E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.02 0.037 -9999.0 0.0 -0.321 1.0 1.0 KLHL20 0.027 0.068 -9999.0 0.0 -0.239 5.0 5.0 CYFIP2 0.014 0.074 -9999.0 0.0 -0.493 4.0 4.0 Rac1/GDP 0.063 0.078 0.277 2.0 -9999.0 0.0 2.0 ENAH 0.014 0.05 -9999.0 0.0 -0.321 1.0 1.0 AP1M1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.017 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.012 0.036 -9999.0 0.0 -0.168 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.064 -9999.0 0.0 -0.266 6.0 6.0 RAPGEF1 0.049 0.079 0.294 2.0 -0.287 1.0 3.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.027 0.038 -9999.0 0.0 -0.329 1.0 1.0 CRK 0.008 0.03 -9999.0 0.0 -0.306 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.048 0.028 -9999.0 0.0 -0.304 1.0 1.0 alphaE/beta7 Integrin 0.014 0.077 -9999.0 0.0 -0.331 8.0 8.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.027 -9999.0 0.0 -0.276 1.0 1.0 DLG1 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.004 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.038 -9999.0 0.0 -0.493 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.024 0.087 -9999.0 0.0 -0.275 14.0 14.0 PI3K 0.008 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 -0.031 0.145 -9999.0 0.0 -0.493 15.0 15.0 E-cadherin(dimer)/Ca2+ 0.057 0.027 -9999.0 0.0 -0.261 1.0 1.0 AKT1 0.031 0.042 0.14 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.074 0.082 0.267 3.0 -9999.0 0.0 3.0 actin cytoskeleton organization 0.035 0.063 0.169 12.0 -0.173 5.0 17.0 CDC42/GDP 0.07 0.081 0.267 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.018 0.019 -9999.0 0.0 -0.239 1.0 1.0 ITGB7 0.002 0.101 -9999.0 0.0 -0.358 12.0 12.0 RAC1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.061 0.029 -9999.0 0.0 -0.278 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.043 0.023 -9999.0 0.0 -0.259 1.0 1.0 mol:GDP 0.066 0.088 0.274 3.0 -9999.0 0.0 3.0 CDC42/GTP/IQGAP1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.081 0.081 0.284 2.0 -9999.0 0.0 2.0 RAC1/GTP/IQGAP1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.038 -9999.0 0.0 -0.493 1.0 1.0 positive regulation of S phase of mitotic cell cycle 0.028 0.045 0.132 11.0 -0.12 2.0 13.0 NME1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.019 0.037 -9999.0 0.0 -0.321 1.0 1.0 regulation of cell-cell adhesion 0.011 0.021 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.011 0.03 -9999.0 0.0 -0.121 1.0 1.0 Rap1/GTP 0.07 0.071 0.234 1.0 -9999.0 0.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.069 -9999.0 0.0 -0.256 7.0 7.0 CCND1 0.032 0.053 0.151 11.0 -0.146 2.0 13.0 VAV2 0.057 0.161 -9999.0 0.0 -0.694 6.0 6.0 RAP1/GDP 0.081 0.079 0.278 3.0 -9999.0 0.0 3.0 adherens junction assembly 0.019 0.036 -9999.0 0.0 -0.313 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.064 -9999.0 0.0 -0.244 7.0 7.0 E-cadherin/beta catenin 0.014 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.013 0.032 -9999.0 0.0 -0.321 1.0 1.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.078 -9999.0 0.0 -0.373 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.049 0.027 -9999.0 0.0 -0.304 1.0 1.0 ITGAE 0.021 0.017 -9999.0 0.0 -0.169 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.039 -9999.0 0.0 -0.335 1.0 1.0