3B(7), KIT(6), KITLG(2), LEF1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MITF(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), POMC(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), TCF7(3), TCF7L1(3), TYR(2), TYRP1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	23644799	290	83	287	106	123	67	6	65	29	0	0.0154	0.526
17	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(10), GNAS(6), GNB1(1), GRB2(2), IGF1R(7), ITGB1(6), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(13), PPP2CA(1), PTPRR(1), RAF1(4), RPS6KA1(1), RPS6KA5(3), SHC1(3), SOS1(5), SRC(3), STAT3(2)	7538648	83	48	79	30	30	16	6	23	7	1	0.0169	0.526
18	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), PON1(5)	6374104	88	43	87	18	32	18	4	24	9	1	0.0169	0.526
19	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(10), ERBB3(11), NRG1(9), UBE2D1(1)	2348873	34	26	31	6	16	7	0	7	4	0	0.0176	0.526
20	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(2), AKT2(5), ANKRD6(5), AXIN1(1), AXIN2(7), CER1(3), CSNK1A1(2), CTNNB1(8), DACT1(5), DKK1(3), DKK2(5), DKK3(2), DKK4(4), FSTL1(5), GSK3A(2), GSK3B(7), LRP1(14), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(2), SFRP1(2), WIF1(2)	7533729	100	50	99	29	47	16	3	21	13	0	0.0184	0.526
21	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(4)	461019	8	8	8	2	2	1	0	4	1	0	0.0187	0.526
22	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(20), MAP2(21), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2), PRKCE(4)	4045327	52	31	52	13	16	11	1	14	10	0	0.0202	0.526
23	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(2), KERA(5), LUM(5)	806504	15	13	15	3	4	6	0	3	2	0	0.0204	0.526
24	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(5), PLCB1(8), PLCG1(4), PRKCA(2), VAV1(11)	2444739	32	26	32	9	13	4	2	8	5	0	0.0205	0.526
25	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(3), GNB1(1), HTR2C(6), PLCB1(8), TUB(4)	1619755	25	18	25	7	13	3	1	5	3	0	0.0215	0.529
26	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	6	CREBBP(21), EP300(13), MAPK1(2), MAPK3(2), PELP1(2), SRC(3)	2997596	43	29	43	13	14	17	1	6	5	0	0.0241	0.571
27	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4)	2805116	38	23	38	11	12	9	0	12	4	1	0.0250	0.571
28	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(3), IL4(3)	890834	15	12	15	8	6	4	0	3	0	2	0.0275	0.606
29	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), GRB2(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3R1(5), RAF1(4), SHC1(3), SOS1(5)	3739105	41	31	39	8	13	8	4	10	6	0	0.0300	0.638
30	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACP1(2), ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ACVR1C(2), CDH1(4), CREBBP(21), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), EGFR(10), EP300(13), ERBB2(6), FARP2(5), FER(4), FGFR1(3), FYN(4), IGF1R(7), INSR(5), IQGAP1(10), LEF1(4), LMO7(18), MAP3K7(2), MAPK1(2), MAPK3(2), MET(4), MLLT4(3), NLK(1), PARD3(5), PTPN1(4), PTPN6(4), PTPRB(4), PTPRF(8), PTPRJ(3), PTPRM(19), PVRL1(4), PVRL2(3), PVRL3(1), PVRL4(4), RHOA(4), SMAD3(6), SNAI1(1), SNAI2(1), SORBS1(7), SRC(3), SSX2IP(3), TCF7(3), TCF7L1(3), TGFBR1(6), TGFBR2(7), TJP1(5), VCL(1), WAS(1), WASF1(1), WASF2(2), WASF3(2), WASL(5), YES1(1)	25184422	319	82	315	96	115	84	5	80	35	0	0.0319	0.645
31	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	164	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY7(3), ADCY8(11), ADCY9(4), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), AGTR1(3), ATP2A1(6), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), ATP2B4(5), AVPR1A(3), AVPR1B(3), BDKRB2(2), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CCKAR(1), CCKBR(3), CD38(1), CHRM1(3), CHRM3(4), CHRM5(1), CYSLTR1(3), CYSLTR2(3), DRD1(1), EDNRA(4), EDNRB(7), EGFR(10), ERBB2(6), ERBB3(11), GNA11(1), GNA14(5), GNA15(3), GNAL(3), GNAQ(3), GNAS(6), GRIN1(1), GRIN2A(15), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), GRPR(3), HRH1(1), HRH2(4), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), LHCGR(4), MYLK(11), MYLK2(2), NOS1(5), NOS3(2), NTSR1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), PDE1A(3), PDE1B(2), PDE1C(7), PDGFRA(13), PDGFRB(5), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PPID(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTAFR(1), PTGER3(6), PTGFR(6), PTK2B(1), RYR1(19), RYR3(31), SLC25A4(1), SLC25A5(1), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK2(1), TACR1(2), TACR2(1), TACR3(4), TNNC2(1), TRHR(6), TRPC1(5), VDAC1(1), VDAC3(1)	55091458	655	121	649	270	286	143	16	154	54	2	0.0334	0.645
32	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(2), AR(4), ASAH1(3), CCL13(1), CCL15(1), DAG1(4), EGFR(10), GNA11(1), GNA15(3), GNAI1(3), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), MAPK10(4), MAPK14(3), PHKA2(5), PIK3CD(2), PIK3R1(5), PITX2(2), PTX3(2), RAF1(4), SRC(3)	9491373	116	53	115	49	49	17	6	34	10	0	0.0346	0.645
33	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), AGTR2(4), ATP8A1(5), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CX3CR1(1), CXCR4(3), EDNRA(4), EDNRB(7), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GNRHR(4), GPR77(1), GRPR(3), LHCGR(4), MC2R(2), MC3R(1), MC4R(3), MC5R(4), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), PPYR1(1), SSTR1(4), SSTR2(2), SSTR4(2), TAC4(1), TACR1(2), TACR2(1), TACR3(4), TRHR(6), TSHR(6)	11247469	155	61	156	61	58	36	3	50	8	0	0.0346	0.645
34	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	AXIN1(1), BTRC(2), CREBBP(21), CSNK1A1(2), CSNK1D(3), CSNK2A1(4), CTBP1(1), CTNNB1(8), GSK3B(7), HDAC1(2), MAP3K7(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	5057069	60	38	60	18	21	15	1	13	10	0	0.0382	0.681
35	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(2), ASAH1(3), ATF1(1), CREB1(1), CREB3(2), CREB5(2), CREBBP(21), CRKL(2), DAG1(4), EGR1(2), EGR2(6), EGR3(2), FRS2(2), GNAQ(3), MAP1B(18), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), NTRK1(6), PIK3C2G(7), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(3), SRC(3), TERF2IP(1)	10374793	119	55	117	41	31	35	3	27	22	1	0.0406	0.681
36	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(1), GAD1(7), GAD2(4), GGT1(3)	1258083	18	15	16	4	7	6	1	4	0	0	0.0416	0.681
37	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(3), ALDH1A2(6), BCMO1(4), RDH5(1)	874199	14	12	14	1	6	2	1	4	1	0	0.0421	0.681
38	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(6), CHKA(2), PCYT1A(4), PDHA1(4), PDHA2(6), PEMT(1), SLC18A3(6)	1548475	29	20	29	13	11	10	0	6	2	0	0.0432	0.681
39	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), CD3G(2), IFNG(1), IL2(3), IL2RA(2), IL4(3), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), TOB2(1)	2407923	38	21	37	13	16	6	1	9	6	0	0.0439	0.681
40	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1)	521258	8	8	8	4	2	3	0	1	0	2	0.0443	0.681
41	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), GRB2(2), KLK2(3), NTRK1(6), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(3), SOS1(5)	3031588	32	27	29	8	5	6	3	12	6	0	0.0458	0.681
42	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), CHRM1(3), CHRM3(4), CHRM5(1), DRD1(1), DRD2(3), DRD3(3), DRD5(2), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6)	5381141	73	42	73	31	35	18	1	10	9	0	0.0465	0.681
43	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(7), ACTN3(2), CSK(1), CTNNA1(10), CTNNA2(10), CTNNB1(8), PECAM1(1), PTK2(5), SRC(3), VCL(1)	4387151	51	33	51	20	26	11	0	8	6	0	0.0503	0.720
44	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(4), GPRC5A(2), GPRC5B(1), GPRC5C(1), GPRC5D(1), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM7(8), GRM8(7)	4608839	61	37	59	36	29	11	1	14	6	0	0.0526	0.737
45	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(4), FYN(4), LRP8(1), RELN(24), VLDLR(3)	3166952	37	25	36	14	10	8	3	11	5	0	0.0567	0.767
46	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(1), FUT2(1), FUT9(4), GCNT2(9), ST8SIA1(3)	1350762	22	15	22	4	6	6	1	6	3	0	0.0584	0.767
47	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1)	2914856	40	26	40	10	12	11	1	16	0	0	0.0611	0.767
48	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), F10(1), F11(4), F12(2), F2(2), F5(14), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), PROC(1), PROS1(3), SERPINC1(3), SERPING1(3)	9953487	132	48	129	31	26	35	3	45	23	0	0.0614	0.767
49	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(3), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL4(3), IL5RA(4), IL6(1)	1203207	18	13	18	5	7	3	0	6	0	2	0.0626	0.767
50	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(8), F2(2), FGA(11), FGB(1), FGG(4), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1)	3039479	45	28	45	13	12	16	1	11	5	0	0.0631	0.767
51	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4), MASP1(9)	4357879	53	29	53	21	17	10	1	16	8	1	0.0643	0.767
52	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(9), BMPR2(7)	1406446	24	16	24	4	5	7	0	5	7	0	0.0648	0.767
53	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), GLCE(3), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4)	4602310	60	36	60	16	26	15	2	13	4	0	0.0660	0.767
54	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4), MASP1(9), MASP2(4)	4746977	57	31	57	22	17	11	2	18	8	1	0.0676	0.771
55	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	241	ACVR1(3), ACVR2B(3), AMHR2(2), BMP7(5), BMPR1A(4), BMPR1B(9), BMPR2(7), CCL13(1), CCL15(1), CCL18(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CD27(3), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(1), CSF1R(3), CSF2RB(7), CSF3R(9), CX3CR1(1), CXCL11(2), CXCL12(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCL9(2), CXCR4(3), EDA(1), EDA2R(2), EDAR(1), EGF(3), EGFR(10), FASLG(1), FLT1(9), FLT3(3), FLT3LG(1), FLT4(4), GDF5(1), GH1(1), GH2(1), GHR(6), HGF(5), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL15(1), IL15RA(1), IL17A(1), IL17RA(5), IL17RB(1), IL18RAP(2), IL19(1), IL1A(1), IL1R1(3), IL1R2(3), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), INHBB(1), INHBC(2), KDR(8), KIT(6), KITLG(2), LEP(1), LEPR(5), LTB(1), LTBR(2), MET(4), MPL(1), NGFR(2), OSM(1), OSMR(4), PDGFC(2), PDGFRA(13), PDGFRB(5), PLEKHO2(5), PRL(2), PRLR(2), RELT(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(2), TNFRSF11A(2), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(4), TNFRSF4(1), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(8), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(3), XCL2(1)	37676919	432	94	426	152	147	95	8	126	55	1	0.0700	0.777
56	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), UGDH(3), UGP2(5), UXS1(6)	1094737	17	14	17	5	7	4	0	4	2	0	0.0711	0.777
57	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C2(3), AKR1C4(2), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2S1(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4)	12103139	143	52	142	33	39	30	4	52	17	1	0.0724	0.777
58	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(6), SLC2A3(1)	5543856	69	34	68	15	16	17	2	20	14	0	0.0732	0.777
59	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(8), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA6(4), NSF(1), SRC(3), UBQLN1(2)	2169094	36	21	35	19	8	7	1	15	5	0	0.0767	0.801
60	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(3), HLA-A(1), ITGB1(6), KLRC3(2), KLRC4(1), KLRD1(1), MAP2K1(3), MAPK3(2), PAK1(4), PIK3R1(5), PTK2B(1), PTPN6(4), VAV1(11)	3661778	44	28	44	11	15	7	3	10	9	0	0.0789	0.807
61	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), ANXA6(2), ARRB1(1), ATP1A4(6), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1S(10), CACNB1(1), CACNB3(1), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(3), CHRM3(4), CHRM5(1), GJA1(3), GJA4(2), GJA5(3), GJB1(3), GJB3(3), GJB4(1), GNA11(1), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNB1(2), KCNJ3(6), KCNJ5(3), NME7(3), PEA15(1), PKIA(1), PKIB(1), PLCB3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR3(31), SLC8A1(11), SLC8A3(4), USP5(3), YWHAB(2), YWHAQ(1)	38102176	426	103	424	192	200	82	11	97	35	1	0.0805	0.807
62	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(1), ALDOB(5), ALDOC(1), TPI1(1)	847422	11	11	11	1	2	0	0	9	0	0	0.0827	0.807
63	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(4), CCNB1(2), CDC25C(3), GNAI1(3), GNAS(6), GNB1(1), MAPK1(2), MAPK3(2), MYT1(8), PIN1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RPS6KA1(1), SRC(3)	4486219	46	35	46	17	18	12	2	12	2	0	0.0831	0.807
64	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4)	5055453	65	34	65	20	21	20	5	8	9	2	0.0852	0.807
65	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4)	5055453	65	34	65	20	21	20	5	8	9	2	0.0852	0.807
66	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(2), CREBBP(21), DFFA(2), DFFB(2), GZMA(2), GZMB(1), HMGB2(1)	2302357	32	22	32	8	7	13	1	5	6	0	0.0930	0.856
67	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(7), IGF1(2), IGF1R(7), INPPL1(3), PDK2(1), PDPK1(1), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3)	3922083	45	28	44	10	17	8	3	6	10	1	0.0933	0.856
68	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(6), AGT(4), AGTR1(3), AGTR2(4), ANPEP(5), CPA3(2), CTSA(3), CTSG(2), ENPEP(7), LNPEP(6), MAS1(1), MME(6), NLN(1), REN(3)	4795277	55	35	55	10	14	17	2	14	8	0	0.0945	0.856
69	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(8), BDKRB2(2), C1QB(1), C1QC(3), C1R(2), C1S(3), C3(10), C3AR1(2), C4BPA(2), C5(9), C5AR1(2), C6(10), C7(2), C8A(3), C9(4), CD46(2), CD55(3), CFB(2), CFH(10), CFI(2), CPB2(1), CR1(7), CR2(9), F10(1), F11(4), F12(2), F13A1(8), F13B(3), F2(2), F3(1), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), KNG1(3), MASP1(9), MASP2(4), PLAT(4), PLAU(2), PLAUR(3), PLG(7), PROC(1), PROS1(3), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(1), SERPING1(3), THBD(2), VWF(10)	19751884	236	67	233	84	67	62	5	75	26	1	0.0973	0.869
70	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), ARHGAP5(6), BAD(1), BCL2(1), BIRC2(2), BIRC3(2), CAPN2(5), CAV2(1), CAV3(2), CCND2(1), CCND3(1), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COMP(2), CRKL(2), CTNNB1(8), DIAPH1(1), DOCK1(5), EGF(3), EGFR(10), ERBB2(6), FARP2(5), FLNA(2), FLNB(14), FLNC(11), FLT1(9), FN1(17), FYN(4), GRB2(2), GRLF1(7), GSK3B(7), HGF(5), IBSP(3), IGF1(2), IGF1R(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), KDR(8), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PDPK1(1), PGF(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(2), PRKCG(8), PTEN(6), PTK2(5), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(4), RELN(24), RHOA(4), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SPP1(1), SRC(3), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TLN1(5), TLN2(5), TNC(13), TNN(15), TNXB(14), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCL(1), VEGFA(2), VEGFB(2), VEGFC(3), VTN(3), VWF(10)	79018710	874	126	865	321	313	207	21	232	99	2	0.0991	0.872
71	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	CDC25A(2), CDC25B(5), CDC25C(3), CDK2(2), CDK4(2), CHEK1(1), MYT1(8), RB1(4), WEE1(3)	2404880	30	21	30	5	7	8	0	12	2	1	0.106	0.920
72	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(2), CDKN1B(1), GRB2(2), ITGB1(6), MAPK1(2), MAPK3(2), PDK2(1), PDPK1(1), PIK3R1(5), PTEN(6), PTK2(5), SHC1(3), SOS1(5)	3845050	41	26	39	11	8	9	3	11	9	1	0.108	0.925
73	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(3), CDK2(2), CUL1(7), RB1(4), SKP2(1), TFDP1(4)	2015990	25	19	25	4	6	3	1	11	3	1	0.113	0.951
74	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	126	ALCAM(2), CADM3(6), CD2(3), CD22(8), CD226(2), CD274(3), CD28(1), CD34(1), CD4(2), CD40LG(6), CD58(1), CD6(3), CD8B(2), CDH1(4), CDH2(16), CDH3(2), CDH4(7), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CNTN1(12), CNTN2(5), CNTNAP1(6), CNTNAP2(8), CTLA4(1), ESAM(3), F11R(1), GLG1(4), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(3), ITGA6(3), ITGA8(5), ITGA9(4), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(6), ITGB2(4), ITGB7(4), ITGB8(4), JAM3(3), L1CAM(2), MAG(5), MPZL1(1), NCAM1(2), NCAM2(9), NEGR1(4), NEO1(4), NFASC(13), NLGN1(4), NLGN2(1), NLGN3(4), NRCAM(6), NRXN2(5), OCLN(1), PDCD1LG2(1), PECAM1(1), PTPRC(9), PTPRF(8), PTPRM(19), PVR(1), PVRL1(4), PVRL2(3), PVRL3(1), SDC2(2), SDC3(2), SDC4(1), SELE(2), SELP(4), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(7), VCAN(23)	31687795	360	86	354	139	115	81	5	111	44	4	0.117	0.976
75	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(2), GH1(1), GHR(6), IGF1(2), IGF1R(7), PIK3R1(5), SHC1(3), SOD2(4)	2486628	32	23	31	7	13	4	1	9	5	0	0.119	0.976
76	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(4), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(9), ZAP70(4)	2046111	29	19	29	8	7	10	2	3	5	2	0.123	0.977
77	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(2), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), NGFR(2), RAF1(4)	1778425	19	16	16	5	6	3	2	5	3	0	0.124	0.977
78	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(2), AKT1(2), ASAH1(3), CAV3(2), DAG1(4), DLG4(2), EPHB2(7), GNAI1(3), GNAQ(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PITX2(2), PTX3(2), RHO(2), RYR1(19)	8538809	100	48	99	45	50	16	4	22	8	0	0.125	0.977
79	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(6), MYL2(1), MYLK(11), NCF2(1), PAK1(4), PDGFRA(13), PIK3R1(5), PLD1(8), PPP1R12B(5), RALBP1(4), RPS6KB1(3), TRIO(12), VAV1(11), WASF1(1)	7273111	94	42	93	28	31	26	3	16	17	1	0.126	0.977
80	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CAT(2), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADHA(2), KMO(3), KYNU(6), MAOA(2), SDS(2), TDO2(2), TPH1(1), WARS(1), WARS2(2)	12169758	152	54	152	38	57	36	2	45	11	1	0.127	0.977
81	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(6), DIAPH1(1), FYN(4), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PIK3R1(5), PTK2(5), RAF1(4), ROCK1(8), SHC1(3), SRC(3), TLN1(5)	7853675	72	43	69	19	21	18	2	17	14	0	0.129	0.979
82	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	CDC25A(2), CDC25B(5), CDC25C(3), CHEK1(1), MYT1(8), WEE1(3)	1694314	22	17	22	3	6	6	0	8	2	0	0.130	0.980
83	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CSK(1), GRB2(2), PRKCA(2), PTPRA(2), SRC(3)	2105138	22	19	22	8	5	6	1	10	0	0	0.138	1.000
84	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(4), GRB2(2), KLK2(3), MAP2K1(3), MAPK3(2), MAPK8(2), NGFR(2), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(3), SOS1(5)	3797951	39	26	35	7	10	9	4	11	5	0	0.138	1.000
85	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(10), C5(9), C6(10), C7(2), ICAM1(2), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), SELP(4), SELPLG(1), VCAM1(7)	5463624	65	33	64	20	23	17	0	18	6	1	0.144	1.000
