E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.161 -9999.0 0.0 -0.407 23.0 23.0 KLHL20 0.021 0.099 0.182 11.0 -0.228 4.0 15.0 CYFIP2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.019 0.103 -9999.0 0.0 -0.259 19.0 19.0 ENAH -0.044 0.158 -9999.0 0.0 -0.406 22.0 22.0 AP1M1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.005 0.084 -9999.0 0.0 -0.309 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.044 -9999.0 0.0 -0.157 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.026 0.114 -9999.0 0.0 -0.225 24.0 24.0 RAPGEF1 -0.04 0.149 -9999.0 0.0 -0.377 21.0 21.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.168 -9999.0 0.0 -0.402 25.0 25.0 CRK -0.044 0.155 -9999.0 0.0 -0.394 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.008 0.115 -9999.0 0.0 -0.244 24.0 24.0 alphaE/beta7 Integrin 0.041 0.041 -9999.0 0.0 -0.275 2.0 2.0 IQGAP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.053 0.024 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.047 0.161 -9999.0 0.0 -0.413 22.0 22.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.047 -9999.0 0.0 -0.146 20.0 20.0 MLLT4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.057 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.042 0.06 -9999.0 0.0 -0.185 20.0 20.0 ARF6 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.012 0.124 -9999.0 0.0 -0.287 24.0 24.0 TIAM1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.028 0.104 -9999.0 0.0 -0.209 23.0 23.0 AKT1 -0.017 0.052 0.151 1.0 -0.168 1.0 2.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.041 0.156 -9999.0 0.0 -0.4 23.0 23.0 RhoA/GDP -0.014 0.116 -9999.0 0.0 -0.258 21.0 21.0 actin cytoskeleton organization 0.019 0.077 0.151 11.0 -0.175 3.0 14.0 CDC42/GDP -0.014 0.116 -9999.0 0.0 -0.258 21.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.019 0.088 -9999.0 0.0 -0.211 25.0 25.0 ITGB7 0.026 0.051 -9999.0 0.0 -0.4 2.0 2.0 RAC1 0.022 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.111 -9999.0 0.0 -0.223 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.096 -9999.0 0.0 -0.205 23.0 23.0 mol:GDP -0.031 0.124 -9999.0 0.0 -0.293 21.0 21.0 CDC42/GTP/IQGAP1 0.043 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.029 0.037 -9999.0 0.0 -0.4 1.0 1.0 p120 catenin/RhoA/GDP -0.003 0.123 -9999.0 0.0 -0.265 21.0 21.0 RAC1/GTP/IQGAP1 0.03 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.045 0.029 -9999.0 0.0 -0.285 1.0 1.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.054 0.114 10.0 -0.12 2.0 12.0 NME1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.045 0.16 -9999.0 0.0 -0.407 23.0 23.0 regulation of cell-cell adhesion -0.014 0.067 -9999.0 0.0 -0.169 20.0 20.0 WASF2 0.006 0.04 0.096 1.0 -9999.0 0.0 1.0 Rap1/GTP -0.005 0.094 0.17 7.0 -0.345 1.0 8.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.117 -9999.0 0.0 -0.215 25.0 25.0 CCND1 0.017 0.064 0.131 10.0 -0.145 2.0 12.0 VAV2 -0.051 0.214 -9999.0 0.0 -0.674 8.0 8.0 RAP1/GDP -0.002 0.102 -9999.0 0.0 -0.387 1.0 1.0 adherens junction assembly -0.043 0.156 -9999.0 0.0 -0.395 23.0 23.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.036 -9999.0 0.0 -0.4 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.017 0.105 -9999.0 0.0 -0.21 25.0 25.0 E-cadherin/beta catenin -0.043 0.114 -9999.0 0.0 -0.303 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.158 -9999.0 0.0 -0.413 21.0 21.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.034 0.101 -9999.0 0.0 -0.348 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.01 0.112 -9999.0 0.0 -0.243 23.0 23.0 ITGAE 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.171 -9999.0 0.0 -0.411 25.0 25.0