Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.026 0.167 -9999.0 0.0 -0.501 7.0 7.0 IHH -0.087 0.281 -9999.0 0.0 -0.897 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.192 0.26 -9999.0 0.0 -0.547 23.0 23.0 LRPAP1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.19 0.258 0.543 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.08 0.222 -9999.0 0.0 -0.661 7.0 7.0 SMO -0.082 0.234 -9999.0 0.0 -0.666 8.0 8.0 AKT1 -0.019 0.094 -9999.0 0.0 -0.333 1.0 1.0 ARRB2 -0.009 0.053 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.08 0.229 -9999.0 0.0 -0.652 8.0 8.0 STIL -0.15 0.272 -9999.0 0.0 -0.515 22.0 22.0 DHH N/PTCH2 -0.062 0.195 -9999.0 0.0 -0.677 6.0 6.0 DHH N/PTCH1 -0.081 0.222 -9999.0 0.0 -0.526 13.0 13.0 PIK3CA 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.071 0.252 -9999.0 0.0 -0.868 6.0 6.0 PTHLH -0.036 0.196 -9999.0 0.0 -0.7 2.0 2.0 determination of left/right symmetry -0.08 0.229 -9999.0 0.0 -0.652 8.0 8.0 PIK3R1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.035 0.194 -9999.0 0.0 -0.693 2.0 2.0 IHH N/Hhip -0.054 0.191 -9999.0 0.0 -0.608 7.0 7.0 DHH N/Hhip -0.062 0.195 -9999.0 0.0 -0.677 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.08 0.229 -9999.0 0.0 -0.652 8.0 8.0 pancreas development 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.061 0.232 -9999.0 0.0 -0.868 5.0 5.0 somite specification -0.08 0.229 -9999.0 0.0 -0.652 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.162 0.287 -9999.0 0.0 -0.546 22.0 22.0 SHH Np/Cholesterol/PTCH2 -0.149 0.244 -9999.0 0.0 -0.547 18.0 18.0 SHH Np/Cholesterol/Megalin -0.54 0.343 -9999.0 0.0 -0.685 52.0 52.0 SHH -0.176 0.307 -9999.0 0.0 -0.678 18.0 18.0 catabolic process -0.036 0.18 -9999.0 0.0 -0.553 7.0 7.0 SMO/Vitamin D3 -0.166 0.297 -9999.0 0.0 -0.558 22.0 22.0 SHH Np/Cholesterol/Hhip -0.149 0.244 -9999.0 0.0 -0.548 18.0 18.0 LRP2 -0.63 0.389 -9999.0 0.0 -0.868 48.0 48.0 receptor-mediated endocytosis -0.425 0.323 -9999.0 0.0 -0.822 22.0 22.0 SHH Np/Cholesterol/BOC -0.149 0.244 -9999.0 0.0 -0.547 18.0 18.0 SHH Np/Cholesterol/CDO -0.15 0.243 -9999.0 0.0 -0.547 18.0 18.0 mesenchymal cell differentiation 0.148 0.242 0.543 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.16 0.288 -9999.0 0.0 -0.546 22.0 22.0 IHH N/PTCH2 -0.053 0.191 -9999.0 0.0 -0.606 7.0 7.0 CDON 0.006 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.035 0.183 -9999.0 0.0 -0.561 7.0 7.0 Megalin/LRPAP1 -0.492 0.301 -9999.0 0.0 -0.676 48.0 48.0 PTCH2 0.008 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.151 0.246 -9999.0 0.0 -0.553 18.0 18.0 PTCH1 -0.036 0.18 -9999.0 0.0 -0.555 7.0 7.0 HHIP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0