Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.022 0.15 -9999.0 0.0 -0.722 8.0 8.0 IHH 0.018 0.036 -9999.0 0.0 -0.428 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.226 0.265 -9999.0 0.0 -0.518 108.0 108.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.224 0.263 0.514 108.0 -9999.0 0.0 108.0 SMO/beta Arrestin2 -0.011 0.089 -9999.0 0.0 -0.567 1.0 1.0 SMO -0.018 0.093 -9999.0 0.0 -0.504 2.0 2.0 AKT1 0.011 0.047 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.092 -9999.0 0.0 -0.496 2.0 2.0 STIL -0.162 0.23 -9999.0 0.0 -0.417 106.0 106.0 DHH N/PTCH2 0.012 0.061 -9999.0 0.0 -0.619 2.0 2.0 DHH N/PTCH1 0.029 0.072 -9999.0 0.0 -0.531 1.0 1.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.021 0.161 -9999.0 0.0 -0.678 10.0 10.0 determination of left/right symmetry -0.018 0.092 -9999.0 0.0 -0.496 2.0 2.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.022 0.159 -9999.0 0.0 -0.669 10.0 10.0 IHH N/Hhip -0.014 0.087 -9999.0 0.0 -0.345 3.0 3.0 DHH N/Hhip -0.013 0.073 -9999.0 0.0 -0.336 1.0 1.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.092 -9999.0 0.0 -0.496 2.0 2.0 pancreas development 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.09 -9999.0 0.0 -0.807 3.0 3.0 somite specification -0.018 0.092 -9999.0 0.0 -0.496 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.175 0.242 -9999.0 0.0 -0.443 106.0 106.0 SHH Np/Cholesterol/PTCH2 -0.205 0.257 -9999.0 0.0 -0.495 107.0 107.0 SHH Np/Cholesterol/Megalin -0.243 0.285 -9999.0 0.0 -0.529 116.0 116.0 SHH -0.257 0.317 -9999.0 0.0 -0.621 105.0 105.0 catabolic process 0.027 0.08 -9999.0 0.0 -0.479 2.0 2.0 SMO/Vitamin D3 -0.156 0.228 -9999.0 0.0 -0.406 106.0 106.0 SHH Np/Cholesterol/Hhip -0.222 0.257 -9999.0 0.0 -0.511 105.0 105.0 LRP2 -0.056 0.219 -9999.0 0.0 -0.807 19.0 19.0 receptor-mediated endocytosis -0.162 0.226 -9999.0 0.0 -0.597 13.0 13.0 SHH Np/Cholesterol/BOC -0.218 0.256 -9999.0 0.0 -0.507 105.0 105.0 SHH Np/Cholesterol/CDO -0.203 0.255 -9999.0 0.0 -0.495 105.0 105.0 mesenchymal cell differentiation 0.22 0.255 0.507 105.0 -9999.0 0.0 105.0 mol:Vitamin D3 -0.172 0.242 -9999.0 0.0 -0.441 106.0 106.0 IHH N/PTCH2 0.014 0.07 -9999.0 0.0 -0.669 2.0 2.0 CDON 0.013 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.029 0.081 -9999.0 0.0 -0.483 2.0 2.0 Megalin/LRPAP1 -0.034 0.171 -9999.0 0.0 -0.619 19.0 19.0 PTCH2 0.006 0.074 -9999.0 0.0 -0.807 2.0 2.0 SHH Np/Cholesterol -0.208 0.256 -9999.0 0.0 -0.501 105.0 105.0 PTCH1 0.027 0.08 -9999.0 0.0 -0.48 2.0 2.0 HHIP 0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0