Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.012 0.085 -9999.0 0.0 -0.205 23.0 23.0 epithelial cell differentiation 0.023 0.101 -9999.0 0.0 -0.207 23.0 23.0 CYFIP2 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.04 0.068 0.42 1.0 -9999.0 0.0 1.0 EGFR -0.07 0.16 -9999.0 0.0 -0.4 28.0 28.0 EPHA2 0.027 0.038 -9999.0 0.0 -0.4 1.0 1.0 MYO6 -0.045 0.071 0.176 2.0 -0.203 22.0 24.0 CTNNB1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.032 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.106 0.191 -9999.0 0.0 -0.456 30.0 30.0 CTNND1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.069 0.174 2.0 -0.199 22.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.05 0.082 0.174 2.0 -0.214 26.0 28.0 EGF 0.004 0.104 -9999.0 0.0 -0.4 9.0 9.0 NCKAP1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.036 0.094 -9999.0 0.0 -0.386 4.0 4.0 cortical microtubule organization 0.023 0.101 -9999.0 0.0 -0.207 23.0 23.0 GO:0000145 -0.043 0.066 0.159 2.0 -0.19 22.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.028 0.104 -9999.0 0.0 -0.209 23.0 23.0 MLLT4 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.054 0.058 -9999.0 0.0 -0.193 21.0 21.0 ARF6 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.072 0.043 -9999.0 0.0 -0.224 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.064 0.169 1.0 -9999.0 0.0 1.0 PVRL2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.036 0.069 0.176 2.0 -0.202 19.0 21.0 ARF6/GTP 0.076 0.047 -9999.0 0.0 -0.204 2.0 2.0 CDH1 -0.041 0.156 -9999.0 0.0 -0.4 23.0 23.0 EGFR/EGFR/EGF/EGF -0.054 0.115 -9999.0 0.0 -0.241 36.0 36.0 RhoA/GDP 0.025 0.099 -9999.0 0.0 -0.201 23.0 23.0 actin cytoskeleton organization -0.04 0.071 0.16 1.0 -0.204 22.0 23.0 IGF-1R heterotetramer 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.011 0.087 -9999.0 0.0 -0.4 6.0 6.0 DIAPH1 -0.099 0.245 -9999.0 0.0 -0.558 3.0 3.0 Wnt receptor signaling pathway -0.023 0.101 0.207 23.0 -9999.0 0.0 23.0 RHOA 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.058 -9999.0 0.0 -0.195 21.0 21.0 CTNNA1 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.072 0.161 1.0 -0.207 22.0 23.0 EFNA1 0.029 0.036 -9999.0 0.0 -0.4 1.0 1.0 LPP -0.048 0.067 0.164 1.0 -0.198 22.0 23.0 Ephrin A1/EPHA2 0.018 0.093 -9999.0 0.0 -0.201 21.0 21.0 SEC6/SEC8 -0.042 0.06 -9999.0 0.0 -0.197 18.0 18.0 MGAT3 -0.051 0.083 0.176 2.0 -0.216 26.0 28.0 HGF/MET -0.032 0.122 -9999.0 0.0 -0.238 34.0 34.0 HGF -0.008 0.103 -9999.0 0.0 -0.4 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.012 0.086 -9999.0 0.0 -0.206 23.0 23.0 actin cable formation -0.027 0.072 0.375 1.0 -0.367 1.0 2.0 KIAA1543 -0.05 0.072 0.16 1.0 -0.202 25.0 26.0 KIFC3 -0.049 0.067 -9999.0 0.0 -0.202 23.0 23.0 NCK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.07 0.176 1.0 -0.203 22.0 23.0 NCK1/GIT1 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.023 0.101 -9999.0 0.0 -0.207 23.0 23.0 EXOC4 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.069 0.176 1.0 -0.203 22.0 23.0 PIP5K1C -0.045 0.07 0.176 2.0 -0.202 22.0 24.0 LIMA1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.043 0.075 0.448 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.04 0.082 0.247 1.0 -0.304 4.0 5.0 IGF-1R heterotetramer/IGF1 0.01 0.107 -9999.0 0.0 -0.209 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.042 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.028 0.124 -9999.0 0.0 -0.4 14.0 14.0 PLEKHA7 -0.052 0.076 0.176 1.0 -0.211 25.0 26.0 mol:GTP 0.07 0.042 -9999.0 0.0 -0.223 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.01 0.122 0.318 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.012 0.085 -9999.0 0.0 -0.205 23.0 23.0 regulation of cell-cell adhesion -0.04 0.071 0.16 1.0 -0.204 22.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.012 0.086 -9999.0 0.0 -0.206 23.0 23.0