86	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	69	ARAF(3), C7orf16(4), CACNA1A(8), CRHR1(1), GNA11(1), GNA12(2), GNA13(2), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GNAZ(1), GRIA2(10), GRIA3(5), GRID2(10), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), IGF1(2), IGF1R(7), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), MAP2K1(3), MAPK1(2), MAPK3(2), NOS1(5), NOS3(2), NPR1(6), NPR2(9), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(4), RYR1(19)	22910303	273	79	270	106	117	64	6	66	20	0	0.151	1.000
87	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL15(1), IL16(5), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL9(1)	2172653	25	19	24	15	11	3	1	9	1	0	0.154	1.000
88	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(2), ARHGAP4(1), ARHGAP5(6), ARHGAP6(1), ARHGEF1(4), ARHGEF11(9), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(1), CFL1(1), DIAPH1(1), LIMK1(4), MYL2(1), MYLK(11), OPHN1(4), PIP5K1A(3), PIP5K1B(1), PPP1R12B(5), ROCK1(8), SRC(3), TLN1(5), VCL(1)	10247563	87	49	85	29	32	15	4	21	15	0	0.167	1.000
89	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(10), AR(4), ESR2(2), ESRRA(2), HNF4A(2), NR0B1(2), NR1D1(4), NR1D2(3), NR1H3(4), NR1I2(2), NR1I3(2), NR2C2(4), NR2E1(1), NR2F1(2), NR2F2(5), NR3C1(3), NR4A1(2), NR4A2(5), NR5A2(4), PGR(4), PPARA(1), PPARD(1), PPARG(1), RARB(7), RARG(5), ROR1(5), RORA(2), RORC(1), RXRA(1), RXRB(2), RXRG(3), THRA(2), THRB(4), VDR(1)	9180124	103	49	103	46	41	22	2	29	9	0	0.169	1.000
90	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(3), GNB1(1), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PIK3C2G(7), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), RELA(2)	5630720	51	32	50	14	20	10	2	8	11	0	0.170	1.000
91	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(4), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(7), IL3(3), KIT(6), KITLG(2), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	4200105	49	32	48	14	21	10	2	9	7	0	0.171	1.000
92	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(1), CKS1B(1), CUL1(7), RB1(4), SKP2(1), TFDP1(4)	1979499	23	18	23	3	4	2	1	11	4	1	0.179	1.000
93	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(3), BFAR(1), CREB1(1), CREB3(2), CREB5(2), MAPK1(2), RAF1(4), SNX13(6), SRC(3), TERF2IP(1)	2188441	25	16	24	11	7	8	0	5	5	0	0.180	1.000
94	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(4), GNA12(2), GNA13(2), GNAQ(3), GNB1(1), MYL2(1), MYLK(11), PLCB1(8), PPP1R12B(5), PRKCA(2), ROCK1(8)	4650654	53	30	51	14	13	10	3	15	12	0	0.180	1.000
95	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(10), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(3), QARS(7)	8826901	105	45	105	24	39	28	2	29	7	0	0.181	1.000
96	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(4), GNAS(6), GNB1(1), PPP2CA(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3353145	32	26	32	16	12	6	2	9	3	0	0.184	1.000
97	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(3), EGFR(10), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(2), PTPRB(4), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SPRY1(2), SPRY4(2), SRC(3)	5246046	52	31	50	19	17	15	4	12	4	0	0.184	1.000
98	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	132	ACTB(2), CHAD(6), COL11A1(18), COL11A2(10), COL17A1(6), COL1A1(11), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COMP(2), DES(1), DSC1(7), DSC2(2), DSC3(3), DSG1(6), DSG2(5), DSG3(8), DSG4(5), FN1(17), GJA1(3), GJA10(5), GJA4(2), GJA5(3), GJA8(4), GJA9(3), GJB1(3), GJB3(3), GJB4(1), GJB7(1), GJC1(4), GJC2(1), GJC3(1), GJD4(2), IBSP(3), INA(2), ITGA6(3), ITGB4(2), KRT1(3), KRT10(2), KRT12(1), KRT13(4), KRT15(1), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT23(1), KRT24(1), KRT25(3), KRT27(1), KRT28(1), KRT3(5), KRT31(4), KRT32(1), KRT33A(2), KRT33B(4), KRT34(4), KRT35(1), KRT36(2), KRT37(3), KRT4(2), KRT5(3), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(1), KRT71(3), KRT72(5), KRT73(2), KRT74(2), KRT75(5), KRT76(2), KRT77(1), KRT78(3), KRT79(2), KRT8(1), KRT81(1), KRT82(4), KRT83(1), KRT84(5), KRT85(5), KRT9(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), LMNB1(2), LMNB2(1), NES(6), PRPH(1), RELN(24), SPP1(1), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNXB(14), VIM(2), VTN(3), VWF(10)	52575166	611	113	608	236	243	143	8	164	53	0	0.186	1.000
99	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(1), CREBBP(21), EP300(13), FYN(4), IL7(1), IL7R(2), JAK1(3), JAK3(6), LCK(2), NMI(1), PIK3R1(5), PTK2B(1), STAT5B(2)	5811777	62	35	61	20	20	18	2	10	12	0	0.186	1.000
100	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), P2RY1(3), P2RY2(2)	1250559	17	14	17	4	7	4	1	4	1	0	0.188	1.000
101	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(9), HLA-DRA(4), HLA-DRB1(1), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	3166501	41	24	41	10	11	14	0	9	5	2	0.191	1.000
102	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(6), FCER1A(2), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PAK2(2), PIK3R1(5), PLA2G4A(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11)	8937546	89	43	87	22	33	19	5	18	14	0	0.191	1.000
103	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(4), AKT1(2), ASAH1(3), GNAI1(3), GNB1(1), ITGAV(1), ITGB3(7), MAPK1(2), MAPK3(2), PDGFA(1), PDGFRA(13), PIK3R1(5), PLCB1(8), PRKCA(2), PTK2(5), SMPD1(6), SRC(3)	5692241	68	33	68	23	22	17	3	16	9	1	0.194	1.000
104	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL11(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), PDGFA(1), TGFB1(1), TGFB2(5)	2979184	36	21	35	17	15	5	0	11	3	2	0.196	1.000
105	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	AXIN1(1), CCND2(1), CCND3(1), CTNNB1(8), DVL2(8), DVL3(2), FBXW2(2), FZD10(4), FZD2(2), FZD3(10), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LDLR(4), MAPK10(4), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), RHOA(4), SFRP4(3), TCF7(3), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2)	11692277	142	58	140	44	63	28	2	34	15	0	0.202	1.000
106	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), PAK1(4), PDGFRA(13), PIK3R1(5), WASL(5)	2527942	38	18	38	11	9	8	2	10	8	1	0.205	1.000
107	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(4), GRB2(2), IGF1(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3)	5028300	54	32	52	10	15	13	3	16	7	0	0.213	1.000
108	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(3), ACVR1C(2), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BMPR1A(4), BMPR1B(9), BMPR2(7), CHRD(5), COMP(2), CREBBP(21), CUL1(7), DCN(3), E2F4(1), E2F5(2), EP300(13), FST(2), GDF5(1), GDF6(2), IFNG(1), INHBB(1), INHBC(2), LTBP1(8), MAPK1(2), MAPK3(2), NODAL(1), PITX2(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), RBL1(3), RBL2(8), RHOA(4), ROCK1(8), ROCK2(2), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD3(6), SMAD9(2), SMURF1(1), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), THBS1(8), THBS2(10), THBS3(2), THBS4(1), ZFYVE16(9), ZFYVE9(6)	21093244	240	69	237	93	81	63	4	56	36	0	0.214	1.000
109	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), F2(2), FYN(4), GNA11(1), GNAI1(3), GNB1(1), GRB2(2), JAK2(6), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPT(4), MYLK(11), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), STAT1(6), STAT3(2), SYT1(1)	9462747	89	42	87	27	25	24	9	21	9	1	0.216	1.000
110	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), SOAT2(1), SRD5A1(1), SRD5A2(1)	5194000	65	33	65	11	20	18	1	23	3	0	0.216	1.000
111	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(3), ACTA2(3), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADM(2), ARRB1(1), ATF1(1), ATF3(1), ATP2A2(5), ATP2A3(3), CACNB3(1), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CORIN(10), CREB3(2), CRHR1(1), DGKZ(2), ETS2(2), GABPA(4), GABPB2(2), GBA2(5), GJA1(3), GNAQ(3), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), GSTO1(1), GUCA2B(2), IGFBP1(2), IGFBP2(1), IGFBP3(2), IGFBP4(2), IL6(1), ITPR1(11), ITPR2(12), ITPR3(11), MYL2(1), MYLK2(2), NFKB1(3), NOS1(5), NOS3(2), OXTR(2), PDE4B(2), PDE4D(3), PKIA(1), PKIB(1), PLCB3(3), PLCD1(6), PLCG1(4), PLCG2(9), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCH(2), PRKCQ(4), PRKD1(10), RAMP1(1), RAMP3(3), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR3(31), SLC8A1(11), SP1(2), TNXB(14), USP5(3), YWHAB(2), YWHAQ(1)	34879115	380	92	376	144	172	75	11	88	34	0	0.216	1.000
112	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(5), BAD(1), BCR(6), BTK(6), CD19(3), CSK(1), DAG1(4), EPHB2(7), GRB2(2), ITPKB(4), LYN(4), MAP2K1(3), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), RAF1(4), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), VAV1(11)	11259569	118	52	114	33	47	24	7	28	12	0	0.217	1.000
113	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), DAG1(4), FN1(17), FNDC1(15), FNDC3A(5), FNDC4(1), GP1BA(1), GP5(5), GP6(1), HMMR(4), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), RELN(24), SDC2(2), SDC3(2), SDC4(1), SPP1(1), SV2A(4), SV2B(4), SV2C(4), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNXB(14), VTN(3), VWF(10)	48018909	549	105	546	223	200	127	10	156	56	0	0.221	1.000
114	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	144	AKT1(2), AKT2(5), BCL2L1(1), CBL(2), CBLB(6), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(21), CSF2RB(7), CSF3R(9), EP300(13), GH1(1), GH2(1), GHR(6), GRB2(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL13RA2(2), IL15(1), IL15RA(1), IL19(1), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), IRF9(3), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), MPL(1), OSM(1), OSMR(4), PIAS1(3), PIAS2(2), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIM1(1), PRL(2), PRLR(2), PTPN11(2), PTPN6(4), SOCS2(2), SOCS5(2), SOS1(5), SOS2(9), SPRED1(6), SPRED2(5), SPRY1(2), SPRY4(2), STAM(1), STAM2(2), STAT1(6), STAT2(5), STAT3(2), STAT5B(2), STAT6(2), TPO(8), TSLP(2), TYK2(1)	30763055	323	79	318	93	118	66	11	91	36	1	0.222	1.000
115	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC2(1), AXIN1(1), AXIN2(7), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(4), CREBBP(21), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(8), CTNNBIP1(1), CUL1(7), CXXC4(1), DAAM1(1), DAAM2(5), DKK1(3), DKK2(5), DKK4(4), DVL2(8), DVL3(2), EP300(13), FBXW11(7), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LEF1(4), LRP5(5), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(2), MAPK9(3), MMP7(3), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PORCN(2), PPARD(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(5), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PSEN1(3), RHOA(4), ROCK1(8), ROCK2(2), RUVBL1(6), SENP2(2), SFRP1(2), SFRP2(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD3(6), SOX17(2), TBL1X(5), TBL1XR1(6), TCF7(3), TCF7L1(3), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1)	33252499	388	89	384	112	159	84	7	93	45	0	0.230	1.000
116	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDK2(2), CUL1(7), RB1(4), TFDP1(4)	1565322	20	15	20	3	4	2	1	9	3	1	0.230	1.000
117	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8)	1812945	24	20	23	10	13	3	0	4	4	0	0.234	1.000
118	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(21), EP300(13), HDAC3(2), IKBKB(2), NFKB1(3), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	5112898	55	32	55	17	20	19	2	7	7	0	0.235	1.000
119	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), CHST1(6), CHST2(1), CHST4(5), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2751228	42	27	42	12	25	7	0	7	3	0	0.238	1.000
120	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8), TYR(2)	2094617	26	21	25	11	13	3	0	6	4	0	0.240	1.000
121	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(7), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTR(6)	3945731	47	29	44	10	23	8	1	8	7	0	0.247	1.000
122	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(21), EP300(13), NCOA3(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RXRA(1)	4603883	51	31	51	12	15	20	2	8	6	0	0.250	1.000
123	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(10), PPP1R1B(1)	814862	13	11	13	3	6	3	0	3	1	0	0.252	1.000
124	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(6), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8IP3(1), PAPPA(13), RPS6KA1(1), RPS6KA3(3), SHC1(3), SOS1(5), VAV1(11), VAV2(2), VAV3(10)	7169485	74	38	72	20	30	13	5	20	6	0	0.253	1.000
125	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4)	3887230	44	23	44	15	14	9	0	13	7	1	0.253	1.000
126	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), DAG1(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFAT5(5), PDE6A(6), PDE6B(5), PDE6C(8), PDE6D(1), SLC6A13(5), TF(7)	7648862	86	38	86	26	35	13	7	23	8	0	0.254	1.000
127	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(3), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), L2HGDH(3), OXCT1(3), PDHA1(4), PDHA2(6), PDHB(2), SDHB(2), SDS(2)	5884604	82	36	82	14	31	20	0	25	6	0	0.255	1.000
128	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNB1(3), CHRNG(2), MUSK(2), PIK3R1(5), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2)	3117935	28	23	28	14	9	6	1	3	9	0	0.255	1.000
129	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(1), FARSB(7), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2), YARS2(3)	1991988	30	18	30	5	10	6	1	8	5	0	0.255	1.000
130	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CHUK(4), MAP2K1(3), MAPK3(2), NFKB1(3), PIK3R1(5), RAF1(4), RALBP1(4), RALGDS(1), RELA(2), RHOA(4)	3844131	38	26	37	8	17	8	3	3	7	0	0.258	1.000
131	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), UGDH(3), UXS1(6)	852892	12	10	12	4	5	3	0	3	1	0	0.260	1.000
132	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(6), AGT(4), AGTR2(4), EDN1(1), EDNRA(4), EDNRB(7), EGF(3), EGFR(10), NFKB1(3), PLCG1(4), PRKCA(2), RELA(2)	4651612	50	31	50	16	22	9	0	14	5	0	0.262	1.000
133	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	63	ADCY1(4), ADCY8(11), ARAF(3), CACNA1C(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CREBBP(21), EP300(13), GNAQ(3), GRIA2(10), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), ITPR1(11), ITPR2(12), ITPR3(11), MAP2K1(3), MAPK1(2), MAPK3(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(3), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5)	20936197	250	69	249	97	107	62	9	48	24	0	0.263	1.000
134	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(2), EIF4A2(4), EIF4G1(8), EIF4G2(7), EIF4G3(8), GHR(6), IRS1(5), MAPK1(2), MAPK14(3), MAPK3(2), MKNK1(1), PABPC1(3), PDK2(1), PDPK1(1), PIK3R1(5), PRKCA(2), PTEN(6), RPS6KB1(3)	5790690	69	34	67	16	17	17	1	23	10	1	0.263	1.000
135	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(7), PC(3), PDHA1(4), SLC25A11(1)	2053472	20	19	20	5	8	5	0	3	4	0	0.264	1.000
136	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(21), DUSP1(2), EP300(13), IKBKB(2), MAP2K3(2), MAP2K6(2), MAP3K14(2), MAP3K7(2), MAPK14(3), MYD88(1), NFKB1(3), NR3C1(3), RELA(2), TGFBR1(6), TGFBR2(7), TLR2(2)	6669795	77	36	76	27	26	20	4	18	9	0	0.268	1.000
137	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), ST3GAL6(4), ST8SIA1(3)	3496006	47	27	47	10	20	8	2	13	4	0	0.270	1.000
138	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(5), CDKN1A(1), GRB2(2), MAP2K1(3), NGFR(2), NTRK1(6), PIK3CD(2), SHC1(3), SOS1(5)	3156280	31	23	30	10	9	5	5	8	4	0	0.277	1.000
139	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(4), RBL1(3), TFDP1(4)	3577268	36	26	36	9	11	7	1	13	3	1	0.278	1.000
140	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), CREB1(1), GRB2(2), MAPK1(2), MAPK3(2), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NTRK1(6), PIK3R1(5), PLCG1(4), RPS6KA1(1), SHC1(3)	3666946	42	25	41	13	14	11	2	9	6	0	0.279	1.000
141	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), DBH(4), DCT(9), DDC(1), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), MAOA(2), TAT(3), TPO(8), TYR(2)	6890114	84	40	83	35	35	19	2	25	3	0	0.279	1.000
142	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CARS2(1), CDO1(1), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(3), SULT4A1(1)	2869834	31	20	29	3	13	7	1	7	3	0	0.283	1.000
143	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(7), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), CASP8AP2(12), CASP9(2), CES1(4)	2327323	36	21	36	8	11	5	0	13	7	0	0.285	1.000
144	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), GRB2(2), IL3(3), JAK2(6), MAP2K1(3), MAPK3(2), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	3740633	41	24	38	9	17	7	4	8	4	1	0.288	1.000
145	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(21), EP300(13), LPL(6), NCOA1(6), NCOA2(4), PPARG(1), RXRA(1)	3981028	52	26	52	18	13	20	3	9	7	0	0.290	1.000
146	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(4), GNAS(6), GNB1(1), PRKAR1A(1)	1425557	12	12	12	8	5	3	1	3	0	0	0.291	1.000
147	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(3), JAK2(6), JAK3(6), PIAS1(3), PIAS3(4), PTPRU(6), REG1A(3), SOAT1(1)	3010939	32	22	30	11	15	7	1	3	5	1	0.294	1.000
148	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(2), AASS(7), KARS(3)	1089983	13	10	13	2	4	2	0	5	2	0	0.295	1.000
149	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	3973236	47	29	47	10	14	8	1	19	5	0	0.298	1.000
150	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), CAD(10), CRAT(3), DARS(3), DDO(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), PC(3)	5858433	68	38	68	18	31	16	0	17	4	0	0.299	1.000
151	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(3), CALCRL(5), CD97(3), CRHR1(1), CRHR2(4), ELTD1(5), EMR1(5), EMR2(2), GHRHR(2), GLP1R(2), GLP2R(3), GPR64(5), LPHN1(3), LPHN2(10), LPHN3(10), SCTR(3), VIPR1(3), VIPR2(3)	5936337	73	35	71	25	25	14	1	24	9	0	0.300	1.000
152	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGAP4(1), ARHGEF11(9), BTK(6), CFL1(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(11), ITPR2(12), ITPR3(11), LIMK1(4), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CD(2), PIK3CG(12), PIK3R1(5), PITX2(2), PPP1R13B(5), PTEN(6), RACGAP1(2), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), SAG(1), WASF1(1), WASL(5)	14719075	159	56	158	52	54	34	6	44	20	1	0.303	1.000
153	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), XDH(7)	1773025	23	15	23	9	6	7	1	6	3	0	0.305	1.000
154	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(4), AGTR1(3), AGTR2(4), BDKRB2(2), KNG1(3), NOS3(2), REN(3)	2194883	23	19	23	5	8	5	0	6	4	0	0.307	1.000
155	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(1), IL11(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), IL9(1)	1411652	16	12	15	4	7	3	0	5	1	0	0.307	1.000
