Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	33.0	1473.0	44.0	-0.166	0.026	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	31.0	2829.0	91.0	-0.655	0.582	1000.0	-1000.0	-0.115	-1000.0
IL23-mediated signaling events	30.0	1856.0	60.0	-0.455	0.025	1000.0	-1000.0	-0.082	-1000.0
Wnt signaling	28.0	196.0	7.0	-0.092	0.02	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by the Hedgehog family	21.0	1106.0	52.0	-0.083	0.045	1000.0	-1000.0	-0.031	-1000.0
Noncanonical Wnt signaling pathway	21.0	556.0	26.0	-0.092	0.025	1000.0	-1000.0	-0.036	-1000.0
HIF-1-alpha transcription factor network	21.0	1642.0	76.0	-0.244	0.031	1000.0	-1000.0	-0.088	-1000.0
Reelin signaling pathway	21.0	1193.0	56.0	-0.096	0.061	1000.0	-1000.0	-0.042	-1000.0
Endothelins	21.0	2058.0	96.0	-0.161	0.026	1000.0	-1000.0	-0.054	-1000.0
Ephrin A  reverse signaling	20.0	146.0	7.0	-0.053	0.014	1000.0	-1000.0	-0.012	-1000.0
Ephrin B reverse signaling	19.0	943.0	48.0	-0.131	0.028	1000.0	-1000.0	-0.025	-1000.0
Syndecan-1-mediated signaling events	18.0	620.0	34.0	-0.085	0.026	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	18.0	1522.0	82.0	-0.123	0.034	1000.0	-1000.0	-0.03	-1000.0
BCR signaling pathway	18.0	1868.0	99.0	-0.151	0.027	1000.0	-1000.0	-0.049	-1000.0
IL12-mediated signaling events	17.0	1517.0	87.0	-0.26	0.037	1000.0	-1000.0	-0.066	-1000.0
Glypican 1 network	17.0	832.0	48.0	-0.109	0.04	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	17.0	1662.0	97.0	-0.129	0.043	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1671.0	93.0	-0.1	0.037	1000.0	-1000.0	-0.041	-1000.0
Osteopontin-mediated events	16.0	643.0	38.0	-0.102	0.036	1000.0	-1000.0	-0.035	-1000.0
p75(NTR)-mediated signaling	16.0	2117.0	125.0	-0.084	0.066	1000.0	-1000.0	-0.055	-1000.0
Signaling events regulated by Ret tyrosine kinase	16.0	1391.0	82.0	-0.075	0.026	1000.0	-1000.0	-0.055	-1000.0
EGFR-dependent Endothelin signaling events	16.0	352.0	21.0	-0.108	0.037	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	15.0	1670.0	105.0	-0.11	0.052	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	15.0	126.0	8.0	-0.013	0.029	1000.0	-1000.0	-0.007	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	242.0	17.0	-0.053	0.026	1000.0	-1000.0	-0.026	-1000.0
BMP receptor signaling	14.0	1177.0	81.0	-0.143	0.048	1000.0	-1000.0	-0.037	-1000.0
LPA receptor mediated events	14.0	1464.0	102.0	-0.1	0.026	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	14.0	989.0	68.0	-0.227	0.098	1000.0	-1000.0	-0.071	-1000.0
Syndecan-4-mediated signaling events	14.0	966.0	67.0	-0.068	0.026	1000.0	-1000.0	-0.034	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	621.0	46.0	-0.283	0.029	1000.0	-1000.0	-0.089	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	426.0	31.0	-0.141	0.026	1000.0	-1000.0	-0.039	-1000.0
Glucocorticoid receptor regulatory network	12.0	1422.0	114.0	-0.286	0.176	1000.0	-1000.0	-0.05	-1000.0
Canonical Wnt signaling pathway	12.0	613.0	51.0	-0.182	0.074	1000.0	-1000.0	-0.047	-1000.0
IGF1 pathway	12.0	686.0	57.0	-0.067	0.049	1000.0	-1000.0	-0.044	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1462.0	120.0	-0.117	0.106	1000.0	-1000.0	-0.045	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	11.0	395.0	34.0	-0.028	0.043	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	614.0	54.0	-0.097	0.035	1000.0	-1000.0	-0.048	-1000.0
IL1-mediated signaling events	11.0	723.0	62.0	-0.061	0.097	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	11.0	976.0	86.0	-0.068	0.047	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	11.0	931.0	78.0	-0.108	0.042	1000.0	-1000.0	-0.061	-1000.0
Syndecan-2-mediated signaling events	10.0	709.0	69.0	-0.067	0.037	1000.0	-1000.0	-0.038	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	623.0	61.0	-0.112	0.067	1000.0	-1000.0	-0.044	-1000.0
