Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.023 0.02 -9999.0 0.0 -0.234 1.0 1.0 epithelial cell differentiation 0.051 0.026 -9999.0 0.0 -0.259 1.0 1.0 CYFIP2 0.014 0.074 -9999.0 0.0 -0.493 4.0 4.0 ENAH -0.014 0.039 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.022 0.038 -9999.0 0.0 -0.493 1.0 1.0 MYO6 0.012 0.025 0.176 2.0 -0.25 1.0 3.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.052 -9999.0 0.0 -0.304 4.0 4.0 AQP5 -0.022 0.132 -9999.0 0.0 -0.45 16.0 16.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.012 0.025 -9999.0 0.0 -0.246 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.074 -9999.0 0.0 -0.266 13.0 13.0 EGF -0.108 0.188 -9999.0 0.0 -0.298 78.0 78.0 NCKAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.01 0.06 -9999.0 0.0 -0.429 3.0 3.0 cortical microtubule organization 0.051 0.026 -9999.0 0.0 -0.259 1.0 1.0 GO:0000145 -0.007 0.024 0.164 2.0 -0.235 1.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.057 0.027 -9999.0 0.0 -0.261 1.0 1.0 MLLT4 0.023 0.038 -9999.0 0.0 -0.493 1.0 1.0 ARF6/GDP -0.014 0.023 -9999.0 0.0 -0.228 2.0 2.0 ARF6 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.033 -9999.0 0.0 -0.278 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.007 0.021 -9999.0 0.0 -0.227 1.0 1.0 PVRL2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.011 0.023 0.176 1.0 -0.25 1.0 2.0 ARF6/GTP 0.061 0.036 -9999.0 0.0 -0.26 1.0 1.0 CDH1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.028 0.105 -9999.0 0.0 -0.246 29.0 29.0 RhoA/GDP 0.052 0.026 -9999.0 0.0 -0.247 1.0 1.0 actin cytoskeleton organization -0.007 0.025 0.165 2.0 -0.246 1.0 3.0 IGF-1R heterotetramer 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.063 0.175 -9999.0 0.0 -0.335 47.0 47.0 DIAPH1 0.025 0.127 -9999.0 0.0 -0.563 7.0 7.0 Wnt receptor signaling pathway -0.051 0.026 0.259 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.014 0.023 -9999.0 0.0 -0.228 2.0 2.0 CTNNA1 0.023 0.038 -9999.0 0.0 -0.493 1.0 1.0 VCL -0.007 0.025 0.167 2.0 -0.251 1.0 3.0 EFNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.008 0.026 0.17 2.0 -0.24 1.0 3.0 Ephrin A1/EPHA2 0.041 0.035 -9999.0 0.0 -0.245 2.0 2.0 SEC6/SEC8 0.01 0.026 -9999.0 0.0 -0.235 2.0 2.0 MGAT3 -0.011 0.075 -9999.0 0.0 -0.27 13.0 13.0 HGF/MET 0.017 0.083 -9999.0 0.0 -0.243 16.0 16.0 HGF -0.026 0.146 -9999.0 0.0 -0.395 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.023 0.02 -9999.0 0.0 -0.236 1.0 1.0 actin cable formation 0.007 0.064 0.203 6.0 -0.305 2.0 8.0 KIAA1543 -0.007 0.025 0.165 2.0 -0.239 1.0 3.0 KIFC3 0.007 0.041 -9999.0 0.0 -0.252 4.0 4.0 NCK1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.012 0.025 0.176 2.0 -0.25 1.0 3.0 NCK1/GIT1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.051 0.026 -9999.0 0.0 -0.259 1.0 1.0 EXOC4 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.012 0.025 -9999.0 0.0 -0.25 1.0 1.0 PIP5K1C 0.012 0.025 -9999.0 0.0 -0.25 1.0 1.0 LIMA1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.006 0.044 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.003 0.054 0.258 1.0 -0.328 3.0 4.0 IGF-1R heterotetramer/IGF1 -0.007 0.101 -9999.0 0.0 -0.243 25.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.031 -9999.0 0.0 -0.357 1.0 1.0 MET 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.013 0.025 -9999.0 0.0 -0.25 1.0 1.0 mol:GTP 0.055 0.032 -9999.0 0.0 -0.276 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.001 0.058 0.319 2.0 -9999.0 0.0 2.0 cortical actin cytoskeleton stabilization 0.023 0.02 -9999.0 0.0 -0.234 1.0 1.0 regulation of cell-cell adhesion -0.007 0.025 0.165 2.0 -0.246 1.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.023 0.02 -9999.0 0.0 -0.236 1.0 1.0