Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.018 0.027 0.155 9.0 -0.077 19.0 28.0 IHH 0.038 0.021 0.112 17.0 -0.044 13.0 30.0 SHH Np/Cholesterol/GAS1 0.014 0.02 -9999.0 0.0 -0.041 37.0 37.0 LRPAP1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.013 0.02 0.041 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 0.066 0.056 0.156 120.0 -0.145 1.0 121.0 SMO 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 AKT1 0.003 0.083 -9999.0 0.0 -0.312 25.0 25.0 ARRB2 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 STIL 0.024 0.085 0.17 125.0 -9999.0 0.0 125.0 DHH N/PTCH2 0.024 0.003 -9999.0 0.0 0.0 10.0 10.0 DHH N/PTCH1 0.017 0.014 -9999.0 0.0 -0.056 7.0 7.0 PIK3CA 0.028 0.018 -9999.0 0.0 -0.063 17.0 17.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.015 0.024 0.149 8.0 -0.094 6.0 14.0 determination of left/right symmetry 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.015 0.024 0.149 8.0 -0.093 6.0 14.0 IHH N/Hhip 0.025 0.012 0.071 17.0 -0.021 7.0 24.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.023 -9999.0 0.0 -0.05 16.0 16.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.03 -9999.0 0.0 -0.063 55.0 55.0 somite specification 0.014 0.019 0.137 3.0 -9999.0 0.0 3.0 SHH Np/Cholesterol/PTCH1 0.014 0.017 -9999.0 0.0 -0.06 5.0 5.0 SHH Np/Cholesterol/PTCH2 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 SHH Np/Cholesterol/Megalin 0.018 0.014 -9999.0 0.0 -0.033 5.0 5.0 SHH -0.015 0.011 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.02 0.017 -9999.0 0.0 -0.063 13.0 13.0 SMO/Vitamin D3 0.016 0.032 0.18 14.0 -9999.0 0.0 14.0 SHH Np/Cholesterol/Hhip -0.011 0.007 0.0 163.0 -9999.0 0.0 163.0 LRP2 0.032 0.005 -9999.0 0.0 -0.063 1.0 1.0 receptor-mediated endocytosis 0.012 0.027 0.153 13.0 -9999.0 0.0 13.0 SHH Np/Cholesterol/BOC -0.011 0.007 0.0 163.0 -9999.0 0.0 163.0 SHH Np/Cholesterol/CDO 0.018 0.014 -9999.0 0.0 -0.031 4.0 4.0 mesenchymal cell differentiation 0.011 0.007 -9999.0 0.0 0.0 163.0 163.0 mol:Vitamin D3 0.041 0.096 0.19 146.0 -9999.0 0.0 146.0 IHH N/PTCH2 0.05 0.012 0.106 8.0 -0.036 1.0 9.0 CDON 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.036 0.021 -9999.0 0.0 -0.06 20.0 20.0 Megalin/LRPAP1 0.047 0.007 -9999.0 0.0 -0.05 1.0 1.0 PTCH2 0.032 0.005 -9999.0 0.0 0.0 10.0 10.0 SHH Np/Cholesterol -0.011 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.017 -9999.0 0.0 -0.063 13.0 13.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0