Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Nephrin/Neph1 signaling in the kidney podocyte 36.0 1254.0 34.0 -0.769 0.008 1000.0 -1000.0 -0.064 -1000.0 FOXA2 and FOXA3 transcription factor networks 26.0 1229.0 46.0 -1.534 0.013 1000.0 -1000.0 -0.104 -1000.0 PDGFR-alpha signaling pathway 16.0 734.0 44.0 -0.365 0.022 1000.0 -1000.0 -0.056 -1000.0 Signaling events mediated by the Hedgehog family 10.0 567.0 52.0 -0.63 0.19 1000.0 -1000.0 -0.075 -1000.0 Glypican 1 network 9.0 444.0 48.0 -0.476 0.023 1000.0 -1000.0 -0.049 -1000.0 Signaling events regulated by Ret tyrosine kinase 8.0 712.0 82.0 -0.265 0.008 1000.0 -1000.0 -0.083 -1000.0 BMP receptor signaling 7.0 585.0 81.0 -0.762 0.013 1000.0 -1000.0 -0.096 -1000.0 Reelin signaling pathway 6.0 339.0 56.0 -0.208 0.008 1000.0 -1000.0 -0.077 -1000.0 Ephrin B reverse signaling 6.0 333.0 48.0 -0.249 0.026 1000.0 -1000.0 -0.077 -1000.0 Thromboxane A2 receptor signaling 5.0 601.0 105.0 -0.162 0.029 1000.0 -1000.0 -0.065 -1000.0 HIF-1-alpha transcription factor network 5.0 442.0 76.0 -1.016 0.014 1000.0 -1000.0 -0.156 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 5.0 644.0 120.0 -0.576 0.221 1000.0 -1000.0 -0.078 -1000.0 Endothelins 4.0 418.0 96.0 -0.615 0.016 1000.0 -1000.0 -0.085 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 4.0 308.0 68.0 -0.658 0.058 1000.0 -1000.0 -0.156 -1000.0 IL23-mediated signaling events 4.0 243.0 60.0 -0.305 0.013 1000.0 -1000.0 -0.167 -1000.0 FOXM1 transcription factor network 4.0 216.0 51.0 -0.338 0.016 1000.0 -1000.0 -0.188 -1000.0 ErbB2/ErbB3 signaling events 3.0 199.0 65.0 -0.112 0.015 1000.0 -1000.0 -0.061 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 3.0 185.0 54.0 -0.208 0.018 1000.0 -1000.0 -0.093 -1000.0 IL4-mediated signaling events 3.0 333.0 91.0 -0.502 0.296 1000.0 -1000.0 -0.176 -1000.0 amb2 Integrin signaling 3.0 308.0 82.0 -0.589 0.008 1000.0 -1000.0 -0.08 -1000.0 Integrins in angiogenesis 3.0 262.0 84.0 -0.657 0.018 1000.0 -1000.0 -0.097 -1000.0 Syndecan-1-mediated signaling events 2.0 89.0 34.0 -0.271 0.008 1000.0 -1000.0 -0.065 -1000.0 Circadian rhythm pathway 2.0 64.0 22.0 -0.414 0.01 1000.0 -1000.0 -0.076 -1000.0 Osteopontin-mediated events 2.0 97.0 38.0 -0.326 0.008 1000.0 -1000.0 -0.09 -1000.0 Presenilin action in Notch and Wnt signaling 2.0 143.0 61.0 -0.364 0.063 1000.0 -1000.0 -0.071 -1000.0 IL1-mediated signaling events 2.0 154.0 62.0 -0.35 0.044 1000.0 -1000.0 -0.09 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 2.0 127.0 52.0 -0.524 0.044 1000.0 -1000.0 -0.056 -1000.0 FoxO family signaling 2.0 188.0 64.0 -0.731 0.055 1000.0 -1000.0 -0.086 -1000.0 Effects of Botulinum toxin 2.0 58.0 26.0 -0.311 0.01 1000.0 -1000.0 -0.056 -1000.0 Nongenotropic Androgen signaling 2.0 135.0 52.0 -0.093 0.013 1000.0 -1000.0 -0.06 -1000.0 TCGA08_rtk_signaling 2.0 57.0 26.0 -0.364 0.02 1000.0 -1000.0 -0.021 -1000.0 LPA receptor mediated events 2.0 227.0 102.0 -0.076 0.026 1000.0 -1000.0 -0.083 -1000.0 