156	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG6(3), ALG8(5), ALG9(1), B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(6), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHST2(1), CHST4(5), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(1), EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), FUT8(1), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GANAB(4), GCNT1(3), GCNT3(2), GCNT4(5), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4), OGT(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), XYLT1(4), XYLT2(2)	24224704	272	75	271	78	107	62	7	69	27	0	0.308	1.000
157	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), MTHFR(6), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8)	2537296	33	23	32	10	18	5	0	7	3	0	0.308	1.000
158	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	166939	2	2	2	0	1	0	0	0	1	0	0.308	1.000
159	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(4), PLCD1(6), PRKCA(2), TGM2(4)	1129699	16	11	16	4	6	2	1	6	1	0	0.309	1.000
160	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ARHGAP5(6), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), CXCL12(1), CXCR4(3), CYBB(1), ESAM(3), EZR(2), F11R(1), GNAI1(3), GRLF1(7), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), ITK(8), JAM3(3), MAPK12(2), MAPK14(3), MLLT4(3), MMP2(2), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(1), NCF2(1), NCF4(2), NOX1(1), NOX3(5), OCLN(1), PECAM1(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), PTK2B(1), PTPN11(2), RAP1A(1), RAP1B(2), RAPGEF3(3), RAPGEF4(7), RASSF5(3), RHOA(4), RHOH(2), ROCK1(8), ROCK2(2), SIPA1(1), TXK(4), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCAM1(7), VCL(1)	26878094	303	79	298	87	122	61	6	72	42	0	0.309	1.000
161	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(3), GNB1(1), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), PLA2G4A(5), PLCB1(8), PRKCA(2), PTGS1(4), PTK2(5), RAF1(4), SRC(3), TBXAS1(5)	5577911	58	32	57	17	23	13	2	17	3	0	0.317	1.000
162	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	1810012	27	19	27	4	14	6	0	5	2	0	0.322	1.000
163	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(14), CPT1A(5), LEP(1), LEPR(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2)	3310353	38	23	38	13	13	8	0	12	5	0	0.322	1.000
164	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3), TPI1(1)	351993	4	4	4	0	0	0	0	4	0	0	0.323	1.000
165	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(1), BECN1(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(5), PIK3R4(12), PRKAA1(2), PRKAA2(6), ULK2(4), ULK3(3)	4664018	59	28	59	14	11	17	2	26	3	0	0.326	1.000
166	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(2), F3(1), F5(14), F7(2), FGA(11), FGB(1), FGG(4), PROC(1), PROS1(3), SERPINC1(3)	3699195	43	24	43	10	9	11	1	18	4	0	0.326	1.000
167	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3)	5432175	63	31	63	22	22	16	3	18	4	0	0.329	1.000
168	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCR1(5), CCR3(3), CCR5(1), CCR7(1), CD28(1), CD4(2), CXCR4(3), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL2(3), IL4(3), IL4R(1), TGFB1(1), TGFB2(5)	4079139	42	25	43	25	11	14	0	13	4	0	0.329	1.000
169	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(4), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(6), GRB2(2), MAPK1(2), MAPK14(3), MAPK3(2), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RPS6KA1(1), RPS6KA5(3), SOS1(5)	5999120	52	32	52	20	17	9	6	16	4	0	0.330	1.000
170	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME3(4), PGK1(3), PGK2(6), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(4), TKTL2(5), TPI1(1)	4448432	59	32	59	14	19	11	0	23	6	0	0.330	1.000
171	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNA2(3), CCNE1(3), CCNE2(1), CDK2(2), CDK4(2), CDKN1B(1), CDKN2A(1), E2F2(1), E2F4(1)	1943874	19	16	19	4	6	3	0	9	1	0	0.333	1.000
172	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(4), CFTR(8), GNAS(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(3)	2834468	28	23	28	10	10	4	1	10	3	0	0.333	1.000
173	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), BCR(6), CAPN1(2), CAPNS1(1), CAPNS2(1), CRKL(2), CSK(1), FYN(4), GRB2(2), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MAPK8(2), PPP1R12B(5), PTK2(5), RAF1(4), RAP1A(1), ROCK1(8), SHC1(3), SOS1(5), SRC(3), TLN1(5), VCL(1)	10350397	92	48	89	29	38	22	3	22	7	0	0.339	1.000
174	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(5), NR1I3(2), PTGS1(4), PTGS2(2)	1190438	15	12	15	2	7	4	0	4	0	0	0.350	1.000
175	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(4), GTF2H4(1), GTF2IRD1(8), TAF1(7), TAF1L(16), TAF2(6), TAF4(4), TAF4B(4), TAF5(3), TAF5L(1), TAF6(2), TAF6L(2), TAF7(1), TAF7L(3), TAF9B(1), TBPL1(1), TBPL2(1)	8143764	78	41	78	21	30	17	1	24	6	0	0.350	1.000
176	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(2), JAK1(3), JAK2(6), JAK3(6), PIAS3(4), PTPRU(6), REG1A(3), SRC(3), STAT3(2)	3429621	36	24	34	16	17	10	1	4	3	1	0.352	1.000
177	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(6), CREB1(1), CTSB(2), CTSL1(3), CTSS(2), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KIR3DL3(4), KLRC3(2), KLRC4(1), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), NFYC(3), PDIA3(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(4), TAPBP(3)	10267263	107	41	104	30	21	27	5	32	17	5	0.356	1.000
178	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(4), ATR(13), CCNA1(4), CCNE1(3), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), GSK3B(7), HDAC1(2), RB1(4), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(5)	5148613	58	29	58	11	20	11	2	16	8	1	0.358	1.000
179	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(7), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP9(2), CD40LG(6), CRADD(1), DFFA(2), DFFB(2), FASLG(1), IKBKE(3), NFKB1(3), NGFR(2), NR3C1(3), NTRK1(6), PTPN13(8), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4), TRAF6(4)	9415263	86	44	85	40	27	16	4	27	11	1	0.359	1.000
180	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(4), GRB2(2), INSR(5), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SLC2A4(3), SOS1(5), SRF(3)	5201403	53	32	51	16	12	14	3	17	7	0	0.359	1.000
181	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(3), EGF(3), EGFR(10), GRB2(2), MET(4), PDGFRA(13), PRKCA(2), SH3GLB1(3), SH3GLB2(2), SH3KBP1(4), SRC(3)	4379823	51	25	51	25	14	12	3	17	4	1	0.359	1.000
182	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4)	3197661	37	25	36	11	17	6	0	8	6	0	0.366	1.000
183	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12B(2), IL2(3)	665213	8	6	8	5	0	3	0	5	0	0	0.370	1.000
184	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(1), HLA-DRA(4), HLA-DRB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL2(3), IL2RA(2), IL4(3), IL4R(1)	2556813	28	17	28	11	10	7	0	8	1	2	0.373	1.000
185	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), GNAS(6), GNB1(1), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3R1(5), RELA(2), SYT1(1)	3517726	26	22	26	13	9	2	2	7	6	0	0.374	1.000
186	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(6), ADCY4(9), ADCY6(1), ADCY8(11), CACNA1A(8), CACNA1B(7), GNAS(6), GNAT3(1), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(11), KCNB1(2), PDE1A(3), PLCB2(3), PRKACB(1), PRKACG(2), PRKX(2), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(6), TAS1R2(5), TAS2R1(1), TAS2R10(3), TAS2R13(3), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R41(1), TAS2R46(1), TAS2R5(1), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(1)	11915572	129	53	129	46	52	24	3	40	10	0	0.375	1.000
187	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(6), PARK2(4), SNCA(1), SNCAIP(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	1454834	17	13	17	7	5	5	0	6	1	0	0.379	1.000
188	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), GRB2(2), JAK1(3), MAP2K1(3), MAP3K1(6), MAPK3(2), MAPK8(2), PDGFA(1), PDGFRA(13), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2)	7087810	75	34	72	22	22	19	5	17	11	1	0.380	1.000
189	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(6), DBH(4), DDC(1), GAD1(7), GAD2(4), HDC(3), MAOA(2), PAH(4), SLC18A3(6), TPH1(1)	3220226	38	26	38	18	16	10	1	10	1	0	0.381	1.000
190	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(1), APOBEC3G(2), APOBEC4(2)	1633065	18	14	18	3	7	4	0	5	2	0	0.381	1.000
191	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(2), HBXIP(2), PTK2B(1), SHC1(3), SOS1(5), SRC(3)	1995497	17	15	16	6	2	4	2	6	3	0	0.382	1.000
192	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(7), ARHGAP5(6), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(1), CASP9(2), GZMB(1)	2588916	24	20	23	9	4	4	0	10	6	0	0.383	1.000
193	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), NCKAP1(8), NTRK1(6), WASF1(1), WASF2(2), WASF3(2), WASL(5)	3437407	38	24	38	9	12	9	2	11	4	0	0.383	1.000
194	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(7), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTFMT(1), MTR(6), TAT(3)	4665290	51	31	48	13	24	10	1	8	8	0	0.383	1.000
195	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GSS(4), GSTA1(1), GSTA3(3), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), MGST1(2), MGST3(1), PGD(1)	3787686	47	26	45	6	7	15	2	18	5	0	0.383	1.000
196	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(4), ARHGEF1(4), F2(2), GNA12(2), GNA13(2), GNAI1(3), GNAQ(3), GNB1(1), MAP3K7(2), PIK3R1(5), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2B(1), ROCK1(8)	5357040	52	29	51	17	16	7	2	17	10	0	0.388	1.000
197	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(5), BTK(6), FCER1A(2), FYN(4), GAB2(1), GRB2(2), IL13(1), IL3(3), IL4(3), INPP5D(2), LCP2(2), LYN(4), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MS4A2(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PRKCA(2), PRKCD(3), PRKCE(4), RAF1(4), SOS1(5), SOS2(9), VAV1(11), VAV2(2), VAV3(10)	15222573	158	56	154	43	60	36	7	41	14	0	0.389	1.000
198	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(4), EPHB1(6), FYN(4), ITGA1(3), ITGB1(6), L1CAM(2), LYN(4), RAP1B(2), SELP(4)	3376427	38	23	38	8	14	12	0	9	3	0	0.390	1.000
199	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	BMPR1B(9), CCND2(1), CDK4(2), CDKN1B(1), DAZL(1), DMC1(3), EGR1(2), ESR2(2), FSHR(6), GJA4(2), INHA(2), LHCGR(4), MLH1(5), MSH5(4), NCOR1(7), NRIP1(5), PGR(4), PRLR(2), PTGER2(1), SMPD1(6), VDR(1), ZP2(6)	6470356	76	34	76	24	25	17	1	22	11	0	0.392	1.000
200	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(3), SHMT1(1), SHMT2(2)	820800	9	9	7	4	2	4	0	0	3	0	0.392	1.000
201	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHB(1), LDHC(2)	1549666	16	13	16	2	7	4	0	3	2	0	0.393	1.000
202	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(5), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(7)	2546207	23	17	23	3	6	7	2	3	5	0	0.396	1.000
203	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(1), IL9(1), KITLG(2), TGFB1(1), TGFB2(5)	1903197	20	16	19	8	8	1	0	8	3	0	0.396	1.000
204	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(2), HGD(1)	380018	4	3	4	3	0	1	0	2	1	0	0.406	1.000
205	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(6), DLG4(2), EPHB2(7), F2(2), F2RL2(2), MAP2K5(2), MAPK1(2), MAPK7(3), MAPK8(2), MYEF2(7), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RAF1(4), RASAL1(1), SRC(3), TEC(1), VAV1(11)	6158399	74	36	72	24	36	18	1	14	5	0	0.407	1.000
206	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), AKT2(5), BCR(6), BTK(6), CD19(3), CDKN2A(1), DAPP1(1), FLOT1(3), GAB1(6), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), PHF11(2), PITX2(2), PLCG2(9), PPP1R13B(5), PREX1(14), PTEN(6), PTPRC(9), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SAG(1), TEC(1), VAV1(11)	11427664	146	49	143	46	58	33	4	33	17	1	0.412	1.000
207	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1)	1454764	14	12	14	4	4	3	1	4	2	0	0.412	1.000
208	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), NFYC(3), RB1(4), SP1(2), SP3(2)	1533323	13	11	13	3	2	4	1	5	0	1	0.415	1.000
209	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCNE1(3), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(2), NFKB1(3), PAK1(4), PIK3R1(5), RAF1(4), RB1(4), RELA(2), TFDP1(4)	4122396	42	25	41	8	11	10	2	12	6	1	0.415	1.000
210	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(3), FARS2(4), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2)	1909324	25	17	25	5	8	8	0	6	3	0	0.417	1.000
211	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(1), BCL2(1), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFKB1(3), NSMAF(1), RAF1(4), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	4171474	39	25	38	10	19	10	2	5	3	0	0.417	1.000
212	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), GORASP1(3), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4)	6800824	56	36	56	19	15	11	0	19	11	0	0.417	1.000
213	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), KARS(3)	1599415	16	12	16	5	5	3	0	6	2	0	0.418	1.000
214	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GCNT1(3), GCNT3(2), GCNT4(5), OGT(4), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2)	7013495	83	36	83	22	32	20	1	18	12	0	0.423	1.000
215	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), BAD(1), CREB1(1), CREB3(2), CREB5(2), DUSP4(1), DUSP6(4), DUSP9(1), GRB2(2), MAP2K1(3), MAP3K8(2), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(5), SOS2(9), TRAF3(4)	6435621	66	34	65	21	20	16	3	16	11	0	0.426	1.000
216	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(5), CD14(1), CD19(3), CD1A(2), CD1D(1), CD2(3), CD22(8), CD33(1), CD34(1), CD36(1), CD37(2), CD38(1), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(2), CD55(3), CD7(1), CD8B(2), CD9(1), CR1(7), CR2(9), CSF1(1), CSF1R(3), CSF3R(9), DNTT(5), FCER2(1), FCGR1A(1), FLT3(3), FLT3LG(1), GP1BA(1), GP5(5), GYPA(1), HLA-DRA(4), HLA-DRB1(1), IL11(1), IL11RA(1), IL1A(1), IL1R1(3), IL1R2(3), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL7(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGAM(5), ITGB3(7), KIT(6), KITLG(2), MME(6), MS4A1(4), TFRC(2), THPO(1), TPO(8)	17608577	194	59	191	59	76	39	3	58	16	2	0.427	1.000
217	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(5), GOT2(1), TAT(3), TYR(2)	1077195	12	10	12	5	5	3	0	3	1	0	0.428	1.000
218	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(3)	471201	5	5	5	2	3	1	0	0	1	0	0.429	1.000
219	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(3), CRKL(2), DOCK1(5), GAB1(6), GRB2(2), HGF(5), ITGA1(3), ITGB1(6), MAP2K1(3), MAP4K1(2), MAPK1(2), MAPK3(2), MAPK8(2), MET(4), PAK1(4), PIK3R1(5), PTEN(6), PTK2(5), PTK2B(1), PTPN11(2), RAF1(4), RAP1A(1), RAP1B(2), RASA1(5), SOS1(5), SRC(3), STAT3(2)	9257961	92	39	90	24	22	29	3	25	12	1	0.436	1.000
220	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), DAG1(4), DGKA(1), ETFA(2), ITGA9(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), MAP2K1(3), MAPK1(2), MAPK3(2), NR1I3(2), PAK1(4), PDE3A(5), PDE3B(2), PIK3C2G(7), PIK3CD(2), PIK3R1(5), PLDN(1), RIPK3(4), RPS4X(1), VASP(3)	9949411	105	44	105	34	38	21	6	22	18	0	0.438	1.000
221	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(5), GOT2(1), TAT(3)	607023	9	7	9	1	4	3	0	1	1	0	0.439	1.000
222	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(2)	344910	5	4	5	0	0	2	0	2	1	0	0.441	1.000
223	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(4), SPCS1(1)	694979	7	7	6	2	4	0	0	1	2	0	0.441	1.000
224	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), CREB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NFKB1(3), PIK3R1(5), RB1(4), RELA(2), SP1(2)	3898591	39	22	39	10	12	9	3	8	6	1	0.442	1.000
225	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(6), NRG2(4), NRG3(3), PRKCA(2), PSEN1(3)	1439981	18	13	18	2	6	5	0	4	3	0	0.442	1.000
226	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(2), MMP9(6), RECK(3), TIMP1(1), TIMP2(2), TIMP3(2), TIMP4(2)	1689618	22	16	22	5	13	3	2	4	0	0	0.445	1.000
227	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(2), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(4), EPHB2(7), GRAP2(2), GRB2(2), ITK(8), ITPKB(4), LCK(2), LCP2(2), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLCG1(4), PTPRC(9), RAF1(4), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), SOS1(5), SOS2(9), VAV1(11), ZAP70(4)	11944552	124	48	121	48	47	29	8	32	8	0	0.445	1.000
228	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(4)	960843	8	8	8	5	6	1	0	1	0	0	0.446	1.000
229	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(1), CFL1(1), CFLAR(2), PDE6D(1)	598787	6	6	6	2	2	0	0	4	0	0	0.450	1.000
230	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(3)	1916590	24	17	24	5	9	7	0	6	2	0	0.458	1.000
231	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATR(13), CDC25C(3), CHEK1(1), CHEK2(1)	2051792	18	13	18	1	6	3	2	4	3	0	0.460	1.000
232	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1)	11374491	121	47	120	44	44	24	2	38	13	0	0.466	1.000
233	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1)	11374491	121	47	120	44	44	24	2	38	13	0	0.466	1.000
234	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(10), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GLS2(2), GLUD1(2), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(3), QARS(7)	7443276	94	37	94	17	31	26	2	28	7	0	0.466	1.000
235	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(6), AXIN1(1), BTRC(2), CTNNB1(8), DLL1(1), GSK3B(7), PSEN1(3), WNT1(1)	3302540	29	20	29	9	11	7	0	5	6	0	0.467	1.000
236	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), WASF1(1), WASL(5)	1805655	20	15	20	5	7	5	1	6	1	0	0.468	1.000
237	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(3), ALG6(3), CCKBR(3), CCR3(3), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(5), CHRM3(4), EDNRA(4), EMR2(2), EMR3(7), FSHR(6), GHRHR(2), GNRHR(4), GPR116(7), GPR132(1), GPR133(7), GPR143(2), GPR17(1), GPR55(1), GPR56(1), GPR61(4), GPR77(1), GPR84(3), GPR88(1), GRM1(9), GRPR(3), HRH4(2), LPHN2(10), LPHN3(10), NTSR1(1), OR8G2(1), P2RY13(2), PTGFR(6), SSTR2(2), TAAR5(5), TSHR(6), VN1R1(4)	14115199	153	57	150	60	60	30	3	45	15	0	0.477	1.000
238	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	1805955	28	17	28	3	12	8	0	8	0	0	0.479	1.000
239	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	1805955	28	17	28	3	12	8	0	8	0	0	0.479	1.000
240	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(5), BCL10(3), CARD11(6), CBL(2), CBLB(6), CD247(2), CD28(1), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDK4(2), CHUK(4), CTLA4(1), FYN(4), GRAP2(2), GRB2(2), ICOS(1), IFNG(1), IKBKB(2), IL10(1), IL2(3), IL4(3), ITK(8), LCK(2), LCP2(2), MALT1(6), MAP3K14(2), MAP3K8(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCQ(4), PTPN6(4), PTPRC(9), RASGRP1(2), RHOA(4), SOS1(5), SOS2(9), TEC(1), VAV1(11), VAV2(2), VAV3(10), ZAP70(4)	21911612	229	66	227	85	85	48	10	60	26	0	0.482	1.000
