rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(27), CHUK(3), FADD(1), FAS(1), FASLG(2), GZMB(1), HELLS(4), IKBKB(5), IRF1(5), IRF2(3), IRF3(1), IRF4(2), IRF5(1), IRF6(4), IRF7(2), LTA(1), MAP2K4(1), MAP3K1(3), MAPK10(3), MDM2(2), MYC(4), NFKB1(2), NFKBIB(1), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(2), TNFRSF10B(1), TNFRSF21(2), TNFRSF25(2), TP53(246), TRAF2(1), TRAF3(3) 26196004 372 243 276 32 61 55 65 61 123 7 <1.00e-15 <1.00e-15 <8.55e-14 2 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(27), FADD(1), FAS(1), FASLG(2), GZMB(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(3), MCL1(1), MDM2(2), MYC(4), NFKB1(2), PARP1(3), PRF1(3), RELA(1), RIPK1(2), TP53(246), TRAF2(1) 17088240 327 237 231 21 53 41 56 56 114 7 <1.00e-15 <1.00e-15 <8.55e-14 3 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), CASP3(1), CASP6(2), CASP7(1), EIF2S1(1), PRKCA(2), PTK2(5), PXN(1), STAT1(5), TLN1(13), TP53(246) 12480574 304 233 211 26 48 40 58 51 100 7 9.48e-12 <1.00e-15 <8.55e-14 4 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNG(1), IFNGR1(5), IFNGR2(2), IKBKB(5), JAK2(2), LIN7A(2), NFKB1(2), RB1(10), RELA(1), TP53(246), USH1C(2) 8287879 279 227 185 20 43 33 48 43 105 7 1.09e-13 <1.00e-15 <8.55e-14 5 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(9), CDC25B(3), CDK4(4), CHEK1(1), MYT1(7), RB1(10), TP53(246), WEE1(1), YWHAH(1) 7991690 282 226 189 12 44 33 49 46 103 7 3.11e-15 <1.00e-15 <8.55e-14 6 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(2), CDK4(4), CDKN1B(2), CDKN2A(65), CFL1(2), E2F2(3), MDM2(2), PRB1(8), TP53(246) 3842593 334 223 206 12 44 34 49 50 149 8 <1.00e-15 <1.00e-15 <8.55e-14 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(1), MYC(4), SP1(1), SP3(1), TP53(246) 3219260 253 214 160 7 41 28 42 42 93 7 <1.00e-15 <1.00e-15 <8.55e-14 8 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(15), HRAS(11), PAX3(4), PML(1), RARA(2), RB1(10), SIRT1(1), SP100(2), TP53(246) 8657665 292 234 194 22 44 35 57 44 105 7 2.76e-13 1.11e-15 8.55e-14 9 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(14), IGF1R(7), MYC(4), POLR2A(9), PRKCA(2), RB1(10), TEP1(8), TERF1(3), TERT(1), TNKS(4), TP53(246), XRCC5(2) 12869416 313 230 220 29 49 41 60 52 104 7 7.27e-14 1.33e-15 9.12e-14 10 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CHUK(3), GH1(1), GHR(4), NFKB1(2), PDPK1(2), PIK3CA(65), PIK3R1(6), RELA(1), YWHAH(1) 6437782 88 82 47 4 3 49 8 23 5 0 2.86e-09 1.55e-15 9.57e-14 11 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ATM(9), ATR(19), CCNA1(4), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(65), DHFR(3), GSK3B(1), RB1(10), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(2), TP53(246) 13736583 377 233 250 19 48 43 56 61 161 8 <1.00e-15 2.00e-15 1.05e-13 12 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(9), ATM(9), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK4(4), MDM2(2), RB1(10), TP53(246) 8248470 287 226 194 16 44 36 46 50 104 7 2.07e-14 2.22e-15 1.05e-13 13 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3D(1), CD80(5), CD86(1), CTLA4(1), HLA-DRA(1), ICOS(1), ITK(1), LCK(5), PIK3CA(65), PIK3R1(6), PTPN11(1) 5827830 90 83 49 4 2 47 11 23 7 0 2.53e-09 2.22e-15 1.05e-13 14 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(1), CALM1(1), CALM3(1), GNAS(6), GNB1(2), NFKB1(2), NOS3(4), NPPA(1), NR3C1(5), PIK3CA(65), PIK3R1(6), RELA(1), SYT1(5) 8161012 102 89 61 4 12 48 12 25 5 0 1.42e-10 2.44e-15 1.05e-13 15 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 CDKN2A(65), MDM2(2), MYC(4), PIK3CA(65), PIK3R1(6), POLR1A(5), POLR1B(3), POLR1C(2), RAC1(10), RB1(10), TBX2(2), TP53(246), TWIST1(1) 9224538 421 255 251 13 50 78 55 71 159 8 <1.00e-15 2.66e-15 1.05e-13 16 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(2), CDC42(1), CHUK(3), ELK1(1), HRAS(11), MAP2K1(4), NFKB1(2), PIK3CA(65), PIK3R1(6), RAC1(10), RAF1(2), RALBP1(2), RALGDS(6), RELA(1), RHOA(4) 8688239 123 97 72 7 12 54 26 24 7 0 4.14e-11 2.89e-15 1.05e-13 17 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(9), ATR(19), BRCA1(9), CCNB1(3), CDC25B(3), CDC34(1), CHEK1(1), CHEK2(5), EP300(25), MDM2(2), MYT1(7), PRKDC(15), RPS6KA1(4), TP53(246), WEE1(1), YWHAH(1), YWHAQ(1) 19102840 352 237 256 25 53 50 66 65 111 7 6.77e-15 3.11e-15 1.05e-13 18 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(11), AKT1(2), ATM(9), BAX(1), CPB2(3), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(2), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1), TP53(246) 9472034 285 220 192 19 45 34 54 47 98 7 6.34e-13 3.44e-15 1.05e-13 19 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(11), NTRK1(3), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), SHC1(1), SOS1(8) 7103380 103 88 57 5 6 49 21 23 4 0 4.12e-10 3.44e-15 1.05e-13 20 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(9), ATR(19), CHEK1(1), CHEK2(5), TP53(246), YWHAH(1) 7290074 281 221 188 10 43 35 47 52 97 7 1.48e-14 3.55e-15 1.05e-13 21 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ATM(9), BRCA1(9), CHEK1(1), CHEK2(5), MAPK8(4), MDM2(2), MRE11A(1), NFKB1(2), RAD50(5), RAD51(1), RBBP8(6), RELA(1), TP53(246) 13588317 292 225 199 20 45 40 53 49 98 7 2.99e-12 3.89e-15 1.05e-13 22 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(2), MAP2K4(1), MAP2K5(2), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(4), MAPK9(4), MYEF2(3), NFATC3(6), NR2C2(1), PAPPA(9), SHC1(1), TP53(246), TRAF6(1), ZAK(2) 22997165 336 232 243 30 52 50 70 53 104 7 3.57e-13 4.11e-15 1.05e-13 23 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(9), ATR(19), BRCA1(9), BRCA2(11), CHEK1(1), CHEK2(5), FANCA(4), FANCC(2), FANCD2(3), FANCG(2), HUS1(2), MRE11A(1), RAD17(3), RAD50(5), RAD51(1), TP53(246), TREX1(2) 20066645 325 233 232 20 47 50 56 61 104 7 4.27e-14 4.22e-15 1.05e-13 24 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), HRAS(11), IGF1R(7), IRS1(1), MAP2K1(4), MAPK1(4), PIK3CA(65), PIK3R1(6), RAF1(2), SHC1(1), SOS1(8), YWHAH(1) 8655628 113 94 64 5 11 50 23 23 6 0 1.87e-11 4.22e-15 1.05e-13 25 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(9), ATM(9), ATR(19), BAI1(4), BAX(1), BID(2), CASP3(1), CASP8(27), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CCNG1(1), CCNG2(2), CDK4(4), CDK6(1), CDKN2A(65), CHEK1(1), CHEK2(5), DDB2(2), EI24(1), FAS(1), GADD45G(1), GTSE1(4), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(2), PTEN(6), RCHY1(1), RFWD2(1), RRM2(1), RRM2B(1), SERPINE1(4), SESN3(1), SFN(5), SIAH1(1), STEAP3(2), THBS1(7), TNFRSF10B(1), TP53(246), TSC2(3) 29795051 468 249 338 38 57 62 73 86 182 8 <1.00e-15 4.33e-15 1.05e-13 26 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IGF1R(7), IRS1(1), MAP2K1(4), MAPK8(4), PIK3CA(65), PIK3R1(6), PTPN11(1), RAF1(2), RASA1(14), SHC1(1), SOS1(8) 11293994 132 110 84 6 11 47 32 25 17 0 1.14e-11 4.44e-15 1.05e-13 27 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), MAP2K1(4), MAPK8(4), NGFR(1), PIK3CA(65), PIK3R1(6), PLCG1(5), RAF1(2), SHC1(1), SOS1(8) 8695189 115 94 69 3 9 46 29 21 10 0 1.09e-12 4.66e-15 1.06e-13 28 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(3), DNAJC3(1), EIF2S1(1), EIF2S2(3), MAP3K14(2), NFKB1(2), RELA(1), TP53(246) 4476449 259 220 166 10 43 30 41 42 96 7 <1.00e-15 5.22e-15 1.11e-13 29 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(65), PIK3R1(6), PLCB1(12), PLCG1(5), PRKCA(2), VAV1(2) 5843024 94 86 53 6 4 46 19 22 3 0 1.69e-08 5.22e-15 1.11e-13 30 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNA2(3), CCND1(2), CCNE1(3), CCNE2(3), CDK4(4), CDKN1B(2), CDKN2A(65), E2F2(3), E2F4(1), PRB1(8) 4091450 98 90 63 6 3 10 11 14 59 1 5.47e-07 5.44e-15 1.12e-13 31 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), INSR(2), IRS1(1), MAP2K1(4), MAPK8(4), PIK3CA(65), PIK3R1(6), PTPN11(1), RAF1(2), RASA1(14), SHC1(1), SLC2A4(1), SOS1(8) 11617808 128 105 80 5 9 47 31 24 17 0 2.59e-12 6.44e-15 1.28e-13 32 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(2), GH1(1), GHR(4), HRAS(11), IGF1R(7), PIK3CA(65), PIK3R1(6), SHC1(1), SOD2(1), SOD3(1) 6068225 101 86 55 5 8 49 18 23 3 0 2.99e-10 7.22e-15 1.39e-13 33 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(11), MAPK1(4), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NTRK1(3), PIK3CA(65), PIK3R1(6), PLCG1(5), RPS6KA1(4), SHC1(1) 8628815 113 96 64 6 10 52 21 24 6 0 2.16e-11 1.02e-14 1.91e-13 34 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(2), CDKN1B(2), ILK(4), ITGB1(12), MAPK1(4), PDPK1(2), PIK3CA(65), PIK3R1(6), PTEN(6), PTK2(5), SHC1(1), SOS1(8) 8837396 119 98 74 9 9 50 20 24 16 0 1.23e-08 7.95e-14 1.44e-12 35 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(12), ARHGEF1(5), F2(2), F2RL3(3), GNA12(1), GNA13(1), GNAI1(1), GNB1(2), MAP3K7(4), PIK3CA(65), PIK3R1(6), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2B(2), ROCK1(11) 11794945 130 109 89 9 12 52 31 29 6 0 2.05e-10 5.49e-13 9.66e-12 36 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(7), HLA-A(9), ITGB1(12), KLRC2(1), KLRC3(2), KLRC4(1), LAT(3), MAP2K1(4), PAK1(1), PIK3CA(65), PIK3R1(6), PTK2B(2), PTPN6(1), RAC1(10), SYK(3), VAV1(2) 8470747 129 104 83 10 12 48 16 30 23 0 2.78e-09 7.67e-13 1.30e-11 37 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), PAK1(1), PDGFRA(6), PIK3CA(65), PIK3R1(6), RAC1(10), WASL(1) 6096912 95 81 52 8 5 47 13 25 5 0 1.52e-06 7.81e-13 1.30e-11 38 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(3), AKT3(4), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CAPN2(4), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(27), CFLAR(2), CHUK(3), CSF2RB(5), FADD(1), FAS(1), FASLG(2), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IL3(1), IL3RA(3), IRAK1(2), IRAK2(2), IRAK3(4), IRAK4(3), MAP3K14(2), NFKB1(2), NFKB2(1), NTRK1(3), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TP53(246), TRAF2(1) 38083445 486 270 349 51 71 110 78 93 126 8 <1.00e-15 3.02e-12 4.89e-11 39 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), HRAS(11), MAPK1(4), NFKB1(2), PAK1(1), PIK3CA(65), PIK3R1(6), RAC1(10), RAF1(2), RB1(10), RELA(1), TFDP1(3) 9219962 129 106 78 10 11 54 19 28 17 0 5.53e-10 1.09e-11 1.72e-10 40 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(65), RB1(10), RBL1(8), TFDP1(3) 7297818 105 97 71 11 5 10 10 13 66 1 2.81e-05 1.31e-11 2.02e-10 41 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(4), DLL1(4), FURIN(1), NOTCH1(62) 4273951 71 66 71 7 13 12 12 7 27 0 7.60e-05 8.66e-11 1.30e-09 42 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(3), AKT3(4), ELK1(1), HRAS(11), MAP2K1(4), MAP2K2(3), NGFR(1), NTRK1(3), PIK3CA(65), PIK3CD(2), SHC1(1), SOS1(8) 7364137 108 90 62 11 9 48 23 25 3 0 1.15e-07 4.84e-09 7.09e-08 43 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(6), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MPL(2), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4) 13650337 142 111 93 10 11 53 33 26 19 0 2.70e-10 7.61e-09 1.09e-07 44 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(1), CASP8(27), CFL1(2), CFLAR(2) 1766707 33 33 30 4 3 8 2 5 15 0 0.0150 8.88e-09 1.24e-07 45 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(12), AKT1(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), GNAS(6), HRAS(11), MAPK1(4), MAPK14(1), PIK3CA(65), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAC1(10), RPS6KA1(4), RPS6KA5(4), SOS1(8) 13246919 150 115 99 11 18 60 32 31 9 0 4.91e-11 1.94e-08 2.66e-07 46 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAX(1), BTK(5), CAD(2), CASP10(2), CASP3(1), CASP8(27), CASP8AP2(3), CD7(2), CSNK1A1(1), DEDD(1), DEDD2(2), DIABLO(1), EGFR(14), EPHB2(2), FADD(1), FAF1(1), IL1A(1), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MET(1), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR0B2(1), PTPN13(9), RALBP1(2), RIPK1(2), ROCK1(11), SMPD1(1), TNFRSF6B(2), TP53(246), TPX2(4), TRAF2(1) 33201124 393 244 294 44 61 57 82 62 124 7 1.06e-12 2.05e-08 2.74e-07 47 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(4), AKT1(2), AKT2(3), AKT3(4), BAD(1), BTK(5), CDKN2A(65), GSK3B(1), IARS(7), IGFBP1(2), INPP5D(7), PDK1(1), PIK3CA(65), PPP1R13B(1), PTEN(6), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SOS1(8), SOS2(9), TEC(2), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 16419845 221 159 146 28 11 65 42 40 62 1 8.55e-09 2.37e-08 3.11e-07 48 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(15), EP300(25), FYN(3), IL7R(3), JAK1(6), JAK3(3), LCK(5), NMI(5), PIK3CA(65), PIK3R1(6), PTK2B(2), STAT5A(1), STAT5B(4) 12730011 144 115 100 13 7 61 25 35 16 0 5.97e-10 9.04e-08 1.16e-06 49 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(9), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), CASP8(27), GZMB(1), PRF1(3) 5879834 51 48 48 3 5 8 5 14 19 0 0.000438 1.79e-07 2.25e-06 50 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PDGFRA(6), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1) 15891070 155 117 106 12 13 51 39 28 24 0 5.92e-10 2.54e-07 3.13e-06 51 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(12), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(2), ITGB3(5), MAPK1(4), PDGFRA(6), PIK3CA(65), PIK3R1(6), PLCB1(12), PRKCA(2), PTK2(5), RAC1(10), SMPD1(1), SMPD2(1), SRC(1) 12503964 138 114 92 13 15 53 31 29 10 0 4.43e-09 3.97e-07 4.79e-06 52 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NFKB1(2), PIK3CA(65), PIK3R1(6), RB1(10), RELA(1), SP1(1) 8844809 107 96 63 11 9 46 14 22 16 0 4.97e-06 1.69e-06 2.00e-05 53 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(1), EIF4B(2), EIF4EBP1(1), EIF4G1(14), EIF4G2(3), EIF4G3(4), MKNK1(1), PDPK1(2), PIK3CA(65), PIK3R1(6), PTEN(6), RPS6KB1(3), TSC1(2), TSC2(3) 12625922 115 96 73 8 1 52 25 22 15 0 1.93e-08 3.42e-06 3.97e-05 54 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF4EBP1(1), GSK3B(1), IGF1R(7), INPPL1(4), PDPK1(2), PIK3CA(65), PIK3R1(6), PTEN(6), RPS6KB1(3) 9000539 103 88 61 10 7 48 17 21 10 0 5.24e-07 5.68e-06 6.48e-05 55 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(4), HRAS(11), INSR(2), IRS1(1), JAK2(2), MAP2K1(4), MAPK1(4), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(8), STAT5A(1), STAT5B(4) 15069480 129 101 80 8 13 57 28 24 7 0 4.58e-12 5.95e-06 6.66e-05 56 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNG(4), MUSK(6), PIK3CA(65), PIK3R1(6), PTK2(5), PTK2B(2), SRC(1), TERT(1), YWHAH(1) 7476640 94 88 53 12 4 46 13 24 7 0 2.98e-06 1.38e-05 0.000152 57 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(12), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(5), IGF1R(7), IL3(1), IL3RA(3), KIT(5), PIK3CA(65), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), YWHAH(1) 10001758 120 99 79 14 11 55 20 28 6 0 1.19e-07 1.42e-05 0.000153 58 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(6), EGF(6), EGFR(14), ELK1(1), FOS(1), HRAS(11), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), RASA1(14), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1) 17057685 169 127 120 16 14 55 42 33 25 0 2.87e-09 1.67e-05 0.000178 59 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(9), CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CCNE2(3), CCNG2(2), CDK4(4), CDKN1B(2), CDKN2A(65), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F2(3), E2F4(1), E2F5(4), E2F6(1), GBA2(3), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MNAT1(2), MYC(4), MYT1(7), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(2), POLE(8), POLE2(1), RB1(10), RBL1(8), RPA1(4), TFDP1(3), TFDP2(1), TNXB(10), TP53(246), WEE1(1) 35142210 451 245 323 55 60 58 86 71 168 8 4.24e-13 1.80e-05 0.000188 60 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIK(1), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(27), DIABLO(1) 6118191 50 49 47 4 5 10 7 9 19 0 0.00143 3.55e-05 0.000364 61 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(3), AKT3(4), BPNT1(1), ILK(4), MAPK1(4), PDK1(1), PIK3CA(65), PIK3CD(2), PTEN(6), PTK2B(2), RBL2(3), SHC1(1), SOS1(8) 9323850 106 89 62 12 7 47 22 23 7 0 1.17e-06 6.48e-05 0.000654 62 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM3(1), CD3D(1), ELK1(1), FOS(1), FYN(3), HRAS(11), LAT(3), LCK(5), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN7(2), RAC1(10), RAF1(2), RASA1(14), RELA(1), SHC1(1), SOS1(8), SYT1(5), VAV1(2), ZAP70(2) 21806921 187 131 137 16 24 61 45 37 20 0 1.65e-11 0.000182 0.00180 63 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(1), CRKL(1), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), MYC(4), PIK3CA(65), PIK3R1(6), RAF1(2), SOS1(8), STAT1(5), STAT5A(1), STAT5B(4) 12830026 126 101 80 12 8 55 30 23 10 0 2.49e-08 0.000281 0.00275 64 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(9), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP7(1), CASP8(27), GZMB(1), PRF1(3), SCAP(1), SREBF1(3), SREBF2(4) 8296936 54 50 51 3 7 8 9 11 19 0 0.000135 0.00110 0.0106 65 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), CRK(1), CRKL(1), DOCK1(8), ELK1(1), FOS(1), GAB1(2), HGF(8), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAP2K2(3), MAP4K1(2), MAPK1(4), MAPK8(4), MET(1), PAK1(1), PIK3CA(65), PIK3R1(6), PTEN(6), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAF1(2), RAP1B(2), RASA1(14), SOS1(8), SRC(1), STAT3(3) 20079123 185 137 131 21 21 55 45 40 24 0 4.27e-08 0.00112 0.0106 66 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G2(3), EIF4G3(4), GHR(4), IRS1(1), MAPK1(4), MAPK14(1), MKNK1(1), PDPK1(2), PIK3CA(65), PIK3R1(6), PRKCA(2), PTEN(6), RPS6KB1(3) 12861161 120 99 75 11 4 55 23 24 14 0 2.32e-07 0.00759 0.0708 67 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), KEAP1(13), MAPK1(4), MAPK14(1), MAPK8(4), NFE2L2(18), PRKCA(2) 4056446 44 39 36 6 8 6 20 7 3 0 0.0195 0.00852 0.0784 68 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(5), CALM1(1), CALM3(1), ELK1(1), FCER1A(2), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PAK2(5), PIK3CA(65), PIK3R1(6), PLA2G4A(3), PLCG1(5), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2) 19606400 167 121 118 17 22 57 40 33 15 0 6.85e-09 0.0105 0.0954 69 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(4), BIRC3(1), CASP8(27), FADD(1), RIPK1(2), TRAF2(1) 3830042 36 35 33 5 3 7 6 5 15 0 0.0227 0.0174 0.156 70 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDC34(1), CUL1(6), FBXW7(16), RB1(10), TFDP1(3) 3734402 39 34 37 5 5 6 7 5 16 0 0.0424 0.0181 0.159 71 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(2), CFLAR(2), CRKL(1), FOS(1), HRAS(11), IL2RA(2), IL2RB(3), IRS1(1), JAK1(6), JAK3(3), MAPK1(4), MYC(4), NMI(5), PIK3CA(65), PIK3R1(6), PTPN6(1), RAF1(2), RPS6KB1(3), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3) 16459868 145 108 96 15 15 60 32 28 10 0 1.18e-09 0.0513 0.445 72 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(3), CYP2C9(5) 922599 8 8 8 0 0 3 4 1 0 0 0.0867 0.0540 0.462 73 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(9), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(27), GZMB(1), LMNB1(1), LMNB2(4), PRF1(3) 8796163 56 54 53 6 8 9 9 12 18 0 0.00300 0.0709 0.598 74 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAI1(1), GNB1(2), HRAS(11), MAP2K1(4), MAPK1(4), NFKB1(2), PIK3C2G(7), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PTK2B(2), PXN(1), RAF1(2), RELA(1) 12614453 125 100 76 17 14 50 26 25 10 0 4.97e-06 0.0826 0.687 75 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(6), FYN(3), GSN(5), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAPK1(4), MYLK(4), PIK3CA(65), PIK3R1(6), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SRC(1), TLN1(13) 17023753 163 119 113 21 17 58 36 40 12 0 8.56e-07 0.0861 0.707 76 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 231812 2 2 2 0 0 0 0 0 2 0 0.660 0.118 0.958 77 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(12), GNAS(6), GNB1(2), PRKACA(4), PRKAR1A(2) 2991458 26 23 26 2 10 3 9 4 0 0 0.0192 0.161 1.000 78 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), B3GNT1(1), FUT1(1), FUT2(2), FUT9(10), GCNT2(4), ST8SIA1(2) 2797416 22 21 22 4 2 7 10 2 1 0 0.124 0.188 1.000 79 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(5), PTGS1(6), PTGS2(2) 2433197 17 15 17 2 2 1 9 0 5 0 0.159 0.267 1.000 80 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(6), ELK1(1), EPO(2), FOS(1), HRAS(11), JAK2(2), MAP2K1(4), MAPK8(4), PLCG1(5), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4) 9768227 53 46 48 4 9 9 25 2 8 0 0.000412 0.321 1.000 81 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 829283 5 5 5 1 1 2 0 1 1 0 0.394 0.328 1.000 82 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 2467452 12 12 12 1 2 2 4 3 1 0 0.127 0.346 1.000 83 