IL6-mediated signaling events 2.0 152.0 75.0 -0.18 0.039 1000.0 -1000.0 -0.09 -1000.0 EGFR-dependent Endothelin signaling events 2.0 46.0 21.0 -0.06 0.008 1000.0 -1000.0 -0.069 -1000.0 Plasma membrane estrogen receptor signaling 2.0 212.0 86.0 -0.062 0.039 1000.0 -1000.0 -0.082 -1000.0 E-cadherin signaling in keratinocytes 2.0 99.0 43.0 -0.267 0.031 1000.0 -1000.0 -0.063 -1000.0 Coregulation of Androgen receptor activity 1.0 100.0 76.0 -0.129 0.036 1000.0 -1000.0 -0.057 -1000.0 ErbB4 signaling events 1.0 116.0 69.0 -0.104 0.018 1000.0 -1000.0 -0.081 -1000.0 Visual signal transduction: Cones 1.0 45.0 38.0 -0.111 0.008 1000.0 -1000.0 -0.061 -1000.0 JNK signaling in the CD4+ TCR pathway 1.0 18.0 17.0 -0.071 0.035 1000.0 -1000.0 -0.065 -1000.0 Noncanonical Wnt signaling pathway 1.0 26.0 26.0 -0.11 0.021 1000.0 -1000.0 -0.09 -1000.0 Syndecan-2-mediated signaling events 1.0 136.0 69.0 -0.589 0.029 1000.0 -1000.0 -0.055 -1000.0 Signaling events mediated by PTP1B 1.0 120.0 76.0 -0.51 0.022 1000.0 -1000.0 -0.082 -1000.0 p75(NTR)-mediated signaling 1.0 193.0 125.0 -0.4 0.019 1000.0 -1000.0 -0.094 -1000.0 Fc-epsilon receptor I signaling in mast cells 1.0 188.0 97.0 -0.121 0.022 1000.0 -1000.0 -0.083 -1000.0 Glucocorticoid receptor regulatory network 1.0 190.0 114.0 -0.358 0.11 1000.0 -1000.0 -0.072 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 60.0 37.0 -0.151 0.01 1000.0 -1000.0 -0.066 -1000.0 FAS signaling pathway (CD95) 1.0 74.0 47.0 -0.281 0.05 1000.0 -1000.0 -0.051 -1000.0 Syndecan-3-mediated signaling events 1.0 47.0 35.0 -0.127 0.008 1000.0 -1000.0 -0.055 -1000.0 Signaling mediated by p38-alpha and p38-beta 1.0 65.0 44.0 -0.217 0.03 1000.0 -1000.0 -0.053 -1000.0 TCR signaling in naïve CD8+ T cells 1.0 105.0 93.0 -0.101 0.039 1000.0 -1000.0 -0.083 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 1.0 129.0 74.0 -0.313 0.043 1000.0 -1000.0 -0.081 -1000.0 Syndecan-4-mediated signaling events 1.0 118.0 67.0 -0.349 0.052 1000.0 -1000.0 -0.095 -1000.0 Angiopoietin receptor Tie2-mediated signaling 1.0 161.0 88.0 -0.225 0.03 1000.0 -1000.0 -0.102 -1000.0 Visual signal transduction: Rods 1.0 103.0 52.0 -0.111 0.008 1000.0 -1000.0 -0.077 -1000.0 Signaling events mediated by PRL 1.0 36.0 34.0 -0.071 0.012 1000.0 -1000.0 -0.042 -1000.0 Class IB PI3K non-lipid kinase events 1.0 3.0 3.0 -0.022 -1000.0 1000.0 -1000.0 -0.016 -1000.0 E-cadherin signaling events 1.0 6.0 5.0 -0.02 0.008 1000.0 -1000.0 -0.042 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 1.0 102.0 78.0 -0.372 0.025 1000.0 -1000.0 -0.086 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 31.0 17.0 -0.071 0.009 1000.0 -1000.0 -0.045 -1000.0 LPA4-mediated signaling events 0.0 7.0 12.0 -0.052 0.013 1000.0 -1000.0 -0.029 -1000.0 Caspase cascade in apoptosis 0.0 16.0 74.0 -0.025 0.033 1000.0 -1000.0 -0.048 -1000.0 Regulation of nuclear SMAD2/3 signaling 0.0 122.0 136.0 -0.364 0.093 1000.0 -1000.0 -0.077 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 