241	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(3), PLCB1(8), PRKCA(2), RELA(2)	1890394	18	14	18	5	6	3	0	6	3	0	0.484	1.000
242	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(9), CAMK2B(2), CAMK4(2), CD3G(2), CDKN1A(1), CNR1(3), CREBBP(21), CSNK2A1(4), CSNK2B(2), CTLA4(1), EGR2(6), EGR3(2), EP300(13), FCER1A(2), GATA3(4), GATA4(1), GRLF1(7), GSK3A(2), GSK3B(7), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL13(1), IL2(3), IL2RA(2), IL3(3), IL4(3), IL6(1), ITK(8), KPNA5(4), MAPK14(3), MAPK8(2), MAPK9(3), MEF2A(3), MEF2D(1), MYF5(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB2(2), NFKBIB(1), NFKBIE(2), NUP214(4), OPRD1(1), P2RX7(2), PAK1(4), PIN1(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PTPRC(9), RELA(2), SLA(4), SP1(2), SP3(2), TGFB1(1), TRAF2(1), TRPV6(9), VAV1(11), VAV2(2), VAV3(10)	19966925	234	64	230	77	84	63	6	53	28	0	0.484	1.000
243	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), HSD3B7(2), LIPA(1), RDH12(2), RDH13(1), SLC27A5(3), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(1)	7061346	71	36	71	20	20	21	2	23	5	0	0.492	1.000
244	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(2), SP3(2), WT1(4)	1394754	11	10	11	3	6	3	1	1	0	0	0.495	1.000
245	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(5), BPNT1(1), GRB2(2), MAPK1(2), MAPK3(2), PIK3CD(2), PTEN(6), PTK2B(1), RBL2(8), SHC1(3), SOS1(5)	4085447	39	22	37	11	11	7	3	9	8	1	0.496	1.000
246	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), CD36(1), FYN(4), MAPK14(3), THBS1(8)	1625380	17	14	17	7	5	6	0	4	2	0	0.501	1.000
247	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(5), BAD(1), BCL2(1), BCR(6), BTK(6), CD19(3), CD22(8), CR2(9), CSK(1), DAG1(4), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), INPP5D(2), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(2), NFATC1(1), NFATC2(3), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PTPRC(9), RAF1(4), SHC1(3), SOS1(5), SOS2(9), VAV1(11)	15494572	180	56	177	48	68	39	7	41	25	0	0.503	1.000
248	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(6), GRB2(2), INSR(5), IRS1(5), JAK2(6), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(4), RAF1(4), RPS6KA1(1), SHC1(3), SLC2A4(3), SOS1(5), SRF(3), STAT5B(2)	6929739	68	34	66	25	24	11	4	22	6	1	0.503	1.000
249	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(5), ASAH1(3), DAG1(4), DRD2(3), EGFR(10), EPHB2(7), GRB2(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), RAF1(4), RGS20(3), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT3(2), TERF2IP(1)	12452362	144	52	141	48	58	30	7	38	11	0	0.504	1.000
250	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(4)	1267882	13	12	13	4	6	3	0	4	0	0	0.506	1.000
251	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), ARSD(3), ARSE(2), CARM1(2), CYP11B1(5), CYP11B2(5), CYP19A1(5), HSD11B1(1), HSD17B12(2), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), WBSCR22(1)	10482985	110	44	109	24	35	26	3	30	16	0	0.510	1.000
252	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(2), SNAP25(1), STX1A(2)	729912	8	8	8	4	6	1	0	1	0	0	0.515	1.000
253	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	23	ASAH1(3), CASP3(1), CERK(1), CREB1(1), CREB3(2), CREB5(2), DAG1(4), EPHB2(7), GNAQ(3), ITPKB(4), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3)	4882114	42	26	41	18	12	10	2	12	6	0	0.515	1.000
254	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), SDS(2)	2761561	36	21	36	4	15	10	0	8	3	0	0.518	1.000
255	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), AKAP10(2), AKAP11(4), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(10), AKAP7(2), AKAP8(3), AKAP9(20), ARHGEF1(4), GNA11(1), GNA12(2), GNA13(2), GNA14(5), GNA15(3), GNAL(3), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG7(1), ITPR1(11), KCNJ3(6), PDE1A(3), PDE1B(2), PDE1C(7), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PLCB3(3), PPP3CA(1), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), PRKD3(6), RHOA(4), SLC9A1(2), USP5(3)	25696558	272	71	268	108	107	58	10	65	31	1	0.519	1.000
256	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2)	2085116	17	16	17	6	7	1	2	6	1	0	0.521	1.000
257	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3D(1), CD3G(2), FYN(4), GRB2(2), LCK(2), MAP2K1(3), MAP3K1(6), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PIK3R1(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(4), RASA1(5), RELA(2), SHC1(3), SOS1(5), SYT1(1), VAV1(11), ZAP70(4)	10000745	94	42	92	29	36	16	6	17	19	0	0.522	1.000
258	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), B3GALT5(2), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	2387145	25	16	25	8	8	6	0	6	5	0	0.523	1.000
259	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(1), IL6(1), LDLR(4), LPL(6)	1189147	13	10	13	2	3	3	0	5	2	0	0.523	1.000
260	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(5), IARS2(6), ILVBL(2), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2), VARS(1), VARS2(6)	4151357	40	25	40	8	18	10	0	6	6	0	0.523	1.000
261	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(4), FBL(3), LDHA(1), LDHB(1), LDHC(2), MAPK14(3), NCL(2)	2012341	21	16	21	10	9	4	1	6	1	0	0.525	1.000
262	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(2), PDE1A(3), PDE1B(2), PLCB1(8), PLCB2(3), PRL(2), TRH(1)	2249955	21	16	21	8	9	6	0	4	2	0	0.527	1.000
263	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(2), CHUK(4), GH1(1), GHR(6), NFKB1(3), PDPK1(1), PIK3R1(5), PPP2CA(1), RELA(2)	2731547	28	18	28	8	9	5	1	8	5	0	0.528	1.000
264	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), EGF(3), EGFR(10), GRB2(2), JAK1(3), MAP2K1(3), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2)	7715443	74	36	71	21	27	17	4	18	8	0	0.528	1.000
265	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	CPEB1(2), EGFR(10), ERBB2(6), ETS2(2), ETV6(4), FMN2(4), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(2), NOTCH2(11), NOTCH3(12), NOTCH4(3), PIWIL1(5), PIWIL2(6), PIWIL3(8), PIWIL4(6), RAF1(4), SOS1(5), SOS2(9), SPIRE1(2), SPIRE2(1)	10813674	109	49	107	35	41	27	3	32	6	0	0.532	1.000
266	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(5), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2)	2253000	24	15	24	4	9	6	0	5	4	0	0.533	1.000
267	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), NFKB1(3), NOX1(1), RELA(2), XDH(7)	2280177	19	15	19	6	5	7	1	3	3	0	0.533	1.000
268	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MPL(1), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), STAT1(6), STAT3(2), STAT5B(2), THPO(1)	6264598	57	29	55	17	16	11	5	16	8	1	0.540	1.000
269	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(1), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	1983193	20	19	19	10	9	1	0	10	0	0	0.542	1.000
270	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	16	ABCB1(6), AKT1(2), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(3), FHL2(1), HIF1A(1), IGFBP3(2), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(1)	2962226	28	20	28	4	4	11	1	11	1	0	0.542	1.000
271	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(3), IFNG(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(6), LIN7A(2), NFKB1(3), RB1(4), RELA(2), TNFRSF1A(1), USH1C(5), WT1(4)	3974272	36	21	36	13	12	4	3	11	4	2	0.547	1.000
272	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(4), F12(2), F13B(3), F2(2), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), LPA(9), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1), VWF(10)	7871547	102	36	100	31	23	29	3	33	14	0	0.547	1.000
273	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(3), DNMT1(12), MTNR1B(3), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1)	2492801	28	19	25	7	11	3	1	12	1	0	0.554	1.000
274	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8)	2574833	27	21	26	9	17	3	0	4	3	0	0.555	1.000
275	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(1), JAK1(3), PTPRU(6), REG1A(3), STAT1(6), STAT2(5), TYK2(1)	2752150	28	19	26	7	13	6	1	5	3	0	0.555	1.000
276	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), GRB2(2), IL6(1), IL6R(2), IL6ST(2), JAK1(3), JAK2(6), JAK3(6), MAP2K1(3), MAPK3(2), PTPN11(2), RAF1(4), SHC1(3), SOS1(5), SRF(3), STAT3(2)	5376589	50	28	47	13	16	10	4	14	5	1	0.562	1.000
277	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(4), ACTN1(3), ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGEF6(7), ARHGEF7(8), CDKN2A(1), CSE1L(4), DOCK1(5), EPHB2(7), FYN(4), GRB2(2), GRB7(1), GRLF1(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGB3BP(1), MAP3K11(4), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MRAS(1), MYLK(11), MYLK2(2), P4HB(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CB(2), PLCG1(4), PLCG2(9), PTEN(6), PTK2(5), RAF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), TERF2IP(1), TLN1(5), TLN2(5), VASP(3), WAS(1)	25995429	242	72	236	92	87	56	6	59	33	1	0.562	1.000
278	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(4), GNAS(6), PLCE1(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3074220	24	20	24	9	10	4	2	5	3	0	0.563	1.000
279	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(2), IFNGR2(1), JAK1(3), JAK2(6), STAT1(6)	1835289	19	13	18	6	7	1	2	7	1	1	0.567	1.000
280	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CACNA1C(10), CACNA1D(7), CACNA1F(12), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CGA(1), EGFR(10), FSHB(1), GNA11(1), GNAQ(3), GNAS(6), GNRHR(4), GRB2(2), HBEGF(1), ITPR1(11), ITPR2(12), ITPR3(11), LHB(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK9(3), MMP14(4), MMP2(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLD1(8), PLD2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCD(3), PRKX(2), PTK2B(1), RAF1(4), SOS1(5), SOS2(9), SRC(3)	27836425	295	75	292	115	116	63	10	82	24	0	0.567	1.000
281	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(6), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), ASS1(1), CAD(10), CRAT(3), DARS(3), DARS2(2), DDO(2), DLAT(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), NARS2(3), PC(3), PDHA1(4), PDHA2(6), PDHB(2)	8525697	94	43	94	23	41	23	0	21	9	0	0.568	1.000
282	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(6), CD79A(3), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK14(3), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11)	8524594	81	38	79	23	34	15	4	17	11	0	0.568	1.000
283	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	363274	2	2	2	3	0	0	0	1	1	0	0.569	1.000
284	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRA(4), EDNRB(7), HSD11B1(1), PLA2G4A(5), PRL(2), PTGER2(1), PTGFR(6), PTGIR(1), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	4589791	55	26	55	14	22	7	0	21	5	0	0.570	1.000
285	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), AKT2(5), BAD(1), BCL2(1), GRB2(2), GSK3A(2), GSK3B(7), IL4R(1), IRS1(5), JAK1(3), JAK3(6), MAP4K1(2), MAPK1(2), MAPK3(2), PIK3CD(2), PIK3R1(5), PPP1R13B(5), RAF1(4), SHC1(3), SOS1(5), SOS2(9), STAT6(2)	7662901	76	38	73	20	24	16	3	19	14	0	0.570	1.000
286	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PLCB1(8), PRKCA(2), RAF1(4), RELA(2)	3476261	28	20	27	9	11	6	1	7	3	0	0.571	1.000
287	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(2), RPE(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), XYLB(2)	5482237	63	27	62	15	16	17	1	18	11	0	0.572	1.000
288	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(4), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(9), FLT4(4), HIF1A(1), KDR(8), NOS3(2), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), SHC1(3)	7148961	61	36	60	21	19	15	2	14	11	0	0.572	1.000
289	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(4), AGTR1(3), EGFR(10), GNAQ(3), GRB2(2), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), MEF2A(3), MEF2C(7), MEF2D(1), PAK1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1)	7310068	76	35	74	26	25	20	3	19	9	0	0.573	1.000
290	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(3), HDAC9(11), MEF2A(3), MEF2C(7), MEF2D(1)	1545529	26	13	26	12	8	7	0	11	0	0	0.573	1.000
291	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(14), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SDS(2), SUCLA2(3), SUCLG1(1)	7531279	88	35	88	16	33	22	0	23	10	0	0.574	1.000
292	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP2U1(1), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(2), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	8722474	84	42	82	29	30	15	0	34	5	0	0.574	1.000
293	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(4), CREB1(1), GNAI1(3), GNAQ(3), GNAS(6), GNB1(1), MAP2K1(3), MAPK3(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1)	7702126	64	39	63	23	30	9	3	14	8	0	0.575	1.000
294	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(8), ABCB4(8), ABCC1(8), ABCC3(5)	3055796	35	21	35	10	5	14	0	10	6	0	0.582	1.000
295	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(3), NDUFA1(1), SDHA(5), SDHB(2), SDHD(1), UQCRC1(2)	1443707	16	11	16	3	5	5	0	5	1	0	0.582	1.000
296	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(2), JAK1(3), JAK2(6), PTPRU(6), REG1A(3), STAT1(6)	2538159	27	16	25	9	11	4	2	7	2	1	0.583	1.000
297	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	2244093	22	15	22	8	5	6	0	6	5	0	0.585	1.000
298	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(14), ACACB(14), ACADM(3), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SUCLA2(3), SUCLG1(1)	9043186	98	40	98	23	37	23	0	28	10	0	0.586	1.000
299	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(7), WEE1(3)	1497944	20	12	19	7	7	4	0	8	1	0	0.588	1.000
300	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), PRDX6(2), TAT(3), TPO(8)	4837673	54	33	53	16	29	12	0	10	3	0	0.589	1.000
301	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(2), IL4(3), IL4R(1), IRS1(5), JAK1(3), JAK3(6), RPS6KB1(3), SHC1(3), STAT6(2)	3273899	30	21	28	10	10	7	2	6	5	0	0.590	1.000
302	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP3(1), CASP6(1), CASP7(1), CASP9(2), DFFA(2), DFFB(2), DIABLO(1)	2837574	27	21	27	8	8	7	0	10	2	0	0.591	1.000
303	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(17), ABCA10(7), ABCA13(23), ABCA3(5), ABCA4(10), ABCA5(15), ABCA6(12), ABCA7(5), ABCA8(10), ABCA9(12), ABCB1(6), ABCB10(3), ABCB11(8), ABCB4(8), ABCB5(10), ABCB6(3), ABCB7(3), ABCB8(4), ABCB9(2), ABCC1(8), ABCC10(7), ABCC11(9), ABCC12(7), ABCC2(11), ABCC3(5), ABCC4(9), ABCC5(5), ABCC6(5), ABCC8(7), ABCC9(7), ABCD1(3), ABCD2(8), ABCD3(3), ABCD4(5), ABCG1(5), ABCG2(5), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(8), TAP1(3), TAP2(4)	24862282	295	67	293	87	95	67	7	84	40	2	0.600	1.000
304	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1)	3059338	31	21	31	14	9	9	0	11	2	0	0.600	1.000
305	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), GSR(1), GSS(4), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), MGST1(2), MGST3(1)	4587428	50	27	48	8	7	15	2	20	6	0	0.601	1.000
306	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ6(1), COQ7(1), NDUFA12(2), NDUFA13(1)	914763	7	7	7	2	1	2	0	2	2	0	0.605	1.000
307	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(6), CRKL(2), GRB2(2), JAK2(6), MAP2K1(3), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3R1(5), RAF1(4), SOS1(5), STAT1(6), STAT5B(2)	5504413	54	28	53	13	20	12	6	10	5	1	0.613	1.000
308	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	266355	3	2	3	1	1	1	0	0	1	0	0.615	1.000
309	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(2), EIF4A2(4), EIF4B(1), EIF4G1(8), EIF4G2(7), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(1), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3), TSC1(3), TSC2(1)	5654666	52	28	50	17	15	14	1	11	10	1	0.615	1.000
310	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(21), PAX3(5), PML(3), RB1(4), SIRT1(4), SP100(4), TNFRSF1A(1)	4066331	42	24	41	18	13	12	3	8	5	1	0.616	1.000
311	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	AKT1(2), AKT2(5), BAD(1), BTK(6), CDKN2A(1), DAPP1(1), GRB2(2), GSK3A(2), GSK3B(7), IARS(5), IGFBP1(2), INPP5D(2), PPP1R13B(5), PTEN(6), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SOS1(5), SOS2(9), TEC(1), YWHAB(2), YWHAE(3), YWHAQ(1)	7466549	86	34	84	21	27	17	3	24	14	1	0.620	1.000
312	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(7), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(2), CDKN1A(1), MDM2(4), PCNA(2), RB1(4), TIMP3(2)	2528786	29	17	29	6	7	6	0	14	1	1	0.623	1.000
313	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(3), DRD1(1), DRD2(3), GRM1(9), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	3496532	35	25	35	13	14	7	1	8	5	0	0.623	1.000
314	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(3), CASP1(2), CASP3(1), CASP7(1), INSR(5), ITCH(3), MAGI1(10), MAGI2(6), RERE(3), WWP1(5), WWP2(4)	5036174	43	32	43	19	15	9	0	13	6	0	0.624	1.000
315	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(4), CDKN1A(1), GRIN1(1), HIF1A(1), JAK2(6), NFKB1(3), RELA(2), SOD2(4)	2875583	22	18	22	5	6	6	1	6	2	1	0.625	1.000
316	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(7), PTK2(5), SPTAN1(9), SRC(3), TLN1(5)	6192956	57	33	57	25	28	11	0	15	2	1	0.627	1.000
317	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1)	5246792	47	28	47	9	17	17	1	9	3	0	0.627	1.000
318	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(17), APOE(1), CETP(6), CYP7A1(4), HMGCR(2), LCAT(1), LDLR(4), LIPC(3), LPL(6), LRP1(14), SOAT1(1)	5645238	59	31	59	18	22	14	2	16	5	0	0.628	1.000
319	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT2(3), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), GK(3), GK2(3), GLA(4), GLB1(3), GPAM(2), LCT(15), LIPA(1), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(4), PPAP2B(1)	12987826	154	50	153	50	49	32	2	59	12	0	0.641	1.000
320	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(1), IFNB1(1), JAK1(3), STAT1(6), STAT2(5), TYK2(1)	2374004	21	16	20	4	10	3	1	5	2	0	0.642	1.000
321	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(4), GNAQ(3), ITPKB(4)	1356844	14	10	14	5	5	3	2	2	2	0	0.643	1.000
322	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(3)	1240596	10	9	10	2	2	2	1	3	2	0	0.643	1.000
323	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(3), GPR161(5), GPR171(3), GPR34(5), GPR39(2), GPR45(4), GPR75(1)	2160775	26	17	26	9	12	4	1	7	2	0	0.644	1.000
324	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(2), DHRS3(2), HSD3B7(2), PON1(5), PON2(1), PON3(2), RDH12(2), RDH13(1)	1878267	18	14	18	7	7	3	1	3	4	0	0.645	1.000