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(4), APC(17), AXIN1(5), BTRC(1), CTNNB1(2), DLL1(4), DVL1(2), FZD1(3), GSK3B(1), NOTCH1(62), WNT1(1) 9819392 102 81 102 16 15 20 21 13 32 1 0.00297 0.364 1.000 84 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UGDH(3), UXS1(2) 1758796 8 8 8 0 0 1 3 3 1 0 0.188 0.386 1.000 85 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR0B2(1), NR1H4(5), RXRA(4) 2480469 15 15 15 1 2 2 6 1 4 0 0.104 0.406 1.000 86 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(4), KERA(4) 1651973 10 8 10 2 0 4 5 0 1 0 0.317 0.461 1.000 87 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12A(1), IL12B(4) 1362330 8 8 8 2 1 2 0 4 1 0 0.515 0.469 1.000 88 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), ASPH(7), COPS5(1), CREB1(1), EP300(25), EPO(2), HIF1A(2), LDHA(1), NOS3(4), P4HB(1) 7747043 48 46 45 6 11 11 9 8 9 0 0.00613 0.490 1.000 89 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ATM(9), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCNE1(3), CCNE2(3), CDAN1(7), CDC14A(2), CDC20(2), CDC25B(3), CDC6(2), CDC7(1), CDH1(4), CDK4(4), CDKN2A(65), CHEK1(1), CHEK2(5), DTX4(3), E2F2(3), E2F4(1), E2F5(4), E2F6(1), EP300(25), ESPL1(9), GSK3B(1), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), HDAC8(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MPEG1(1), MPL(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PLK1(2), PRKDC(15), PTPRA(4), RB1(10), RBL1(8), SKP2(2), SMAD4(8), TBC1D8(2), TFDP1(3), TGFB1(1), TP53(246), WEE1(1) 50036274 526 260 396 70 71 78 98 83 188 8 3.18e-13 0.503 1.000 90 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1) 2786733 13 11 13 0 1 4 4 3 1 0 0.0325 0.503 1.000 91 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(10) 1693069 11 11 11 2 1 2 8 0 0 0 0.287 0.506 1.000 92 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UGDH(3), UGP2(1), UXS1(2) 2237857 9 9 9 0 0 1 4 3 1 0 0.158 0.536 1.000 93 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(5), RXRA(4) 2635335 11 11 11 0 2 1 4 2 2 0 0.0436 0.570 1.000 94 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(4), EIF1(2), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(3), ELAVL1(1), FLT1(10), FLT4(6), HIF1A(2), HRAS(11), KDR(5), NOS3(4), PIK3CA(65), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PXN(1), SHC1(1) 15483194 140 110 94 22 18 54 34 25 9 0 3.32e-05 0.577 1.000 95 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA6(1), PSMB10(3), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMB8(1) 3977611 17 16 17 0 0 4 6 4 3 0 0.0122 0.590 1.000 96 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST12(2), CHST13(3), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1) 4218503 21 19 21 2 3 4 6 6 2 0 0.0500 0.591 1.000 97 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HBXIP(1), HRAS(11), PTK2B(2), SHC1(1), SOS1(8), SRC(1) 4021884 25 23 20 4 5 4 11 3 2 0 0.136 0.612 1.000 98 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(10), SP1(1), SP3(1) 3024881 14 14 14 3 0 1 1 2 10 0 0.581 0.658 1.000 99 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(17), AXIN1(5), CCND1(2), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(2), LBP(7), LEF1(2), LY96(1), NFKB1(2), PDPK1(2), PIK3CA(65), PIK3R1(6), RELA(1), TLR4(7), WNT1(1) 14054248 133 106 92 23 9 58 25 30 10 1 0.000107 0.684 1.000 100 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(6), BCMO1(2) 1777605 8 8 8 2 2 1 2 1 2 0 0.458 0.693 1.000 101 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(4), RDH11(1), RDH12(3) 2186793 11 10 11 2 2 2 5 2 0 0 0.279 0.695 1.000 102 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), PSMD14(2), RPN1(1), RPN2(2), UBE3A(4) 5879770 23 22 23 1 0 5 8 7 3 0 0.0157 0.697 1.000 103 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 752631 2 2 2 0 1 1 0 0 0 0 0.450 0.697 1.000 104 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), HRAS(11), MAP2K1(4), MAPK1(4), MYC(4), NFKB1(2), PLCB1(12), PRKCA(2), RAF1(2), RELA(1) 7091847 46 44 38 8 10 8 20 5 3 0 0.0284 0.702 1.000 105 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(3), MAPK14(1), THBS1(7) 3373854 13 12 13 1 0 4 4 4 1 0 0.0798 0.705 1.000 106 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(3), HRAS(11), MAP2K1(4), MAP2K2(3), MAPK1(4), NGFR(1), RAF1(2) 3712483 28 26 20 6 9 3 10 2 4 0 0.121 0.711 1.000 107 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(4), FYN(3), LRP8(1), RELN(37), VLDLR(1) 6372797 46 39 44 7 5 5 13 15 8 0 0.108 0.716 1.000 108 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2) 2580190 11 10 11 1 1 3 3 1 3 0 0.138 0.717 1.000 109 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDC34(1), CUL1(6), RB1(10), SKP2(2), TFDP1(3) 3866305 29 27 29 7 4 4 5 3 13 0 0.335 0.726 1.000 110 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 1018738 3 3 3 1 1 1 1 0 0 0 0.607 0.734 1.000 111 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), HLA-DRA(1) 1077093 3 3 3 1 0 1 0 1 1 0 0.732 0.735 1.000 112 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(65), PIK3CD(2), PIK3R1(6), SYT1(5), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 15339814 123 103 79 19 14 48 24 26 11 0 8.40e-06 0.743 1.000 113 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDKN1B(2), CKS1B(1), CUL1(6), NEDD8(1), RB1(10), RBX1(2), SKP2(2), TFDP1(3) 3895401 30 29 30 7 3 5 5 4 13 0 0.277 0.748 1.000 114 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IL2RA(2), IL2RB(3), JAK1(6), JAK3(3), LCK(5), MAP2K1(4), MAPK8(4), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4), SYK(3) 10601580 65 53 60 9 9 11 27 6 12 0 0.00383 0.762 1.000 115 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(2), HADHA(3) 2211166 7 7 7 0 0 1 1 3 2 0 0.159 0.763 1.000 116 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(3), FDPS(2), IDI1(1) 1460995 6 6 6 2 2 3 1 0 0 0 0.481 0.764 1.000 117 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(12), CAP1(2), CCNB1(3), GNAI1(1), GNAS(6), GNB1(2), HRAS(11), MAPK1(4), MYT1(7), PIN1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(4), SRC(1) 9339279 64 57 56 9 20 11 21 10 2 0 0.00160 0.773 1.000 118 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2) 2570828 13 12 13 3 1 5 1 3 3 0 0.407 0.774 1.000 119 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(6), ELK1(1), FOS(1), HRAS(11), IL6R(4), IL6ST(2), JAK1(6), JAK2(2), JAK3(3), MAP2K1(4), PTPN11(1), RAF1(2), SHC1(1), SOS1(8), STAT3(3) 10836566 56 50 50 7 8 7 23 9 9 0 0.00909 0.779 1.000 120 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(4) 2142884 16 15 16 4 2 2 8 1 3 0 0.440 0.788 1.000 121 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 695872 1 1 1 0 0 0 0 1 0 0 0.757 0.793 1.000 122 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB1A(1), RAB3A(1), RAB5A(2) 1919717 6 6 6 0 2 2 1 1 0 0 0.115 0.801 1.000 123 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(17), CDH1(4), CREBBP(15), EP300(25), MAP2K1(4), MAP3K7(4), SKIL(4), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11) 11685351 88 76 83 13 10 16 25 15 22 0 0.0156 0.807 1.000 124 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(1), HRAS(11), IL3(1), IL3RA(3), JAK2(2), MAP2K1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(8), STAT5A(1), STAT5B(4) 8056065 44 39 39 6 7 12 17 4 4 0 0.00826 0.828 1.000 125 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA3(2), LTB4R(2), P2RY1(4), P2RY2(2), P2RY6(2) 2718389 17 15 17 4 4 5 6 2 0 0 0.127 0.833 1.000 126 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(2), PRKCA(2), TGM2(3) 2255806 8 8 8 1 0 3 3 2 0 0 0.172 0.838 1.000 127 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1), ALDOB(3), ALDOC(1), TPI1(2) 1785922 7 7 7 2 1 2 2 2 0 0 0.543 0.852 1.000 128 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(3), SNCAIP(1), UBE2L3(1), UBE2L6(1) 2927495 11 10 11 2 1 2 2 4 2 0 0.360 0.854 1.000 129 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(1), HLA-DRA(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL2RA(2), IL4(1), IL4R(2) 5765533 34 31 33 5 3 9 9 6 7 0 0.0366 0.856 1.000 130 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CA(65), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4) 20405654 167 123 125 26 22 56 37 38 13 1 2.24e-06 0.857 1.000 131 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), REG1A(8), SOAT1(3) 6236900 32 31 32 4 4 6 11 5 6 0 0.0445 0.857 1.000 132 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(9), EPHB1(9), FYN(3), ITGA1(3), ITGB1(12), L1CAM(3), LYN(3), RAP1B(2), SELP(11) 7201984 57 43 56 9 8 11 13 14 11 0 0.0272 0.857 1.000 133 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3) 3564134 10 10 10 1 1 2 1 4 2 0 0.182 0.860 1.000 134 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(1), STX1A(3) 1483617 4 4 4 1 1 0 1 1 1 0 0.756 0.863 1.000 135 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(3), CHEK1(1), NEK1(4), WEE1(1) 3132462 9 9 9 1 2 1 4 0 2 0 0.556 0.889 1.000 136 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 516198 1 1 1 0 0 0 1 0 0 0 0.843 0.892 1.000 137 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(3), TAT(1) 1197770 5 5 5 2 1 0 3 1 0 0 0.740 0.902 1.000 138 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(1), OXCT1(1) 1542084 3 3 3 1 1 0 0 1 1 0 0.692 0.912 1.000 139 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(1), IFNGR1(5), JAK1(6), JAK2(2), PTPRU(6), REG1A(8), STAT1(5) 5208584 34 31 33 6 4 8 9 4 9 0 0.0651 0.912 1.000 140 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(3), FDPS(2), IDI1(1) 1951946 6 6 6 2 2 3 1 0 0 0 0.482 0.918 1.000 141 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(7), IFNAR1(2), IFNAR2(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1) 5062810 22 22 22 4 3 4 5 6 4 0 0.303 0.919 1.000 142 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(1), IFNG(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TGFBR3(3), TOB2(2) 4814025 27 25 25 5 2 6 4 6 9 0 0.188 0.927 1.000 143 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(2), HDC(2), PNMT(1), TH(2), TPH1(2) 2763324 13 13 13 3 2 1 6 1 3 0 0.476 0.929 1.000 144 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD80(5), HLA-DRA(1), IL4(1) 1807437 9 9 9 3 0 4 2 2 1 0 0.525 0.930 1.000 145 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(5), IFNGR2(2), JAK1(6), JAK2(2), STAT1(5) 3727435 21 20 20 6 1 5 4 2 9 0 0.406 0.930 1.000 146 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(2), CD3D(1) 1461751 3 3 3 1 0 0 1 1 1 0 0.841 0.936 1.000 147 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3), AOC2(2), AOC3(5), CES1(4), ESD(1) 2756712 15 15 15 4 1 6 6 0 2 0 0.320 0.937 1.000 148 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(4), CD3D(1), CD58(1), CD8A(2), IL3(1) 2820651 10 10 10 3 2 1 2 1 4 0 0.618 0.947 1.000 149 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR2(5), MTMR6(2), NFS1(1), PHPT1(1), TPK1(3) 2920637 13 11 13 3 3 2 3 3 2 0 0.484 0.948 1.000 150 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PCYT1A(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2) 6395286 28 26 28 4 9 7 7 2 3 0 0.0385 0.950 1.000 151 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(2), SRP19(2), SRP68(2), SRPR(2) 3433083 9 8 9 1 0 2 4 2 1 0 0.349 0.952 1.000 152 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(12), TUB(2) 3252404 17 17 17 4 5 3 7 2 0 0 0.298 0.953 1.000 153 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(1), GPI(2), HK1(3), PFKL(4), PGAM1(1), PKLR(1), TPI1(2) 4218425 17 16 17 3 6 3 1 4 3 0 0.215 0.954 1.000 154 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2) 3809273 11 11 11 2 1 1 3 4 2 0 0.369 0.959 1.000 155 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BAX(1), BCL2(1), CASP8(27), FADD(1), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(2), SMPD1(1), TRAF2(1) 9375042 59 54 53 10 11 7 14 8 19 0 0.0348 0.963 1.000 156 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1) 3173054 8 8 8 1 1 3 2 1 1 0 0.257 0.967 1.000 157 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), PRKCE(2) 3578364 31 28 31 9 2 6 12 5 6 0 0.502 0.969 1.000 158 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2RL3(3), GNAI1(1), GNB1(2), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAPK1(4), PLA2G4A(3), PLCB1(12), PRKCA(2), PTGS1(6), PTK2(5), RAF1(2), SRC(1), SYK(3), TBXAS1(5) 11108969 81 65 72 13 17 10 29 13 12 0 0.00746 0.970 1.000 159 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), HLA-DRA(1), IL1B(1), IL4(1), IL5(1), IL5RA(1) 2426471 8 8 8 2 0 4 4 0 0 0 0.379 0.974 1.000 160 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(3), CTH(2), MUT(2) 2232722 8 7 8 2 0 4 3 0 1 0 0.464 0.979 1.000 161 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(1), CABIN1(7), CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(7), INSR(2), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NFATC1(7), NFATC2(6), PIK3CA(65), PIK3R1(6), SYT1(5), YWHAH(1) 15890207 127 104 86 25 11 54 24 31 7 0 0.000137 0.980 1.000 162 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1) 4056012 15 13 15 3 1 5 6 2 1 0 0.274 0.985 1.000 163 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), ST3GAL3(1) 2320444 10 10 10 3 2 3 2 1 2 0 0.446 0.986 1.000 164 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6R(4), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), REG1A(8), SRC(1), STAT3(3) 6925632 37 36 36 6 5 6 12 9 5 0 0.0586 0.987 1.000 165 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 CS(2), MDH1(1), ME1(2), PC(7), PDHA1(3), SLC25A1(1) 4234898 16 16 16 4 3 5 3 3 2 0 0.375 0.988 1.000 166 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4) 6131663 24 22 24 4 2 5 10 2 5 0 0.131 0.989 1.000 167 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(3), AKT3(4), BRD4(5), CAP1(2), CBL(2), CDC42(1), CDKN2A(65), F2RL2(1), FLOT1(1), FLOT2(3), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), LNPEP(2), MAPK1(4), PARD3(10), PARD6A(1), PDK1(1), PIK3CA(65), PIK3CD(2), PIK3R1(6), PPYR1(1), PTEN(6), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SERPINB6(3), SFN(5), SHC1(1), SLC2A4(1), SORBS1(2), SOS1(8), SOS2(9), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 27146454 262 176 183 39 26 70 50 45 70 1 7.50e-09 0.990 1.000 168 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST8SIA1(2) 4897881 28 25 28 6 1 5 13 4 5 0 0.240 0.991 1.000 169 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(12), FHL5(4), FSHB(1), FSHR(5), GNAS(6), XPO1(3) 4347116 31 29 31 6 8 6 10 7 0 0 0.199 0.994 1.000 170 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), ITPKA(1), ITPKB(5) 2748280 8 6 8 2 2 2 2 2 0 0 0.361 0.996 1.000 171 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(2), GLB1(4), HEXA(3), LCT(8), SLC33A1(1), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4) 7487856 40 35 40 8 7 10 10 9 4 0 0.0779 0.996 1.000 172 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(2), OXCT1(1), OXCT2(1) 3277286 10 9 10 3 3 1 2 3 1 0 0.569 0.996 1.000 173 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), ANGPTL2(2), DAG1(1), DGKA(2), ETFA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), MAP2K1(4), MAPK1(4), PAK1(1), PDE3A(13), PDE3B(1), PI3(1), PIK3C2G(7), PIK3CA(65), PIK3CD(2), PIK3R1(6), PLDN(2), PSME1(1), SGCB(3), VASP(1) 22099097 154 112 110 25 15 58 30 32 19 0 9.51e-06 0.996 1.000 174 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(11), MEF2A(1), MEF2B(2), MEF2C(7), YWHAH(1) 3486563 24 22 24 7 3 5 10 3 3 0 0.440 0.997 1.000 175 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(3), KARS(2) 2143652 6 6 6 3 0 1 1 2 2 0 0.863 0.997 1.000 176 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(10), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2) 4572101 16 14 16 3 2 9 3 2 0 0 0.127 0.997 1.000 177 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(1), DUSP14(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), MYOG(3), NR4A3(2) 4869061 17 15 17 3 2 5 4 5 1 0 0.236 0.997 1.000 178 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2) 4614870 28 25 28 7 1 6 12 4 5 0 0.318 0.997 1.000 179 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(15), NRG2(4), NRG3(8), PRKCA(2) 4087307 33 28 33 9 4 5 13 8 3 0 0.481 0.998 1.000 180 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5) 2209291 5 4 5 2 1 2 1 1 0 0 0.737 0.998 1.000 181 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(3) 3118783 13 13 13 4 4 0 7 2 0 0 0.578 0.998 1.000 182 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(9), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(27), CFLAR(2), CHUK(3), FADD(1), GAS2(1), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1) 15233085 77 66 74 10 13 15 15 12 22 0 0.000878 0.999 1.000 183 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(3) 2852136 4 4 4 1 0 1 2 1 0 0 0.693 0.999 1.000 184 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(2), AFMID(3), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 6097801 28 24 28 5 3 6 9 6 4 0 0.148 0.999 1.000 185 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), ATM(9), ATR(19), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CDC14A(2), CDC16(1), CDC20(2), CDC23(1), CDC25B(3), CDC27(5), CDC6(2), CDC7(1), CDK4(4), CDK6(1), CDKN1B(2), CDKN2A(65), CHEK1(1), CHEK2(5), CREBBP(15), CUL1(6), E2F2(3), EP300(25), ESPL1(9), FZR1(2), GADD45G(1), GSK3B(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(15), RB1(10), RBL1(8), RBL2(3), RBX1(2), SFN(5), SKP1(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(8), SMC1A(3), SMC1B(5), TFDP1(3), TGFB1(1), TGFB2(2), TP53(246), WEE1(1), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 61936726 584 265 454 81 72 93 112 102 197 8 7.09e-13 0.999 1.000 186 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(2), GGT1(1) 2616298 10 10 10 4 2 3 1 1 3 0 0.701 0.999 1.000 187 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(1), IL12A(1), IL12B(4), IL13(1), IL16(11), IL1A(1), IL3(1), IL4(1), IL5(1), IL9(1), LTA(1) 4526342 24 22 24 7 8 6 4 5 1 0 0.290 0.999 1.000 188 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(6), EGFR(14), HRAS(11), MAP2K1(4), MAPK1(4), PTPRB(12), RAF1(2), RASA1(14), SHC1(1), SOS1(8), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), SRC(1) 11371632 84 75 74 16 13 13 29 14 15 0 0.0378 0.999 1.000 189 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F3(1), F5(12), F7(2), FGA(7), FGB(2), FGG(3), PROS1(5), SERPINC1(3) 7476710 40 33 40 8 2 9 16 6 7 0 0.118 0.999 1.000 190 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT1(1), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(2), ST3GAL3(1), ST3GAL4(1) 3283505 12 11 12 5 2 2 4 0 4 0 0.826 0.999 1.000 191 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(21), MAP2(13), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(2) 8254538 41 34 41 8 2 6 14 8 11 0 0.373 0.999 1.000 192 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), GSK3B(1), IL4R(2), IRS1(1), IRS2(2), JAK1(6), JAK3(3), MAP4K1(2), MAPK1(4), PDK1(1), PIK3CA(65), PIK3CD(2), PIK3R1(6), PPP1R13B(1), RAF1(2), SHC1(1), SOS1(8), SOS2(9), STAT6(2) 16670911 129 98 85 23 11 55 27 29 7 0 8.60e-05 0.999 1.000 193 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(3), KARS(2) 3161374 9 9 9 4 0 1 2 3 3 0 0.830 0.999 1.000 194 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(8), MBTPS2(1), SCAP(1), SREBF1(3), SREBF2(4) 5420463 22 20 22 5 2 4 8 5 3 0 0.348 0.999 1.000 195 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(2), CS(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 5821305 25 22 25 5 3 6 8 5 3 0 0.190 0.999 1.000 196 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(9), HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(2) 3689804 17 16 17 5 2 4 6 4 1 0 0.478 0.999 1.000 197 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(1), COQ6(1), COQ7(1), NDUFA12(1), NDUFA13(2) 1824339 6 6 6 4 0 2 2 1 1 0 0.934 0.999 1.000 198 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(6) 3846743 7 7 7 2 2 0 2 1 2 0 0.730 1.000 1.000 199 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25B(3), CSK(1), PRKCA(2), PTPRA(4), SRC(1) 4193055 14 13 14 4 4 3 6 1 0 0 0.361 1.000 1.000 200 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), FYN(3), HLA-DRA(1), LCK(5), PTPRC(13), ZAP70(2) 4113288 25 21 25 8 2 6 5 7 5 0 0.392 1.000 1.000 201 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(1), BRAF(4), CREB1(1), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(1), EEF2K(4), MAP2K1(4), MAP2K2(3), MAP3K8(1), MAPK1(4), MKNK1(1), MKNK2(1), MOS(5), NFKB1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(8), SOS2(9), TRAF3(3) 13427113 75 56 71 11 15 15 23 12 10 0 0.00453 1.000 1.000 202 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(14), ERBB3(8), NRG1(1) 