S1P1 pathway	10.0	369.0	36.0	-0.088	0.026	1000.0	-1000.0	-0.041	-1000.0
FAS signaling pathway (CD95)	10.0	484.0	47.0	-0.177	0.04	1000.0	-1000.0	-0.031	-1000.0
Integrins in angiogenesis	10.0	844.0	84.0	-0.103	0.057	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	10.0	280.0	26.0	-0.088	0.025	1000.0	-1000.0	-0.007	-1000.0
Nongenotropic Androgen signaling	10.0	544.0	52.0	-0.05	0.04	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	10.0	897.0	88.0	-0.102	0.035	1000.0	-1000.0	-0.055	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	184.0	17.0	-0.032	0.046	1000.0	-1000.0	-0.022	-1000.0
Caspase cascade in apoptosis	9.0	736.0	74.0	-0.082	0.061	1000.0	-1000.0	-0.045	-1000.0
Arf6 signaling events	9.0	601.0	62.0	-0.108	0.057	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by PTP1B	9.0	689.0	76.0	-0.105	0.043	1000.0	-1000.0	-0.029	-1000.0
TCGA08_p53	9.0	68.0	7.0	-0.025	0.025	1000.0	-1000.0	-0.009	-1000.0
EPHB forward signaling	9.0	824.0	85.0	-0.053	0.083	1000.0	-1000.0	-0.059	-1000.0
Glypican 2 network	9.0	38.0	4.0	-0.003	0.01	1000.0	-1000.0	0.01	-1000.0
IL6-mediated signaling events	9.0	721.0	75.0	-0.065	0.049	1000.0	-1000.0	-0.048	-1000.0
PDGFR-beta signaling pathway	9.0	917.0	97.0	-0.079	0.069	1000.0	-1000.0	-0.046	-1000.0
S1P4 pathway	9.0	241.0	25.0	-0.05	0.034	1000.0	-1000.0	-0.028	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	40.0	5.0	0.002	0.022	1000.0	-1000.0	0.006	-1000.0
Cellular roles of Anthrax toxin	8.0	329.0	39.0	-0.035	0.024	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	8.0	649.0	76.0	-0.108	0.066	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	8.0	489.0	58.0	-0.064	0.048	1000.0	-1000.0	-0.043	-1000.0
IL27-mediated signaling events	8.0	427.0	51.0	-0.102	0.029	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	8.0	464.0	52.0	-0.058	0.03	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	7.0	85.0	12.0	-0.07	0.007	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	7.0	276.0	38.0	-0.022	0.038	1000.0	-1000.0	-0.015	-1000.0
PDGFR-alpha signaling pathway	7.0	345.0	44.0	-0.041	0.046	1000.0	-1000.0	-0.039	-1000.0
S1P5 pathway	7.0	121.0	17.0	-0.05	0.026	1000.0	-1000.0	-0.017	-1000.0
Syndecan-3-mediated signaling events	7.0	271.0	35.0	-0.046	0.066	1000.0	-1000.0	-0.025	-1000.0
Regulation of p38-alpha and p38-beta	7.0	418.0	54.0	-0.062	0.05	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	7.0	560.0	73.0	-0.061	0.035	1000.0	-1000.0	-0.041	-1000.0
ErbB2/ErbB3 signaling events	6.0	413.0	65.0	-0.042	0.037	1000.0	-1000.0	-0.054	-1000.0
Coregulation of Androgen receptor activity	6.0	494.0	76.0	-0.146	0.055	1000.0	-1000.0	-0.02	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	190.0	28.0	-0.05	0.037	1000.0	-1000.0	-0.022	-1000.0
IFN-gamma pathway	6.0	460.0	68.0	-0.043	0.039	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	6.0	414.0	63.0	-0.018	0.066	1000.0	-1000.0	-0.039	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	231.0	37.0	-0.064	0.054	1000.0	-1000.0	-0.029	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	337.0	52.0	-0.074	0.076	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by STAT5	6.0	149.0	22.0	-0.053	0.026	1000.0	-1000.0	-0.039	-1000.0
S1P3 pathway	6.0	292.0	42.0	-0.05	0.038	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	6.0	328.0	51.0	-0.094	0.075	1000.0	-1000.0	-0.111	-1000.0
ErbB4 signaling events	5.0	410.0	69.0	-0.124	0.058	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	493.0	85.0	-0.061	0.039	1000.0	-1000.0	-0.036	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	364.0	65.0	-0.05	0.049	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	5.0	306.0	58.0	-0.025	0.044	1000.0	-1000.0	-0.041	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	576.0	136.0	-0.067	0.053	1000.0	-1000.0	-0.042	-1000.0