325	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(3), GLB1(3), HEXB(1), LCT(15), SLC33A1(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4)	3657306	44	25	44	15	20	8	2	9	5	0	0.647	1.000
326	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	CRKL(2), GNAQ(3), GRB2(2), MAP2K1(3), MAP2K3(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), PAK1(4), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1)	6232939	54	29	52	20	15	13	4	15	7	0	0.651	1.000
327	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(5), PNPO(1), PSAT1(3)	1106092	9	8	9	5	4	4	0	0	1	0	0.654	1.000
328	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2)	2841027	26	18	25	8	8	9	0	7	2	0	0.655	1.000
329	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), DAD1(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), GANAB(4), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), ST6GAL1(1), STT3B(4)	9381957	87	44	86	17	30	17	2	33	5	0	0.656	1.000
330	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), OXCT1(3)	773281	6	6	6	2	1	1	0	4	0	0	0.662	1.000
331	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(3), ACO2(2), FH(1), IDH1(3), MDH1(1), MDH2(1), SDHB(2), SUCLA2(3)	1842831	16	13	16	3	5	3	0	6	2	0	0.663	1.000
332	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3D(1), CD3G(2), CD4(2)	642460	7	6	8	5	2	4	0	0	1	0	0.664	1.000
333	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(4), CDKN2A(1), MDM2(4), PIK3R1(5), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), RB1(4)	3751265	35	21	35	6	7	15	0	8	4	1	0.665	1.000
334	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(3), GSK3B(7), MAPT(4), PPP2CA(1)	1918009	22	14	22	4	9	6	0	4	3	0	0.667	1.000
335	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(5), BRD4(4), CBL(2), CDKN2A(1), F2RL2(2), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), LNPEP(6), MAPK1(2), MAPK3(2), PARD3(5), PIK3CD(2), PIK3R1(5), PPYR1(1), PTEN(6), PTPN1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SERPINB6(1), SHC1(3), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(9), YWHAB(2), YWHAE(3), YWHAQ(1)	12733833	137	49	133	42	44	29	4	42	17	1	0.669	1.000
336	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(1), ADCY9(4), ARF4(2), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(4), PLCG2(9), PRKCA(2), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(5)	8288239	79	39	75	27	38	19	3	13	6	0	0.673	1.000
337	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATR(13), BRCA1(5), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(13), MDM2(4), MYT1(8), PRKDC(13), RPS6KA1(1), WEE1(3), YWHAQ(1)	7576009	76	34	76	19	22	24	3	19	8	0	0.676	1.000
338	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), IDS(2), IDUA(1), LCT(15), NAGLU(3)	3254815	37	22	37	10	16	6	2	9	4	0	0.679	1.000
339	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(1), ACADM(3), ACADSB(5), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SDS(2), SMS(2), UPB1(3)	6527462	92	34	92	16	34	25	1	25	7	0	0.680	1.000
340	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(3), CDK7(1), MNAT1(1), XPO1(1)	2008281	17	12	17	7	5	5	0	6	1	0	0.681	1.000
341	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(2), CBS(2), CTH(1), MUT(3)	1117684	9	8	9	1	4	2	0	0	3	0	0.681	1.000
342	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1955432	19	14	19	6	11	4	0	4	0	0	0.682	1.000
343	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1955432	19	14	19	6	11	4	0	4	0	0	0.682	1.000
344	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(2), AP2M1(4), BAD(1), BTK(6), EEA1(5), GRASP(1), GSK3A(2), GSK3B(7), LYN(4), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(4), PRKCE(4), RPS6KB1(3), VAV2(2)	5563795	52	29	52	12	21	14	1	7	8	1	0.682	1.000
345	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(7), ATR(13), BAI1(2), BAX(1), BID(1), CASP3(1), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNG1(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), IGF1(2), IGFBP3(2), MDM2(4), MDM4(2), PPM1D(4), PTEN(6), RCHY1(2), RFWD2(4), RPRM(1), RRM2(2), SERPINE1(1), SESN1(2), SESN2(3), SESN3(5), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(2), TSC2(1), ZMAT3(3)	12643349	108	47	107	29	30	27	4	34	12	1	0.683	1.000
346	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), ARSB(5), ARSD(3), ARSE(2), CYP11B1(5), CYP11B2(5), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2)	5811271	57	29	57	8	29	10	1	10	7	0	0.689	1.000
347	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), GRB2(2), IL2(3), IL2RA(2), IL2RB(1), JAK1(3), JAK3(6), LCK(2), MAP2K1(3), MAPK3(2), MAPK8(2), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	5226699	44	26	41	16	14	11	4	12	3	0	0.689	1.000
348	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(7), HDC(3), TPH1(1)	1334752	15	12	15	6	6	2	1	6	0	0	0.690	1.000
349	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), DBH(4), DCT(9), DDC(1), ECH1(1), ESCO1(7), ESCO2(3), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), MYST3(13), MYST4(5), PNPLA3(4), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(3), TPO(8), TYR(2), TYRP1(2), WBSCR22(1)	12994415	145	49	144	56	58	37	3	40	7	0	0.691	1.000
350	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(5), ITGAM(5), ITGB2(4), PECAM1(1), SELE(2)	2380691	22	16	22	6	8	8	0	4	2	0	0.695	1.000
351	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(3), HADHA(2), SDHB(2), SDS(2)	1765483	17	11	17	1	5	3	0	5	4	0	0.695	1.000
352	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(5), CARM1(2), CREBBP(21), EP300(13), ERCC3(6), GRIP1(7), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MEF2C(7), NCOR2(2), NR0B1(2), NRIP1(5), PELP1(2), POLR2A(6), TBP(1)	10062051	105	44	105	24	41	31	2	18	13	0	0.695	1.000
353	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(5), BCL10(3), BTK(6), CARD11(6), CD19(3), CD22(8), CD72(3), CD79A(3), CHUK(4), CR2(9), GSK3B(7), IFITM1(1), IKBKB(2), INPP5D(2), LILRB3(1), LYN(4), MALT1(6), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(4), VAV1(11), VAV2(2), VAV3(10)	15721559	173	55	171	46	74	31	4	44	20	0	0.700	1.000
354	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK2(2), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1)	1550562	14	10	14	4	2	4	0	7	1	0	0.700	1.000
355	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(4), PSMD11(3), PSMD12(2), PSMD13(1), PSMD2(3), PSMD6(2)	3679575	32	22	32	15	10	7	2	10	3	0	0.701	1.000
356	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(4), ACO1(3), ACO2(2), ACSS1(3), ACSS2(5), FH(1), IDH1(3), MDH1(1), MDH2(1), SUCLA2(3)	2841449	26	18	26	5	11	6	0	7	2	0	0.703	1.000
357	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(4), ABLIM1(5), ABLIM2(4), ABLIM3(5), ARHGEF12(7), CFL1(1), CXCL12(1), CXCR4(3), DCC(14), DPYSL2(3), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB3(2), EPHA1(3), EPHA2(5), EPHA4(4), EPHA5(11), EPHA6(5), EPHA7(7), EPHA8(5), EPHB1(6), EPHB2(7), EPHB3(2), EPHB4(2), EPHB6(4), FYN(4), GNAI1(3), GSK3B(7), ITGB1(6), L1CAM(2), LIMK1(4), LIMK2(4), LRRC4C(6), MAPK1(2), MAPK3(2), MET(4), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NGEF(1), NRP1(1), NTN1(4), NTN4(4), NTNG1(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLXNA1(2), PLXNA2(5), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNB3(2), PLXNC1(7), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(5), RGS3(8), RHOA(4), RND1(1), ROBO2(15), ROBO3(2), ROCK1(8), ROCK2(2), SEMA3A(6), SEMA3B(1), SEMA3C(2), SEMA3D(9), SEMA3E(5), SEMA3F(1), SEMA3G(3), SEMA4A(2), SEMA4B(1), SEMA4D(12), SEMA4F(5), SEMA4G(5), SEMA5A(7), SEMA5B(7), SEMA6A(2), SEMA6C(2), SEMA6D(5), SEMA7A(2), SLIT1(9), SLIT2(12), SLIT3(7), SRGAP1(7), SRGAP2(3), SRGAP3(3), UNC5A(1), UNC5B(5), UNC5C(9), UNC5D(9)	41561322	429	94	424	148	172	88	4	109	56	0	0.703	1.000
358	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(2), FH(1), MDH1(1), OGDH(4), SDHA(5), SUCLA2(3)	1907641	16	14	16	5	7	3	0	3	3	0	0.703	1.000
359	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(7), ARHGDIB(3), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP9(2), DFFA(2), DFFB(2), GZMB(1), LMNB1(2), LMNB2(1)	4102067	36	24	36	12	8	8	1	16	3	0	0.705	1.000
360	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(4), AKT1(2), CAMK1(1), CAMK1G(3), CAMK4(2), CREBBP(21), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(2), GATA4(1), GSK3B(7), HAND1(1), HAND2(1), IGF1(2), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MEF2C(7), MYH2(9), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKX2-5(1), NPPA(1), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RAF1(4), RPS6KB1(3), SYT1(1)	10588366	124	44	123	32	43	34	4	24	19	0	0.711	1.000
361	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(5), DARS(3), EPRS(10), FARS2(4), GARS(3), HARS(2), IARS(5), KARS(3), LARS(4), LARS2(2), MARS(3), NARS(2), QARS(7), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(2), YARS(2)	7296707	68	33	68	11	27	15	1	18	7	0	0.711	1.000
362	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(3), EGFR(10), TF(7), TFRC(2)	2953464	27	18	27	6	14	4	1	5	2	1	0.712	1.000
363	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), MAPK3(2), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	2819144	25	18	25	5	12	6	1	5	1	0	0.714	1.000
364	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(5), CPO(3), FECH(2), GATA1(4), HBB(2), HMBS(2), UROS(1)	1854085	24	14	24	5	13	5	0	5	1	0	0.714	1.000
365	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), RDH12(2), RDH13(1)	5411937	46	26	46	22	17	10	1	15	2	1	0.716	1.000
366	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(3), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2E1(3), UBE2G1(2), UBE2I(1), UBE2J2(1), UBE2L3(2), UBE3A(6)	2340485	25	14	25	10	7	2	2	9	5	0	0.717	1.000
367	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), ESCO1(7), ESCO2(3), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), MYST3(13), MYST4(5), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(3), TPO(8)	7618227	89	39	88	26	45	22	1	16	5	0	0.717	1.000
368	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(1), FUT2(1), FUT3(3), FUT6(1), ST3GAL3(4)	1019671	12	9	12	4	7	2	0	3	0	0	0.718	1.000
369	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), PGM1(2), PGM3(4)	2304758	22	16	22	11	6	6	0	10	0	0	0.718	1.000
370	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADK(1), ADSL(7), ADSS(1), AK5(4), AK7(5), ALLC(3), AMPD1(7), AMPD2(4), AMPD3(2), ATIC(4), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), FHIT(1), GART(3), GMPR(1), GMPR2(2), GMPS(5), GUCY1A2(8), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NME6(3), NME7(3), NPR1(6), NPR2(9), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT9(2), PAPSS1(1), PAPSS2(2), PDE10A(6), PDE11A(7), PDE1A(3), PDE1C(7), PDE3B(2), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6D(1), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PDE9A(5), PFAS(1), PKM2(2), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1), PPAT(3), PRIM2(6), PRPS1L1(1), PRPS2(2), RFC5(2), RRM1(1), RRM2(2), XDH(7)	36444503	380	81	377	122	124	103	11	91	51	0	0.719	1.000
371	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), IMPA2(2), PGM1(2), PGM3(4)	2615706	24	18	24	11	7	6	0	10	1	0	0.719	1.000
372	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(10), IGF1R(7), POLR2A(6), PPP2CA(1), PRKCA(2), RB1(4), TEP1(7), TERT(2), TNKS(4), XRCC5(4)	6198051	50	33	50	15	24	7	1	14	3	1	0.720	1.000
373	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(3), GGT1(3), SHMT1(1), SHMT2(2)	1137708	9	9	7	6	2	4	0	0	3	0	0.721	1.000
374	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BTRC(2), CSNK1A1(2), CSNK1A1L(5), CSNK1D(3), CSNK1G1(1), CSNK1G3(2), DHH(1), FBXW11(7), GLI1(3), GLI2(2), GLI3(9), GSK3B(7), HHIP(4), IHH(1), LRP2(39), PRKACB(1), PRKACG(2), PRKX(2), PTCH1(8), PTCH2(4), RAB23(1), STK36(4), SUFU(4), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1), ZIC2(1)	13405539	156	56	155	70	71	33	2	32	18	0	0.721	1.000
375	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2)	939684	10	8	10	2	3	6	0	1	0	0	0.731	1.000
376	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMB9(4)	1998179	17	14	17	6	6	3	2	3	3	0	0.737	1.000
377	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(5), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(3), FASN(1), HADHA(2), HSD17B12(2), SCD(2)	3282086	25	19	25	4	11	6	1	4	3	0	0.738	1.000
378	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(4), CMAS(5), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NAGK(2), NPL(2), PGM3(4), PHPT1(1), RENBP(1)	6495567	63	33	63	17	25	17	0	16	5	0	0.739	1.000
379	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(1), IL3(3), IL6(1), KITLG(2)	1443001	16	10	15	6	5	6	0	4	1	0	0.740	1.000
380	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(1), ADAM17(6), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(4), CSK(1), EGFR(10), F11R(1), GIT1(2), HBEGF(1), IGSF5(6), IKBKB(2), JAM3(3), LYN(4), MAP3K14(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK8(2), MAPK9(3), MET(4), NFKB1(3), NFKB2(2), NOD1(3), PAK1(4), PLCG1(4), PLCG2(9), PTPN11(2), PTPRZ1(12), RELA(2), SRC(3), TCIRG1(2), TJP1(5)	15505644	149	51	147	41	56	37	3	38	15	0	0.743	1.000
381	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(4), ASPH(2), CREB1(1), EDN1(1), EP300(13), HIF1A(1), LDHA(1), NOS3(2), P4HB(2)	3793446	27	21	27	10	8	11	0	6	2	0	0.749	1.000
382	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(5), FECH(2), HMBS(2), PPOX(3), UROS(1)	1751382	18	12	18	3	10	3	0	4	1	0	0.750	1.000
383	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(1), DFFA(2), DFFB(2), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(5)	1842185	16	12	15	4	3	4	0	8	1	0	0.750	1.000
384	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), ATIC(4), FTCD(2), GART(3), MTFMT(1), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2)	4240150	43	25	43	11	18	9	0	11	5	0	0.752	1.000
385	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(3), CNDP1(3), DDC(1), HAL(3), HARS(2), HDC(3), HNMT(4), MAOA(2), PRPS2(2)	5415728	63	31	63	15	26	19	0	17	1	0	0.752	1.000
386	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(1), SIRT7(1), VNN2(1)	2666211	22	17	22	8	8	7	0	2	5	0	0.755	1.000
387	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(3), AGPAT4(6), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), GK(3), GLA(4), GLB1(3), LCT(15), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2B(1)	10636871	136	43	135	36	43	31	2	49	11	0	0.755	1.000
388	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), AOX1(5), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), PCCA(3), PCCB(3), SDS(2)	8179982	85	37	85	18	33	19	0	24	9	0	0.762	1.000
389	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(1), CAMK1G(3), FPR1(2), GNA15(3), GNB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NCF1(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PAK1(4), PIK3C2G(7), PLCB1(8), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), RELA(2), SYT1(1)	8462003	81	37	80	27	31	16	3	16	15	0	0.768	1.000
390	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(1), CD3G(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	2394233	27	17	27	9	6	10	0	6	5	0	0.771	1.000
391	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3)	3609005	40	21	40	13	19	10	1	6	4	0	0.772	1.000
392	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(1), IFNAR1(3), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(3), RELA(2), TNFRSF11A(2), TNFSF11(1), TRAF6(4)	2474213	20	14	20	7	7	7	0	1	5	0	0.772	1.000
393	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9)	2530710	29	18	29	11	6	12	0	6	5	0	0.773	1.000
394	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	120	ARAF(3), BID(1), CASP3(1), CD244(3), CD247(2), FASLG(1), FYN(4), GRB2(2), GZMB(1), HLA-A(1), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(1), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), ITGAL(5), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KLRC3(2), KLRD1(1), KLRK1(3), LCK(2), LCP2(2), MAP2K1(3), MAPK1(2), MAPK3(2), MICB(1), NCR1(1), NCR3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PAK1(4), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTK2B(1), PTPN11(2), PTPN6(4), RAF1(4), SH2D1A(2), SH2D1B(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), TNFRSF10A(3), TNFRSF10B(2), TNFSF10(1), ULBP1(2), ULBP2(2), VAV1(11), VAV2(2), VAV3(10), ZAP70(4)	24031129	249	61	244	69	81	57	10	69	30	2	0.774	1.000
395	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(4), GLI2(2), GLI3(9), GSK3B(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SUFU(4)	3624283	37	23	37	21	18	9	2	3	5	0	0.776	1.000
396	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), CPS1(8), GLUD1(2), GOT1(5)	1722990	16	10	16	4	4	5	0	4	3	0	0.777	1.000
397	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), IDI1(1), SQLE(1)	671672	4	4	4	3	1	2	0	0	1	0	0.778	1.000
398	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(2), AKT2(5), BAD(1), BCL2L1(1), CDK2(2), CDKN1B(1), CDKN2A(1), CREB1(1), CREB3(2), CREB5(2), EBP(2), F2RL2(2), GAB1(6), GRB2(2), GSK3A(2), GSK3B(7), IGF1(2), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARD3(5), PIK3CD(2), PPP1R13B(5), PREX1(14), PTEN(6), PTK2(5), PTPN1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SLC2A4(3), SOS1(5), SOS2(9), TSC1(3), TSC2(1), YWHAB(2), YWHAE(3), YWHAQ(1)	16036497	173	53	169	64	60	36	5	48	23	1	0.778	1.000
399	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(10), MAP2K1(3), MAP3K1(6), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	3852603	34	21	34	13	17	7	2	6	2	0	0.779	1.000
400	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(6), CARS(5), CARS2(1), DARS(3), DARS2(2), EPRS(10), FARS2(4), FARSA(1), FARSB(7), GARS(3), HARS(2), HARS2(2), IARS(5), IARS2(6), KARS(3), LARS(4), LARS2(2), MARS(3), MTFMT(1), NARS(2), NARS2(3), QARS(7), RARS(2), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(4), VARS(1), VARS2(6), WARS(1), WARS2(2), YARS(2), YARS2(3)	12243810	116	44	116	19	45	23	2	30	16	0	0.779	1.000
401	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(2), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), NOS1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(1)	5585619	54	29	54	31	25	12	1	9	7	0	0.787	1.000
402	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(1), CREB1(1), CREB3(2), CREB5(2), DUSP1(2), DUSP10(4), IL1R1(3), MAP2K3(2), MAP2K6(2), MAP3K10(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAPK1(2), MAPK12(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(2), MYEF2(7), NFKB1(3), NR2C2(4), SRF(3), TRAF6(4)	7488839	80	36	79	22	25	19	2	22	12	0	0.789	1.000