4690084 29 26 29 8 4 6 8 7 4 0 0.420 1.000 1.000 203 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(1), LDLR(3), LPL(2) 2422249 8 8 8 4 1 1 4 1 1 0 0.853 1.000 1.000 204 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(2), EDNRB(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 9389909 44 35 43 8 11 5 11 8 9 0 0.0441 1.000 1.000 205 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), DHFR(3), FPGS(2) 2971869 16 14 16 6 2 1 9 2 2 0 0.682 1.000 1.000 206 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(9), BAD(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), CASP8AP2(3), CES1(4) 4964296 25 23 25 6 3 8 6 4 4 0 0.362 1.000 1.000 207 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(12), CFTR(7), GNAS(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(1) 5944860 34 30 34 8 10 6 12 6 0 0 0.200 1.000 1.000 208 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3) 3002239 17 17 17 6 3 2 6 3 3 0 0.516 1.000 1.000 209 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3) 3002239 17 17 17 6 3 2 6 3 3 0 0.516 1.000 1.000 210 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(1), FARS2(2), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3) 3783264 16 13 16 7 1 4 5 3 3 0 0.739 1.000 1.000 211 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(5), PRKCA(2), PTK2B(2) 3053975 11 11 11 4 2 2 5 2 0 0 0.492 1.000 1.000 212 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(3), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 3610573 11 10 11 4 2 2 2 2 3 0 0.692 1.000 1.000 213 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(2), CSF1(1), EPO(2), IL3(1), IL4(1), IL5(1), IL9(1) 2773360 9 9 9 7 4 1 2 1 1 0 0.944 1.000 1.000 214 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(4), CHPF(4), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHSY1(2), UST(1), XYLT1(7), XYLT2(3) 6353940 30 29 30 7 6 2 12 6 4 0 0.247 1.000 1.000 215 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(17), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(1), EPHB2(2), FOS(1), ITPKA(1), ITPKB(5), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4) 12987964 64 52 61 10 12 13 20 8 11 0 0.0154 1.000 1.000 216 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), GNB1(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2) 4344323 20 17 20 5 8 5 5 2 0 0 0.279 1.000 1.000 217 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1) 4623164 12 11 12 4 2 1 4 2 3 0 0.599 1.000 1.000 218 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM3(1), CCL2(2), CXCL12(1), CXCR4(1), FOS(1), MAPK14(1), MAPK8(4), PLCG1(5), PRKCA(2), PTK2B(2), SYT1(5) 6275083 26 22 26 6 3 3 14 5 1 0 0.291 1.000 1.000 219 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), TYR(4) 4427430 24 22 24 8 2 4 13 1 4 0 0.734 1.000 1.000 220 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(3), DHRS1(1), DHRS2(3), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2) 6838421 31 29 31 8 8 8 8 4 3 0 0.199 1.000 1.000 221 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(1), ALOX15B(2), ALOX5(2), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 6863320 27 25 27 6 5 4 9 4 5 0 0.112 1.000 1.000 222 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CDC25B(3), MNAT1(2), XPO1(3) 3932458 11 11 11 4 4 3 2 2 0 0 0.593 1.000 1.000 223 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(6), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF5(2), GSK3B(1) 5274480 16 15 16 8 3 3 5 0 5 0 0.953 1.000 1.000 224 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(14), ELK1(1), GNAS(6), GNB1(2), HRAS(11), IGF1R(7), ITGB1(12), MAP2K1(4), MAP2K2(3), MAPK1(4), MKNK1(1), MKNK2(1), MYC(4), NGFR(1), PDGFRA(6), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(3) 15030150 104 77 94 18 24 16 36 16 12 0 0.00424 1.000 1.000 225 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2) 3636958 11 11 11 7 3 1 3 1 3 0 0.921 1.000 1.000 226 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2) 3636958 11 11 11 7 3 1 3 1 3 0 0.921 1.000 1.000 227 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(3), CTH(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(6), MARS(2), MARS2(4), MAT1A(1), METTL2B(2), METTL6(2), PAPSS1(3), PAPSS2(3), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SEPHS1(1), SEPHS2(3) 11353289 47 39 46 8 12 13 13 5 4 0 0.0179 1.000 1.000 228 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(2), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALT2(3), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GCNT2(4), ST3GAL6(1), ST8SIA1(2) 7367361 37 33 37 9 4 12 14 3 4 0 0.120 1.000 1.000 229 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(3), AKT3(4), BCR(1), BTK(5), CD19(2), CDKN2A(65), FLOT1(1), FLOT2(3), GAB1(2), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), NR0B2(1), PDK1(1), PIK3CA(65), PITX2(1), PLCG2(4), PPP1R13B(1), PREX1(6), PTEN(6), PTPRC(13), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SYK(3), TEC(2), VAV1(2) 25067193 235 160 160 40 14 71 31 45 73 1 8.13e-08 1.000 1.000 230 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(12), CALM1(1), CALM3(1), CREB1(1), ELK1(1), FOS(1), GNAI1(1), GNAS(6), GNB1(2), HRAS(11), MAP2K1(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(2), RPS6KA3(3), SYT1(5) 15869077 87 67 82 14 24 16 29 13 5 0 0.00128 1.000 1.000 231 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(15), EP300(25), ESR1(3), MAPK1(4), PELP1(1), SRC(1) 6706886 49 47 43 12 6 11 13 9 10 0 0.184 1.000 1.000 232 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(15), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1) 4837360 22 21 22 7 3 4 8 5 2 0 0.581 1.000 1.000 233 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(7), ACO2(2), ACSS1(5), ACSS2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1) 6056947 22 19 22 6 2 6 7 3 4 0 0.403 1.000 1.000 234 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(3), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF13B(2), TNFRSF13C(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 6641117 25 25 24 7 2 5 10 1 7 0 0.598 1.000 1.000 235 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(2), SDHA(5), SDHC(1), UQCRC1(1) 3015547 9 8 9 4 0 1 4 3 1 0 0.794 1.000 1.000 236 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(2), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), NAGS(2), ODC1(1), OTC(1), PYCR1(1), SMS(2) 7984329 33 31 33 7 7 9 10 7 0 0 0.105 1.000 1.000 237 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(9), CDC25B(3), CHEK1(1), MYT1(7), WEE1(1), YWHAH(1) 6259861 22 21 22 5 3 2 9 6 2 0 0.549 1.000 1.000 238 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(2), AGTR2(2), EDNRB(3), EGF(6), EGFR(14), FOS(1), HRAS(11), MYC(4), NFKB1(2), PLCG1(5), PRKCA(2), RELA(1) 9370753 59 52 54 13 7 12 25 11 4 0 0.0623 1.000 1.000 239 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(2), NAT1(1), XDH(3) 3638553 12 11 12 5 1 2 4 3 2 0 0.753 1.000 1.000 240 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(2), DHFR(3), HPRT1(1), IMPDH1(3), MTHFD2(1), OAZ1(1), POLB(1), POLD1(3), POLG(2), PRPS2(1), RRM1(1) 5688117 23 21 23 6 5 3 12 0 3 0 0.292 1.000 1.000 241 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(1), IL1B(1), MST1(5), MST1R(5) 2968399 14 13 13 6 3 3 7 0 1 0 0.706 1.000 1.000 242 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADHA(3), HADHB(2), HSD17B4(3), PPT1(1), PPT2(1) 3860702 13 13 13 5 0 2 3 6 2 0 0.728 1.000 1.000 243 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(3), AKT3(4), CISH(1), IARS(7), IL13RA1(1), IL4(1), IL4R(2), INPP5D(7), JAK1(6), JAK2(2), JAK3(3), NR0B2(1), PI3(1), PIK3CA(65), PPP1R13B(1), RPS6KB1(3), SERPINA4(6), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT6(2), TYK2(2) 16804747 139 106 98 29 9 59 34 30 7 0 0.00116 1.000 1.000 244 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), BTK(5), CALM1(1), CALM3(1), ELK1(1), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP3K1(3), MAPK14(1), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SYK(3), SYT1(5), VAV1(2) 17423793 97 73 90 18 19 17 35 16 10 0 0.00949 1.000 1.000 245 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(2), LDHA(1), LDHB(1), LDHC(3), MAPK14(1), NCL(3) 4092084 11 11 11 6 2 0 4 3 2 0 0.935 1.000 1.000 246 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMKK1(1), CAMKK2(5), CREB1(1), SYT1(5) 5260732 22 22 22 7 3 4 7 5 3 0 0.605 1.000 1.000 247 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(4), CREB1(1), CREB5(5), MAPK1(4), RAF1(2), SRC(1) 5080555 18 15 15 5 4 2 8 1 3 0 0.563 1.000 1.000 248 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM3(1), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), SP1(1), SP3(1), SYT1(5) 9559825 37 32 37 8 10 7 10 7 3 0 0.0781 1.000 1.000 249 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2) 4776708 15 14 15 6 3 4 4 1 3 0 0.694 1.000 1.000 250 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2) 4776708 15 14 15 6 3 4 4 1 3 0 0.694 1.000 1.000 251 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(3), CREBBP(15), EP300(25), IKBKB(5), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(2), MAP3K7(4), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(5), RELA(1), TGFBR1(1), TGFBR2(11), TLR2(1) 13536821 83 71 78 17 8 18 22 15 20 0 0.0613 1.000 1.000 252 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(2), JAK3(3), MAPK1(4), STAT3(3), TYK2(2) 5322868 20 18 16 7 4 3 4 5 4 0 0.637 1.000 1.000 253 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(8), MPI(3), PGM1(3), PYGL(4), PYGM(3), TPI1(2) 6059784 28 26 28 9 7 5 6 5 5 0 0.411 1.000 1.000 254 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), MIOX(2), UGDH(3) 3873966 12 12 12 6 3 1 3 3 2 0 0.824 1.000 1.000 255 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(4), GOT1(1), GOT2(3), PAH(4), TAT(1), YARS(3), YARS2(3) 3964861 21 19 21 7 2 7 7 4 1 0 0.423 1.000 1.000 256 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), PGM1(3), PGM3(1), TGDS(2) 4651478 21 20 21 7 4 4 7 3 3 0 0.574 1.000 1.000 257 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), CASP7(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(3) 4030067 10 9 10 4 1 3 3 2 1 0 0.804 1.000 1.000 258 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(4), IL1A(1), IL3(1), IL9(1), TGFB1(1), TGFB2(2) 3766855 13 11 13 6 4 1 5 2 1 0 0.767 1.000 1.000 259 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), CS(2), FH(2), MDH1(1), OGDH(6), SDHA(5), SUCLA2(1) 4286283 19 18 19 7 1 2 10 4 2 0 0.812 1.000 1.000 260 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(1) 5399408 13 13 13 7 0 3 3 4 3 0 0.938 1.000 1.000 261 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(2), GGT1(1), MARS(2), MARS2(4), MAT1A(1), PAPSS1(3), PAPSS2(3), SEPHS1(1) 5637988 18 17 17 5 4 5 5 3 1 0 0.366 1.000 1.000 262 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CHPT1(1), ENPP2(6), ENPP6(3), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(8), PLD2(1), PPAP2B(1) 10583122 40 37 40 9 4 10 11 8 7 0 0.157 1.000 1.000 263 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(3), IL10RB(1), IL1A(1), JAK1(6), STAT1(5), STAT3(3), STAT5A(1) 5548120 22 20 21 8 1 7 6 4 4 0 0.463 1.000 1.000 264 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3) 5540691 18 17 18 7 3 2 4 4 5 0 0.718 1.000 1.000 265 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(2), AP2M1(3), BAD(1), BTK(5), EEA1(8), GSK3B(1), LYN(3), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PLCG1(5), PRKCE(2), PRKCZ(3), RAB5A(2), RAC1(10), RPS6KB1(3), VAV2(1) 11387678 63 52 61 13 6 18 22 10 7 0 0.0348 1.000 1.000 266 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2D2(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2L6(1), UBE3A(4) 4805613 14 14 14 6 2 5 5 0 2 0 0.778 1.000 1.000 267 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(14), MAP2K1(4), MAP3K1(3), MAPK14(1), NCOR2(11), RARA(2), RXRA(4), THRA(5), THRB(1) 7874705 51 45 51 12 8 8 18 9 8 0 0.152 1.000 1.000 268 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(9), BCL2(1), CASP3(1), FAS(1), FASLG(2), IL1A(1), MAPKAPK3(2) 5153734 19 18 19 6 3 5 4 5 2 0 0.507 1.000 1.000 269 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), PER1(5) 3886607 17 17 17 7 3 3 6 4 1 0 0.735 1.000 1.000 270 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), IDS(3), IDUA(3), LCT(8), NAGLU(1) 6522401 26 25 26 8 5 6 7 7 1 0 0.431 1.000 1.000 271 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(2), IRS1(1), JAK1(6), JAK3(3), RPS6KB1(3), SHC1(1), STAT6(2) 6720228 21 20 21 5 4 6 6 3 2 0 0.226 1.000 1.000 272 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(2), ARFGEF2(5), CLTA(1), COPA(7), GBF1(6), GPLD1(3) 7390021 27 25 27 7 5 7 9 3 3 0 0.278 1.000 1.000 273 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2) 6029403 22 19 22 9 3 7 4 4 4 0 0.715 1.000 1.000 274 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM1(1), CALM3(1), CRKL(1), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK14(1), MAPK8(4), PAK1(1), PLCG1(5), PRKCA(2), PTK2B(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5) 12976954 76 57 66 16 17 12 28 12 7 0 0.0639 1.000 1.000 275 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CDO1(1), CTH(2), GOT1(1), GOT2(3), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), SULT1B1(2), SULT1C2(2), SULT4A1(1) 5707741 23 21 23 8 5 3 9 3 3 0 0.595 1.000 1.000 276 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPNS1(1), CAPNS2(2), CSNK1A1(1), GSK3B(1), MAPT(6) 4192884 14 13 14 5 2 3 7 1 1 0 0.620 1.000 1.000 277 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), AGTR1(8), ATF2(1), CALM1(1), CALM3(1), EGFR(14), ELK1(1), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), MEF2A(1), MEF2B(2), MEF2C(7), PAK1(1), PRKCA(2), PTK2(5), PTK2B(2), RAC1(10), RAF1(2), SHC1(1), SOS1(8), SRC(1), SYT1(5) 15233076 105 79 95 23 16 19 40 21 9 0 0.0498 1.000 1.000 278 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(4), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), RDH11(1), RDH12(3) 10897024 50 42 50 10 7 9 22 7 5 0 0.0534 1.000 1.000 279 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(15), EP300(25), LPL(2), NCOA1(4), NCOA2(3), RXRA(4) 8423398 53 50 50 13 6 11 16 11 9 0 0.251 1.000 1.000 280 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(9), CASP1(2), CASP3(1), CASP7(1), CASP8(27), INSR(2), ITCH(5), MAGI1(3), MAGI2(10), RERE(6), WWP1(3), WWP2(2) 10925625 71 62 67 17 6 18 14 12 21 0 0.193 1.000 1.000 281 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(4), CASP3(1), CASP8(27), CRADD(1), FADD(1), LMNB1(1), LMNB2(4), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), RB1(10), RIPK1(2), SPTAN1(11), TRAF2(1) 17711681 102 80 99 20 14 15 28 13 32 0 0.0493 1.000 1.000 282 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(2), BRAF(4), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(1), EGR1(3), EGR2(2), ELK1(1), MAP1B(12), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(7), PIK3CA(65), PIK3CD(2), PIK3R1(6), PTPN11(1), RPS6KA3(3), SHC1(1), SRC(1), TH(2) 23421397 169 127 125 30 16 63 40 33 17 0 4.90e-05 1.000 1.000 283 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(3), IKBKB(5), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), TNFAIP3(3), TRAF3(3), TRAF6(1) 8277422 23 22 23 9 3 5 5 4 6 0 0.699 1.000 1.000 284 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(3), CREB1(1), CREBBP(15), EP300(25), NCOA3(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(2), RXRA(4) 9405441 63 54 60 16 10 17 15 9 12 0 0.197 1.000 1.000 285 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), BLNK(3), ELK1(1), FOS(1), HRAS(11), LYN(3), MAP2K1(4), MAP3K1(3), MAPK1(4), MAPK8IP3(5), PAPPA(9), RAC1(10), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(8), SYK(3), VAV1(2), VAV2(1), VAV3(1) 14612756 79 66 69 17 18 14 24 12 11 0 0.0571 1.000 1.000 286 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CREBBP(15), CSNK1A1(1), F2(2), FGF2(1), GSK3B(1), HAND2(2), HRAS(11), LIF(2), MAP2K1(4), MAPK1(4), MAPK14(1), MAPK8(4), MEF2C(7), MYH2(16), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKX2-5(1), NPPA(1), PIK3CA(65), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(2), RPS6KB1(3), SYT1(5) 23134226 195 138 146 38 27 69 48 35 16 0 2.01e-05 1.000 1.000 287 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 APOA2(1), CPT1B(3), CREBBP(15), EHHADH(2), EP300(25), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), ME1(2), MYC(4), NCOA1(4), NCOR1(12), NCOR2(11), NR0B2(1), NR2F1(2), NRIP1(4), PIK3CA(65), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(10), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(4) 28856356 200 142 151 34 15 74 41 39 31 0 5.16e-06 1.000 1.000 288 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 289 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 290 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 291 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(1), ELOVL5(1), ELOVL6(1), FADS2(2), FASN(4), HADHA(3), HSD17B12(1), SCD(1) 6543336 14 13 14 6 1 2 5 2 4 0 0.823 1.000 1.000 292 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), GOSR1(3), SEC22B(1), SNAP25(1), STX11(3), STX17(1), STX18(2), STX19(1), STX4(4), STX5(1), STX7(2), STX8(2), TSNARE1(1), USE1(1), VAMP1(1), VAMP5(1) 7593036 26 25 26 7 4 7 8 2 5 0 0.302 1.000 1.000 293 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(17), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(25), FZD1(3), GSK3B(1), LDB1(1), LEF1(2), PITX2(1), TRRAP(10), WNT1(1) 15127941 85 65 82 19 9 23 22 16 14 1 0.0530 1.000 1.000 294 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKL(4), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7) 11046189 49 46 49 12 7 5 18 12 7 0 0.288 1.000 1.000 295 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT2(3), FBP2(1), G6PC(2), GAA(3), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKM(2), PFKP(4), PGM1(3), PGM3(1) 14813090 72 62 72 15 13 17 21 10 11 0 0.0309 1.000 1.000 296 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), IDI1(1), LSS(3), PMVK(1) 5046464 14 12 14 9 5 5 2 1 1 0 0.871 1.000 1.000 297 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(4), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(3) 7279642 23 23 23 8 2 3 11 4 3 0 0.779 1.000 1.000 298 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR7(1), CD28(2), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(5), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL4(1), IL4R(2), IL5(1), TGFB1(1), TGFB2(2) 9102244 45 38 44 12 7 9 12 8 9 0 0.168 1.000 1.000 299 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(3), B4GALT2(3), G6PC(2), G6PC2(3), GAA(3), GALK2(1), GALT(1), GANC(3), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKL(4), PFKM(2), PFKP(4), PGM1(3), PGM3(1), RDH11(1), RDH12(3), UGP2(1) 17569991 88 72 88 18 16 18 29 13 12 0 0.0191 1.000 1.000 300 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), EPO(2), HIF1A(2), JAK2(2), NFKB1(2), RELA(1), SOD2(1) 5790559 14 14 14 6 2 5 3 3 1 0 0.672 1.000 1.000 301 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(4), BIRC2(1), BIRC3(1), CASP3(1), CASP8(27), CFLAR(2), FADD(1), MAP2K4(1), MAP3K3(1), MAP3K7(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(2), RIPK1(2), TNFAIP3(3), TRAF2(1) 12455668 57 52 54 13 7 14 11 6 19 0 0.0753 1.000 1.000 302 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP3(1), CASP6(2), CASP7(1), CASP8(27), CFLAR(2), FADD(1), FAF1(1), LMNB1(1), LMNB2(4), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), PTPN13(9), RB1(10), RIPK2(1), SPTAN1(11) 18597609 106 86 103 22 15 18 24 14 35 0 0.0748 1.000 1.000 303 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(3), CREBBP(15), EP300(25), FADD(1), HDAC3(1), IKBKB(5), NFKB1(2), RELA(1), RIPK1(2), TRAF6(1) 10219755 56 52 53 14 6 15 16 10 9 0 0.169 1.000 1.000 304 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2L1(2), CDC42(1), CDKN1B(2), CDKN2A(65), CREB1(1), CREB5(5), ERBB4(15), F2RL2(1), GAB1(2), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(10), MET(1), MYC(4), NOLC1(3), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARD3(10), PARD6A(1), PDK1(1), PIK3CA(65), PIK3CD(2), PPP1R13B(1), PREX1(6), PTEN(6), PTK2(5), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SLC2A4(1), SOS1(8), SOS2(9), TSC1(2), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 35249880 300 185 224 51 20 82 63 52 82 1 4.69e-08 1.000 1.000 305 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), OPRK1(2), POLR2A(9), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 5865799 21 19 21 9 2 7 9 2 1 0 0.729 1.000 1.000 306 