Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.004 0.127 -9999.0 0.0 -0.486 9.0 9.0 IHH 0.021 0.051 -9999.0 0.0 -0.167 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.011 0.075 -9999.0 0.0 -0.236 13.0 13.0 LRPAP1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.074 0.234 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.046 0.117 -9999.0 0.0 -0.522 3.0 3.0 SMO -0.004 0.092 -9999.0 0.0 -0.481 4.0 4.0 AKT1 -0.004 0.102 -9999.0 0.0 -0.374 8.0 8.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.037 -9999.0 0.0 -0.4 1.0 1.0 ADRBK1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.004 0.091 -9999.0 0.0 -0.474 4.0 4.0 STIL 0.015 0.12 0.181 28.0 -0.315 7.0 35.0 DHH N/PTCH2 0.022 0.078 -9999.0 0.0 -0.288 8.0 8.0 DHH N/PTCH1 0.01 0.107 -9999.0 0.0 -0.32 12.0 12.0 PIK3CA 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.073 -9999.0 0.0 -0.4 4.0 4.0 PTHLH -0.014 0.155 -9999.0 0.0 -0.609 8.0 8.0 determination of left/right symmetry -0.004 0.091 -9999.0 0.0 -0.474 4.0 4.0 PIK3R1 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.014 0.153 -9999.0 0.0 -0.604 8.0 8.0 IHH N/Hhip -0.014 0.124 -9999.0 0.0 -0.326 18.0 18.0 DHH N/Hhip -0.014 0.119 -9999.0 0.0 -0.298 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.004 0.091 -9999.0 0.0 -0.474 4.0 4.0 pancreas development -0.032 0.141 -9999.0 0.0 -0.399 18.0 18.0 HHAT 0.026 0.05 -9999.0 0.0 -0.4 2.0 2.0 PI3K 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.074 -9999.0 0.0 -0.4 4.0 4.0 somite specification -0.004 0.091 -9999.0 0.0 -0.474 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.017 0.091 -9999.0 0.0 -0.296 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.007 0.07 -9999.0 0.0 -0.237 11.0 11.0 SHH Np/Cholesterol/Megalin -0.038 0.102 -9999.0 0.0 -0.246 26.0 26.0 SHH -0.032 0.07 -9999.0 0.0 -0.286 10.0 10.0 catabolic process 0.001 0.1 -9999.0 0.0 -0.368 9.0 9.0 SMO/Vitamin D3 -0.013 0.105 -9999.0 0.0 -0.47 4.0 4.0 SHH Np/Cholesterol/Hhip -0.024 0.082 -9999.0 0.0 -0.224 20.0 20.0 LRP2 -0.072 0.175 -9999.0 0.0 -0.4 32.0 32.0 receptor-mediated endocytosis -0.041 0.129 -9999.0 0.0 -0.434 9.0 9.0 SHH Np/Cholesterol/BOC -0.004 0.062 -9999.0 0.0 -0.219 10.0 10.0 SHH Np/Cholesterol/CDO -0.005 0.064 -9999.0 0.0 -0.219 11.0 11.0 mesenchymal cell differentiation 0.024 0.082 0.223 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.029 0.131 0.197 28.0 -0.326 7.0 35.0 IHH N/PTCH2 0.029 0.07 -9999.0 0.0 -0.33 4.0 4.0 CDON 0.023 0.062 -9999.0 0.0 -0.4 3.0 3.0 IHH N/PTCH1 0.011 0.104 -9999.0 0.0 -0.37 9.0 9.0 Megalin/LRPAP1 -0.035 0.135 -9999.0 0.0 -0.285 32.0 32.0 PTCH2 0.02 0.071 -9999.0 0.0 -0.4 4.0 4.0 SHH Np/Cholesterol -0.009 0.058 -9999.0 0.0 -0.215 10.0 10.0 PTCH1 0.001 0.1 -9999.0 0.0 -0.369 9.0 9.0 HHIP -0.032 0.141 -9999.0 0.0 -0.4 18.0 18.0