403	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(2), IL10(1), IL10RA(1), IL10RB(4), IL1A(1), IL6(1), JAK1(3), STAT1(6), STAT3(2)	2708425	24	16	22	16	10	4	1	8	1	0	0.790	1.000
404	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(1), CTSD(3), GREB1(10), HSPB2(1), MTA1(1), PDZK1(1), TUBA8(1)	2051679	18	13	18	8	6	3	0	6	3	0	0.792	1.000
405	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(8), RANGAP1(1)	1717595	10	8	10	1	4	1	1	0	4	0	0.793	1.000
406	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(1), HPRT1(2), IMPDH1(1), POLB(1), POLD1(5), POLG(4), PRPS2(2), RRM1(1)	2788374	24	19	24	9	11	5	0	7	1	0	0.793	1.000
407	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(2), DUSP10(4), DUSP4(1), GAB1(6), GCK(1), IL1R1(3), MAP2K5(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK7(3), MAPK8(2), MAPK9(3), MYEF2(7), NFATC3(4), NR2C2(4), PAPPA(13), SHC1(3), TRAF6(4), ZAK(4)	10933243	122	44	120	31	44	25	2	33	18	0	0.794	1.000
408	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(2), B3GNT5(1), FUT1(1), FUT2(1), FUT3(3), ST3GAL3(4), ST3GAL4(2)	1559353	20	13	20	3	9	4	0	5	2	0	0.795	1.000
409	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), APC2(1), ARAF(3), ARHGEF1(4), ARHGEF12(7), ARHGEF4(3), ARHGEF6(7), ARHGEF7(8), ARPC1A(5), ARPC1B(2), ARPC2(1), ARPC5(1), ARPC5L(1), BDKRB2(2), CD14(1), CFL1(1), CHRM1(3), CHRM3(4), CHRM5(1), CRKL(2), CSK(1), CYFIP1(5), CYFIP2(4), DIAPH1(1), DIAPH2(9), DIAPH3(3), DOCK1(5), EGF(3), EGFR(10), EZR(2), F2(2), FGD1(6), FGD3(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FN1(17), GIT1(2), GNA12(2), GNA13(2), GRLF1(7), IQGAP1(10), IQGAP2(9), IQGAP3(11), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), LIMK1(4), LIMK2(4), MAP2K1(3), MAPK1(2), MAPK3(2), MOS(2), MRAS(1), MSN(3), MYH10(8), MYH14(9), MYH9(9), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), NCKAP1(8), NCKAP1L(7), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PDGFA(1), PDGFRA(13), PDGFRB(5), PFN2(1), PFN4(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(5), RAF1(4), RDX(2), RHOA(4), ROCK1(8), ROCK2(2), RRAS2(1), SCIN(2), SLC9A1(2), SOS1(5), SOS2(9), SSH1(4), SSH2(4), TIAM1(12), TIAM2(14), TMSL3(1), VAV1(11), VAV2(2), VAV3(10), VCL(1), WAS(1), WASF1(1), WASF2(2), WASL(5)	58542651	599	104	592	203	246	115	21	157	58	2	0.796	1.000
410	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), NAGLU(3), SPAM1(1)	4565629	55	26	54	15	20	9	2	17	7	0	0.796	1.000
411	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(1), ACADM(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SMS(2), UPB1(3)	6061630	77	31	77	17	28	21	1	21	6	0	0.796	1.000
412	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(2), CTH(1), GGT1(3), MARS(3), MAT1A(5), MAT2B(2), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(1)	2745454	24	16	22	9	11	7	1	4	1	0	0.797	1.000
413	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(4), EGF(3), EGFR(10), ETS2(2), HOXA7(1), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), NFKB1(3), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), RAF1(4), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	10732034	91	45	90	30	44	22	3	19	3	0	0.798	1.000
414	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ACSS2(5), ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GALM(2), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	12729919	134	49	133	40	46	33	1	46	8	0	0.799	1.000
415	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MIOX(1), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CB(2), PIK3CG(12), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9)	9369516	94	40	93	23	41	22	2	21	8	0	0.805	1.000
416	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(14), ACAT1(1), ACAT2(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(2), LDHA(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2)	8286323	89	36	89	22	32	23	1	23	10	0	0.805	1.000
417	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), HAL(3)	4751377	38	25	38	20	16	10	0	5	7	0	0.809	1.000
418	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(2), CTH(1), GGT1(3), LCMT1(1), LCMT2(2), MARS(3), MAT1A(5), MAT2B(2), METTL2B(1), METTL6(5), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SCLY(1), SEPHS1(1), SEPHS2(3), WBSCR22(1)	5418630	49	28	47	18	18	14	1	13	3	0	0.811	1.000
419	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(8), AMY2A(3), ENPP1(4), ENPP3(3), G6PC(3), GANAB(4), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), MGAM(9), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), SI(12), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UXS1(6)	12134352	123	47	123	44	42	34	0	32	15	0	0.812	1.000
420	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADK(1), ADSL(7), ADSS(1), AK5(4), ALLC(3), AMPD1(7), AMPD2(4), AMPD3(2), ATIC(4), ATP1B1(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(8), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NPR1(6), NPR2(9), NT5E(2), NT5M(1), PAPSS1(1), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6B(5), PDE6C(8), PDE7B(3), PDE8A(1), PDE9A(5), PFAS(1), PKM2(2), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), PPAT(3), PRPS1L1(1), PRPS2(2), RRM1(1), RRM2(2)	28421001	285	71	281	80	98	68	8	76	35	0	0.812	1.000
421	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(2), SDS(2)	1109940	8	6	8	1	3	2	0	0	3	0	0.819	1.000
422	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(2), GALNT10(5), GALNT2(3), GALNT3(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GCNT1(3), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2)	2910158	28	17	28	12	10	8	0	4	6	0	0.819	1.000
423	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(3), CD33(1), CD5(2), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(4), TLR2(2), TLR4(7), TLR7(4), TLR9(4)	4101271	46	22	45	19	18	7	4	15	2	0	0.820	1.000
424	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(1), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), GCDH(3), HADHA(2), ITGB1BP3(1), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1)	5735998	58	29	58	16	25	14	1	10	8	0	0.828	1.000
425	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2), SELP(4)	3585058	35	19	34	10	12	10	0	10	3	0	0.829	1.000
426	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(2), GOSR2(2), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX11(1), STX12(3), STX16(3), STX19(1), STX2(2), STX3(2), STX4(2), STX5(3), STX6(1), STX7(2), STX8(2), TSNARE1(1), VAMP1(1), VAMP3(1), VAMP4(2), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1)	3656686	45	22	44	14	19	4	0	12	10	0	0.830	1.000
427	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1)	1955404	12	10	12	5	2	2	0	3	5	0	0.831	1.000
428	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3)	406881	3	3	3	2	2	0	0	0	1	0	0.833	1.000
429	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MAPK8(2), PLCG1(4), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2)	4816101	41	22	39	11	16	8	4	9	3	1	0.833	1.000
430	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(2), EPX(6), GGT1(3), LPO(2), MPO(3), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PRDX6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5), TPO(8)	6193955	63	33	60	21	30	13	0	16	4	0	0.834	1.000
431	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(3), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(5), CPT2(1), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(1)	3827170	31	19	31	11	9	8	0	10	4	0	0.836	1.000
432	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(3), MARCKS(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	4644159	36	26	36	12	14	4	0	10	8	0	0.838	1.000
433	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6)	2897069	28	17	27	8	11	5	0	10	2	0	0.838	1.000
434	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	35	ACTA1(3), ACTA2(3), ACTN2(7), ACTN3(2), ACTN4(2), DES(1), FAM48A(4), MYBPC1(5), MYBPC2(4), MYBPC3(2), MYH3(9), MYH6(8), MYH7(7), MYH8(17), MYL1(1), MYL2(1), MYOM1(8), NEB(38), TMOD1(2), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(5), TPM3(2), TPM4(3), VIM(2)	11470307	145	46	139	51	62	28	1	42	12	0	0.840	1.000
435	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(5), FADS2(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2)	2336103	20	13	20	6	8	5	1	4	2	0	0.841	1.000
436	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3D(1), CD3G(2), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(5), ITGB2(4)	1874734	19	14	19	5	5	5	0	3	6	0	0.843	1.000
437	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	19	CCR5(1), CD3D(1), CD3G(2), ETV5(5), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), JAK2(6), MAP2K6(2), MAPK14(3), MAPK8(2), TYK2(1)	3826369	33	20	34	18	7	12	1	7	5	1	0.844	1.000
438	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(3), AADAC(2), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(1), ALDH9A1(1), BDH1(1), DDHD1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADH(1), HADHA(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(4), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH12(2), RDH13(1)	9221022	98	39	98	27	41	25	0	23	9	0	0.846	1.000
439	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(3), ACAT1(1), ECHS1(2), HADHA(2)	1230053	8	6	8	2	0	2	0	2	4	0	0.846	1.000
440	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(15), MPI(1), PGM1(2), PYGL(2), PYGM(2), TPI1(1), TREH(2)	2956045	32	21	32	13	10	10	1	11	0	0	0.847	1.000
441	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(2), ACADM(3), ACOX1(3), ACOX2(2), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(5), CPT1B(5), CPT2(1), CYP27A1(3), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FADS2(3), GK(3), GK2(3), LPL(6), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK2(3), PDPK1(1), PLTP(5), PPARA(1), PPARD(1), PPARG(1), RXRA(1), RXRB(2), RXRG(3), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(4), SORBS1(7), UCP1(1)	14600391	148	52	147	48	42	39	3	48	16	0	0.849	1.000
442	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), ATIC(4), GART(3), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2)	4047718	40	23	40	10	17	9	0	11	3	0	0.849	1.000
443	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(9), CAPN2(5), CAPNS1(1), CAPNS2(1), EP300(13), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SYT1(1)	5422412	49	27	49	12	20	12	1	7	9	0	0.850	1.000
444	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(4), ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), ATR(13), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(1), CDC14B(3), CDC16(3), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(3), CDC27(9), CDC7(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(21), CUL1(7), DBF4(2), E2F2(1), E2F3(1), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PKMYT1(1), PLK1(6), PRKDC(13), PTTG1(1), RB1(4), RBL1(3), RBL2(8), SKP1(1), SKP2(1), SMAD3(6), SMC1A(10), SMC1B(4), TFDP1(4), TGFB1(1), TGFB2(5), WEE1(3), YWHAB(2), YWHAE(3), YWHAQ(1)	28129910	278	68	275	70	84	65	8	79	41	1	0.851	1.000
445	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1)	2300981	15	13	14	6	7	0	2	4	1	1	0.851	1.000
446	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1)	2300981	15	13	14	6	7	0	2	4	1	1	0.851	1.000
447	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	10780789	120	44	119	32	40	31	1	42	6	0	0.852	1.000
448	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1)	10780789	120	44	119	32	40	31	1	42	6	0	0.852	1.000
449	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(1), IL6R(2), SPN(1), TGFB1(1), TGFB2(5), TNFRSF1A(1), TNFRSF8(1), TNFSF8(1)	2999410	18	13	18	10	5	4	1	4	4	0	0.852	1.000
450	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(10), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTK2(5), TLN1(5)	7238657	67	34	67	18	28	18	2	15	4	0	0.852	1.000
451	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(4), MAN1B1(2), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), ST6GAL1(1)	4429180	40	26	40	10	18	8	2	11	1	0	0.855	1.000
452	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), ITPA(2), NME6(3), NME7(3), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(6), POLR3GL(1), POLR3H(1), PRIM2(6), RFC5(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TXNRD2(2), TYMS(2), UCK2(1), UPB1(3), UPP2(1), UPRT(3)	18261551	194	57	193	47	55	57	4	56	22	0	0.855	1.000
453	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC3(3), UBE2A(2), UBE3A(6)	2930348	24	15	24	11	8	5	2	6	3	0	0.855	1.000
454	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(6), JAK3(6), MAPK1(2), MAPK3(2), STAT3(2), TYK2(1)	2633821	22	15	21	9	9	4	1	5	2	1	0.857	1.000
455	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHRS1(1), DHRS2(2), DHRS3(2), PON1(5), PON2(1), PON3(2)	3868730	33	19	32	13	13	5	4	6	4	1	0.860	1.000
456	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), CSNK1D(3), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(7)	3847778	37	22	36	8	18	7	0	10	2	0	0.860	1.000
457	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5)	3370104	33	21	31	9	11	9	0	12	1	0	0.861	1.000
458	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(21), DUSP1(2), EHHADH(2), EP300(13), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(2), ME1(7), NCOA1(6), NCOR1(7), NCOR2(2), NR1H3(4), NR2F1(2), NRIP1(5), PDGFA(1), PIK3R1(5), PPARA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(4), RELA(2), RXRA(1), SP1(2), STAT5B(2)	13500963	125	45	125	41	34	34	4	32	20	1	0.862	1.000
459	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	2649326	17	13	17	12	6	5	2	3	1	0	0.863	1.000
460	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), CAT(2), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), INMT(1), KMO(3), KYNU(6), LCMT1(1), LCMT2(2), LNX1(7), MAOA(2), METTL2B(1), METTL6(5), NFX1(5), OGDH(4), OGDHL(8), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), TDO2(2), TPH1(1), TPH2(5), WARS(1), WARS2(2), WBSCR22(1)	13417652	139	51	139	42	53	37	0	38	11	0	0.864	1.000
461	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(2), AKT2(5), DAG1(4), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PITX2(2), PLD1(8), PLD2(1), PLD3(5), VN1R1(4)	9605968	87	39	87	36	36	19	5	20	7	0	0.865	1.000
462	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(5), CYB5R3(1), GCK(1), GFPT1(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), PGM3(4), RENBP(1)	3860620	32	22	32	12	11	9	0	11	1	0	0.865	1.000
463	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CYP2C19(4), CYP2C9(4), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), HADHA(2), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1)	6880810	78	30	78	21	33	20	1	16	8	0	0.866	1.000
464	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), IDI1(1), IDI2(1), SQLE(1)	920154	5	5	5	4	1	2	0	0	2	0	0.867	1.000
465	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACADM(3), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CPT1A(5), CPT1B(5), CPT2(1), CYP4A11(2), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(3), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), PECI(1)	10960377	115	40	115	32	34	29	3	38	11	0	0.867	1.000
466	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(5), GRB2(2), IARS(5), IL13RA1(1), IL4(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(6), JAK3(6), PPP1R13B(5), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT6(2), TYK2(1)	7666023	69	33	67	29	21	12	4	21	10	1	0.875	1.000
467	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(5), B4GALT2(3), FBP2(2), G6PC(3), GALE(1), GALK2(2), GALT(2), GANAB(4), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), LCT(15), MGAM(9), PFKM(1), PFKP(2), PGM1(2), PGM3(4)	7106413	78	35	78	28	34	22	1	19	2	0	0.875	1.000
468	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), ABP1(1), AOC2(4), AOC3(4), CES1(4), DDHD1(1), ESCO1(7), ESCO2(3), LIPA(1), MYST3(13), MYST4(5), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(3)	5626099	59	27	59	18	26	17	1	10	5	0	0.878	1.000
469	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6)	3033890	28	17	27	8	11	5	0	10	2	0	0.881	1.000
470	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), GCK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), KHK(1), MPI(1), PFKFB1(6), PFKFB4(2), PFKM(1), PFKP(2), PMM1(1), TPI1(1)	5398793	50	31	50	22	19	11	0	17	3	0	0.882	1.000
471	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(3), GNAQ(3), MAPK14(3), MAPK8(2), PLCG1(4), PRKCA(2), PTK2B(1), SYT1(1)	2998488	21	17	22	9	6	6	0	5	4	0	0.882	1.000
472	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(5), BLVRA(2), BLVRB(1), COX10(2), COX15(1), CP(3), EPRS(10), FECH(2), FTMT(3), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UROS(1)	8879587	94	34	92	21	25	26	1	32	10	0	0.884	1.000
473	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), ILVBL(2), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3), VNN1(5)	3874437	39	21	39	11	10	14	2	10	3	0	0.885	1.000
474	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), CFL1(1), FLNA(2), FLNC(11), FSCN3(2), GDI1(1), GDI2(1), LIMK1(4), MYH2(9), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PFN2(1), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), VASP(3), WASF1(1), WASL(5)	10466462	97	40	97	31	28	25	4	28	12	0	0.885	1.000
475	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(6), CAD(10), CASP10(2), CASP3(1), CASP8AP2(12), CD7(1), CSNK1A1(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(7), FAF1(4), FAIM2(3), IL1A(1), MAP3K1(6), MAP3K5(5), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MET(4), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(8), RALBP1(4), RIPK1(2), ROCK1(8), SMPD1(6), TPX2(7), TRAF2(1), TUFM(1)	15229964	148	49	146	42	51	29	0	53	14	1	0.886	1.000
476	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(2), RPE(2), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2)	3633569	30	18	30	10	13	8	0	4	5	0	0.886	1.000
477	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(14), ACACB(14), ACAT1(1), ACAT2(2), ACOT12(6), ACSS1(3), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), DLAT(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PCK2(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2)	10568226	114	41	114	31	42	27	1	30	14	0	0.886	1.000
478	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR1H3(4), NR1H4(1), RXRA(1)	1186453	11	9	11	7	4	6	0	1	0	0	0.887	1.000
479	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AGPS(2), ENPP2(10), ENPP6(1), PAFAH1B1(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PPAP2B(1)	5336176	46	26	45	21	17	13	1	12	3	0	0.889	1.000
480	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(3), PPARG(1), RXRA(1)	1298420	12	8	12	9	1	2	0	7	2	0	0.890	1.000