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), ELK1(1), FPR1(3), GNA15(2), GNB1(2), HRAS(11), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NCF2(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(1), PIK3C2G(7), PLCB1(12), RAC1(10), RAF1(2), RELA(1), SYT1(5) 17422621 107 84 97 25 27 17 37 17 9 0 0.0427 1.000 1.000 307 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(3), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), JAK2(2), MAP2K6(1), MAPK14(1), MAPK8(4), STAT4(3), TYK2(2) 8497800 36 32 36 10 2 9 14 5 6 0 0.438 1.000 1.000 308 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(4), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), HAL(2) 8653411 45 40 45 12 8 13 10 12 2 0 0.236 1.000 1.000 309 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB5(5), DUSP10(2), EEF2K(4), ELK1(1), IL1R1(2), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K10(4), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), TRAF6(1) 15189407 64 53 61 14 11 14 17 13 9 0 0.0695 1.000 1.000 310 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), CAPNS1(1), CAPNS2(2), ITGA1(3), ITGB1(12), ITGB3(5), PTK2(5), PXN(1), RAC1(10), SPTAN1(11), SRC(1), TLN1(13) 12980577 80 64 77 18 16 13 30 14 7 0 0.0822 1.000 1.000 311 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTAP(3), MTFMT(3), MTR(4), TAT(1) 9453517 38 31 37 10 7 9 14 5 3 0 0.173 1.000 1.000 312 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKM(2), PFKP(4), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TAL1(2), TKT(1) 9302962 37 37 37 11 6 4 13 9 5 0 0.440 1.000 1.000 313 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(2), F12(1), F13B(9), F2(2), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), LPA(8), PLAT(2), PLAU(1), PLG(8), SERPINB2(2), SERPINE1(4), VWF(6) 16082803 83 65 83 19 7 18 28 16 14 0 0.0802 1.000 1.000 314 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(7), CALM1(1), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(2), EP300(25), NFATC1(7), NFATC2(6), PRKCA(2), SYT1(5) 11135039 61 55 58 17 10 13 13 15 10 0 0.169 1.000 1.000 315 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(17), ATF2(1), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(2), BMP7(3), BMPR2(3), CHRD(6), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MEF2C(7), NKX2-5(1), NPPA(1), NPPB(1), RFC1(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TGFBR3(3), WNT1(1) 16615699 91 71 89 21 8 22 26 17 17 1 0.0910 1.000 1.000 316 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(3), AKT3(4), BRAF(4), DDIT4(1), EIF4B(2), EIF4EBP1(1), HIF1A(2), MAPK1(4), PDPK1(2), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKAA1(3), PRKAA2(2), RICTOR(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), STK11(3), TSC1(2), TSC2(3), ULK1(5), ULK2(2), VEGFC(3) 24188572 172 129 128 32 24 61 34 35 17 1 9.09e-05 1.000 1.000 317 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX12B(4), ALOX15(1), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP2U1(1), CYP4A11(8), CYP4A22(6), CYP4F2(3), CYP4F3(1), DHRS4(2), EPHX2(4), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 17719710 95 75 95 21 13 22 31 15 14 0 0.0175 1.000 1.000 318 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), CFL1(2), GNAS(6), GNB1(2), HRAS(11), LIMK1(5), MAP2K1(4), MAPK1(4), NOX1(5), PIK3C2G(7), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2(5), RAF1(2), ROCK2(6) 11447945 77 68 69 19 17 15 29 7 9 0 0.216 1.000 1.000 319 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2A1(1), BCL2L1(2), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CASP8(27), CD40(4), CD40LG(3), CRADD(1), FADD(1), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(2), NGFR(1), NR3C1(5), NTRK1(3), PTPN13(9), RIPK1(2), SFRS2IP(5), TFG(1), TRAF2(1), TRAF3(3), TRAF6(1) 19828057 100 84 97 22 17 20 18 20 25 0 0.0348 1.000 1.000 320 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), BCR(1), CAPNS1(1), CAPNS2(2), CRKL(1), CSK(1), FYN(3), HRAS(11), ITGA1(3), ITGB1(12), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK8(4), PPP1R12B(1), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SOS1(8), SRC(1), TLN1(13), VCL(6), ZYX(2) 21480827 119 81 110 26 20 23 47 18 11 0 0.0310 1.000 1.000 321 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2) 10440262 66 50 66 19 12 16 19 12 7 0 0.199 1.000 1.000 322 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2) 10440262 66 50 66 19 12 16 19 12 7 0 0.199 1.000 1.000 323 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5B(2), GPRC5C(2), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM7(8), GRM8(12) 9519867 72 59 72 23 16 15 26 13 2 0 0.123 1.000 1.000 324 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(4), ARRB1(2), ARRB2(1), ATF2(1), ATF4(1), BDNF(2), BRAF(4), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CACNA2D1(12), CACNA2D3(2), CACNA2D4(4), CACNB1(5), CACNB2(4), CACNB3(2), CACNB4(1), CACNG1(1), CACNG2(2), CACNG4(2), CACNG5(3), CACNG6(4), CACNG7(1), CACNG8(4), CASP3(1), CD14(1), CDC25B(3), CDC42(1), CHUK(3), CRK(1), CRKL(1), DUSP10(2), DUSP14(1), DUSP16(2), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(3), DUSP6(3), DUSP7(1), DUSP9(1), ECSIT(1), EGF(6), EGFR(14), ELK1(1), ELK4(3), FAS(1), FASLG(2), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(5), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FLNA(8), FLNB(4), FLNC(8), FOS(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(11), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAPT(6), MAX(1), MEF2C(7), MKNK1(1), MKNK2(1), MOS(5), MYC(4), NF1(10), NFATC2(6), NFATC4(2), NFKB1(2), NFKB2(1), NLK(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(1), PAK1(1), PAK2(5), PDGFRA(6), PDGFRB(7), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PPM1A(3), PPP5C(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTPN7(2), PTPRR(4), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF2(2), RASA1(14), RASA2(6), RASGRF1(9), RASGRF2(5), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KA6(4), RRAS2(1), SOS1(8), SOS2(9), STK3(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TP53(246), TRAF2(1), TRAF6(1), ZAK(2) 129857442 906 283 796 204 162 159 241 150 187 7 5.10e-09 1.000 1.000 325 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(17), APC2(3), AXIN1(5), AXIN2(5), BTRC(1), CACYBP(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND1(2), CHD8(7), CREBBP(15), CSNK1A1(1), CSNK1E(3), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(2), CUL1(6), CXXC4(1), DAAM1(7), DAAM2(6), DKK1(3), DKK2(3), DVL1(2), DVL2(1), DVL3(4), EP300(25), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LEF1(2), LRP5(3), LRP6(12), MAP3K7(4), MAPK10(3), MAPK8(4), MAPK9(4), MMP7(1), MYC(4), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKD1(5), NKD2(1), NLK(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PORCN(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRICKLE1(5), PRICKLE2(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAC1(10), RAC2(1), RAC3(2), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), SENP2(2), SFRP1(1), SFRP4(8), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(3), SMAD3(2), SMAD4(8), SOX17(1), TBL1X(4), TBL1XR1(3), TBL1Y(2), TCF7(2), TCF7L1(1), TP53(246), VANGL1(1), VANGL2(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1) 73578741 644 277 543 120 109 117 165 99 146 8 7.24e-11 1.000 1.000 326 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), BRAF(4), CAPN2(4), CCND1(2), CDC42(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(6), DOCK1(8), EGF(6), EGFR(14), ELK1(1), ERBB2(8), FARP2(1), FLNA(8), FLNB(4), FLNC(8), FLT1(10), FN1(14), FYN(3), GRLF1(12), GSK3B(1), HGF(8), HRAS(11), IBSP(1), IGF1R(7), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAV(2), ITGB1(12), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KDR(5), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), MAP2K1(4), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MET(1), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(7), PDPK1(2), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP5K1C(2), PPP1R12A(3), PRKCA(2), PRKCG(7), PTEN(6), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF1(2), RELN(37), RHOA(4), ROCK1(11), ROCK2(6), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SPP1(1), SRC(1), THBS1(7), THBS2(7), THBS4(5), TLN1(13), TLN2(7), TNC(8), TNN(15), TNR(7), TNXB(10), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), VEGFC(3), VTN(2), VWF(6), ZYX(2) 169197317 978 266 919 271 125 240 318 168 125 2 0.000674 1.000 1.000 327 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), APC(17), APC2(3), ARHGEF1(5), ARHGEF12(8), ARHGEF4(2), ARHGEF6(3), ARHGEF7(1), ARPC1B(1), ARPC2(2), ARPC4(1), BCAR1(2), BDKRB1(1), BRAF(4), C3orf10(1), CD14(1), CDC42(1), CFL1(2), CHRM2(4), CHRM3(5), CHRM5(1), CRK(1), CRKL(1), CSK(1), CYFIP1(5), CYFIP2(5), DIAPH1(6), DIAPH2(6), DIAPH3(9), DOCK1(8), EGF(6), EGFR(14), F2(2), FGD1(10), FGD3(4), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(5), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FN1(14), GIT1(1), GNA12(1), GNA13(1), GNG12(1), GRLF1(12), GSN(5), HRAS(11), IQGAP1(6), IQGAP2(4), IQGAP3(7), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB1(12), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KRAS(1), LIMK1(5), LIMK2(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MOS(5), MSN(3), MYH10(17), MYH14(3), MYH9(13), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), NCKAP1(5), NCKAP1L(5), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDGFRA(6), PDGFRB(7), PFN4(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PPP1R12A(3), PPP1R12B(1), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), RHOA(4), ROCK1(11), ROCK2(6), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(8), SOS2(9), SSH1(3), SSH2(4), SSH3(1), TIAM1(7), TIAM2(9), TMSB4Y(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), WASF1(3), WASF2(2), WASL(1) 125718632 703 255 646 208 110 174 203 127 88 1 0.00823 1.000 1.000 328 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY7(2), ADCY8(13), ADCY9(4), ADORA2A(1), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), AGTR1(8), ATP2A1(2), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), ATP2B4(4), AVPR1A(5), AVPR1B(4), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1F(6), CACNA1G(12), CACNA1H(6), CACNA1I(7), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCKAR(4), CCKBR(3), CD38(2), CHRM2(4), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), EDNRB(3), EGFR(14), ERBB2(8), ERBB3(8), ERBB4(15), GNA15(2), GNAL(2), GNAS(6), GRIN2A(14), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), GRPR(1), HRH1(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), LHCGR(2), LTB4R2(1), MYLK(4), MYLK2(2), NOS1(3), NOS3(4), NTSR1(2), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRA(6), PDGFRB(7), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(2), RYR1(16), RYR2(44), RYR3(23), SLC25A6(1), SLC8A1(8), SLC8A2(4), SLC8A3(10), SPHK2(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), TRHR(4), TRPC1(4) 122233916 667 237 665 236 134 143 214 112 63 1 0.0935 1.000 1.000 329 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR1(8), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKAR(4), CCKBR(3), CGA(1), CHRM2(4), CHRM3(5), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHB(1), FSHR(5), GABBR1(2), GABBR2(4), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GABRB1(5), GABRB2(7), GABRB3(11), GABRE(2), GABRG1(4), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(2), GALR2(3), GH1(1), GH2(2), GHR(4), GHRHR(2), GHSR(3), GIPR(1), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(3), GLRA3(2), GLRB(3), GPR156(2), GPR50(1), GPR63(4), GRIA1(9), GRIA2(10), GRIA3(5), GRIA4(7), GRID1(11), GRID2(13), GRIK1(4), GRIK2(4), GRIK3(5), GRIK4(4), GRIK5(6), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRIN3A(10), GRM1(16), GRM2(4), GRM3(14), GRM4(2), GRM5(7), GRM6(3), GRM7(8), GRM8(12), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HRH4(3), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), LEP(1), LEPR(11), LHB(1), LHCGR(2), LTB4R(2), LTB4R2(1), MAS1(3), MC2R(7), MC3R(3), MC4R(3), MC5R(5), MCHR1(1), MCHR2(4), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR2(8), NPY1R(5), NPY2R(3), NPY5R(7), NR3C1(5), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PARD3(10), PPYR1(1), PRL(3), PRLHR(2), PRLR(4), PRSS1(8), PRSS3(1), PTGDR(1), PTGER2(4), PTGER3(2), PTGER4(2), PTGFR(2), PTH2R(6), RXFP1(4), RXFP2(4), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TAAR1(2), TAAR2(2), TAAR6(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), THRA(5), THRB(1), TRHR(4), TRPV1(5), TSHR(2), UTS2R(1), VIPR2(3) 100896362 707 232 704 244 113 130 262 131 71 0 0.0582 1.000 1.000 330 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABLIM1(4), ABLIM2(3), ABLIM3(2), ARHGEF12(8), CDC42(1), CFL1(2), CXCL12(1), CXCR4(1), DCC(19), DPYSL2(2), DPYSL5(2), EFNA5(2), EFNB1(2), EFNB2(1), EPHA1(6), EPHA2(16), EPHA3(12), EPHA4(9), EPHA5(12), EPHA6(10), EPHA7(11), EPHA8(3), EPHB1(9), EPHB2(2), EPHB3(5), EPHB4(3), EPHB6(4), FES(4), FYN(3), GNAI1(1), GNAI3(1), GSK3B(1), HRAS(11), ITGB1(12), KRAS(1), L1CAM(3), LIMK1(5), LIMK2(3), LRRC4C(18), MAPK1(4), MET(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTNG1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLXNA1(16), PLXNA2(6), PLXNA3(9), PLXNB1(3), PLXNB2(14), PLXNB3(5), PLXNC1(7), PTK2(5), RAC1(10), RAC2(1), RAC3(2), RASA1(14), RGS3(2), RHOA(4), RHOD(1), ROBO1(7), ROBO2(11), ROBO3(2), ROCK1(11), ROCK2(6), SEMA3A(10), SEMA3B(1), SEMA3C(4), SEMA3D(1), SEMA3E(8), SEMA3F(3), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(2), SEMA4F(3), SEMA4G(2), SEMA5A(20), SEMA5B(8), SEMA6A(2), SEMA6B(2), SEMA6C(1), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(15), SLIT3(3), SRGAP1(6), SRGAP2(1), SRGAP3(2), UNC5A(3), UNC5B(4), UNC5C(12), UNC5D(14) 89670176 557 228 537 156 86 114 175 104 77 1 0.00432 1.000 1.000 331 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(2), CHAD(3), COL11A1(38), COL11A2(6), COL17A1(7), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DES(1), DSC1(1), DSC2(1), DSG1(4), DSG2(2), DSG3(2), DSG4(1), FN1(14), GJA1(1), GJA10(3), GJA3(1), GJA5(2), GJA8(6), GJA9(2), GJB3(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(1), ITGA6(3), ITGB4(3), KRT1(2), KRT10(4), KRT12(3), KRT13(2), KRT14(6), KRT15(1), KRT16(1), KRT18(1), KRT2(3), KRT23(1), KRT24(5), KRT25(5), KRT27(2), KRT28(2), KRT31(3), KRT32(1), KRT33A(1), KRT33B(2), KRT34(3), KRT35(1), KRT36(4), KRT38(5), KRT39(4), KRT4(6), KRT40(2), KRT5(8), KRT6A(2), KRT6B(1), KRT6C(3), KRT7(2), KRT71(1), KRT72(1), KRT73(4), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(6), KRT79(2), KRT83(3), KRT85(2), KRT86(2), KRT9(2), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), LMNB1(1), LMNB2(4), NES(7), RELN(37), SPP1(1), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VIM(2), VTN(2), VWF(6) 113623912 592 216 590 176 87 118 211 91 84 1 0.0537 1.000 1.000 332 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD44(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(10), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DAG1(1), FN1(14), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(3), GP6(1), GP9(1), HMMR(1), HSPG2(11), IBSP(1), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAV(2), ITGB1(12), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), LAMA1(22), LAMA2(32), LAMA3(8), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), RELN(37), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(7), THBS2(7), THBS4(5), TNC(8), TNN(15), TNR(7), TNXB(10), VTN(2), VWF(6) 102323635 547 207 544 163 80 116 182 95 74 0 0.0737 1.000 1.000 333 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ANXA6(4), ARRB1(2), ARRB2(1), ATP1A4(4), ATP1B3(3), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(17), CACNA1S(11), CACNB1(5), CACNB3(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CASQ1(1), CASQ2(2), CHRM2(4), CHRM3(5), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GNAI3(1), GNAO1(2), GNAZ(3), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNB1(3), KCNJ3(4), KCNJ5(3), MIB1(5), NME7(2), PEA15(1), PKIG(1), PLCB3(5), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SLC8A3(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1) 85222888 486 204 483 169 97 109 141 83 55 1 0.159 1.000 1.000 334 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), AMOTL1(2), ASH1L(11), CASK(1), CDC42(1), CDK4(4), CGN(3), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTTN(4), EPB41L1(5), EPB41L2(7), EPB41L3(16), EXOC3(1), EXOC4(10), F11R(1), GNAI1(1), GNAI3(1), HCLS1(2), HRAS(11), IGSF5(3), INADL(7), KRAS(1), LLGL2(3), MAGI1(3), MAGI2(10), MAGI3(6), MLLT4(5), MPDZ(8), MPP5(5), MYH1(11), MYH10(17), MYH11(11), MYH13(16), MYH14(3), MYH15(9), MYH2(16), MYH3(8), MYH4(13), MYH6(10), MYH7(9), MYH7B(5), MYH8(18), MYH9(13), MYL7(1), MYL9(2), MYLPF(2), NRAS(1), PARD3(10), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PPP2R3A(5), PPP2R3B(3), PPP2R4(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PTEN(6), RAB13(1), RHOA(4), RRAS2(1), SPTAN1(11), SRC(1), SYMPK(4), TJAP1(1), TJP1(9), TJP2(4), TJP3(5), VAPA(1), YES1(1), ZAK(2) 88285284 497 203 488 154 79 110 172 76 58 2 0.0971 1.000 1.000 335 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(3), AKT3(4), BCL2L1(2), CBL(2), CBLB(2), CCND1(2), CISH(1), CREBBP(15), CSF2RA(1), CSF2RB(5), CSF3R(2), EP300(25), EPO(2), GH1(1), GH2(2), GHR(4), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL13RA2(1), IL19(2), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), IRF9(2), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), LIF(2), LIFR(9), MPL(2), MYC(4), OSMR(3), PIAS2(1), PIAS3(3), PIAS4(2), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIM1(2), PRL(3), PRLR(4), PTPN11(1), PTPN6(1), SOCS4(1), SOCS5(5), SOCS7(2), SOS1(8), SOS2(9), SPRED1(2), SPRED2(1), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), STAM(2), STAM2(2), STAT1(5), STAT2(3), STAT3(3), STAT4(3), STAT5A(1), STAT5B(4), STAT6(2), TPO(10), TYK2(2) 66248791 391 200 344 102 39 119 104 86 42 1 0.00171 1.000 1.000 336 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ACTN1(2), ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(2), BRAF(4), CDC42(1), CDKN2A(65), CRK(1), CSE1L(2), DOCK1(8), EPHB2(2), FYN(3), GRB7(2), GRLF1(12), ILK(4), ITGA1(3), ITGA10(5), ITGA11(5), ITGA2(4), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGB3BP(1), MAP2K4(1), MAP3K11(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MYLK(4), MYLK2(2), P4HB(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CA(65), PIK3CB(5), PKLR(1), PLCG1(5), PLCG2(4), PTEN(6), PTK2(5), RAF1(2), RHO(3), ROCK1(11), ROCK2(6), SHC1(1), SOS1(8), SOS2(9), SRC(1), TLN1(13), TLN2(7), VASP(1), ZYX(2) 55717740 381 200 302 77 37 89 102 62 90 1 3.19e-06 1.000 1.000 337 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(11), ACACB(12), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), CALM1(1), CALM3(1), CBL(2), CBLB(2), CRK(1), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(1), FASN(4), FBP2(1), FLOT1(1), FLOT2(3), FOXO1(3), G6PC(2), G6PC2(3), GCK(2), GSK3B(1), GYS1(5), GYS2(5), HRAS(11), IKBKB(5), INPP5D(7), INSR(2), IRS1(1), IRS2(2), IRS4(10), KRAS(1), LIPE(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(1), NRAS(1), PCK2(3), PDE3A(13), PDE3B(1), PDPK1(2), PFKL(4), PFKM(2), PFKP(4), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PKLR(1), PKM2(3), PPARGC1A(3), PPP1R3A(7), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(2), PRKCZ(3), PRKX(1), PTPN1(2), PTPRF(10), PYGB(3), PYGL(4), PYGM(3), RAF1(2), RAPGEF1(2), RHOQ(1), RPS6KB1(3), RPS6KB2(1), SH2B2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SLC2A4(1), SOCS4(1), SORBS1(2), SOS1(8), SOS2(9), SREBF1(3), TRIP10(5), TSC1(2), TSC2(3) 72926308 412 199 363 104 76 106 118 76 35 1 0.000235 1.000 1.000 338 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(2), ACTA2(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ARRB1(2), ARRB2(1), ATF1(2), ATF2(1), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(3), CACNB3(2), CALCA(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(4), ETS2(5), FOS(1), GABPA(2), GBA2(3), GJA1(1), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), GSTO1(2), GUCY1A3(4), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL1B(1), ITPR1(9), ITPR2(11), ITPR3(5), MIB1(5), MYLK2(2), NFKB1(2), NOS1(3), NOS3(4), OXTR(2), PDE4B(4), PDE4D(5), PKIG(1), PLCB3(5), PLCD1(2), PLCG1(5), PLCG2(4), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SP1(1), TNXB(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1) 