E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.053 -9999.0 0.0 -0.295 14.0 14.0 KLHL20 0.028 0.068 0.175 30.0 -0.189 13.0 43.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.005 0.039 0.168 9.0 -0.163 10.0 19.0 ENAH 0.005 0.055 -9999.0 0.0 -0.295 15.0 15.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.111 20.0 -0.122 7.0 27.0 ABI1/Sra1/Nap1 -0.01 0.022 -9999.0 0.0 -0.122 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.035 -9999.0 0.0 -0.069 1.0 1.0 RAPGEF1 -0.003 0.059 0.164 30.0 -0.276 11.0 41.0 CTNND1 0.03 0.014 -9999.0 0.0 -0.063 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.056 -9999.0 0.0 -0.297 14.0 14.0 CRK 0.005 0.061 0.173 25.0 -0.287 13.0 38.0 E-cadherin/gamma catenin/alpha catenin 0.058 0.029 -9999.0 0.0 -0.054 20.0 20.0 alphaE/beta7 Integrin 0.046 0.012 -9999.0 0.0 -0.05 2.0 2.0 IQGAP1 0.01 0.04 -9999.0 0.0 -0.063 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.018 -9999.0 0.0 -0.024 40.0 40.0 DLG1 0.006 0.055 -9999.0 0.0 -0.294 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.03 0.018 -9999.0 0.0 -0.093 12.0 12.0 MLLT4 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.018 -9999.0 0.0 -0.024 30.0 30.0 PI3K -0.036 0.022 -9999.0 0.0 -0.116 12.0 12.0 ARF6 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.043 0.021 -9999.0 0.0 -0.057 19.0 19.0 TIAM1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.066 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.016 0.036 0.14 9.0 -0.103 1.0 10.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.063 8.0 8.0 RhoA/GDP 0.012 0.061 0.182 26.0 -0.171 16.0 42.0 actin cytoskeleton organization 0.023 0.054 0.142 32.0 -0.143 12.0 44.0 CDC42/GDP 0.011 0.057 0.175 23.0 -0.169 16.0 39.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -9999.0 0.0 -0.108 19.0 19.0 ITGB7 0.032 0.008 -9999.0 0.0 -0.063 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.036 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.022 -9999.0 0.0 -0.04 9.0 9.0 mol:GDP -0.002 0.063 0.181 26.0 -0.185 16.0 42.0 CDC42/GTP/IQGAP1 0.023 0.035 -9999.0 0.0 -0.04 118.0 118.0 JUP 0.029 0.017 -9999.0 0.0 -0.063 16.0 16.0 p120 catenin/RhoA/GDP 0.025 0.064 0.191 27.0 -0.176 15.0 42.0 RAC1/GTP/IQGAP1 0.016 0.032 -9999.0 0.0 -0.04 89.0 89.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.015 0.041 0.111 29.0 -0.095 14.0 43.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 5.0 5.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.006 0.055 -9999.0 0.0 -0.295 15.0 15.0 regulation of cell-cell adhesion -0.03 0.017 0.043 1.0 -0.1 13.0 14.0 WASF2 -0.006 0.012 -9999.0 0.0 -0.067 14.0 14.0 Rap1/GTP -0.022 0.045 0.144 29.0 -0.142 4.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.082 0.043 -9999.0 0.0 -0.089 1.0 1.0 CCND1 0.017 0.047 0.129 28.0 -0.115 14.0 42.0 VAV2 0.013 0.113 -9999.0 0.0 -0.577 13.0 13.0 RAP1/GDP -0.011 0.052 0.163 31.0 -0.174 3.0 34.0 adherens junction assembly 0.006 0.053 -9999.0 0.0 -0.288 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.189 2.0 -0.091 1.0 3.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.153 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 6.0 6.0 SRC 0.005 0.053 -9999.0 0.0 -0.295 14.0 14.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.063 17.0 17.0 Rac1/GTP -0.007 0.055 -9999.0 0.0 -0.283 14.0 14.0 E-cadherin/beta catenin/alpha catenin 0.059 0.025 -9999.0 0.0 -0.049 9.0 9.0 ITGAE 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.057 -9999.0 0.0 -0.302 14.0 14.0