481	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	25	ARHGDIB(3), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CFLAR(2), DFFA(2), DFFB(2), FAF1(4), LMNB1(2), LMNB2(1), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), PTPN13(8), RB1(4), RIPK2(3), SPTAN1(9)	8239813	74	33	74	28	16	21	1	23	10	3	0.891	1.000
482	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), PHPT1(1), TYR(2)	3411607	29	18	28	13	10	7	1	8	3	0	0.891	1.000
483	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(3), ACVRL1(3), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(7), BUB1(4), CDKL1(2), CDKL2(4), CDS1(1), CDS2(4), CLK1(5), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MAP3K10(2), MOS(2), NEK1(7), NEK3(4), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9), PLK3(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), PRKG1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), TGFBR1(6), VRK1(3)	24419008	264	68	260	75	110	58	6	68	22	0	0.892	1.000
484	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(1), CDS2(4), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPP5D(2), INPPL1(3), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), OCRL(5), PI4KA(11), PI4KB(2), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3C3(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PRKCA(2), PRKCG(8), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5)	26627877	260	68	256	77	109	52	8	59	31	1	0.892	1.000
485	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), TYR(2)	2184890	18	12	17	7	7	5	1	4	1	0	0.895	1.000
486	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(7), BCL2(1), CASP3(1), CASP9(2), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	2536946	21	15	21	10	6	6	0	6	3	0	0.897	1.000
487	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(2), CDK7(1), ERCC3(6), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), MNAT1(1), POLR1A(7), POLR1B(6), POLR2A(6), POLR2B(5), POLR2E(1), POLR2H(1), POLR2I(1), POLR3B(6), POLR3D(3), POLR3E(3), POLR3H(1), TAF5(3), TAF6(2), TAF7(1), TBP(1)	7988114	66	33	66	22	23	23	1	14	5	0	0.898	1.000
488	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3)	3111342	31	17	31	7	6	12	1	9	3	0	0.898	1.000
489	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(2), APAF1(7), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(1), CASP6(1), CASP7(1), CASP9(2), PRKCA(2), PTK2(5), STAT1(6), TLN1(5)	4577281	37	24	37	14	14	7	2	11	3	0	0.899	1.000
490	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(4), ACO1(3), ACO2(2), CLYBL(5), FH(1), IDH1(3), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(8), PC(3), PCK2(3), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1)	6455145	53	31	53	18	23	13	0	13	4	0	0.899	1.000
491	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), SDS(2)	1911177	14	10	14	2	3	5	0	3	3	0	0.901	1.000
492	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1)	3101478	27	17	27	12	9	6	0	8	4	0	0.903	1.000
493	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1)	3666155	37	22	37	12	15	12	1	8	1	0	0.904	1.000
494	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(3), MEF2C(7), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), SLC2A4(3), SYT1(1)	4466644	40	22	40	22	16	9	2	8	5	0	0.905	1.000
495	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(5), POLA2(2), POLB(1), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLG(4), POLG2(1), POLH(4), POLI(7), POLK(2), POLM(1), POLQ(8), PRIM2(6), REV1(4), REV3L(15), RFC5(2)	9226370	88	34	86	25	23	24	0	30	10	1	0.906	1.000
496	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(2), AKT2(5), CD14(1), CHUK(4), CXCL11(2), CXCL9(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(3), IL12B(2), IL6(1), IRAK1(1), IRAK4(2), IRF5(3), LBP(1), LY96(2), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K7(2), MAP3K8(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(5), TICAM1(1), TIRAP(1), TLR1(2), TLR2(2), TLR3(4), TLR4(7), TLR5(3), TLR6(2), TLR7(4), TLR8(3), TLR9(4), TOLLIP(1), TRAF3(4), TRAF6(4)	19125946	174	53	174	57	46	39	9	59	21	0	0.906	1.000
497	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), TNFAIP3(2), TRAF3(4), TRAF6(4)	3976714	33	20	33	13	17	3	0	8	5	0	0.908	1.000
498	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2)	1413911	10	9	10	12	4	1	1	3	1	0	0.908	1.000
499	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2)	1413911	10	9	10	12	4	1	1	3	1	0	0.908	1.000
500	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(3), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(3), HARS(2), HARS2(2), HDC(3), HNMT(4), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), PRPS2(2), UROC1(1), WBSCR22(1)	8678763	86	37	86	30	32	26	0	23	5	0	0.909	1.000
501	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2)	1567225	12	10	12	4	4	3	0	4	1	0	0.911	1.000
502	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(7), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(2), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP9(2), CHUK(4), DFFA(2), DFFB(2), FASLG(1), GZMB(1), HELLS(4), IKBKB(2), IRF1(1), IRF2(3), IRF4(1), IRF5(3), IRF6(2), MAP3K1(6), MAPK10(4), MDM2(4), NFKB1(3), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(2), TNFRSF1A(1), TNFRSF21(4), TNFSF10(1), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4)	12214370	101	44	101	36	32	25	2	31	11	0	0.912	1.000
503	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPPL1(3), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MIOX(1), OCRL(5), PI4KA(11), PI4KB(2), PIK3C3(5), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5)	15792659	159	50	155	39	69	33	6	31	18	2	0.912	1.000
504	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(1), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SUOX(2)	1367733	9	7	9	1	5	0	0	1	3	0	0.914	1.000
505	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(5), SCAP(1), SREBF1(1), SREBF2(2)	2711560	14	13	14	10	4	6	1	0	3	0	0.915	1.000
506	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(1)	1526248	9	8	9	3	4	1	1	2	1	0	0.916	1.000
507	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(2), MAPK14(3), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2)	2630285	25	18	25	7	15	2	2	4	2	0	0.917	1.000
508	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(5), C9orf95(1), CD38(1), ENPP1(4), ENPP3(3), NADK(1), NADSYN1(2), NMNAT1(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(1), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT12(2), QPRT(1)	4949432	44	26	44	17	15	15	0	9	5	0	0.918	1.000
509	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), AKT2(5), BAD(1), CASP9(2), KDR(8), MAP2K1(3), MAPK1(2), MAPK12(2), MAPK14(3), MAPK3(2), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NOS3(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTGS2(2), PTK2(5), RAF1(4), SH2D2A(1), SPHK2(1), SRC(3), VEGFA(2)	15464931	136	51	134	47	60	24	3	30	19	0	0.921	1.000
510	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(7), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP7(1), CASP9(2), DFFA(2), DFFB(2), GZMB(1), SCAP(1), SREBF1(1), SREBF2(2)	3868815	26	19	26	14	5	6	1	10	4	0	0.922	1.000
511	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), ADRBK2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CLCA1(4), CLCA2(4), CLCA4(5), CNGA3(5), CNGA4(5), CNGB1(7), GNAL(3), GUCA1A(1), GUCA1B(2), PDC(2), PDE1C(7), PRKACB(1), PRKACG(2), PRKG1(4), PRKG2(3), PRKX(2)	6875932	66	29	65	30	22	14	2	20	8	0	0.923	1.000
512	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), BTRC(2), CDC16(3), CDC20(3), CDC23(6), CDC27(9), CUL1(7), CUL2(4), CUL3(1), FBXW11(7), ITCH(3), SKP1(1), SKP2(1), SMURF1(1), SMURF2(2), UBA1(1), UBE2C(2), UBE2D1(1), UBE2D4(1), UBE2E1(3), WWP1(5), WWP2(4)	8728214	80	37	76	28	23	14	2	28	13	0	0.923	1.000
513	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(6), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(2), NCOA1(6), NCOA2(4), NCOA3(6), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	5500768	45	26	45	17	15	15	2	11	2	0	0.924	1.000
514	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(4), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(3), NR4A3(2), WDR1(3)	2390028	21	13	21	5	5	9	0	5	2	0	0.924	1.000
515	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
516	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
517	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1)	3448610	29	19	28	8	11	11	1	3	3	0	0.925	1.000
518	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(4), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(1), CDC14A(1), CDC14B(3), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(3), CDC7(2), CDH1(4), CDK2(2), CDK4(2), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(1), E2F4(1), E2F5(2), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MPEG1(2), MPL(1), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(6), PRKDC(13), PTPRA(2), PTTG1(1), RB1(4), RBL1(3), SKP2(1), TBC1D8(5), TFDP1(4), TGFB1(1), WEE1(3)	22437469	192	58	192	52	51	56	4	55	25	1	0.925	1.000
519	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(6), CREBBP(21), CTBP1(1), CTBP2(2), DLL1(1), DLL3(2), DLL4(1), DTX1(4), DTX2(3), DTX3L(3), DTX4(3), DVL2(8), DVL3(2), EP300(13), HDAC1(2), HDAC2(2), HES1(1), JAG1(7), MAML1(1), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(11), NOTCH3(12), NOTCH4(3), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(1), RBPJ(1), RBPJL(3), SNW1(4)	15056595	139	51	138	54	48	42	1	27	21	0	0.929	1.000
520	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	5281950	54	25	54	17	19	14	2	16	3	0	0.930	1.000
521	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(2), IL22RA1(1), JAK1(3), JAK2(6), JAK3(6), STAT1(6), STAT3(2), STAT5B(2), TYK2(1)	4123712	30	20	29	14	12	6	2	7	2	1	0.931	1.000
522	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2)	1499829	13	9	13	6	6	3	0	4	0	0	0.932	1.000
523	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), CABIN1(9), CAMK1(1), CAMK1G(3), HDAC5(1), IGF1(2), IGF1R(7), INSR(5), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NFATC1(1), NFATC2(3), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYT1(1)	7145769	67	34	67	27	31	12	2	12	10	0	0.934	1.000
524	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), BLVRB(1), CP(3), EPRS(10), FECH(2), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UROS(1)	5872591	49	26	48	16	17	12	0	15	5	0	0.936	1.000
525	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(3), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALNT1(3), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT6(5), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGX(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(4), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4), UGCG(2)	10749110	110	40	110	30	45	21	4	23	17	0	0.938	1.000
526	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(8), ABCC2(11), ABCG2(5), BCHE(7), CES1(4), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5)	5140080	55	23	55	18	21	11	0	16	7	0	0.939	1.000
527	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), JAK2(6), TYK2(1)	3225578	26	15	27	17	5	10	1	6	3	1	0.942	1.000
528	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	4495812	39	26	39	14	15	8	0	15	1	0	0.942	1.000
529	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUL(3), HAL(3)	4253878	33	20	33	18	13	9	0	5	6	0	0.943	1.000
530	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), GAMT(1), GATM(1), GLUD1(2), ODC1(2), OTC(4), SMS(2)	3891102	39	21	39	14	11	12	0	9	7	0	0.945	1.000
531	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(2), CFLAR(2), CRKL(2), GRB2(2), IL2RA(2), IL2RB(1), IRS1(5), JAK1(3), JAK3(6), MAPK1(2), MAPK3(2), NMI(1), PIK3R1(5), PTPN6(4), RAF1(4), RPS6KB1(3), SHC1(3), SOS1(5), STAT5B(2)	7540908	61	31	58	23	21	12	3	17	8	0	0.945	1.000
532	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACADM(3), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), AOX1(5), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HADHB(1), HMGCS1(1), HSD17B10(1), HSD17B4(3), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), OXCT2(1), PCCA(3), PCCB(3)	9836332	84	38	84	23	35	19	0	21	9	0	0.947	1.000
533	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), AMOTL1(10), ASH1L(17), CASK(3), CDK4(2), CGN(6), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), EPB41(3), EPB41L1(8), EPB41L2(6), EPB41L3(15), EXOC4(4), F11R(1), GNAI1(3), HCLS1(7), IGSF5(6), INADL(3), JAM3(3), LLGL1(1), MAGI1(10), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(7), MPP5(3), MRAS(1), MYH1(8), MYH10(8), MYH11(22), MYH13(10), MYH14(9), MYH15(8), MYH2(9), MYH3(9), MYH4(11), MYH6(8), MYH7(7), MYH7B(4), MYH8(17), MYH9(9), MYL2(1), MYL7(1), OCLN(1), PARD3(5), PARD6G(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP2R3A(3), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PTEN(6), RAB3B(1), RHOA(4), RRAS2(1), SPTAN1(9), SRC(3), SYMPK(5), TJP1(5), TJP2(5), TJP3(1), YES1(1), ZAK(4)	42152446	460	84	453	145	202	94	10	106	45	3	0.950	1.000
534	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IFNB1(1), IKBKB(2), IL1A(1), IL1R1(3), IL1RN(2), IL6(1), IRAK1(1), IRAK2(8), IRAK3(1), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), RELA(2), TGFB1(1), TGFB2(5), TOLLIP(1), TRAF6(4)	6521723	61	27	61	18	26	9	1	18	7	0	0.950	1.000
535	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(4), IFNG(1), IKBKB(2), IL2(3), IL4(3), MAP3K1(6), MAP3K5(5), MAP4K5(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF9(2), TRAF2(1)	4337863	39	20	39	11	17	8	1	11	2	0	0.951	1.000
536	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(1), ENPP7(1), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(2), SGMS2(4), SGPP2(2), SMPD1(6), SMPD3(3), SMPD4(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(6)	7755348	76	34	75	26	25	23	2	21	5	0	0.951	1.000
537	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(4), IKBKB(2), IRAK1(1), LY96(2), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), PPARA(1), RELA(2), TIRAP(1), TLR10(1), TLR2(2), TLR3(4), TLR4(7), TLR6(2), TLR7(4), TLR9(4), TOLLIP(1), TRAF6(4)	7790703	66	31	66	26	25	11	4	19	7	0	0.952	1.000
538	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(1), SHMT1(1)	3646018	30	19	29	9	11	11	1	4	3	0	0.953	1.000
539	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(2), BIRC3(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	1653269	9	9	9	4	3	2	1	3	0	0	0.955	1.000
540	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	75	AIFM1(1), AKT1(2), AKT2(5), APAF1(7), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP9(2), CFLAR(2), CHUK(4), CSF2RB(7), DFFA(2), DFFB(2), FASLG(1), IKBKB(2), IL1A(1), IL1R1(3), IL3(3), IRAK1(1), IRAK2(8), IRAK3(1), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(6), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(2), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(1)	16085517	144	50	143	45	52	32	4	38	18	0	0.958	1.000
541	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(6), DLL1(1), FURIN(2), PSEN1(3)	2035925	12	10	12	2	5	4	0	0	3	0	0.959	1.000
542	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), CAPN1(2), CAPN10(3), CAPN11(1), CAPN2(5), CAPN3(6), CAPN5(5), CAPN6(2), CAPN7(3), CAPN9(1), CAPNS1(1), CAV2(1), CAV3(2), CSK(1), DOCK1(5), FYN(4), GIT2(6), GRB2(2), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAPK10(4), MAPK12(2), MAPK4(1), MAPK6(2), MAPK7(3), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SORBS1(7), SOS1(5), SRC(3), TLN1(5), TNS1(11), VASP(3), VAV2(2), VAV3(10), VCL(1)	29475050	268	71	264	105	97	50	7	83	31	0	0.960	1.000
543	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(4), EGR2(6), EGR3(2), GNAQ(3), MAP3K1(6), NFATC1(1), NFATC2(3), NFKB1(3), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(1), VIPR2(3)	6108680	53	29	52	16	25	9	2	8	9	0	0.962	1.000
544	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLUD1(2)	1206787	5	5	5	2	3	2	0	0	0	0	0.962	1.000
545	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(2), CREB3L1(3), CREB3L3(1), CREB3L4(1), E2F2(1), E2F3(1), E2F4(1), E2F5(2), GBA2(5), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MNAT1(1), MYT1(8), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLE(17), RB1(4), RBL1(3), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(14), WEE1(3)	14909750	130	45	129	29	38	32	1	44	14	1	0.962	1.000
546	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(14), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), ADIPOR1(1), ADIPOR2(2), AKT1(2), AKT2(5), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(4), CPT1A(5), CPT1B(5), CPT2(1), G6PC(3), IKBKB(2), IRS1(5), IRS4(11), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), MAPK10(4), MAPK8(2), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NPY(1), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRB(2), RXRG(3), SLC2A4(3), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	18673754	179	55	178	65	55	48	4	54	17	1	0.963	1.000
547	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), HSD3B7(2), NSD1(11), OGDH(4), OGDHL(8), PIPOX(4), PLOD1(3), PLOD2(4), PLOD3(3), RDH12(2), RDH13(1), SETD1A(7), SETD7(2), SETDB1(7), SHMT1(1), SHMT2(2), SPCS1(1), SUV39H1(1), SUV39H2(2), TMLHE(1)	13066752	120	46	120	33	50	22	0	32	16	0	0.964	1.000
548	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8)	3767056	36	19	34	9	15	6	0	12	3	0	0.964	1.000
549	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), GNA12(2), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2)	2305248	14	11	14	10	4	3	0	2	5	0	0.965	1.000
550	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(5), CLTA(1), COPA(1), GBF1(11), GPLD1(4), KDELR1(2), KDELR3(1)	3720912	29	20	29	12	12	7	0	8	2	0	0.966	1.000
551	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	B3GALT4(1), CDR1(1), DGKI(6), IL6ST(2), MRPL19(1), PIGK(3), RPL18A(1), RPL21(1), RPL22(2), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL6(1), RPL7(1), RPL9(3), RPLP0(2), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS4X(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), RPS9(2), RPSA(1), SLC36A2(1), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(1)	9571858	80	36	79	22	30	15	0	20	15	0	0.966	1.000
552	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(4), ASS1(1), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), EPRS(10), GAMT(1), GATM(1), GLUD1(2), GLUD2(4), GOT1(5), GOT2(1), LAP3(1), NOS1(5), NOS3(2), OTC(4), P4HA2(2), P4HA3(1), RARS(2), RARS2(3)	8004672	69	31	69	25	22	19	0	17	11	0	0.966	1.000
553	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(13), ATP4A(8), ATP4B(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(2), COX15(1), COX17(1), COX4I1(2), COX4I2(2), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(1), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(1), NDUFA9(2), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(4), NDUFS3(2), NDUFS6(2), NDUFV1(2), PPA1(2), PPA2(1), SDHA(5), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRH(1)	12651670	133	44	132	32	55	36	1	29	12	0	0.969	1.000