78750008 413 191 412 131 76 102 116 71 47 1 0.0611 1.000 1.000 339 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADK(1), ADSL(4), ADSS(2), ADSSL1(2), AK1(1), AK2(1), AK3L1(1), AK5(5), AK7(2), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ENTPD8(1), GART(3), GDA(4), GMPR2(1), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NME7(2), NPR1(1), NPR2(5), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(3), PAPSS2(3), PDE10A(12), PDE11A(2), PDE1A(3), PDE1C(9), PDE2A(1), PDE3B(1), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE7A(3), PDE8B(7), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), PNPT1(4), POLA1(2), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRIM2(9), PRPS1(3), PRPS1L1(4), PRPS2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(3) 74382344 363 190 361 109 61 73 124 56 49 0 0.143 1.000 1.000 340 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI3(1), GRLF1(12), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB1(12), ITGB2(2), ITK(1), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(5), MMP2(2), MSN(3), MYL7(1), MYL9(2), MYLPF(2), NCF2(4), NCF4(1), NOX1(5), NOX3(4), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAC1(10), RAC2(1), RAP1B(2), RAPGEF3(5), RASSF5(1), RHOA(4), ROCK1(11), ROCK2(6), SIPA1(1), THY1(1), TXK(3), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(3), VCL(6) 56623490 348 189 300 106 39 93 96 75 43 2 0.0844 1.000 1.000 341 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL2(7), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), BTC(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(2), CBLB(2), CDKN1B(2), CRK(1), CRKL(1), EGF(6), EGFR(14), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(8), ERBB4(15), GAB1(2), GSK3B(1), HRAS(11), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MYC(4), NCK1(4), NCK2(3), NRAS(1), NRG1(1), NRG2(4), NRG3(8), NRG4(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), RAF1(2), RPS6KB1(3), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SRC(1), STAT5A(1), STAT5B(4) 46883115 333 186 283 82 38 99 101 65 29 1 0.00143 1.000 1.000 342 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ADRB1(1), DRD1(1), DRD2(2), EGF(6), EGFR(14), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAS(6), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HRAS(11), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K5(2), MAPK1(4), MAPK7(1), NPR1(1), NPR2(5), NRAS(1), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(7), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), PRKX(1), RAF1(2), SOS1(8), SOS2(9), SRC(1), TJP1(9), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1) 60083924 352 186 342 101 64 74 119 58 37 0 0.0126 1.000 1.000 343 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM3(1), CDIPT(1), CDS1(1), CDS2(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPP5D(7), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), OCRL(4), PI4KA(5), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3C3(2), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(7), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(5) 56607342 336 182 294 83 40 96 86 72 41 1 0.000221 1.000 1.000 344 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(3), CADM1(2), CADM3(1), CD2(1), CD22(1), CD226(3), CD28(2), CD34(4), CD40(4), CD40LG(3), CD58(1), CD6(1), CD80(5), CD86(1), CD8A(2), CD8B(1), CDH1(4), CDH15(2), CDH2(5), CDH3(6), CDH4(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CNTN1(7), CNTN2(4), CNTNAP1(6), CNTNAP2(21), CTLA4(1), ESAM(1), F11R(1), GLG1(3), HLA-A(9), HLA-B(10), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(6), ITGA6(3), ITGA8(13), ITGA9(1), ITGAL(3), ITGAM(3), ITGAV(2), ITGB1(12), ITGB2(2), ITGB7(1), ITGB8(3), L1CAM(3), MAG(1), MPZL1(2), NCAM1(1), NCAM2(7), NEGR1(2), NEO1(1), NFASC(3), NLGN1(12), NLGN2(3), NRCAM(9), NRXN1(20), NRXN2(9), NRXN3(14), PDCD1(1), PTPRC(13), PTPRF(10), PTPRM(14), PVR(2), PVRL2(3), PVRL3(4), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SELE(4), SELL(2), SELP(11), SIGLEC1(11), SPN(2), VCAM1(3), VCAN(15) 67191827 389 182 387 141 67 65 122 66 68 1 0.481 1.000 1.000 345 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(2), BRAF(4), CASP3(1), CD247(1), CD48(1), FAS(1), FASLG(2), FCGR3A(4), FCGR3B(3), FYN(3), GZMB(1), HLA-A(9), HLA-B(10), HLA-C(3), HRAS(11), ICAM1(2), ICAM2(2), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), ITGAL(3), ITGB2(2), KIR2DL1(3), KIR2DL3(1), KIR3DL1(7), KLRC2(1), KLRC3(2), KRAS(1), LAT(3), LCK(5), LCP2(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MICB(3), NCR1(5), NCR2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRF1(3), PRKCA(2), PRKCG(7), PTK2B(2), PTPN11(1), PTPN6(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SH2D1A(4), SH2D1B(2), SH3BP2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(8), SOS2(9), SYK(3), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP2(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(2) 51680949 344 182 290 90 53 88 86 68 47 2 0.00228 1.000 1.000 346 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(4), ACVRL1(3), AKT1(2), AURKB(3), BMPR2(3), BUB1(2), CDIPT(1), CDKL1(1), CDKL2(3), CDS1(1), CDS2(3), CLK1(3), CLK2(5), COL4A3BP(4), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(5), MAP3K10(4), MOS(5), NEK1(4), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CA(65), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4), PLK3(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKG1(3), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KB1(3), STK11(3), TGFBR1(1), VRK1(1) 51365862 336 181 293 78 56 88 84 68 39 1 0.000159 1.000 1.000 347 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(1), ACTN2(6), ACTN3(6), ACTN4(3), DES(1), DMD(33), FAM48A(2), MYBPC1(11), MYBPC2(3), MYBPC3(3), MYH3(8), MYH6(10), MYH7(9), MYH8(18), MYL1(1), MYL9(2), MYOM1(11), NEB(26), TNNI2(1), TNNI3(1), TNNT1(2), TNNT3(1), TPM1(1), TTN(249), VIM(2) 62136330 413 181 411 110 44 98 161 62 45 3 0.200 1.000 1.000 348 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(4), CREBBP(15), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), EGFR(14), EP300(25), ERBB2(8), FARP2(1), FER(2), FGFR1(1), FYN(3), IGF1R(7), INSR(2), IQGAP1(6), LEF1(2), LMO7(6), MAP3K7(4), MAPK1(4), MET(1), MLLT4(5), NLK(1), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(12), PTPRF(10), PTPRJ(6), PTPRM(14), PVRL2(3), PVRL3(4), PVRL4(2), RAC1(10), RAC2(1), RAC3(2), RHOA(4), SMAD2(3), SMAD3(2), SMAD4(8), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7(2), TCF7L1(1), TGFBR1(1), TGFBR2(11), TJP1(9), VCL(6), WASF1(3), WASF2(2), WASF3(2), WASL(1), YES1(1) 54508747 325 180 311 86 45 74 92 62 51 1 0.0210 1.000 1.000 349 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(4), ACVR2A(2), AMHR2(1), BMP2(3), BMP7(3), BMPR1B(1), BMPR2(3), CCL1(3), CCL15(1), CCL2(2), CCL20(1), CCL23(2), CCL25(2), CCL28(1), CCL3(1), CCL7(1), CCL8(2), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CD27(2), CD40(4), CD40LG(3), CSF1(1), CSF2RA(1), CSF2RB(5), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL10(2), CXCL12(1), CXCL13(1), CXCL2(1), CXCL3(1), CXCL9(2), CXCR3(1), CXCR4(1), EDA(4), EDAR(1), EGF(6), EGFR(14), EPO(2), FAS(1), FASLG(2), FLT1(10), FLT3(4), FLT3LG(1), FLT4(6), GDF5(3), GH1(1), GH2(2), GHR(4), HGF(8), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(5), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL17A(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(2), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL1RAP(4), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL25(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), INHBA(1), INHBB(2), INHBC(3), INHBE(1), KDR(5), KIT(5), LEP(1), LEPR(11), LIF(2), LIFR(9), LTA(1), LTBR(2), MET(1), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(6), PDGFRB(7), PF4V1(1), PLEKHO2(2), PPBP(2), PRL(3), PRLR(4), RELT(3), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(2), TNFRSF13C(2), TNFRSF19(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(2), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF13B(1), TNFSF14(2), TNFSF18(1), TNFSF4(2), TNFSF8(2), TPO(10), VEGFC(3), XCL1(1), XCL2(1), XCR1(2) 80688818 395 179 389 129 57 76 136 74 52 0 0.294 1.000 1.000 350 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR1(8), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCBP2(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CCRL1(1), CCRL2(1), CHML(3), CHRM2(4), CHRM3(5), CHRM5(1), CMKLR1(4), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR17(1), GPR174(2), GPR27(2), GPR3(2), GPR37(5), GPR37L1(2), GPR50(1), GPR6(4), GPR63(4), GPR77(2), GRPR(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), LHCGR(2), LTB4R(2), MAS1(3), MC3R(3), MC4R(3), MC5R(5), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPY1R(5), NPY2R(3), NPY5R(7), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(3), OR1Q1(2), OR2H1(3), OR5V1(4), OR7A5(3), OR8B8(1), OXTR(2), P2RY1(4), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PPYR1(1), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), RGR(3), RHO(3), RRH(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(4) 55307010 333 178 332 134 62 61 128 59 23 0 0.357 1.000 1.000 351 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(3), AKT3(4), CASP8(27), CCL3(1), CD14(1), CD40(4), CD80(5), CD86(1), CHUK(3), CXCL10(2), CXCL9(2), FADD(1), FOS(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(2), IL12A(1), IL12B(4), IL1B(1), IRAK1(2), IRAK4(3), IRF3(1), IRF5(1), IRF7(2), LBP(7), LY96(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K7(4), MAP3K8(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), RAC1(10), RELA(1), RIPK1(2), SPP1(1), STAT1(5), TBK1(1), TICAM1(4), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR6(3), TLR7(4), TLR8(2), TLR9(2), TRAF3(3), TRAF6(1) 40910053 289 178 240 56 35 85 70 59 39 1 1.28e-06 1.000 1.000 352 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(2), CBLB(2), CD247(1), CD28(2), CD3D(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CDK4(4), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(1), HRAS(11), ICOS(1), IFNG(1), IKBKB(5), IL4(1), IL5(1), ITK(1), KRAS(1), LAT(3), LCK(5), LCP2(1), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDCD1(1), PDK1(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PRKCQ(5), PTPN6(1), PTPRC(13), RASGRP1(5), RHOA(4), SOS1(8), SOS2(9), TEC(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(2) 46325167 293 178 244 70 37 89 74 58 34 1 0.000922 1.000 1.000 353 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(11), ASH2L(2), C17orf79(1), CARM1(3), CTCFL(2), DOT1L(3), EED(2), EHMT1(6), EHMT2(6), EZH1(3), EZH2(1), FBXO11(6), HCFC1(6), JMJD4(2), JMJD6(2), KDM6A(8), MEN1(2), MLL(15), MLL2(58), MLL3(25), MLL4(9), MLL5(7), NSD1(36), OGT(3), PAXIP1(2), PRDM2(5), PRDM7(1), PRDM9(22), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SATB1(5), SETD1A(6), SETD2(8), SETD7(2), SETD8(1), SETDB1(6), SETMAR(1), SMYD3(1), STK38(2), SUV39H1(2), SUV420H1(4), SUV420H2(2), SUZ12(1), WHSC1(11), WHSC1L1(1) 53952329 310 175 305 61 24 53 86 36 105 6 0.00727 1.000 1.000 354 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), ATF4(1), CACNA1C(11), CACNA1D(15), CACNA1F(6), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDC42(1), CGA(1), EGFR(14), ELK1(1), FSHB(1), GNAS(6), HRAS(11), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LHB(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K3(1), MAP3K4(5), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK9(4), MMP14(2), MMP2(2), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLD1(8), PLD2(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(1), PTK2B(2), RAF1(2), SOS1(8), SOS2(9), SRC(1) 57679661 316 175 308 86 56 69 99 56 36 0 0.00668 1.000 1.000 355 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), AKAP1(5), AKAP10(3), AKAP11(6), AKAP12(10), AKAP2(1), AKAP3(5), AKAP4(5), AKAP5(2), AKAP6(14), AKAP7(1), AKAP8(2), AKAP9(21), ARHGEF1(5), CALM1(1), CALM3(1), CHMP1B(2), GNA12(1), GNA13(1), GNA15(2), GNAI3(1), GNAL(2), GNAO1(2), GNAZ(3), GNB1(2), GNB2(3), GNB3(3), GNB5(1), GNG12(1), HRAS(11), ITPR1(9), KCNJ3(4), KRAS(1), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE7A(3), PDE8B(7), PLCB3(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKD3(9), RHOA(4), SLC9A1(4), USP5(4) 53167995 315 173 306 80 64 66 90 51 44 0 0.00654 1.000 1.000 356 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADCY9(4), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREB3L4(1), CREBBP(15), CTNNB1(2), DCT(1), DVL1(2), DVL2(1), DVL3(4), EDNRB(3), EP300(25), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GSK3B(1), HRAS(11), KIT(5), KRAS(1), LEF1(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MITF(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), POMC(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), TCF7(2), TCF7L1(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1) 49557003 283 169 272 79 60 52 90 50 30 1 0.00932 1.000 1.000 357 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(12), ADCY2(18), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(2), ADCY8(13), ADK(1), ADSL(4), ADSS(2), AK1(1), AK2(1), AK5(5), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), GART(3), GDA(4), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NPR1(1), NPR2(5), NUDT2(1), PAPSS1(3), PAPSS2(3), PDE1A(3), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE6C(2), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RRM1(1), RRM2(1) 58405584 284 163 282 82 48 55 102 42 37 0 0.0730 1.000 1.000 358 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(12), ADCY8(13), ATF4(1), BRAF(4), CACNA1C(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREBBP(15), EP300(25), GRIA1(9), GRIA2(10), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), HRAS(11), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP1R12A(3), PPP1R1A(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), RAP1B(2), RAPGEF3(5), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4) 45145076 291 162 280 85 48 68 90 55 30 0 0.0246 1.000 1.000 359 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(2), AMY2B(6), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHX58(2), ENPP1(5), ENPP3(5), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), G6PC(2), G6PC2(3), GAA(3), GANC(3), GBA(2), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), IFIH1(5), MGAM(18), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(9), SI(40), SKIV2L2(3), SMARCA2(8), SMARCA5(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), UXS1(2) 56297057 289 160 288 90 32 56 108 59 34 0 0.547 1.000 1.000 360 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(3), AKT3(4), BTK(5), FCER1A(2), FYN(3), GAB2(2), HRAS(11), IL13(1), IL3(1), IL4(1), IL5(1), INPP5D(7), KRAS(1), LAT(3), LCP2(1), LYN(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MS4A2(2), NRAS(1), PDK1(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCD(4), PRKCE(2), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SOS1(8), SOS2(9), SYK(3), VAV1(2), VAV2(1), VAV3(1) 32854167 252 157 201 54 31 78 68 52 22 1 0.000165 1.000 1.000 361 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(4), ACVR1C(3), ACVR2A(2), ACVRL1(3), AMHR2(1), BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BMPR1B(1), BMPR2(3), CHRD(6), CREBBP(15), CUL1(6), DCN(2), E2F4(1), E2F5(4), EP300(25), FST(1), GDF5(3), GDF6(1), ID1(1), ID3(1), IFNG(1), INHBA(1), INHBB(2), INHBC(3), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(16), MAPK1(4), MYC(4), PITX2(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), RBL1(8), RBL2(3), RBX1(2), RHOA(4), ROCK1(11), ROCK2(6), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(3), SMAD3(2), SMAD4(8), SMAD5(2), SMAD9(2), SMURF1(2), SMURF2(4), SP1(1), TFDP1(3), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR2(11), THBS1(7), THBS2(7), THBS4(5), ZFYVE16(3), ZFYVE9(5) 45099846 258 156 247 46 29 54 74 47 54 0 1.75e-05 1.000 1.000 362 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(4), BCAR1(2), CAPN10(3), CAPN11(1), CAPN2(4), CAPN3(3), CAPN5(1), CAPN6(3), CAPN7(1), CAPN9(3), CAPNS1(1), CDC42(1), CRK(1), CSK(1), DOCK1(8), FYN(3), GIT2(1), ILK(4), ITGA10(5), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(3), ITGAM(3), ITGAV(2), ITGAX(5), ITGB1(12), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAPK10(3), MAPK12(1), MAPK4(6), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(2), RHO(3), ROCK1(11), ROCK2(6), SDCCAG8(3), SHC1(1), SHC3(3), SORBS1(2), SOS1(8), SRC(1), TLN1(13), TNS1(5), VASP(1), VAV2(1), VAV3(1), VCL(6), ZYX(2) 61028069 279 150 275 86 40 64 93 42 40 0 0.130 1.000 1.000 363 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(4), C7orf16(1), CACNA1A(7), GNA12(1), GNA13(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GNAZ(3), GRIA1(9), GRIA2(10), GRIA3(5), GRID2(13), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(8), HRAS(11), IGF1R(7), ITPR1(9), ITPR2(11), ITPR3(5), KRAS(1), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NOS1(3), NOS3(4), NPR1(1), NPR2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), RAF1(2), RYR1(16) 49985031 269 149 258 82 47 55 93 49 25 0 0.140 1.000 1.000 364 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPPL1(4), IPMK(2), ISYNA1(2), ITPK1(2), ITPKA(1), ITPKB(5), MIOX(2), OCRL(4), PI4KA(5), PIK3C3(2), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(5) 33834954 222 148 180 56 29 66 58 47 21 1 0.00153 1.000 1.000 365 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), CPEB1(4), EGFR(14), ERBB2(8), ERBB4(15), ETS1(2), ETS2(5), ETV6(4), ETV7(1), FMN2(21), KRAS(1), MAP2K1(4), MAPK1(4), NOTCH1(62), NOTCH2(13), NOTCH3(14), NOTCH4(5), PIWIL1(8), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(2), SOS1(8), SOS2(9), SPIRE1(4) 23875620 221 148 215 46 36 41 65 30 49 0 0.0105 1.000 1.000 366 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(3), AKT3(4), BAD(1), CDC42(1), HRAS(11), KDR(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK3(2), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NOS3(4), NRAS(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTGS2(2), PTK2(5), PXN(1), RAC1(10), RAC2(1), RAC3(2), RAF1(2), SHC2(3), SPHK2(1), SRC(1) 32851505 232 148 181 57 40 73 56 46 16 1 0.000491 1.000 1.000 367 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(3), AKT3(4), BCL10(1), BLNK(3), BTK(5), CARD11(4), CD19(2), CD22(1), CD72(1), CHUK(3), CR2(5), FCGR2B(1), FOS(1), GSK3B(1), HRAS(11), IFITM1(3), IKBKB(5), INPP5D(7), KRAS(1), LILRB3(5), LYN(3), MALT1(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PIK3CA(65), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG2(4), PTPN6(1), RAC1(10), RAC2(1), RAC3(2), RASGRP3(3), SYK(3), VAV1(2), VAV2(1), VAV3(1) 34002593 232 148 183 57 34 78 51 48 20 1 0.000752 1.000 1.000 368 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BAD(1), BCL2(1), CABIN1(7), CALM1(1), CALM3(1), CAMK2B(2), CD69(1), CEBPB(1), CNR1(3), CREBBP(15), CSNK2A1(6), CSNK2B(2), CTLA4(1), EGR2(2), EP300(25), FCER1A(2), FCGR3A(4), FOS(1), GATA3(6), GRLF1(12), GSK3B(1), HRAS(11), ICOS(1), IFNG(1), IL13(1), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), KPNA5(1), MAPK14(1), MAPK8(4), MAPK9(4), MEF2A(1), MEF2B(2), MYF5(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(8), OPRD1(2), PAK1(1), PIN1(1), PTPRC(13), RELA(1), RPL13A(1), SFN(5), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(2), VAV2(1), VAV3(1), XPO5(1) 41543321 213 142 205 66 29 46 63 43 32 0 0.196 1.000 1.000 369 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(4), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(2), DLL1(4), DLL3(1), DLL4(2), DTX1(5), DTX2(1), DTX3(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(1), DVL3(4), EP300(25), JAG1(6), JAG2(4), LFNG(2), MAML1(1), MAML2(2), MAML3(1), NCOR2(11), NCSTN(1), NOTCH1(62), NOTCH2(13), NOTCH3(14), NOTCH4(5), NUMB(2), PTCRA(2), RBPJ(2), RBPJL(2), RFNG(2), SNW1(2) 31654235 209 139 204 55 37 42 48 28 54 0 0.0320 1.000 1.000 370 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(5), ARHGEF11(3), BTK(5), CDC42(1), CFL1(2), GDI1(2), GDI2(2), INPPL1(4), ITPR1(9), ITPR2(11), ITPR3(5), LIMK1(5), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDK1(1), PIK3CA(65), PIK3CD(2), PIK3CG(8), PIK3R1(6), PITX2(1), PPP1R13B(1), PTEN(6), RACGAP1(3), RHO(3), ROCK1(11), ROCK2(6), WASF1(3), WASL(1) 31886975 209 139 167 55 19 80 45 43 21 1 0.00448 1.000 1.000 371 