Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	160 (71%)	64	0.0075952	1	0.026727	1	0.22131	1	NA	NA	0.65326	1	0.45244	1	0.68882	1	0.46352	1
FBXW7	38 (17%)	186	0.059212	1	0.043687	1	0.00012197	0.0171	NA	NA	0.0088052	1	0.03617	1	0.35553	1	0.11823	1
NRAS	20 (9%)	204	0.046463	1	0.12488	1	0.27376	1	NA	NA	0.24697	1	0.47408	1	1	1	1	1
BRAF	22 (10%)	202	9.1287e-07	0.000131	2.3101e-08	3.35e-06	4.1681e-05	0.00592	NA	NA	0.21535	1	0.30406	1	0.59965	1	1	1
KRAS	96 (43%)	128	7.4452e-05	0.0105	4.0502e-05	0.00579	0.48475	1	0.25714	1	0.63449	1	1	1	0.068803	1	0.73504	1
TP53	120 (54%)	104	0.0020178	0.276	0.00048185	0.0668	7.2821e-11	1.06e-08	NA	NA	0.45289	1	0.78239	1	0.025164	1	0.13421	1
SMAD4	26 (12%)	198	0.030844	1	0.28789	1	0.035544	1	NA	NA	0.52087	1	0.33919	1	1	1	0.84563	1
FAM123B	25 (11%)	199	0.072343	1	0.091812	1	0.0053927	0.728	NA	NA	0.53564	1	0.5876	1	1	1	0.45854	1
PIK3CA	33 (15%)	191	0.20484	1	0.56994	1	0.00048031	0.0668	NA	NA	0.087574	1	0.12884	1	0.085302	1	1	1
SMAD2	15 (7%)	209	0.13307	1	0.51785	1	0.039307	1	NA	NA	0.53277	1	0.13321	1	1	1	0.71089	1
TCF7L2	18 (8%)	206	1	1	0.41298	1	0.4171	1	NA	NA	0.73745	1	0.89617	1	1	1	0.22996	1
ACVR2A	9 (4%)	215	0.0071729	0.961	0.18431	1	0.032525	1	NA	NA	0.42928	1	0.46856	1	1	1	0.54492	1
SOX9	10 (4%)	214	0.12913	1	0.12286	1	0.0045074	0.613	NA	NA	0.20421	1	0.694	1	1	1	0.58399	1
ELF3	6 (3%)	218	0.36312	1	0.81051	1	0.051417	1	NA	NA	0.61173	1	0.43551	1	1	1	0.40594	1
CRTC1	6 (3%)	218	0.12306	1	0.16488	1	0.83703	1	NA	NA	0.20899	1	0.48214	1	1	1	0.40594	1
TNFRSF10C	6 (3%)	218	0.31707	1	0.28709	1	0.67512	1	NA	NA	0.85324	1	0.378	1	1	1	1	1
KRTAP5-5	4 (2%)	220	0.3272	1	0.48238	1	0.48002	1	NA	NA	0.38788	1	1	1	1	1	1	1
KIAA1804	15 (7%)	209	0.26731	1	0.39731	1	0.065855	1	NA	NA	0.75803	1	0.47408	1	1	1	0.73635	1
ACOT4	3 (1%)	221	0.25523	1	0.48995	1	0.82905	1	NA	NA	NA	NA	NA	NA	1	1	1	1
PTEN	7 (3%)	217	0.027588	1	0.33674	1	0.042895	1	NA	NA	0.61173	1	0.43551	1	0.24427	1	0.057507	1
MYO1B	13 (6%)	211	0.0086213	1	0.0087863	1	0.007523	1	NA	NA	0.012988	1	0.46856	1	1	1	0.65286	1