554	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(7), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP9(2), CFLAR(2), CHUK(4), DFFA(2), DFFB(2), GAS2(2), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF10A(3), TNFRSF10B(2), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	7256651	60	31	60	27	22	15	0	18	4	1	0.970	1.000
555	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(5), CD38(1), ENPP1(4), ENPP3(3), NADSYN1(2), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(1), NT5E(2), NT5M(1), QPRT(1)	3362885	23	16	23	11	9	8	0	4	2	0	0.970	1.000
556	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(2), AKT2(5), ARHGEF11(9), BCL2(1), DLG4(2), GNA13(2), LPA(9), MAP3K1(6), MAP3K5(5), MAPK8(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RDX(2), ROCK1(8), ROCK2(2), SERPINA4(2), SRF(3)	10647426	94	39	94	34	40	17	1	25	11	0	0.971	1.000
557	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(2), NFE2L2(1), PRKCA(2)	1909327	14	9	14	3	2	5	0	7	0	0	0.973	1.000
558	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), CDS1(1), CDS2(4), CHAT(6), CHKA(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), ESCO1(7), ESCO2(3), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(2), GPD1(1), GPD1L(2), GPD2(3), LCAT(1), MYST3(13), MYST4(5), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PNPLA3(4), PPAP2B(1), PTDSS1(4), SH3GLB1(3)	14992014	139	47	138	56	50	38	1	40	10	0	0.974	1.000
559	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADHA(2), PLOD1(3), PLOD2(4), PLOD3(3), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1)	8307032	76	34	76	17	29	17	0	20	10	0	0.974	1.000
560	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(1), CASP2(4), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	5189587	42	22	42	18	18	11	4	6	3	0	0.974	1.000
561	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH12(2), RDH13(1)	1067763	6	5	6	3	3	1	0	2	0	0	0.975	1.000
562	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(14), ACACB(14), AKT1(2), AKT2(5), ARAF(3), BAD(1), CBL(2), CBLB(6), CRKL(2), EXOC7(1), FASN(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GCK(1), GRB2(2), GSK3B(7), GYS1(1), GYS2(8), IKBKB(2), INPP5D(2), INSR(5), IRS1(5), IRS4(11), LIPE(3), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MKNK1(1), MKNK2(2), PCK2(3), PDE3A(5), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(1), PPP1CC(1), PPP1R3A(8), PPP1R3B(1), PPP1R3C(2), PPP1R3D(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(2), PTPN1(4), PTPRF(8), PYGB(4), PYGL(2), PYGM(2), RAF1(4), RAPGEF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(2), SORBS1(7), SOS1(5), SOS2(9), SREBF1(1), TSC1(3), TSC2(1)	34862232	302	75	298	119	105	71	8	87	31	0	0.975	1.000
563	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(1), DERA(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKL(1), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(4), TKTL2(5)	5372056	50	28	50	16	20	12	0	16	2	0	0.976	1.000
564	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	26	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(1), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MADD(13), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), RB1(4), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF2(1)	7973716	78	31	78	31	23	20	4	19	10	2	0.976	1.000
565	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), IKBKB(2), IL1A(1), IL1R1(3), IRAK1(1), MAP3K1(6), MAP3K14(2), MAP3K7(2), MYD88(1), NFKB1(3), RELA(2), RIPK1(2), TLR4(7), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	5376907	44	21	44	15	18	7	2	12	5	0	0.977	1.000
566	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCS1(1), OXCT1(3), OXCT2(1)	1654560	9	8	9	3	4	1	0	4	0	0	0.978	1.000
567	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(8), AMY2A(3), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENPP1(4), ENPP3(3), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), G6PC(3), GANC(2), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), IFIH1(5), MGAM(9), MOV10L1(6), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SI(12), SKIV2L2(2), SMARCA2(8), SMARCA5(3), TREH(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UXS1(6)	26917431	278	64	274	85	96	76	3	69	33	1	0.978	1.000
568	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(14), ACACB(14), FASN(1), MCAT(1), OLAH(1), OXSM(4)	3645065	35	18	35	8	13	10	0	10	2	0	0.978	1.000
569	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(2), CHST12(2), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A1(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SULT2B1(1), SUOX(2)	2068896	17	11	17	3	9	2	0	3	3	0	0.979	1.000
570	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFAIP3(2), TRAF1(1), TRAF2(1), TRAF3(4)	4932283	36	21	36	13	19	6	0	7	4	0	0.980	1.000
571	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(13), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2), PPA2(1), SDHA(5), SDHB(2), SHMT1(1), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	7885338	80	31	79	21	33	25	1	15	6	0	0.981	1.000
572	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1)	4503008	42	23	42	15	15	14	1	11	1	0	0.982	1.000
573	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(5), EIF4B(1), HIF1A(1), IGF1(2), MAPK1(2), MAPK3(2), PDPK1(1), PGF(1), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PRKAA1(2), PRKAA2(6), RICTOR(10), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), TSC1(3), TSC2(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(3)	11043171	97	37	96	28	34	21	2	24	16	0	0.982	1.000
574	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	ATR(13), BRCA1(5), BRCA2(11), CHEK1(1), CHEK2(1), FANCA(5), FANCC(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(3), RAD1(1), RAD17(2), RAD50(5), TREX1(2)	8371032	63	26	63	12	21	10	5	16	11	0	0.982	1.000
575	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), PER1(1)	1928382	16	10	16	4	7	2	0	5	2	0	0.982	1.000
576	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(2), HMGCR(2), IDI1(1), LSS(1), MVK(1), NQO1(1), PMVK(1), SC5DL(1), SQLE(1)	2478269	13	12	13	6	7	4	0	1	1	0	0.983	1.000
577	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(3), ACO2(2), FH(1), IDH1(3), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), PC(3), SDHA(5), SDHB(2), SUCLA2(3), SUCLG1(1)	4380359	28	19	28	12	13	6	0	6	3	0	0.984	1.000
578	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(4), DNAJC3(1), EIF2S2(1), MAP3K14(2), NFKB1(3), RELA(2)	1979947	13	7	13	5	8	2	0	1	2	0	0.984	1.000
579	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(3), AKT1(2), BDKRB2(2), CHRM1(3), CHRNA1(2), FLT1(9), FLT4(4), KDR(8), NOS3(2), PDE3A(5), PDE3B(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), SLC7A1(2), SYT1(1), TNNI1(2)	7075463	61	30	61	30	26	11	3	15	6	0	0.984	1.000
580	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(3), CLK3(2), CLK4(2), COL2A1(8), CPSF1(4), CPSF2(1), CPSF3(1), CPSF4(3), CSTF1(1), CSTF2T(5), CSTF3(2), DDX1(4), DDX20(3), DHX15(1), DHX16(6), DHX38(10), DHX8(6), DHX9(4), DICER1(7), DNAJC8(2), METTL3(3), NCBP1(4), NCBP2(1), NONO(1), NUDT21(1), NXF1(5), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(3), PRPF3(1), PRPF4(4), PRPF4B(3), PRPF8(9), PSKH1(1), PTBP1(1), PTBP2(3), RBM17(2), RBM5(1), RNGTT(6), RNMT(3), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(9), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPB2(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(7), SRPK2(2), SRRM1(8), SUPT5H(10), TXNL4A(1), U2AF1(1), U2AF2(2), XRN2(6)	23732676	210	63	210	60	69	53	3	51	34	0	0.985	1.000
581	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(7), AP2A1(2), AP2M1(4), BIN1(1), DNM1(8), EPN1(1), EPS15(4), PICALM(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYNJ1(8), SYNJ2(5), SYT1(1)	4961899	51	22	49	22	14	11	1	13	12	0	0.986	1.000
582	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL10L(2), RPL18A(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(1), RPL7(1), RPL9(3), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS9(2), RPSA(1)	4720501	34	21	34	10	14	7	0	10	3	0	0.986	1.000
583	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ITPA(2), NT5E(2), NT5M(1), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TYMS(2), UCK2(1), UNG(1), UPB1(3)	12889515	118	42	116	30	36	34	3	36	9	0	0.987	1.000
584	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(5), FUCA1(1), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NAGLU(3), NEU2(1), NEU3(1), SPAM1(1)	7626724	78	31	77	26	27	18	2	23	8	0	0.988	1.000
585	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(1), ACY1(2), ADC(1), ALDH18A1(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), ASS1(1), CPS1(8), GATM(1), MAOA(2), ODC1(2), OTC(4), SAT2(1), SMS(2)	6573135	63	28	63	23	21	21	0	16	5	0	0.989	1.000
586	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1G(1), EEF2(3), EIF2AK1(5), EIF2AK3(1), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4A2(4), EIF4G1(8), EIF4G3(8), EIF5(3), EIF5A(1), EIF5B(4), ETF1(2), KIAA0664(4), PABPC1(3), PABPC3(4), PAIP1(1), SLC35A4(2)	9672283	66	34	65	19	21	15	2	18	10	0	0.990	1.000
587	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GOT1(5), GOT2(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(1), MDH2(1), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PKM2(2), TNFAIP1(3), TPI1(1)	9359869	88	36	87	30	38	17	1	25	7	0	0.990	1.000
588	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), GGCX(2), HMGCR(2), IDI1(1), IDI2(1), LSS(1), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1)	4305366	28	19	28	9	10	7	1	6	4	0	0.990	1.000
589	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CPT1B(5), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), MAOA(2), PEMT(1), PLCB2(3), PLCG1(4), PLCG2(9), SARDH(7), SARS(1), SHMT1(1), SHMT2(2), TARS(3)	9396084	85	36	84	30	38	22	0	14	11	0	0.991	1.000
590	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), B4GALT1(5), B4GALT2(3), G6PC(3), GALE(1), GALK2(2), GALT(2), GANC(2), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), HSD3B7(2), LCT(15), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(2), PGM3(4), RDH12(2), RDH13(1), UGP2(5)	8464403	85	33	85	31	39	23	1	19	3	0	0.991	1.000
591	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP19(1), SRP54(1), SRP68(1), SRP72(3)	1699033	9	8	9	4	4	2	0	3	0	0	0.991	1.000
592	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1C(2), AKT1(2), AKT2(5), ARRB1(1), BDNF(1), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(3), CACNB1(1), CACNB2(5), CACNB3(1), CACNG1(2), CACNG2(2), CACNG3(5), CACNG4(2), CACNG5(5), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(5), CHUK(4), CRKL(2), DUSP1(2), DUSP10(4), DUSP16(3), DUSP3(1), DUSP4(1), DUSP5(1), DUSP6(4), DUSP7(1), DUSP9(1), ECSIT(2), EGF(3), EGFR(10), ELK4(1), FASLG(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FLNA(2), FLNB(14), FLNC(11), GNA12(2), GRB2(2), IKBKB(2), IL1A(1), IL1R1(3), IL1R2(3), MAP2K1(3), MAP2K3(2), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(4), MAX(1), MEF2C(7), MKNK1(1), MKNK2(2), MOS(2), MRAS(1), NF1(5), NFATC2(3), NFATC4(4), NFKB1(3), NFKB2(2), NLK(1), NR4A1(2), NTF3(1), NTRK1(6), NTRK2(3), PAK1(4), PAK2(2), PDGFA(1), PDGFRA(13), PDGFRB(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PPM1A(7), PPM1B(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PPP5C(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTPN5(1), PTPN7(1), PTPRR(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(8), RASA1(5), RASA2(1), RASGRF1(9), RASGRF2(5), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KA6(5), RRAS2(1), SOS1(5), SOS2(9), SRF(3), STK3(3), STK4(3), STMN1(1), TAOK1(5), TAOK2(2), TAOK3(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF1A(1), TRAF2(1), TRAF6(4), ZAK(4)	61078255	615	97	606	231	255	129	13	151	65	2	0.991	1.000
593	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(3), DDX20(3), E2F4(1), ETS2(2), HDAC2(2), HDAC5(1), NCOR2(2), RBL1(3), RBL2(8), SIN3A(4), SIN3B(3)	5863448	33	20	33	18	10	6	0	9	8	0	0.991	1.000
594	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPS(2), CDS1(1), CDS2(4), CHAT(6), CHKA(2), CLC(2), CPT1B(5), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD1(1), GPD2(3), LCAT(1), PAFAH1B1(3), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PLCB2(3), PLCG1(4), PLCG2(9), PPAP2B(1)	11282175	106	40	104	41	40	25	1	29	11	0	0.992	1.000
595	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(2), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), GAMT(1), GATM(1), GLUD1(2), GOT1(5), GOT2(1), MAOA(2), NOS1(5), NOS3(2), ODC1(2), OTC(4), P4HA2(2), P4HA3(1), P4HB(2), RARS(2), SMS(2)	9781881	95	35	95	32	36	27	0	22	10	0	0.992	1.000
596	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(17), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(7), DOT1L(3), EED(2), EHMT1(2), EHMT2(1), EZH1(4), EZH2(4), FBXO11(4), JMJD6(2), KDM6A(1), MEN1(1), MLL(15), MLL2(14), MLL3(10), MLL4(8), MLL5(11), NSD1(11), OGT(4), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(13), PRDM7(1), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), RBBP5(2), SATB1(1), SETD1A(7), SETD2(10), SETD7(2), SETD8(2), SETDB1(7), SETDB2(1), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(2), SUV420H1(5), SUZ12(2), WHSC1(6), WHSC1L1(4)	25649276	210	56	207	70	85	40	2	55	27	1	0.992	1.000
597	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(2), HMGCR(2), HMGCS1(1), IDI1(1), LSS(1), MVK(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1)	2946365	18	13	18	7	8	5	0	3	2	0	0.992	1.000
598	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	25	BAG4(2), BIRC2(2), BIRC3(2), CASP3(1), CFLAR(2), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(4), RIPK1(2), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	5658027	36	22	36	10	12	10	1	12	1	0	0.993	1.000
599	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), CHPF(3), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHSY1(5), DSE(2), UST(1), XYLT1(4), XYLT2(2)	3125802	24	15	24	21	8	7	2	5	2	0	0.993	1.000
600	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(2), CDK2(2), DIAPH2(9), GMNN(1), MCM10(6), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), RFC1(10), RFC4(3), RFC5(2), RPA1(2), RPA2(1), RPA4(2), UBA52(2), UBB(1)	11275109	94	37	93	21	22	23	0	36	13	0	0.993	1.000
601	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(2), DLAT(2), FH(1), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PDK2(1), PDK4(2), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1)	6171117	46	24	46	16	21	10	0	7	8	0	0.993	1.000
602	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1)	3030829	22	12	22	3	7	8	1	5	1	0	0.993	1.000
603	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	CREB1(1), GRB2(2), HSPB2(1), MAP2K6(2), MAP3K1(6), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(2), RPS6KA5(3), SHC1(3), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1)	7903522	74	27	72	25	29	19	2	16	8	0	0.994	1.000
604	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	38	APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP9(2), FASLG(1), GZMB(1), MAP3K1(6), MAP3K14(2), MAPK10(4), MDM2(4), NFKB1(3), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF1(1), TRAF2(1)	7652944	59	29	59	25	23	16	2	15	3	0	0.994	1.000
605	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), MST1(1), MST1R(1)	1358366	3	3	3	1	1	1	0	1	0	0	0.995	1.000
606	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD3B1(2)	1844290	12	8	12	2	4	4	0	3	1	0	0.995	1.000
607	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), FUK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), HSD3B7(2), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(1), MTMR6(4), PFKFB1(6), PFKFB4(2), PFKL(1), PFKM(1), PFKP(2), PHPT1(1), PMM1(1), RDH12(2), RDH13(1), TPI1(1), TSTA3(1)	8400861	68	33	68	32	27	14	0	22	5	0	0.996	1.000
608	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), GGH(1)	1353847	5	5	5	1	2	1	1	1	0	0	0.996	1.000
609	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	CHUK(4), CREB1(1), GRB2(2), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP3K9(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAP4K5(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK4(1), MAPK6(2), MAPK7(3), MAPK8(2), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), MKNK2(2), NFKB1(3), PAK1(4), PAK2(2), RAF1(4), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KB1(3), RPS6KB2(1), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1)	20608939	197	53	193	60	74	44	5	51	23	0	0.996	1.000
610	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), GNMT(1), HSD3B7(2), MAOA(2), PEMT(1), PHGDH(2), PIPOX(4), PSAT1(3), RDH12(2), RDH13(1), SARDH(7), SARS(1), SARS2(2), SDS(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(4)	9632105	87	35	87	31	35	22	0	19	11	0	0.997	1.000
611	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), GGH(1), IFIH1(5), MOV10L1(6), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SKIV2L2(2), SMARCA2(8), SMARCA5(3)	14115773	129	40	126	38	54	35	3	24	12	1	0.997	1.000
612	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(7), AZIN1(2), BTG1(1), CBX3(1), CLOCK(5), CRY1(2), CRY2(1), DNAJA1(1), EIF4G2(7), ETV6(4), GFRA1(3), GSTM3(2), HERPUD1(1), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(8), NCOA4(3), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PSMA4(2), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(2), UGP2(5), ZFR(1)	8255610	74	29	72	17	33	14	3	16	8	0	0.997	1.000
613	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	APAF1(7), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP9(2), CFLAR(2), CHUK(4), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK8(2), MDM2(4), NFKB1(3), NUMA1(8), PAK2(2), PRKCD(3), PRKDC(13), PSEN1(3), PSEN2(2), PTK2(5), RASA1(5), RB1(4), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1)	14812128	125	41	125	44	40	33	5	33	12	2	0.999	1.000
614	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(4), BRCA1(5), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(2), MDM2(4), MRE11A(3), NFKB1(3), RAD50(5), RBBP8(2), RELA(2)	5127746	33	17	33	7	9	12	2	6	4	0	0.999	1.000
615	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(4), PGAP1(6), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGW(1), PIGX(2)	5321874	31	18	31	13	10	6	1	9	5	0	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		117141	0	0	0	1	0	0	0	0	0	0	1.000	1.000