Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.053 0.192 -9999.0 0.0 -0.569 19.0 19.0 IHH -0.039 0.173 -9999.0 0.0 -0.523 20.0 20.0 SHH Np/Cholesterol/GAS1 -0.039 0.117 0.17 1.0 -0.288 31.0 32.0 LRPAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.039 0.116 0.286 31.0 -0.168 1.0 32.0 SMO/beta Arrestin2 -0.057 0.201 -9999.0 0.0 -0.481 27.0 27.0 SMO -0.064 0.205 -9999.0 0.0 -0.482 30.0 30.0 AKT1 -0.026 0.132 -9999.0 0.0 -0.404 11.0 11.0 ARRB2 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.028 0.138 -9999.0 0.0 -0.305 31.0 31.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.065 0.203 -9999.0 0.0 -0.47 31.0 31.0 STIL -0.03 0.145 -9999.0 0.0 -0.445 13.0 13.0 DHH N/PTCH2 -0.027 0.151 -9999.0 0.0 -0.396 24.0 24.0 DHH N/PTCH1 -0.048 0.169 -9999.0 0.0 -0.322 45.0 45.0 PIK3CA 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.146 -9999.0 0.0 -0.416 21.0 21.0 PTHLH -0.079 0.26 -9999.0 0.0 -0.777 19.0 19.0 determination of left/right symmetry -0.065 0.203 -9999.0 0.0 -0.47 31.0 31.0 PIK3R1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.078 0.257 -9999.0 0.0 -0.767 19.0 19.0 IHH N/Hhip -0.083 0.191 -9999.0 0.0 -0.399 45.0 45.0 DHH N/Hhip -0.074 0.177 -9999.0 0.0 -0.376 44.0 44.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.065 0.203 -9999.0 0.0 -0.47 31.0 31.0 pancreas development -0.072 0.187 -9999.0 0.0 -0.369 47.0 47.0 HHAT 0.019 0.053 -9999.0 0.0 -0.493 2.0 2.0 PI3K 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.185 -9999.0 0.0 -0.354 49.0 49.0 somite specification -0.065 0.203 -9999.0 0.0 -0.47 31.0 31.0 SHH Np/Cholesterol/PTCH1 -0.035 0.145 -9999.0 0.0 -0.362 24.0 24.0 SHH Np/Cholesterol/PTCH2 -0.011 0.089 -9999.0 0.0 -0.279 17.0 17.0 SHH Np/Cholesterol/Megalin 0.001 0.07 -9999.0 0.0 -0.291 9.0 9.0 SHH -0.004 0.075 -9999.0 0.0 -0.358 8.0 8.0 catabolic process -0.037 0.152 -9999.0 0.0 -0.346 33.0 33.0 SMO/Vitamin D3 -0.048 0.182 -9999.0 0.0 -0.419 30.0 30.0 SHH Np/Cholesterol/Hhip -0.045 0.123 -9999.0 0.0 -0.293 34.0 34.0 LRP2 0.009 0.048 -9999.0 0.0 -0.169 13.0 13.0 receptor-mediated endocytosis -0.052 0.173 -9999.0 0.0 -0.506 17.0 17.0 SHH Np/Cholesterol/BOC -0.018 0.1 0.17 1.0 -0.287 20.0 21.0 SHH Np/Cholesterol/CDO 0.003 0.075 -9999.0 0.0 -0.28 12.0 12.0 mesenchymal cell differentiation 0.045 0.122 0.291 34.0 -9999.0 0.0 34.0 mol:Vitamin D3 -0.026 0.155 -9999.0 0.0 -0.364 24.0 24.0 IHH N/PTCH2 -0.033 0.154 -9999.0 0.0 -0.383 27.0 27.0 CDON 0.013 0.07 -9999.0 0.0 -0.308 7.0 7.0 IHH N/PTCH1 -0.032 0.156 -9999.0 0.0 -0.349 33.0 33.0 Megalin/LRPAP1 0.024 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 -0.012 0.121 -9999.0 0.0 -0.331 20.0 20.0 SHH Np/Cholesterol 0.0 0.061 -9999.0 0.0 -0.272 9.0 9.0 PTCH1 -0.038 0.153 -9999.0 0.0 -0.347 33.0 33.0 HHIP -0.072 0.187 -9999.0 0.0 -0.369 47.0 47.0