Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
NSD1	33 (11%)	273	0.30235	1	1.2738e-05	0.0055	0.24387	1	0.73048	1	0.00041073	0.174	6.406e-06	0.00277	0.0097425	1	0.035463	1	0.029731	1	0.0072015	1
PIK3CA	64 (21%)	242	0.065374	1	0.03337	1	0.094762	1	0.92753	1	0.11863	1	0.39808	1	0.037958	1	0.044582	1	0.094247	1	0.30369	1
CDKN2A	65 (21%)	241	0.021996	1	0.49381	1	0.034863	1	0.58275	1	0.20091	1	0.20586	1	0.41837	1	0.11308	1	0.19051	1	0.14996	1
HRAS	10 (3%)	296	8.1748e-05	0.0351	0.026098	1	0.16801	1	0.5987	1	0.003386	1	0.0010975	0.457	0.099101	1	0.18821	1	0.048358	1	0.21025	1
TP53	214 (70%)	92	1.6992e-12	7.44e-10	0.009478	1	0.11042	1	0.77572	1	0.011311	1	0.001427	0.592	0.061121	1	0.00080004	0.334	0.041733	1	0.0081141	1
NFE2L2	17 (6%)	289	0.80734	1	0.26729	1	0.12543	1	0.76487	1	1	1	0.46393	1	0.24819	1	0.073621	1	0.35712	1	0.47083	1
NOTCH1	57 (19%)	249	0.88005	1	0.00056249	0.236	0.018664	1	0.27863	1	0.00042781	0.181	2.5388e-06	0.0011	0.0001124	0.0481	0.29169	1	0.00078567	0.329	0.0016979	0.703
FAT1	72 (24%)	234	0.2396	1	0.62103	1	0.79449	1	0.48676	1	0.15214	1	0.2878	1	0.88535	1	0.31671	1	0.16232	1	0.15131	1
CASP8	27 (9%)	279	1.6153e-05	0.00695	0.00033525	0.142	0.69899	1	0.73884	1	2.999e-07	0.000131	5.2752e-07	0.00023	0.37743	1	0.56392	1	0.00030152	0.128	0.024423	1
JUB	18 (6%)	288	0.20141	1	0.18078	1	0.064612	1	0.081604	1	0.30529	1	0.22128	1	0.32755	1	1	1	0.01207	1	0.70566	1
MLL2	56 (18%)	250	0.07269	1	0.0065677	1	0.68729	1	0.5209	1	0.05323	1	0.0079522	1	0.052878	1	0.010213	1	0.22524	1	0.030271	1
FBXW7	15 (5%)	291	0.76031	1	0.8505	1	0.091967	1	0.30302	1	0.88141	1	0.63644	1	0.94504	1	0.85356	1	0.87167	1	0.80388	1
EPHA2	14 (5%)	292	0.11068	1	0.0079414	1	0.81071	1	0.90612	1	0.49923	1	0.57024	1	0.77529	1	0.18409	1	0.00035665	0.151	0.059177	1
ZNF750	13 (4%)	293	0.3956	1	0.0062847	1	0.94567	1	0.35321	1	0.11882	1	0.12797	1	0.63185	1	1	1	0.29037	1	0.69248	1
FLG	48 (16%)	258	0.73307	1	0.040387	1	0.53204	1	0.5747	1	0.13915	1	0.22329	1	0.063107	1	0.16268	1	0.067187	1	0.27474	1
B2M	7 (2%)	299	0.24087	1	0.22455	1	NA	NA	NA	NA	0.51513	1	0.51674	1	0.14069	1	0.75633	1	0.15699	1	0.49896	1
IL32	4 (1%)	302	0.045099	1	0.12864	1	NA	NA	NA	NA	0.56087	1	1	1	0.5614	1	0.66918	1	0.82757	1	1	1
EP300	25 (8%)	281	0.037556	1	0.72849	1	0.76939	1	0.26447	1	0.0095454	1	0.0046706	1	0.35195	1	0.33465	1	0.23244	1	0.026012	1
RHOA	4 (1%)	302	0.72363	1	0.17657	1	0.37867	1	0.44449	1	0.24544	1	0.14075	1	0.24563	1	0.23134	1	0.13868	1	0.36076	1
HLA-A	9 (3%)	297	0.91584	1	0.7112	1	1	1	1	1	0.072015	1	0.03106	1	0.63444	1	0.58809	1	0.17478	1	0.33657	1
CTCF	11 (4%)	295	0.24803	1	0.12236	1	0.39328	1	0.54076	1	0.63562	1	0.6318	1	0.86061	1	0.8099	1	0.66028	1	0.72179	1