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), BCR(1), BLNK(3), BTK(5), CD19(2), CD22(1), CR2(5), CSK(1), DAG1(1), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(7), ITPR1(9), ITPR2(11), ITPR3(5), LYN(3), MAP4K1(2), MAPK1(4), NFATC1(7), NFATC2(6), NR0B2(1), PDK1(1), PIK3CA(65), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), PTPRC(13), RAF1(2), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2) 33672807 207 134 163 57 22 75 40 47 23 0 0.00684 1.000 1.000 372 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(4), ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG6(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(3), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), CHPF(4), CHST1(3), CHST11(3), CHST12(2), CHST13(3), CHST14(1), CHST2(2), CHST4(3), CHST6(6), CHSY1(2), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(4), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GANAB(1), GCNT1(1), GCNT4(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), MGAT5B(2), NDST1(1), NDST2(2), NDST3(4), NDST4(7), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(4), STT3B(2), UST(1), WBSCR17(8), XYLT1(7), XYLT2(3) 50282171 218 133 218 92 45 32 78 33 30 0 0.934 1.000 1.000 373 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(12), ABCA12(12), ABCA13(24), ABCA2(8), ABCA3(4), ABCA4(9), ABCA5(3), ABCA6(7), ABCA7(5), ABCA8(5), ABCA9(7), ABCB1(11), ABCB11(6), ABCB4(9), ABCB5(5), ABCB6(5), ABCB7(4), ABCB8(3), ABCC10(5), ABCC11(4), ABCC12(5), ABCC2(4), ABCC3(4), ABCC5(4), ABCC6(2), ABCC8(11), ABCC9(16), ABCD1(2), ABCD2(6), ABCD3(3), ABCD4(3), ABCG1(3), ABCG2(2), ABCG4(4), ABCG8(8), CFTR(7), TAP1(3), TAP2(5) 53812685 246 133 245 79 32 59 79 39 37 0 0.115 1.000 1.000 374 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(4), CHUK(3), CREB1(1), ELK1(1), FOS(1), HRAS(11), IKBKB(5), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP3K9(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAP4K5(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK4(6), MAPK6(3), MAPK7(1), MAPK8(4), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MKNK2(1), MYC(4), NFKB1(2), PAK1(1), PAK2(5), RAC1(10), RAF1(2), RELA(1), RIPK1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KB1(3), RPS6KB2(1), SHC1(1), SP1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1) 43410159 206 130 195 56 33 41 74 30 28 0 0.109 1.000 1.000 375 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(17), AR(4), ASAH1(1), BRAF(4), CCL15(1), DAG1(1), EGFR(14), GNA15(2), GNAI1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), MAPK10(3), MAPK14(1), PHKA2(9), PIK3CA(65), PIK3CD(2), PIK3R1(6), PITX2(1), PTX3(2), RAF1(2), SRC(1) 24169058 182 130 137 38 21 63 41 38 19 0 0.000197 1.000 1.000 376 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(2), CLK2(5), CLK3(3), COL2A1(4), CPSF1(3), CPSF2(3), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDX1(3), DDX20(3), DHX15(1), DHX16(4), DHX38(1), DHX8(3), DHX9(5), DICER1(7), DNAJC8(2), FUS(2), GIPC1(1), LOC440563(2), LSM2(1), METTL3(2), NCBP1(4), NCBP2(3), NONO(2), NUDT21(2), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(9), PRPF4(1), PRPF4B(4), PRPF8(6), PTBP2(1), RBM17(1), RBM5(6), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(3), SF3B2(1), SF3B5(1), SF4(1), SFRS12(2), SFRS14(2), SFRS16(5), SFRS2(2), SFRS4(3), SFRS5(3), SFRS6(4), SFRS7(3), SFRS8(5), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPN(5), SNURF(1), SPOP(4), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(4), XRN2(5) 48212981 191 126 190 64 24 49 58 33 27 0 0.682 1.000 1.000 377 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), C1QC(1), C1R(3), C1S(3), C3(7), C3AR1(2), C4BPA(1), C4BPB(2), C5(5), C5AR1(1), C6(13), C7(5), C8A(6), C8B(4), C8G(1), C9(5), CD46(1), CFB(1), CFH(9), CFI(5), CPB2(3), CR1(8), CR2(5), F10(3), F11(2), F12(1), F13B(9), F2(2), F3(1), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), KNG1(3), MASP1(4), MASP2(4), MBL2(2), PLAT(2), PLAU(1), PLG(8), PROS1(5), SERPINA1(4), SERPINA5(4), SERPINC1(3), SERPIND1(4), SERPINE1(4), SERPING1(3), THBD(2), VWF(6) 41287979 212 123 212 82 16 53 71 35 36 1 0.853 1.000 1.000 378 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCR(1), BLNK(3), BTK(5), CD19(2), CSK(1), DAG1(1), EPHB2(2), ITPKA(1), ITPKB(5), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PI3(1), PIK3CA(65), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(6), SHC1(1), SOS1(8), SOS2(9), SYK(3), VAV1(2) 24096068 165 123 121 38 19 62 33 33 18 0 0.00151 1.000 1.000 379 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(12), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ADIPOR1(2), ADIPOR2(3), AKT1(2), AKT2(3), AKT3(4), CAMKK1(1), CAMKK2(5), CHUK(3), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), G6PC(2), G6PC2(3), IKBKB(5), IRS1(1), IRS2(2), IRS4(10), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), MAPK10(3), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIB(1), NPY(2), PCK2(3), POMC(1), PPARGC1A(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2), PRKAG3(2), PRKCQ(5), PTPN11(1), RELA(1), RXRA(4), RXRB(2), RXRG(6), SLC2A1(3), SLC2A4(1), STAT3(3), STK11(3), TRAF2(1), TYK2(2) 37823107 178 120 177 57 26 36 59 32 25 0 0.379 1.000 1.000 380 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(8), AGTR2(2), ATP8A1(9), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(2), MC2R(7), MC3R(3), MC4R(3), MC5R(5), NMBR(2), NPY1R(5), NPY2R(3), NPY5R(7), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), PPYR1(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TACR1(2), TACR2(2), TACR3(5), TRHR(4), TSHR(2) 23840888 162 115 162 62 29 38 54 22 19 0 0.223 1.000 1.000 381 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(9), BAG4(4), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CASP8(27), CFLAR(2), CHUK(3), CRADD(1), FADD(1), GSN(5), LMNB1(1), LMNB2(4), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK8(4), MDM2(2), NFKB1(2), NUMA1(5), PAK2(5), PRKCD(4), PRKDC(15), PTK2(5), RASA1(14), RB1(10), RELA(1), RIPK1(2), SPTAN1(11), TRAF2(1) 31565281 159 112 154 39 19 27 37 24 52 0 0.0836 1.000 1.000 382 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(2), CHN1(3), LIMK1(5), MAP3K1(3), MYLK(4), NCF2(4), PAK1(1), PDGFRA(6), PIK3CA(65), PIK3R1(6), PLD1(8), PPP1R12B(1), RAC1(10), RALBP1(2), RPS6KB1(3), TRIO(10), VAV1(2), WASF1(3) 15923225 138 110 95 33 10 60 32 28 8 0 0.0111 1.000 1.000 383 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(2), CD1A(4), CD1B(1), CD1C(2), CD1D(4), CD1E(8), CD2(1), CD22(1), CD33(2), CD34(4), CD38(2), CD3D(1), CD44(1), CD7(2), CD8A(2), CD8B(1), CD9(1), CR1(8), CR2(5), CSF1(1), CSF2RA(1), CSF3R(2), EPO(2), FCER2(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(3), GP9(1), GYPA(3), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL7R(3), IL9R(4), ITGA1(3), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(5), KIT(5), MME(11), MS4A1(2), TFRC(3), TPO(10) 37192773 164 108 163 62 26 36 59 27 16 0 0.752 1.000 1.000 384 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(2), AMY2B(6), ENPP1(5), ENPP3(5), G6PC(2), GAA(3), GANAB(1), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), MGAM(18), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), SI(40), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UXS1(2) 25874629 159 108 158 55 21 28 55 35 20 0 0.755 1.000 1.000 385 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ENTPD8(1), ITPA(3), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), PNPT1(4), POLA1(2), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PRIM2(9), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(3), TXNRD2(1), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UPB1(1), UPP1(1), UPP2(4), UPRT(2) 36879615 149 106 149 59 25 27 52 22 23 0 0.894 1.000 1.000 386 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(2), CCKBR(3), CCR2(2), CCR3(3), CELSR1(9), CELSR2(18), CELSR3(12), CHRM2(4), CHRM3(5), CXCR3(1), DRD4(1), EMR2(2), EMR3(2), FSHR(5), GHRHR(2), GPR116(4), GPR132(2), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR55(1), GPR77(2), GPR84(2), GRM1(16), GRPR(1), HRH4(3), LGR6(5), LPHN2(8), LPHN3(14), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(3), P2RY13(2), PTGFR(2), SMO(1), SSTR2(1), TSHR(2), VN1R1(1) 30291802 160 103 160 62 25 45 51 27 12 0 0.337 1.000 1.000 387 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(2), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(16), GRAP2(1), ITK(1), ITPKA(1), ITPKB(5), LAT(3), LCK(5), LCP2(1), MAPK1(4), NCK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLCG1(5), PTPRC(13), RAF1(2), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), SOS1(8), SOS2(9), VAV1(2), ZAP70(2) 25462763 134 101 129 38 20 26 40 21 27 0 0.224 1.000 1.000 388 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(3), ACOX2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ANGPTL4(3), APOA2(1), APOA5(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(8), CYP4A22(6), CYP7A1(2), CYP8B1(3), DBI(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(2), FABP5(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(7), HMGCS2(2), ILK(4), LPL(2), ME1(2), MMP1(4), OLR1(1), PCK2(3), PDPK1(2), RXRA(4), RXRB(2), RXRG(6), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(5), SORBS1(2), UBC(4) 29828246 137 100 137 42 21 27 49 16 24 0 0.274 1.000 1.000 389 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(3), ADAM17(4), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(14), F11R(1), GIT1(1), IGSF5(3), IKBKB(5), LYN(3), MAP2K4(1), MAP3K14(2), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MET(1), NFKB1(2), NFKB2(1), NOD1(5), PAK1(1), PLCG1(5), PLCG2(4), PTPN11(1), PTPRZ1(6), RAC1(10), RELA(1), SRC(1), TCIRG1(7), TJP1(9) 32024790 142 100 140 45 14 33 48 31 16 0 0.441 1.000 1.000 390 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(4), ASAH1(1), BRAF(4), DAG1(1), DRD2(2), EGFR(14), EPHB2(2), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PI3(1), PIK3CB(5), PITX2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), RAF1(2), RGS20(2), SHC1(1), SOS1(8), SOS2(9), SRC(1), STAT3(3) 26560548 139 99 135 43 21 29 42 33 14 0 0.240 1.000 1.000 391 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(9), CARM1(3), CCND1(2), CREBBP(15), EP300(25), ERCC3(4), ESR1(3), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), MEF2C(7), NCOR2(11), NR0B1(3), NRIP1(4), PELP1(1), POLR2A(9), TBP(1) 20929634 122 98 119 38 10 30 40 21 21 0 0.372 1.000 1.000 392 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(3), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), HSD17B4(3), NSD1(36), OGDH(6), OGDHL(9), PIPOX(1), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(1), RDH12(3), SETD1A(6), SETD7(2), SETDB1(6), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(2), TMLHE(2) 26417001 138 97 138 44 18 23 40 23 32 2 0.519 1.000 1.000 393 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(17), AXIN1(5), CCND1(2), CSNK1E(3), CTNNB1(2), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LDLR(3), MAPK10(3), MAPK9(4), MYC(4), PLAU(1), PPP2R5C(2), PPP2R5E(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), RAC1(10), RHOA(4), SFRP4(8), TCF7(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1) 27339419 148 96 143 52 20 29 58 27 13 1 0.563 1.000 1.000 394 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), AFMID(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CARM1(3), CAT(2), CYP1A2(4), CYP1B1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HEMK1(1), HSD17B4(3), KMO(1), KYNU(6), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), NFX1(2), OGDH(6), OGDHL(9), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), TDO2(2), TPH1(2), TPH2(4), WARS2(5) 27547564 124 95 124 38 20 26 36 18 24 0 0.343 1.000 1.000 395 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BTRC(1), CSNK1A1(1), CSNK1E(3), CSNK1G1(1), GLI1(5), GLI2(8), GLI3(5), GSK3B(1), HHIP(2), LRP2(26), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(11), PTCH2(5), RAB23(2), SMO(1), STK36(4), SUFU(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1), ZIC2(5) 27678560 132 95 132 47 29 22 50 17 14 0 0.542 1.000 1.000 396 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CAT(2), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), KMO(1), KYNU(6), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS2(5) 25058904 116 90 116 34 18 23 37 17 21 0 0.205 1.000 1.000 397 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), CARM1(3), DBH(4), DCT(1), DDC(7), ESCO1(3), ESCO2(3), FAH(1), GOT1(1), GOT2(3), HEMK1(1), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), MYST3(4), MYST4(6), PNMT(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SH3GLB1(2), TAT(1), TH(2), TPO(10), TYR(4), TYRP1(1) 27085348 118 89 117 39 21 30 37 13 17 0 0.418 1.000 1.000 398 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CEL(1), DAK(3), DGAT2(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), GK(1), GK2(7), GLA(3), GLB1(4), GPAM(3), LCT(8), LIPA(1), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1) 26704718 119 87 119 32 17 28 29 26 19 0 0.0611 1.000 1.000 399 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), ITGB1(12), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2) 23930095 116 87 112 42 25 25 38 11 16 1 0.471 1.000 1.000 400 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), ITGB1(12), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(6), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2) 23930095 116 87 112 42 25 25 38 11 16 1 0.471 1.000 1.000 401 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHFR(3), DHX58(2), ENTPD7(3), EP400(8), ERCC2(2), ERCC3(4), FPGS(2), IFIH1(5), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(9), SKIV2L2(3), SMARCA2(8), SMARCA5(1) 28632935 106 86 106 31 12 21 39 20 14 0 0.389 1.000 1.000 402 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(6), ADCY4(6), ADCY6(4), ADCY8(13), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(3), GNB1(2), GNB3(3), GRM4(2), ITPR3(5), KCNB1(3), PDE1A(3), PLCB2(4), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), SCNN1A(3), SCNN1B(2), SCNN1G(4), TAS1R1(2), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(1), TAS2R40(4), TAS2R41(1), TAS2R42(1), TAS2R43(1), TAS2R46(2), TAS2R60(1), TAS2R7(2), TAS2R8(3), TRPM5(3) 25874670 122 86 122 60 34 18 28 26 16 0 0.943 1.000 1.000 403 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(2), CALM1(1), CALM3(1), FLT1(10), FLT4(6), KDR(5), NOS3(4), PDE2A(1), PDE3A(13), PDE3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(3), PRKG2(1), RYR2(44), SLC7A1(2), SYT1(5) 18432057 109 86 109 41 20 26 36 18 8 1 0.646 1.000 1.000 404 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(3), EGF(6), EGFR(14), ETS1(2), ETS2(5), FOS(1), HOXA7(2), HRAS(11), IKBKB(5), MAP2K1(4), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK1(4), MAPK13(3), MAPK14(1), MAPK8(4), NFKB1(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), RAF1(2), RELA(1), RIPK1(2), SP1(1), TRAF2(1) 22378222 113 85 105 38 22 20 37 17 17 0 0.519 1.000 1.000 405 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(3), GAPDHS(1), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGAM4(1), PGK2(3), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 26472566 107 84 107 40 20 21 28 17 21 0 0.688 1.000 1.000 406 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(7), CALR(2), CD74(3), CD8A(2), CD8B(1), CIITA(7), CREB1(1), CTSS(3), HLA-A(9), HLA-B(10), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(3), HSP90AA1(6), HSP90AB1(7), HSPA5(3), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), KIR2DL1(3), KIR2DL3(1), KIR2DS4(1), KIR3DL1(7), KIR3DL3(2), KLRC2(1), KLRC3(2), KLRC4(1), LGMN(3), LTA(1), NFYC(2), PSME1(1), PSME2(1), RFX5(4), RFXAP(1), TAP1(3), TAP2(5), TAPBP(1) 21129955 122 83 119 36 9 26 31 21 34 1 0.228 1.000 1.000 407 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ITPA(3), NUDT2(1), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), RRM1(1), RRM2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(1) 26116929 107 82 107 37 16 20 40 14 17 0 0.493 1.000 1.000 408 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), AKR1D1(2), ARSD(1), ARSE(1), CARM1(3), CYP11B1(4), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4) 22848351 109 81 109 37 18 20 43 18 10 0 0.588 1.000 1.000 409 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CHPT1(1), CRLS1(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), ESCO1(3), ESCO2(3), ETNK2(1), GNPAT(3), GPAM(3), GPD1(1), GPD2(2), LCAT(2), MYST3(4), MYST4(6), PCYT1A(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(8), PLD2(1), PPAP2B(1), PTDSS1(6), PTDSS2(1), SH3GLB1(2) 29766289 114 81 114 36 12 22 35 21 24 0 0.430 1.000 1.000 410 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), ALDH3B1(1), ALDH3B2(2), CYP1A2(4), CYP1B1(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2F1(2), CYP2S1(1), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), EPHX1(1), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4) 26186719 123 81 122 42 13 26 49 24 11 0 0.514 1.000 1.000 411 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(21), B3GALT4(3), CDR1(3), DGKI(8), IL6ST(2), MRPL19(1), PIGK(5), RPL10(2), RPL12(1), RPL13A(1), RPL18(2), RPL22(2), RPL23(1), RPL26(1), RPL28(1), RPL31(1), RPL36(2), RPL37(1), RPL3L(1), RPL4(1), RPL6(2), RPLP0(2), RPLP2(1), RPS10(1), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBA52(2), UBB(1), UBC(4) 23815448 108 80 107 46 12 21 45 13 17 0 0.969 1.000 1.000 412 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(3), ACTR2(1), AKT1(2), ANGPTL2(2), CDC42(1), CFL1(2), FLNA(8), FLNC(8), FSCN1(1), FSCN2(1), FSCN3(5), GDI1(2), GDI2(2), LIMK1(5), MYH2(16), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), RHO(3), ROCK1(11), ROCK2(6), VASP(1), WASF1(3), WASL(1) 21807472 110 79 110 38 15 35 28 19 13 0 0.310 1.000 1.000 413 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), CEL(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GK(1), GLA(3), GLB1(4), LCT(8), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1) 21937918 97 76 97 27 15 22 20 21 19 0 0.0891 1.000 1.000 414 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(11), ACACB(12), ACAT2(1), ACOT12(2), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(2), ME2(1), ME3(6), PC(7), PCK2(3), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3) 21292840 91 76 91 36 25 17 26 15 8 0 0.781 1.000 1.000 415 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(6), ATP4A(3), ATP4B(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(1), COX15(2), COX17(2), COX5B(1), COX7B2(1), COX8A(1), LHPP(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(1), NDUFA9(1), NDUFB10(1), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB9(1), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS7(1), NDUFS8(1), NDUFV1(1), PPA1(1), SDHA(5), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRFS1(3) 25453896 90 73 90 31 10 23 27 17 13 0 0.480 1.000 1.000 416 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), F10(3), F11(2), F12(1), F2(2), F5(12), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), PROS1(5), SERPINC1(3), SERPING1(3) 20236242 93 73 93 25 6 28 32 13 14 0 0.322 1.000 1.000 417 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(2), APC(17), ASAH1(1), DAG1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(9), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PITX2(1), PTX3(2), RAC1(10), RHO(3), RYR1(16) 20762040 95 73 90 34 22 23 22 15 13 0 0.383 1.000 1.000 418 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACADVL(4), ACAT2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP4A11(8), CYP4A22(6), DCI(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HADHB(2), HSD17B4(3), PECI(1) 22294292 95 72 95 29 9 25 26 21 14 0 0.345 1.000 1.000 419 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(4), ARHGEF11(3), BCL2(1), CDC42(1), DLG4(1), GNA13(1), LPA(8), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK8(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(5), PLD1(8), PLD2(1), PLD3(1), PTK2(5), ROCK1(11), ROCK2(6), SERPINA4(6), TBXA2R(1) 22402792 97 72 97 35 9 26 29 15 18 0 0.720 1.000 1.000 420 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(4), ANKRD6(2), APC(17), AXIN1(5), AXIN2(5), CSNK1A1(1), CTNNB1(2), DACT1(3), DKK1(3), DKK2(3), DKK3(2), DVL1(2), FSTL1(3), GSK3B(1), LRP1(17), MVP(3), NKD1(5), NKD2(1), PIN1(1), PTPRA(4), SENP2(2), SFRP1(1) 18399429 92 72 92 32 10 30 22 18 11 1 0.398 1.000 1.000 421 