HIF-2-alpha transcription factor network	4.0	179.0	43.0	-0.069	0.071	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	64.0	15.0	-0.036	0.022	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	182.0	45.0	-0.05	0.071	1000.0	-1000.0	-0.044	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	352.0	74.0	-0.108	0.061	1000.0	-1000.0	-0.055	-1000.0
Regulation of Telomerase	4.0	449.0	102.0	-0.136	0.06	1000.0	-1000.0	-0.04	-1000.0
Insulin Pathway	4.0	320.0	74.0	-0.102	0.078	1000.0	-1000.0	-0.041	-1000.0
VEGFR1 specific signals	4.0	246.0	56.0	-0.0	0.078	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	4.0	325.0	70.0	-0.168	0.051	1000.0	-1000.0	-0.053	-1000.0
Aurora B signaling	4.0	332.0	67.0	-0.179	0.064	1000.0	-1000.0	-0.029	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	0.006	0.025	1000.0	-1000.0	-0.017	-1000.0
Arf6 downstream pathway	3.0	168.0	43.0	-0.031	0.041	1000.0	-1000.0	-0.022	-1000.0
PLK1 signaling events	3.0	331.0	85.0	-0.01	0.056	1000.0	-1000.0	-0.021	-1000.0
mTOR signaling pathway	3.0	165.0	53.0	-0.06	0.027	1000.0	-1000.0	-0.037	-1000.0
ceramide signaling pathway	3.0	148.0	49.0	0.0	0.035	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	330.0	83.0	-0.066	0.052	1000.0	-1000.0	-0.037	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	132.0	36.0	-0.045	0.047	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	422.0	125.0	-0.022	0.086	1000.0	-1000.0	-0.041	-1000.0
TCGA08_rtk_signaling	3.0	81.0	26.0	-0.03	0.055	1000.0	-1000.0	-0.015	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	106.0	33.0	-0.026	0.062	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PRL	3.0	131.0	34.0	-0.027	0.066	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.009	-1000.0
EPO signaling pathway	2.0	162.0	55.0	-0.009	0.067	1000.0	-1000.0	-0.043	-1000.0
Insulin-mediated glucose transport	2.0	86.0	32.0	-0.11	0.043	1000.0	-1000.0	-0.026	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	177.0	68.0	-0.045	0.054	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class III	2.0	89.0	40.0	-0.047	0.05	1000.0	-1000.0	-0.017	-1000.0
FoxO family signaling	2.0	135.0	64.0	-0.084	0.084	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	181.0	76.0	-0.031	0.081	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	2.0	186.0	71.0	-0.038	0.045	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	1.0	51.0	39.0	-0.0	0.055	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class II	1.0	134.0	75.0	-0.026	0.065	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	1.0	60.0	57.0	-0.038	0.069	1000.0	-1000.0	-0.04	-1000.0
Aurora C signaling	1.0	10.0	7.0	0.0	0.032	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	1.0	128.0	104.0	-0.05	0.062	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	1.0	38.0	31.0	-0.011	0.044	1000.0	-1000.0	-0.019	-1000.0
Rapid glucocorticoid signaling	1.0	30.0	20.0	-0.009	0.027	1000.0	-1000.0	-0.006	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	0.011	0.042	1000.0	-1000.0	-0.028	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.008	0.058	1000.0	-1000.0	-0.029	-1000.0
Aurora A signaling	0.0	45.0	60.0	-0.007	0.069	1000.0	-1000.0	-0.019	-1000.0
TRAIL signaling pathway	0.0	32.0	48.0	-0.0	0.057	1000.0	-1000.0	-0.031	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.053	1000.0	-1000.0	-0.031	-1000.0
E-cadherin signaling in keratinocytes	0.0	15.0	43.0	-0.043	0.078	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.025	0.051	1000.0	-1000.0	0.005	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.0	0.058	1000.0	-1000.0	-0.024	-1000.0
Arf1 pathway	0.0	52.0	54.0	-0.008	0.038	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.071	1000.0	-1000.0	0.0	-1000.0
Total	1126	69539	7203	-10.4824969513	6.8384878064	131000	-131000	-4.75881961041	-131000