RB1	10 (3%)	296	0.029681	1	0.0088776	1	0.28218	1	0.1294	1	0.0060739	1	0.0083805	1	0.05606	1	1	1	0.26315	1	0.07075	1
TGFBR2	10 (3%)	296	0.081428	1	0.48289	1	0.46896	1	1	1	0.3133	1	0.78514	1	0.91945	1	1	1	0.15885	1	0.45967	1
CSMD3	70 (23%)	236	0.054896	1	0.0023367	0.965	0.0097293	1	0.46333	1	1.3524e-05	0.00583	6.6618e-07	0.00029	0.00054193	0.228	0.0010286	0.429	0.00013715	0.0586	0.0029892	1
NECAB1	6 (2%)	300	0.043766	1	1	1	0.8562	1	0.67201	1	0.11401	1	0.062239	1	0.77328	1	0.49039	1	0.76935	1	0.44993	1
KRTAP1-5	3 (1%)	303	0.92708	1	1	1	NA	NA	NA	NA	0.78043	1	0.63019	1	0.024495	1	1	1	0.37031	1	0.7943	1
MAPK1	4 (1%)	302	0.80792	1	0.69793	1	0.56865	1	1	1	0.69142	1	0.68627	1	0.68963	1	0.66918	1	0.6847	1	0.7128	1
PLSCR1	5 (2%)	301	0.32915	1	0.29139	1	1	1	1	1	0.52389	1	0.52618	1	0.15694	1	0.44174	1	0.73874	1	0.76074	1
CNPY3	3 (1%)	303	0.44283	1	0.66014	1	NA	NA	NA	NA	0.50041	1	0.49872	1	0.50055	1	0.58966	1	0.49822	1	0.7943	1
EPB41L3	16 (5%)	290	0.81527	1	0.30783	1	0.25267	1	0.015151	1	0.0509	1	0.013187	1	0.15351	1	0.20249	1	0.16118	1	0.18476	1
RAC1	9 (3%)	297	0.30159	1	1	1	1	1	0.51895	1	0.19472	1	0.1923	1	0.21808	1	0.32114	1	0.49578	1	0.33175	1
CUL3	10 (3%)	296	0.81987	1	0.33604	1	0.73733	1	0.6364	1	0.40329	1	0.85167	1	0.79029	1	0.35896	1	0.90373	1	0.56733	1
TRPV4	7 (2%)	299	0.30172	1	0.41172	1	0.79635	1	0.26983	1	0.57134	1	0.063376	1	0.56859	1	0.37115	1	0.71378	1	0.33175	1
PRB2	10 (3%)	296	0.49897	1	0.080125	1	0.88845	1	1	1	0.66869	1	0.23147	1	0.66669	1	0.14964	1	0.23499	1	0.16403	1
PRB1	7 (2%)	299	0.56849	1	0.6392	1	0.75664	1	0.67201	1	0.88966	1	0.63923	1	0.10584	1	1	1	0.15725	1	0.79669	1
WHSC1	10 (3%)	296	0.079246	1	0.11193	1	0.28388	1	0.62185	1	0.85536	1	0.85167	1	0.17359	1	1	1	0.083207	1	0.9296	1
STEAP4	10 (3%)	296	0.29236	1	0.080125	1	0.17512	1	0.65586	1	0.081342	1	0.099651	1	0.08172	1	1	1	0.10854	1	0.137	1
HIST1H1B	7 (2%)	299	0.046593	1	0.15162	1	0.70542	1	0.82166	1	0.80235	1	0.71677	1	0.56859	1	0.10783	1	0.89044	1	0.1306	1
KCNA3	8 (3%)	298	0.85505	1	0.10458	1	0.80194	1	0.051762	1	0.60571	1	0.49136	1	0.90707	1	0.30573	1	0.58218	1	0.50292	1
EPDR1	6 (2%)	300	0.45012	1	1	1	0.56135	1	0.77857	1	0.32685	1	0.67497	1	0.87981	1	1	1	1	1	0.70513	1
SLC26A7	8 (3%)	298	0.64589	1	0.60596	1	0.56865	1	0.20931	1	0.19956	1	0.31063	1	0.90707	1	0.76371	1	1	1	0.82782	1
OR8D4	6 (2%)	300	0.92658	1	0.61831	1	0.89435	1	0.438	1	0.38709	1	1	1	0.38677	1	0.71963	1	0.32761	1	0.26425	1
POU4F2	7 (2%)	299	0.6706	1	0.80232	1	0.42798	1	0.40376	1	0.57134	1	0.56324	1	0.34392	1	0.75633	1	0.30449	1	0.33175	1
FCRL4	13 (4%)	293	0.67683	1	0.40558	1	0.78846	1	1	1	0.40452	1	0.10557	1	0.37689	1	0.83282	1	0.43033	1	0.57199	1
TXK	3 (1%)	303	0.41697	1	0.54685	1	NA	NA	NA	NA	0.78043	1	0.78201	1	0.11437	1	1	1	NA	NA	NA	NA