Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.018 0.054 1.0 -0.116 4.0 5.0 KIRREL 0.035 0.011 0.084 1.0 -0.038 5.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.019 0.117 4.0 -0.054 1.0 5.0 PLCG1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.069 0.046 0.18 7.0 -9999.0 0.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.016 0.019 -9999.0 0.0 -0.118 4.0 4.0 FYN -0.009 0.045 0.168 28.0 -9999.0 0.0 28.0 mol:Ca2+ 0.074 0.036 0.172 19.0 -9999.0 0.0 19.0 mol:DAG 0.076 0.037 0.175 19.0 -9999.0 0.0 19.0 NPHS2 0.035 0.01 0.084 1.0 -0.03 4.0 5.0 mol:IP3 0.076 0.037 0.175 19.0 -9999.0 0.0 19.0 regulation of endocytosis 0.055 0.03 0.135 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.062 0.029 0.157 19.0 -9999.0 0.0 19.0 establishment of cell polarity 0.049 0.018 0.116 4.0 -0.054 1.0 5.0 Nephrin/NEPH1/podocin/NCK1-2 0.091 0.039 0.189 10.0 -9999.0 0.0 10.0 Nephrin/NEPH1/beta Arrestin2 0.058 0.03 0.14 1.0 -9999.0 0.0 1.0 NPHS1 0.035 0.011 0.093 1.0 -9999.0 0.0 1.0 Nephrin/NEPH1/podocin 0.059 0.024 0.167 4.0 -0.056 4.0 8.0 TJP1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.03 0.015 -9999.0 0.0 -0.063 11.0 11.0 NCK2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.077 0.038 0.179 19.0 -9999.0 0.0 19.0 CD2AP 0.023 0.028 -9999.0 0.0 -0.063 48.0 48.0 Nephrin/NEPH1/podocin/GRB2 0.079 0.035 0.179 16.0 -9999.0 0.0 16.0 GRB2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.012 0.052 0.177 30.0 -9999.0 0.0 30.0 cytoskeleton organization -0.008 0.032 0.172 11.0 -0.147 3.0 14.0 Nephrin/NEPH1 0.041 0.016 0.097 4.0 -0.029 5.0 9.0 Nephrin/NEPH1/ZO-1 0.063 0.024 -9999.0 0.0 -0.049 1.0 1.0