Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.034 -9999.0 0.0 -0.343 2.0 2.0 epithelial cell differentiation 0.05 0.035 -9999.0 0.0 -0.251 2.0 2.0 CYFIP2 0.026 0.032 -9999.0 0.0 -0.512 1.0 1.0 ENAH 0.019 0.07 0.241 6.0 -9999.0 0.0 6.0 EGFR 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.022 0.054 -9999.0 0.0 -0.512 3.0 3.0 MYO6 0.018 0.039 0.21 1.0 -0.263 2.0 3.0 CTNNB1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.029 -9999.0 0.0 -0.318 1.0 1.0 AQP5 -0.323 0.219 -9999.0 0.0 -0.463 205.0 205.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.018 0.037 0.195 3.0 -0.258 1.0 4.0 regulation of calcium-dependent cell-cell adhesion 0.003 0.064 -9999.0 0.0 -0.26 5.0 5.0 EGF -0.094 0.225 -9999.0 0.0 -0.512 67.0 67.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.1 0.199 -9999.0 0.0 -0.439 73.0 73.0 cortical microtubule organization 0.05 0.035 -9999.0 0.0 -0.251 2.0 2.0 GO:0000145 -0.001 0.038 0.173 9.0 -0.247 1.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.055 0.037 -9999.0 0.0 -0.253 2.0 2.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.055 0.047 -9999.0 0.0 -0.291 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.031 0.201 2.0 -9999.0 0.0 2.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.035 0.21 1.0 -0.262 1.0 2.0 ARF6/GTP 0.059 0.049 -9999.0 0.0 -0.272 3.0 3.0 CDH1 0.024 0.044 -9999.0 0.0 -0.512 2.0 2.0 EGFR/EGFR/EGF/EGF -0.024 0.121 -9999.0 0.0 -0.262 51.0 51.0 RhoA/GDP 0.051 0.034 -9999.0 0.0 -0.259 1.0 1.0 actin cytoskeleton organization -0.002 0.038 0.194 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.023 0.157 -9999.0 0.0 -0.491 30.0 30.0 DIAPH1 0.031 0.123 -9999.0 0.0 -0.577 1.0 1.0 Wnt receptor signaling pathway -0.05 0.035 0.251 2.0 -9999.0 0.0 2.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.002 0.039 0.195 1.0 -9999.0 0.0 1.0 EFNA1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.002 0.032 0.195 3.0 -9999.0 0.0 3.0 Ephrin A1/EPHA2 0.04 0.045 -9999.0 0.0 -0.257 4.0 4.0 SEC6/SEC8 0.01 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.003 0.065 -9999.0 0.0 -0.264 5.0 5.0 HGF/MET 0.033 0.063 -9999.0 0.0 -0.265 9.0 9.0 HGF 0.012 0.086 -9999.0 0.0 -0.47 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.035 -9999.0 0.0 -0.345 2.0 2.0 actin cable formation 0.057 0.093 0.233 44.0 -9999.0 0.0 44.0 KIAA1543 -0.012 0.062 0.19 3.0 -0.272 10.0 13.0 KIFC3 0.015 0.031 -9999.0 0.0 -0.262 1.0 1.0 NCK1 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.017 0.036 0.21 1.0 -0.262 1.0 2.0 NCK1/GIT1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.05 0.035 -9999.0 0.0 -0.251 2.0 2.0 EXOC4 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.019 0.037 0.21 1.0 -0.262 1.0 2.0 PIP5K1C 0.018 0.037 0.197 3.0 -0.262 1.0 4.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.027 0.081 0.271 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.008 0.09 0.275 3.0 -0.54 3.0 6.0 IGF-1R heterotetramer/IGF1 0.019 0.089 -9999.0 0.0 -0.258 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.04 -9999.0 0.0 -0.449 2.0 2.0 PLEKHA7 0.007 0.067 0.21 1.0 -0.278 12.0 13.0 mol:GTP 0.053 0.046 -9999.0 0.0 -0.289 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.028 0.084 0.328 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.021 0.034 -9999.0 0.0 -0.343 2.0 2.0 regulation of cell-cell adhesion -0.002 0.038 0.194 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.035 -9999.0 0.0 -0.345 2.0 2.0