E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.025 0.029 -9999.0 0.0 -0.154 8.0 8.0 KLHL20 0.004 0.065 -9999.0 0.0 -0.131 94.0 94.0 CYFIP2 0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.033 0.027 -9999.0 0.0 -0.144 2.0 2.0 ENAH 0.016 0.054 -9999.0 0.0 -0.178 34.0 34.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -0.0 4.0 4.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.0 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.032 -9999.0 0.0 -0.088 79.0 79.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.037 -9999.0 0.0 -0.231 9.0 9.0 RAPGEF1 0.027 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.009 0.058 -9999.0 0.0 -0.412 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.024 0.03 -9999.0 0.0 -0.132 18.0 18.0 CRK 0.026 0.028 -9999.0 0.0 -0.145 8.0 8.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.064 -9999.0 0.0 -0.293 19.0 19.0 alphaE/beta7 Integrin 0.024 0.019 -9999.0 0.0 -0.285 2.0 2.0 IQGAP1 -0.086 0.183 -9999.0 0.0 -0.412 127.0 127.0 NCKAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.025 0.03 -9999.0 0.0 -0.155 9.0 9.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.025 -9999.0 0.0 -0.125 12.0 12.0 MLLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.008 0.031 -9999.0 0.0 -0.158 12.0 12.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -0.001 96.0 96.0 E-cadherin/gamma catenin 0.012 0.073 -9999.0 0.0 -0.35 19.0 19.0 TIAM1 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.032 0.043 -9999.0 0.0 -0.195 18.0 18.0 AKT1 0.016 0.028 -9999.0 0.0 -0.125 8.0 8.0 PIK3R1 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.01 0.052 -9999.0 0.0 -0.412 8.0 8.0 RhoA/GDP 0.034 0.025 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.004 0.049 -9999.0 0.0 -0.098 94.0 94.0 CDC42/GDP 0.035 0.025 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.043 -9999.0 0.0 -0.16 28.0 28.0 ITGB7 0.015 0.026 -9999.0 0.0 -0.412 2.0 2.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.046 -9999.0 0.0 -0.208 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.027 0.028 -9999.0 0.0 -0.198 8.0 8.0 mol:GDP 0.027 0.027 -9999.0 0.0 -0.155 2.0 2.0 CDC42/GTP/IQGAP1 -0.04 0.112 -9999.0 0.0 -0.238 127.0 127.0 JUP 0.004 0.073 -9999.0 0.0 -0.412 16.0 16.0 p120 catenin/RhoA/GDP 0.036 0.032 -9999.0 0.0 -0.146 5.0 5.0 RAC1/GTP/IQGAP1 -0.04 0.112 -9999.0 0.0 -0.238 127.0 127.0 PIP5K1C/AP1M1 0.012 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.013 0.074 -9999.0 0.0 -0.167 98.0 98.0 NME1 -0.0 0.0 -9999.0 0.0 -0.001 98.0 98.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.025 0.029 -9999.0 0.0 -0.154 8.0 8.0 regulation of cell-cell adhesion -0.003 0.016 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.049 79.0 79.0 Rap1/GTP 0.025 0.026 -9999.0 0.0 -0.14 4.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.039 0.061 -9999.0 0.0 -0.25 20.0 20.0 CCND1 -0.017 0.09 -9999.0 0.0 -0.205 98.0 98.0 VAV2 0.031 0.03 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.028 0.026 -9999.0 0.0 -0.148 2.0 2.0 adherens junction assembly 0.025 0.028 -9999.0 0.0 -0.15 8.0 8.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.037 0.058 -9999.0 0.0 -0.237 20.0 20.0 E-cadherin/beta catenin 0.019 0.032 -9999.0 0.0 -0.164 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.001 98.0 98.0 SRC 0.025 0.029 -9999.0 0.0 -0.138 13.0 13.0 PIK3CA -0.003 0.091 -9999.0 0.0 -0.412 25.0 25.0 Rac1/GTP -0.037 0.077 -9999.0 0.0 -0.2 94.0 94.0 E-cadherin/beta catenin/alpha catenin 0.03 0.033 -9999.0 0.0 -0.235 8.0 8.0 ITGAE 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.024 0.03 -9999.0 0.0 -0.134 18.0 18.0