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(2), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), F2(2), FYN(3), GNAI1(1), GNB1(2), HRAS(11), JAK2(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK14(1), MAPK8(4), MAPT(6), MYLK(4), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(8), STAT1(5), STAT3(3), STAT5A(1), SYT1(5) 18922261 93 71 84 23 15 18 36 15 9 0 0.0813 1.000 1.000 422 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 22234026 86 70 86 36 16 18 21 14 17 0 0.846 1.000 1.000 423 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CLC(2), CPT1B(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GNPAT(3), GPD1(1), GPD2(2), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB2(4), PLCG1(5), PLCG2(4), PPAP2B(1) 22761376 87 70 87 26 10 13 25 19 20 0 0.265 1.000 1.000 424 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(4), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 22234026 86 70 86 36 16 18 21 14 17 0 0.846 1.000 1.000 425 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN2(4), CAPNS1(1), CAPNS2(2), CXCR3(1), EGF(6), EGFR(14), HRAS(11), ITGA1(3), ITGB1(12), MAPK1(4), MYLK(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(5), PXN(1), TLN1(13) 14883507 91 70 82 28 18 16 31 15 11 0 0.338 1.000 1.000 426 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), CREB1(1), ELK1(1), HRAS(11), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK14(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MYC(4), PLA2G4A(3), RAC1(10), RIPK1(2), RPS6KA5(4), SHC1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1) 16659441 79 68 72 23 11 19 29 10 10 0 0.305 1.000 1.000 427 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GAPDHS(1), GCK(2), GOT1(1), GOT2(3), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MDH1(1), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PFKL(4), PFKM(2), PFKP(4), PGAM1(1), PGK2(3), PKLR(1), PKM2(3), TNFAIP1(2), TPI1(2) 19321716 84 67 84 32 21 14 24 14 11 0 0.637 1.000 1.000 428 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(8), AR(4), ESR1(3), ESR2(1), ESRRA(4), HNF4A(2), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(2), NR1I2(2), NR2C2(1), NR2E1(3), NR2F1(2), NR2F2(4), NR3C1(5), NR4A2(2), NR5A2(2), PGR(2), RARA(2), RARB(2), RARG(5), ROR1(5), RORA(1), RORC(2), RXRA(4), RXRB(2), RXRG(6), THRA(5), THRB(1), VDR(1) 19120352 88 67 86 32 18 13 30 11 16 0 0.669 1.000 1.000 429 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(3), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), FUK(1), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), LHPP(1), MPI(3), MTMR2(5), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB4(2), PFKL(4), PFKM(2), PFKP(4), PGM2(1), PHPT1(1), RDH11(1), RDH12(3), SORD(1), TPI1(2), TSTA3(2) 16906477 73 66 73 19 17 9 25 12 10 0 0.154 1.000 1.000 430 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(4), BLVRA(2), COX10(1), COX15(2), CP(4), CPOX(1), EARS2(1), EPRS(2), FECH(1), FTMT(4), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), UROD(1), UROS(3) 19248154 84 66 84 35 7 14 40 20 3 0 0.932 1.000 1.000 431 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(2), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALNT1(2), B4GALT2(3), B4GALT6(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GBGT1(2), GCNT2(4), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(5), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4), UGCG(1) 22103183 86 66 86 32 11 21 29 13 12 0 0.512 1.000 1.000 432 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(2), ARHGAP4(5), ARHGAP5(6), ARHGAP6(6), ARHGEF1(5), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(2), ARPC4(1), CFL1(2), DIAPH1(6), GSN(5), LIMK1(5), MYLK(4), PIP5K1A(4), PIP5K1B(4), PPP1R12B(1), ROCK1(11), SRC(1), TLN1(13), VCL(6) 20642161 97 66 97 37 11 26 32 22 6 0 0.727 1.000 1.000 433 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ACY3(3), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(2), AOC3(5), ASPA(1), CARM1(3), CNDP1(3), DDC(7), FTCD(1), HAL(2), HARS2(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), PRPS1(3), PRPS2(1), UROC1(3) 18011757 77 65 77 20 16 22 24 5 10 0 0.0515 1.000 1.000 434 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC23(1), CDC27(5), CUL1(6), CUL2(1), CUL3(10), FBXW7(16), FZR1(2), ITCH(5), RBX1(2), SKP1(1), SKP2(2), SMURF1(2), SMURF2(4), TCEB1(1), UBE2D2(1), UBE2E1(1), WWP1(3), WWP2(2) 18239486 77 65 75 19 9 18 18 17 15 0 0.268 1.000 1.000 435 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(2), POLB(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLG(2), POLG2(1), POLH(2), POLI(2), POLK(3), POLL(5), POLM(1), POLQ(16), PRIM2(9), REV1(1), REV3L(11), RFC5(2) 18438079 76 64 76 24 9 20 21 10 16 0 0.501 1.000 1.000 436 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(2), GTF2H4(1), GTF2I(3), GTF2IRD1(3), TAF1(8), TAF10(4), TAF1L(13), TAF2(5), TAF4(2), TAF4B(4), TAF5(5), TAF5L(1), TAF6(3), TAF7(1), TAF7L(2), TAF9(2), TBPL1(2), TBPL2(1) 16412255 76 63 76 25 6 20 24 13 13 0 0.620 1.000 1.000 437 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(2), AKT2(3), AKT3(4), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PIK3CB(5), PITX2(1), PLD1(8), PLD2(1), PLD3(1), VN1R1(1) 20370491 77 63 77 32 8 26 15 14 14 0 0.688 1.000 1.000 438 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(5), ACACA(11), ACACB(12), ACADM(3), ACAT2(1), ACSS1(5), ACSS2(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3) 18088116 76 61 76 26 16 15 23 12 10 0 0.601 1.000 1.000 439 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(11), ACAT2(1), ACYP1(1), ADH5(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(2), ME2(1), ME3(6), PC(7), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3) 16825998 69 61 69 25 20 13 16 14 6 0 0.591 1.000 1.000 440 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), DBH(4), DCT(1), DDC(7), FAH(1), GOT1(1), GOT2(3), HGD(2), HPD(1), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(2), TPO(10), TYR(4) 14444053 71 61 70 27 12 19 22 7 11 0 0.554 1.000 1.000 441 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(2), ABAT(5), ACADS(2), ACAT2(1), ACSM1(2), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), ILVBL(3), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(3), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(3) 18485529 73 60 73 33 11 16 24 14 8 0 0.906 1.000 1.000 442 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(3), CARS(2), DARS(2), DARS2(1), EARS2(1), EPRS(2), FARS2(2), FARSB(4), GARS(1), HARS2(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), MTFMT(3), NARS(2), NARS2(1), PARS2(3), QARS(1), RARS(1), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(1), VARS(5), VARS2(1), WARS2(5), YARS(3), YARS2(3) 24731006 74 60 73 28 8 15 30 15 6 0 0.788 1.000 1.000 443 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), CHRM2(4), CHRM3(5), CHRM5(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), HRH1(1), HRH2(1), HTR1A(7), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3) 11657802 72 60 72 34 16 10 25 16 5 0 0.718 1.000 1.000 444 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(6), GMNN(1), MCM10(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), RFC1(2), RFC2(2), RFC3(1), RFC4(4), RFC5(2), RPA1(4), RPS27A(1), UBA52(2), UBB(1), UBC(4) 23074021 80 59 79 38 8 20 34 7 11 0 0.984 1.000 1.000 445 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), CYP51A1(1), PON1(6) 13347882 70 59 70 20 10 11 28 13 8 0 0.273 1.000 1.000 446 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(6), ADRBK2(4), ARRB2(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(5), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(9), GNAL(2), PDC(1), PDE1C(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKG1(3), PRKG2(1), PRKX(1) 13896049 68 59 68 27 13 13 18 16 8 0 0.653 1.000 1.000 447 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(4), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GCNT1(1), GCNT4(2), OGT(3), ST3GAL1(1), ST6GALNAC1(4), WBSCR17(8) 14694128 79 58 79 27 14 16 23 11 15 0 0.585 1.000 1.000 448 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), BTG1(1), CBX3(1), CEBPB(1), CLOCK(4), CRY1(3), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(3), ETV6(4), G0S2(1), GFRA1(6), HERPUD1(3), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(5), NCOA4(2), NR1D2(2), PER1(5), PER2(2), PPP1R3C(1), PPP2CB(1), TUBB3(2), UCP3(3), UGP2(1), VAPA(1), ZFR(3) 16654955 66 57 66 25 9 13 27 10 7 0 0.818 1.000 1.000 449 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(6), ATP4B(2), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(8), ATP7B(4), COX10(1), COX5B(1), COX8A(1), NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1), SDHA(5), SHMT1(1), UQCRC1(1), UQCRFS1(3) 17384861 63 57 63 21 6 18 17 15 7 0 0.420 1.000 1.000 450 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(3), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SHMT1(1), SHMT2(2), TMLHE(2) 16863752 66 56 66 31 13 13 17 12 11 0 0.887 1.000 1.000 451 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(9), BMPR1B(1), CDK4(4), CDKN1B(2), CEBPB(1), DMC1(2), EGR1(3), ESR2(1), FSHR(5), INHA(1), LHCGR(2), MLH1(4), MSH5(1), NCOR1(12), NRIP1(4), PGR(2), PRLR(4), PTGER2(4), SMPD1(1), VDR(1), ZP2(4) 15955331 68 56 66 18 7 15 24 13 9 0 0.277 1.000 1.000 452 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(5), ACAA2(1), ACADM(3), ACADS(2), ACAT2(1), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOX1(5), AUH(1), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(5), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), OXCT2(1), PCCA(5), PCCB(1) 19616344 67 55 67 24 12 18 18 11 8 0 0.638 1.000 1.000 453 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(5), ACACA(11), ACADL(2), ACADM(3), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), LDHA(1), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3) 15097273 60 55 60 17 13 11 18 9 9 0 0.360 1.000 1.000 454 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF2(1), EEF2K(4), EIF2AK1(6), EIF2AK3(1), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF4A1(1), EIF4EBP1(1), EIF4G1(14), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(4), KIAA0664(4), PABPC3(7), PAIP1(4) 19913415 70 55 67 20 8 10 23 12 17 0 0.699 1.000 1.000 455 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(1), CRHR2(4), ELTD1(6), EMR1(5), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(5), LPHN2(8), LPHN3(14), VIPR2(3) 12129177 68 54 68 22 7 7 24 22 8 0 0.506 1.000 1.000 456 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(3), ABAT(5), ACY3(3), ADSL(4), ADSS(2), ADSSL1(2), AGXT2(2), ASNS(4), ASPA(1), ASRGL1(1), ASS1(1), CAD(2), DARS(2), DARS2(1), DLAT(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), NARS2(1), PC(7), PDHA1(3), PDHA2(5) 17243718 64 54 64 29 12 18 21 8 5 0 0.824 1.000 1.000 457 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), ESCO1(3), ESCO2(3), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), MYST3(4), MYST4(6), PRDX6(1), SH3GLB1(2), TAT(1), TPO(10) 15581425 67 54 66 32 13 13 27 5 9 0 0.931 1.000 1.000 458 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(3), ADCY3(6), ADCY9(4), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(2), GNAS(6), PLCG1(5), PLCG2(4), PRKCA(2), SEC61A1(3), SEC61A2(2), SEC61B(1), TRIM23(1) 16815893 68 54 68 20 13 13 22 11 9 0 0.232 1.000 1.000 459 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(4), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), ILK(4), MNAT1(2), POLR1A(5), POLR1B(3), POLR2A(9), POLR2B(3), POLR2G(2), POLR2H(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3H(1), TAF5(5), TAF6(3), TAF7(1), TAF9(2), TBP(1) 15971986 60 54 60 24 8 15 17 7 13 0 0.782 1.000 1.000 460 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(17), AXIN1(5), BTRC(1), CCND1(2), CREBBP(15), CSNK1A1(1), CSNK2A1(6), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MYC(4), NLK(1), TLE1(4), WNT1(1) 13396234 70 54 70 21 4 16 24 10 15 1 0.520 1.000 1.000 461 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), AGMAT(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(3), NOS3(4), ODC1(1), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(2) 20123489 68 53 68 26 17 16 18 11 6 0 0.577 1.000 1.000 462 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(1), RPE(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), XYLB(2) 12441231 63 53 63 23 7 10 27 16 3 0 0.793 1.000 1.000 463 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(5), ABP1(3), ACADL(2), ACADM(3), ACADSB(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), MLYCD(1), SMS(2), UPB1(1) 13246982 64 51 64 20 10 17 18 9 10 0 0.361 1.000 1.000 464 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(7), C5(5), C6(13), C7(5), ICAM1(2), IL1A(1), ITGA4(6), ITGAL(3), ITGB1(12), ITGB2(2), SELP(11), VCAM1(3) 11313717 70 51 69 25 7 17 21 12 13 0 0.592 1.000 1.000 465 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), AGXT2(2), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CPT1B(3), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PLCB2(4), PLCG1(5), PLCG2(4), SARDH(5), SARS(1), SHMT1(1), SHMT2(2), TARS(3) 19087059 61 50 61 29 12 12 25 5 7 0 0.845 1.000 1.000 466 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(1), AGT(2), AGTR1(8), AGTR2(2), CMA1(3), CPA3(2), CTSG(1), ENPEP(11), LNPEP(2), MAS1(3), MME(11), NLN(2), REN(3) 9641447 56 50 56 20 9 7 24 11 5 0 0.646 1.000 1.000 467 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(1), NCOA1(4), NCOA2(3), NCOA3(5), NCOR2(11), POLR2A(9), RARA(2), RXRA(4), TBP(1) 11377258 55 50 55 17 7 12 22 8 6 0 0.464 1.000 1.000 468 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(1), MAPK8(4), MYEF2(3), PLD1(8), PLD2(1), PLD3(1), PTK2(5), RAF1(2), RASAL1(5), SRC(1), TEC(2), VAV1(2) 12511791 56 50 53 18 7 10 18 8 13 0 0.532 1.000 1.000 469 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(2), AGTR1(8), AGTR2(2), CMA1(3), COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), REN(3) 11498508 55 49 55 22 5 19 19 7 5 0 0.881 1.000 1.000 470 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(5), ADC(1), ALDH4A1(1), CAD(2), CPS1(11), EARS2(1), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GNPNAT1(1), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1) 18015965 60 49 60 30 12 14 17 14 3 0 0.942 1.000 1.000 471 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), CS(2), DLAT(2), DLST(4), FH(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PDK1(1), PDK4(4), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3) 12919449 55 49 55 22 7 11 21 9 7 0 0.778 1.000 1.000 472 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(3), ELK1(1), FOS(1), IKBKB(5), IRAK1(2), LY96(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TLR2(1), TLR3(1), TLR4(7), TLR6(3), TLR7(4), TLR9(2), TRAF6(1) 16629202 55 49 55 21 8 8 24 8 7 0 0.797 1.000 1.000 473 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOX1(5), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), PCCA(5), PCCB(1) 16411285 54 49 54 20 8 12 16 8 10 0 0.723 1.000 1.000 474 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), OGDHL(9), PC(7), PCK2(3), SDHA(5), SDHC(1), SUCLA2(1), SUCLG2(3) 13606372 57 48 57 19 8 11 18 13 7 0 0.482 1.000 1.000 475 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), LIPA(1), RDH11(1), RDH12(3), SLC27A5(2), SOAT1(3), SOAT2(2), SRD5A2(2) 14411602 58 47 58 20 9 14 22 8 5 0 0.514 1.000 1.000 476 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AGXT2(2), AKR1B10(3), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PHGDH(1), PIPOX(1), RDH11(1), RDH12(3), SARDH(5), SARS(1), SARS2(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(1) 19401255 57 47 57 25 11 12 25 3 6 0 0.746 1.000 1.000 477 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(5), ABP1(3), ACADM(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(1) 12311011 57 47 57 19 9 17 15 9 7 0 0.410 1.000 1.000 478 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(1), FUCA1(1), GALNS(1), GBA(2), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NAGLU(1), NEU1(1), NEU2(1), SPAM1(2) 15650075 50 47 50 20 10 10 12 11 7 0 0.654 1.000 1.000 479 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM3(1), DLG4(1), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), NOS1(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(5) 11640690 57 47 57 23 11 15 18 10 3 0 0.588 1.000 1.000 480 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), GCK(2), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), MPI(3), PFKFB1(4), PFKFB4(2), PFKM(2), PFKP(4), SORD(1), TPI1(2) 10869121 47 46 47 15 9 7 17 7 7 0 0.419 1.000 1.000 481 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG5(1), ALG6(2), ALG9(1), B4GALT2(3), DHDDS(2), DOLPP1(1), DPAGT1(1), DPM1(2), FUT8(2), GANAB(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(2) 19334839 56 46 56 25 10 7 21 9 9 0 0.893 1.000 1.000 482 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), DDX20(3), E2F4(1), ETS1(2), ETS2(5), FOS(1), HDAC5(1), HRAS(11), NCOR2(11), RBL1(8), RBL2(3), SIN3A(2), SIN3B(5) 11862901 54 45 49 16 9 15 19 6 5 0 0.175 1.000 1.000 483 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(1), DEGS2(1), ENPP7(4), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SGMS1(1), SGMS2(1), SGPP1(2), SMPD1(1), SMPD2(1), SMPD3(1), SMPD4(3), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(1) 16282181 51 45 51 19 10 12 12 10 7 0 0.467 1.000 1.000 484 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(19), CTNNB1(2), PTK2(5), PXN(1), SRC(1), VCL(6) 8727281 56 44 56 23 5 11 23 8 8 1 0.870 1.000 1.000 485 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(3), C1S(3), C3(7), C5(5), C6(13), C7(5), C8A(6), C8B(4), C9(5), MASP1(4) 9495654 55 44 55 20 2 18 17 9 9 0 0.646 1.000 1.000 486 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(3), C1S(3), C3(7), C5(5), C6(13), C7(5), C8A(6), C9(5), MASP1(4), MASP2(4), MBL2(2) 9729844 57 44 57 18 2 19 16 11 9 0 0.447 1.000 1.000 487 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), GOT1(1), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(5), PRDX2(1), PRDX6(1), TAT(1), TPO(10) 10002009 50 44 49 23 12 10 19 3 6 0 0.716 1.000 1.000 488 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(3), CYP4F3(1), EPX(5), GGT1(1), MPO(5), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PRDX2(1), PRDX6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5), TPO(10) 12736158 56 44 55 25 13 10 19 8 6 0 0.719 1.000 1.000 489 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(10), COL4A5(7), COL4A6(2), P4HB(1), SLC23A1(3), SLC23A2(5), SLC2A1(3), SLC2A3(2) 11395523 50 44 50 21 4 19 16 6 5 0 0.885 1.000 1.000 490 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), AKR1D1(2), ARSB(1), ARSD(1), ARSE(1), CYP11B1(4), CYP11B2(3), HSD11B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8) 12401080 49 43 49 24 9 8 19 10 3 0 0.930 1.000 1.000 491 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(5), ALDH4A1(1), CAD(2), CPS1(11), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), GMPS(4), GOT1(1), GOT2(3), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1) 15140759 51 43 51 23 9 13 13 13 3 0 0.859 1.000 1.000 492 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASS1(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), EPRS(2), GATM(2), GLUD1(2), GLUD2(4), GOT1(1), GOT2(3), LAP3(1), NOS1(3), NOS3(4), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 16376141 55 43 55 17 15 9 15 15 1 0 0.402 1.000 1.000 493 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(4), ASRGL1(1), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), HAL(2) 9675351 50 43 50 15 11 13 12 12 2 0 0.352 1.000 1.000 494 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(3), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IRAK1(2), IRAK2(2), IRAK3(4), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TGFB1(1), TGFB2(2), TRAF6(1) 13545349 49 43 49 14 9 11 14 7 8 0 0.385 1.000 1.000 495 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM3(1), CHUK(3), EGR2(2), MAP3K1(3), MYC(4), NFATC1(7), NFATC2(6), NFKB1(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), SYT1(5), VIP(1), VIPR2(3) 12742226 52 43 52 19 12 9 15 12 4 0 0.521 1.000 1.000 496 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(5), ITPR1(9), ITPR2(11), ITPR3(5), NFAT5(5), PDE6A(1), PDE6C(2), SLC6A13(3), TF(3) 16196113 52 42 52 21 5 18 12 10 7 0 0.636 1.000 1.000 497 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), ASS1(1), CPS1(11), GATM(2), MAOA(1), MAOB(1), NAGS(2), ODC1(1), OTC(1), SAT1(3), SAT2(1), SMS(2) 13395037 50 41 50 15 11 14 14 6 5 0 0.261 1.000 1.000 498 