Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.026 0.091 -9999.0 0.0 -0.708 1.0 1.0 IHH 0.033 0.062 -9999.0 0.0 -0.624 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.055 0.15 -9999.0 0.0 -0.32 30.0 30.0 LRPAP1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.055 0.149 0.318 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.038 0.085 -9999.0 0.0 -0.533 1.0 1.0 SMO 0.027 0.07 -9999.0 0.0 -0.558 1.0 1.0 AKT1 0.013 0.11 -9999.0 0.0 -0.385 2.0 2.0 ARRB2 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.027 0.069 -9999.0 0.0 -0.549 1.0 1.0 STIL -0.011 0.118 -9999.0 0.0 -0.36 7.0 7.0 DHH N/PTCH2 0.049 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.045 0.069 -9999.0 0.0 -0.492 1.0 1.0 PIK3CA 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.026 0.097 -9999.0 0.0 -0.867 1.0 1.0 determination of left/right symmetry 0.027 0.069 -9999.0 0.0 -0.549 1.0 1.0 PIK3R1 0.033 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.026 0.096 -9999.0 0.0 -0.857 1.0 1.0 IHH N/Hhip -0.044 0.191 -9999.0 0.0 -0.415 30.0 30.0 DHH N/Hhip -0.038 0.17 -9999.0 0.0 -0.37 30.0 30.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.027 0.069 -9999.0 0.0 -0.549 1.0 1.0 pancreas development -0.078 0.219 -9999.0 0.0 -0.509 30.0 30.0 HHAT -0.015 0.155 -9999.0 0.0 -0.51 13.0 13.0 PI3K 0.049 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.074 0.206 -9999.0 0.0 -0.455 32.0 32.0 somite specification 0.027 0.069 -9999.0 0.0 -0.549 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.008 0.099 -9999.0 0.0 -0.373 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.003 0.092 -9999.0 0.0 -0.285 13.0 13.0 SHH Np/Cholesterol/Megalin 0.003 0.093 -9999.0 0.0 -0.285 13.0 13.0 SHH -0.016 0.114 0.236 1.0 -0.359 14.0 15.0 catabolic process 0.03 0.071 -9999.0 0.0 -0.544 1.0 1.0 SMO/Vitamin D3 0.011 0.1 -9999.0 0.0 -0.493 1.0 1.0 SHH Np/Cholesterol/Hhip -0.057 0.156 -9999.0 0.0 -0.317 36.0 36.0 LRP2 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.007 0.099 -9999.0 0.0 -0.455 1.0 1.0 SHH Np/Cholesterol/BOC 0.005 0.09 -9999.0 0.0 -0.285 12.0 12.0 SHH Np/Cholesterol/CDO 0.003 0.092 -9999.0 0.0 -0.285 13.0 13.0 mesenchymal cell differentiation 0.057 0.155 0.315 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 0.016 0.107 -9999.0 0.0 -0.374 3.0 3.0 IHH N/PTCH2 0.049 0.039 -9999.0 0.0 -0.389 1.0 1.0 CDON 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.038 0.074 -9999.0 0.0 -0.551 1.0 1.0 Megalin/LRPAP1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.009 0.088 -9999.0 0.0 -0.285 13.0 13.0 PTCH1 0.03 0.071 -9999.0 0.0 -0.546 1.0 1.0 HHIP -0.078 0.22 -9999.0 0.0 -0.51 30.0 30.0