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(5), GNA12(1), GNA13(1), GNB1(2), MYLK(4), PLCB1(12), PPP1R12B(1), PRKCA(2), ROCK1(11) 9422362 45 41 45 13 7 10 15 9 4 0 0.436 1.000 1.000 499 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOC1(1), CETP(2), CYP7A1(2), HMGCR(3), LCAT(2), LDLR(3), LIPC(3), LPL(2), LRP1(17), SCARB1(1), SOAT1(3) 12484942 45 41 45 13 5 10 15 9 6 0 0.353 1.000 1.000 500 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), AOC2(2), AOC3(5), ASPA(1), CNDP1(3), DDC(7), HAL(2), HDC(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(1) 11101012 45 40 45 13 8 11 14 4 8 0 0.234 1.000 1.000 501 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CHIT1(2), CTBS(1), CYB5R1(1), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(3), HK1(3), HK2(5), HK3(4), LHPP(1), MTMR2(5), MTMR6(2), NANS(2), PGM3(1), PHPT1(1), RENBP(3), UAP1(2) 13065355 47 40 47 16 10 11 12 5 9 0 0.549 1.000 1.000 502 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(5), ACADS(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(3), PDHA2(5) 11758995 45 39 45 21 7 11 11 6 10 0 0.875 1.000 1.000 503 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(2), ME3(6), PGK2(3), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7), TPI1(2) 9208910 43 39 43 15 10 7 15 6 5 0 0.573 1.000 1.000 504 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(3), AOC2(2), AOC3(5), CES1(4), CES7(2), DDHD1(2), ESCO1(3), ESCO2(3), LIPA(1), MYST3(4), MYST4(6), PLA1A(5), PRDX6(1), SH3GLB1(2) 11562887 45 39 45 17 4 11 18 7 5 0 0.811 1.000 1.000 505 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(5), ADSL(4), ADSS(2), AGXT2(2), ASNS(4), ASPA(1), CAD(2), DARS(2), GAD1(2), GAD2(2), GOT1(1), GOT2(3), GPT2(2), NARS(2), PC(7) 11884905 42 38 42 17 9 10 14 6 3 0 0.624 1.000 1.000 506 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(3), C1S(3), C3(7), C5(5), C6(13), C7(5), C8A(6), C9(5) 7993843 47 38 47 17 2 17 15 7 6 0 0.626 1.000 1.000 507 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), BST1(2), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT12(3) 9826266 41 38 41 19 5 6 18 8 4 0 0.930 1.000 1.000 508 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), EGF(6), EGFR(14), MET(1), PDGFRA(6), PRKCA(2), SH3GLB1(2), SH3KBP1(6), SRC(1) 8839014 40 37 40 13 4 8 14 8 6 0 0.457 1.000 1.000 509 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), CMBL(2), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3) 8202193 44 37 44 19 8 5 15 10 6 0 0.857 1.000 1.000 510 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(4), NDST4(7) 9435294 41 37 41 19 10 7 15 6 3 0 0.836 1.000 1.000 511 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CYP2C19(3), CYP2C9(5), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1) 14092645 48 37 48 21 4 9 19 10 6 0 0.927 1.000 1.000 512 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGAM(3), ITGB1(12), ITGB2(2), SELE(4), SELL(2), SELP(11) 7253618 46 37 45 18 6 8 12 9 11 0 0.738 1.000 1.000 513 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(2), DARS(2), EPRS(2), FARS2(2), GARS(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), NARS(2), QARS(1), RARS(1), SARS(1), TARS(3), WARS2(5), YARS(3) 14571823 42 36 41 17 5 6 19 10 2 0 0.862 1.000 1.000 514 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), AKR1D1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), SOAT2(2), SRD5A2(2) 10577856 42 36 42 17 6 10 14 6 6 0 0.749 1.000 1.000 515 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), NAGLU(1), SPAM1(2) 9290213 38 36 38 12 7 7 10 10 4 0 0.507 1.000 1.000 516 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(8), AP2A1(2), AP2M1(3), BIN1(1), CALM1(1), CALM3(1), DNM1(1), EPN1(4), EPS15(2), PICALM(3), SYNJ1(6), SYNJ2(5), SYT1(5) 9847906 42 36 42 17 5 6 16 9 6 0 0.888 1.000 1.000 517 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(4), CPOX(1), EPRS(2), FECH(1), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UROD(1), UROS(3) 12503061 39 36 39 21 4 8 15 11 1 0 0.969 1.000 1.000 518 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CHUK(3), CRADD(1), IKBKB(5), LTA(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP4K2(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TRAF2(1) 11015915 36 36 36 11 6 6 13 6 5 0 0.523 1.000 1.000 519 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(8), CR2(5), FCGR2B(1), HLA-DRA(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13) 6927972 40 35 40 22 3 11 8 8 10 0 0.956 1.000 1.000 520 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL13(1), IL4(1), IL5(1), JUNB(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(7), NFATC2(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 5525405 36 35 36 15 10 8 7 7 4 0 0.467 1.000 1.000 521 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2) 11377238 43 35 43 17 4 11 12 10 6 0 0.833 1.000 1.000 522 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(3), FADD(1), IKBKB(5), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(3), MAP3K14(2), MAP3K7(4), NFKB1(2), RELA(1), RIPK1(2), TLR4(7), TNFAIP3(3), TRAF6(1) 11126084 39 35 39 16 7 8 14 7 3 0 0.738 1.000 1.000 523 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(6), DBH(4), DDC(7), GAD1(2), GAD2(2), HDC(2), MAOA(1), PAH(4), PNMT(1), SLC18A3(3), TH(2), TPH1(2) 6571771 39 34 39 16 5 9 11 5 9 0 0.656 1.000 1.000 524 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16) 7617736 36 34 36 14 6 8 8 5 9 0 0.573 1.000 1.000 525 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(8), EGF(6), EGFR(14), HGS(1), RAB5A(2), TF(3), TFRC(3) 5847123 37 34 37 12 3 10 13 7 4 0 0.587 1.000 1.000 526 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(11), CPT1A(4), LEP(1), LEPR(11), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2) 6592726 37 34 37 17 5 6 13 8 5 0 0.932 1.000 1.000 527 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(7), C5(5), C6(13), C7(5), C8A(6), C9(5) 5737115 41 33 41 13 2 13 14 7 5 0 0.569 1.000 1.000 528 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(12), GNAS(6), GNB1(2), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 6953378 38 33 38 11 11 6 12 7 2 0 0.411 1.000 1.000 529 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(7), SDHA(5), SUCLA2(1), SUCLG2(3) 9387222 38 33 38 13 5 9 13 8 3 0 0.445 1.000 1.000 530 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), NCK1(4), NCKAP1(5), NTRK1(3), PIR(1), RAC1(10), WASF1(3), WASF2(2), WASF3(2), WASL(1) 6942248 38 32 36 14 8 11 8 10 1 0 0.607 1.000 1.000 531 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), LHPP(1), MTMR2(5), MTMR6(2), PHPT1(1), TYR(4) 6851614 37 32 37 12 7 4 16 3 7 0 0.752 1.000 1.000 532 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1) 10695384 39 32 39 12 5 10 11 4 9 0 0.445 1.000 1.000 533 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(4), ABCG2(2), BCHE(5), CES1(4), CES2(7), CYP3A4(3), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2) 10406050 36 32 36 23 6 6 15 5 4 0 0.983 1.000 1.000 534 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), ACADS(2), ACADVL(4), ACSL1(2), ACSL3(1), ACSL4(6), CPT1A(4), CPT2(2), DCI(1), EHHADH(2), HADHA(3), SLC25A20(1) 7655447 33 32 33 11 4 7 9 8 5 0 0.574 1.000 1.000 535 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(12), GNAS(6), PLCE1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAP2B(1) 6702553 39 32 39 12 10 7 15 4 3 0 0.423 1.000 1.000 536 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(2), GRM1(16), PLCB1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 7259989 39 31 39 15 6 10 15 8 0 0 0.528 1.000 1.000 537 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GPHN(1), NSF(1), SRC(1), UBQLN1(2) 5449046 35 31 35 14 2 8 14 4 7 0 0.809 1.000 1.000 538 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SMPD1(1), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(1) 10965422 33 31 33 15 5 9 8 5 6 0 0.770 1.000 1.000 539 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(2), ACYP1(1), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), FN3K(2), GCDH(1), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1) 11846896 38 31 38 16 3 7 12 11 5 0 0.884 1.000 1.000 540 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD7(2), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(1), ITGAX(5), TLR2(1), TLR4(7), TLR7(4), TLR9(2) 8478474 34 30 34 16 5 5 12 8 4 0 0.842 1.000 1.000 541 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F2(2), FGA(7), FGB(2), FGG(3), PLAT(2), PLAU(1), PLG(8), SERPINB2(2), SERPINE1(4) 6104274 34 30 34 11 4 6 12 4 8 0 0.569 1.000 1.000 542 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(11), ACACB(12), FASN(4), MCAT(2), OLAH(2), OXSM(2) 7231847 33 30 33 13 7 8 10 6 2 0 0.615 1.000 1.000 543 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GPX6(1), GPX7(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), OPLAH(2) 10041415 32 30 31 15 4 9 10 7 2 0 0.757 1.000 1.000 544 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(1), COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), ILVBL(3), PANK2(1), PANK4(1), PPCS(2), UPB1(1), VNN1(2) 7897888 35 30 35 17 4 5 16 7 3 0 0.955 1.000 1.000 545 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(6), GLI2(8), GLI3(5), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(1) 7572285 33 30 33 13 5 8 11 6 3 0 0.678 1.000 1.000 546 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(6), PTPRU(6), REG1A(8), STAT1(5), STAT2(3), TYK2(2) 5696518 32 30 32 10 4 8 10 4 6 0 0.390 1.000 1.000 547 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(3), GPT2(2), MDH1(1), ME1(2), ME2(1), ME3(6), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TPI1(2) 8239345 31 29 31 11 9 5 11 4 2 0 0.559 1.000 1.000 548 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(6), ATIC(2), DHFR(3), FTCD(1), GART(3), MTFMT(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 8616231 35 29 35 14 4 6 17 4 4 0 0.788 1.000 1.000 549 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(3), TRH(2), VIP(1) 5059206 32 29 32 14 4 3 17 5 3 0 0.812 1.000 1.000 550 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(3), HK1(3), HK2(5), HK3(4), PGM3(1), RENBP(3), UAP1(2) 7717229 29 28 29 10 7 7 7 4 4 0 0.536 1.000 1.000 551 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(2), GPR109B(4), GPR161(4), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR45(3), GPR68(1), GPR75(4), GPR81(2) 4478212 29 28 29 13 8 7 6 6 2 0 0.638 1.000 1.000 552 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(2), PIK3R4(7), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(2) 9628879 32 28 32 19 5 4 14 8 1 0 0.985 1.000 1.000 553 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22(1), IL22RA1(2), JAK1(6), JAK2(2), JAK3(3), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4), TYK2(2) 8357068 32 28 31 14 2 11 9 5 5 0 0.665 1.000 1.000 554 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(11), ABCB11(6), ABCB4(9), ABCC3(4) 6520323 30 28 30 15 3 8 12 2 5 0 0.818 1.000 1.000 555 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(2), GALNT2(3), GALNT3(3), GALNT4(2), GALNT6(3), GALNT8(5), GCNT1(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(8) 6580765 31 28 31 14 5 7 10 2 7 0 0.800 1.000 1.000 556 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(1), RPE(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8) 8010556 28 28 28 15 6 3 8 10 1 0 0.932 1.000 1.000 557 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), ESRRA(4), HDAC5(1), MEF2A(1), MEF2B(2), MEF2C(7), SLC2A4(1), SYT1(5), YWHAH(1) 9228378 32 28 31 10 2 9 12 7 2 0 0.426 1.000 1.000 558 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ICAM1(2), ITGA4(6), ITGAL(3), ITGB1(12), ITGB2(2), SELE(4), SELL(2) 5523452 32 27 31 16 6 6 5 6 9 0 0.875 1.000 1.000 559 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), DHFR(3), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 8139038 31 27 31 14 4 5 15 4 3 0 0.870 1.000 1.000 560 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(3), IKBKB(5), LTA(1), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TNFAIP3(3), TRAF2(1), TRAF3(3) 10244486 28 27 28 10 4 5 7 6 6 0 0.591 1.000 1.000 561 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(3), IFNG(1), IKBKB(5), IL4(1), MAP3K1(3), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF9(1), TRAF2(1) 8870258 30 26 30 13 4 5 11 5 5 0 0.867 1.000 1.000 562 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(2), AGTR1(8), AGTR2(2), KNG1(3), NOS3(4), REN(3) 4501421 27 26 27 13 6 7 7 4 3 0 0.724 1.000 1.000 563 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(7), CD3D(1), GZMB(1), HLA-A(9), ICAM1(2), ITGAL(3), ITGB2(2), PRF1(3) 3992315 28 26 26 12 3 2 3 4 16 0 0.755 1.000 1.000 564 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(1), IARS(7), ILVBL(3), LARS2(1), PDHA1(3), PDHA2(5), VARS(5), VARS2(1) 8506475 26 26 26 16 0 7 11 5 3 0 0.981 1.000 1.000 565 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(2), EPX(5), MPO(5), MTHFR(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10) 5297708 29 26 28 14 11 3 12 2 1 0 0.807 1.000 1.000 566 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), NPAS2(1), NR1D1(1), PER1(5), PER2(2), PER3(8) 7772119 29 26 29 11 6 6 9 6 2 0 0.624 1.000 1.000 567 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), CAT(2), EPX(5), MPO(5), PRDX2(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10) 5381448 29 26 28 14 10 3 12 3 1 0 0.807 1.000 1.000 568 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), PANK2(1), PANK4(1), PPCS(2), UPB1(1) 6363188 29 26 29 13 4 4 13 6 2 0 0.914 1.000 1.000 569 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), GBA3(5), MPO(5), PRDX2(1), PRDX6(1), TPO(10), TYR(4) 4402726 31 26 30 15 7 2 16 4 2 0 0.879 1.000 1.000 570 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX5(1), GSS(2), GSTA1(2), GSTA2(2), GSTA3(2), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), PGD(2) 8229452 27 25 26 10 5 7 6 6 3 0 0.540 1.000 1.000 571 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTR(4) 7926355 31 25 30 10 6 7 12 5 1 0 0.383 1.000 1.000 572 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3) 6643280 28 25 28 12 2 5 14 4 3 0 0.881 1.000 1.000 573 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD8A(2), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1) 4902911 27 25 27 16 3 3 4 7 10 0 0.940 1.000 1.000 574 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1) 9258084 25 24 25 13 7 4 5 5 4 0 0.827 1.000 1.000 575 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), IMPA2(2), ISYNA1(2), PGM1(3), PGM3(1), TGDS(2) 5308888 25 24 25 10 5 5 8 3 4 0 0.646 1.000 1.000 576 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL18(2), RPL26(1), RPL28(1), RPL31(1), RPL37(1), RPL37A(1), RPL3L(1), RPL6(2), RPS10(1), RPS13(2), RPS20(1), RPS21(1), RPS23(1), RPS28(1), RPS3(1), RPS5(1) 10315877 26 24 25 10 4 6 11 1 4 0 0.829 1.000 1.000 577 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT2(3), B4GALT5(2), DPAGT1(1), DPM1(2), FUT8(2), MAN1B1(3), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), RPN1(1), RPN2(2) 9135403 28 24 28 10 5 4 6 7 6 0 0.586 1.000 1.000 578 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), JAK2(2), STAT4(3), TYK2(2) 6687738 26 24 26 10 1 7 8 5 5 0 0.656 1.000 1.000 579 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), GBA(2), GBA3(5), MPO(5), PRDX6(1), TPO(10) 3820579 28 23 27 13 7 4 13 3 1 0 0.773 1.000 1.000 580 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1) 7291311 26 23 26 10 5 5 9 3 4 0 0.725 1.000 1.000 581 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), TBXA2R(1) 5099081 23 23 23 12 5 4 11 2 1 0 0.693 1.000 1.000 582 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), ICAM1(2), ITGAL(3), ITGB2(2), PTPRC(13), THY1(1) 5143284 25 23 25 17 2 3 4 7 9 0 0.975 1.000 1.000 583 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(5), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1) 10844023 24 22 24 22 4 4 7 4 5 0 0.999 1.000 1.000 584 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), ESR1(3), GREB1(11), MTA1(4), MTA3(3), PDZK1(2), TUBA8(2) 4996950 26 22 26 12 7 0 10 6 3 0 0.820 1.000 1.000 585 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(1), CSF1(1), FCGR3A(4), IL1B(1), IL6R(4), SELL(2), SPN(2), TGFB1(1), TGFB2(2), TNFRSF8(1), TNFSF8(2) 6006613 26 22 26 11 6 6 6 6 2 0 0.567 1.000 1.000 586 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(3), CHST1(3), CHST2(2), CHST4(3), CHST6(6), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5735233 25 21 25 14 10 3 8 1 3 0 0.891 1.000 1.000 587 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1) 7511162 22 21 22 10 6 3 5 5 3 0 0.757 1.000 1.000 588 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(11), MMP14(2), MMP2(2), RECK(6), TIMP1(1) 3418227 22 21 17 10 2 7 9 4 0 0 0.675 1.000 1.000 589 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2) 4183404 20 20 20 11 4 4 8 2 2 0 0.865 1.000 1.000 590 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2) 4183404 20 20 20 11 4 4 8 2 2 0 0.865 1.000 1.000 591 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2) 7553221 23 20 23 14 1 4 10 5 3 0 0.992 1.000 1.000 592 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), RAC1(10), WASF1(3), WASL(1) 3692808 22 20 20 9 5 8 3 6 0 0 0.650 1.000 1.000 593 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), GGCX(3), HMGCR(3), IDI1(1), LSS(3), PMVK(1), SC4MOL(1), TM7SF2(1) 8797914 21 19 21 12 6 5 4 1 5 0 0.919 1.000 1.000 594 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3), RDH11(1), RDH12(3) 4102728 22 19 22 12 1 3 8 9 1 0 0.934 1.000 1.000 595 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(6), STAT1(5), STAT2(3), TYK2(2) 4935436 19 18 19 11 2 6 4 2 5 0 0.907 1.000 1.000 596 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(6), PCYT1A(1), PDHA1(3), PDHA2(5), SLC18A3(3) 3189313 20 17 20 14 2 4 7 4 3 0 0.976 1.000 1.000 597 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ICAM1(2), ITGAL(3), ITGAM(3), ITGB2(2), SELE(4), SELL(2) 4720160 17 17 17 15 1 2 4 4 6 0 0.996 1.000 1.000 598 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(12), PRKCA(2), RELA(1) 3759828 17 17 17 7 3 3 8 3 0 0 0.733 1.000 1.000 599 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(4), CPO(2), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3) 3556541 16 16 16 7 2 3 7 4 0 0 0.760 1.000 1.000 600 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), HMGCS1(2), IDI1(1), LSS(3), PMVK(1), SC4MOL(1) 6015011 18 16 18 10 5 5 2 3 3 0 0.897 1.000 1.000 601 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(7), LARS2(1), PDHA1(3), PDHA2(5) 4561919 16 16 16 12 0 4 7 4 1 0 0.996 1.000 1.000 602 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), HLA-DRA(1), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL3(1), IL4(1), IL5(1), LTA(1), TGFB1(1), TGFB2(2) 6055633 17 15 17 12 4 4 2 5 2 0 0.960 1.000 1.000 603 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(11), GLS(1), GLUD1(2), GOT1(1) 3554471 15 15 15 5 3 3 3 6 0 0 0.596 1.000 1.000 604 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(2), NFKB1(2), NOX1(5), RELA(1), XDH(3) 4517257 13 13 13 10 2 3 3 3 2 0 0.959 1.000 1.000 605 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(4), CPOX(1), FECH(1), UROD(1), UROS(3) 3442046 12 12 12 6 1 3 4 4 0 0 0.835 1.000 1.000 606 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(5), GGT1(1), SHMT1(1), SHMT2(2) 2504290 12 12 12 5 3 2 4 3 0 0 0.767 1.000 1.000 607 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(2) 3147790 12 11 12 11 2 1 6 1 2 0 0.978 1.000 1.000 608 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(5), GGT1(1), SHMT1(1), SHMT2(2) 1887272 9 9 9 5 2 0 4 3 0 0 0.927 1.000 1.000 609 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1), GLUD1(2), GLUD2(4) 2078035 8 8 8 4 2 2 2 2 0 0 0.859 1.000 1.000 610 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC1(1), APOBEC2(1), APOBEC3B(3) 3342125 7 7 7 6 1 1 2 3 0 0 0.974 1.000 1.000 611 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(1), IL3(1), IL5(1) 1379968 6 6 6 4 1 3 2 0 0 0 0.856 1.000 1.000 612 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1) 2521890 5 5 5 3 1 1 0 3 0 0 0.843 1.000 1.000 613 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(1) 959652 4 4 4 3 0 0 4 0 0 0 0.925 1.000 1.000 614 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1), SPCS3(1) 1392715 2 2 2 2 0 1 1 0 0 0 0.894 1.000 1.000 615 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 779493 2 2 2 3 0 1 1 0 0 0 0.962 1.000 1.000 616 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 328481 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000