0.0 23.0 0.0 0.031 1000.0 -1000.0 -0.064 -1000.0 Canonical NF-kappaB pathway 0.0 0.0 39.0 -0.002 0.057 1000.0 -1000.0 -0.083 -1000.0 Signaling events mediated by HDAC Class II 0.0 12.0 75.0 -0.058 0.027 1000.0 -1000.0 -0.066 -1000.0 IL12-mediated signaling events 0.0 24.0 87.0 -0.104 0.052 1000.0 -1000.0 -0.147 -1000.0 BARD1 signaling events 0.0 22.0 57.0 -0.011 0.038 1000.0 -1000.0 -0.065 -1000.0 Sphingosine 1-phosphate (S1P) pathway 0.0 4.0 28.0 -0.005 0.023 1000.0 -1000.0 -0.055 -1000.0 PLK2 and PLK4 events 0.0 0.0 3.0 0.006 0.012 1000.0 -1000.0 -0.024 -1000.0 Ephrin A reverse signaling 0.0 5.0 7.0 -0.012 0.001 1000.0 -1000.0 -0.031 -1000.0 a4b1 and a4b7 Integrin signaling 0.0 0.0 5.0 0.0 0.008 1000.0 -1000.0 -0.036 -1000.0 Cellular roles of Anthrax toxin 0.0 31.0 39.0 -0.077 0.013 1000.0 -1000.0 -0.023 -1000.0 Arf6 signaling events 0.0 42.0 62.0 -0.045 0.034 1000.0 -1000.0 -0.063 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0 20.0 85.0 -0.032 0.041 1000.0 -1000.0 -0.08 -1000.0 Hedgehog signaling events mediated by Gli proteins 0.0 51.0 65.0 -0.096 0.052 1000.0 -1000.0 -0.065 -1000.0 Aurora A signaling 0.0 3.0 60.0 -0.037 0.018 1000.0 -1000.0 -0.072 -1000.0 Arf6 downstream pathway 0.0 0.0 43.0 -0.021 0.021 1000.0 -1000.0 -0.045 -1000.0 Aurora C signaling 0.0 0.0 7.0 -0.014 0.0 1000.0 -1000.0 -0.038 -1000.0 EPO signaling pathway 0.0 6.0 55.0 -0.098 0.053 1000.0 -1000.0 -0.099 -1000.0 PLK1 signaling events 0.0 0.0 85.0 -0.051 0.012 1000.0 -1000.0 -0.053 -1000.0 Insulin-mediated glucose transport 0.0 13.0 32.0 -0.168 0.021 1000.0 -1000.0 -0.069 -1000.0 mTOR signaling pathway 0.0 0.0 53.0 -0.0 0.023 1000.0 -1000.0 -0.059 -1000.0 IFN-gamma pathway 0.0 56.0 68.0 -0.234 0.045 1000.0 -1000.0 -0.099 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 13.0 68.0 -0.168 0.033 1000.0 -1000.0 -0.067 -1000.0 Nectin adhesion pathway 0.0 48.0 63.0 -0.045 0.029 1000.0 -1000.0 -0.07 -1000.0 Ceramide signaling pathway 0.0 10.0 76.0 -0.062 0.03 1000.0 -1000.0 -0.066 -1000.0 Signaling events mediated by HDAC Class III 0.0 14.0 40.0 -0.071 0.015 1000.0 -1000.0 -0.041 -1000.0 TRAIL signaling pathway 0.0 16.0 48.0 -0.02 0.03 1000.0 -1000.0 -0.059 -1000.0 S1P5 pathway 0.0 3.0 17.0 -0.005 0.017 1000.0 -1000.0 -0.058 -1000.0 ceramide signaling pathway 0.0 4.0 49.0 -0.018 0.033 1000.0 -1000.0 -0.051 -1000.0 HIF-2-alpha transcription factor network 0.0 8.0 43.0 -0.124 0.127 1000.0 -1000.0 -0.094 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0 73.0 83.0 -0.217 0.07 1000.0 -1000.0 -0.094 -1000.0 S1P1 pathway 0.0 4.0 36.0 -0.004 0.034 1000.0 -1000.0 -0.063 -1000.0 Signaling events mediated by HDAC Class I 0.0 2.0 104.0 -0.008 0.038 1000.0 -1000.0 -0.075 -1000.0 TCGA08_p53 0.0 0.0 7.0 -0.078 0.047 1000.0 -1000.0 -0.017 -1000.0 Signaling mediated by p38-gamma and p38-delta 0.0 9.0 15.0 -0.003 0.02 1000.0 -1000.0 -0.039 -1000.0 Retinoic acid receptors-mediated signaling 0.0 0.0 58.0 -0.003 0.037 1000.0 -1000.0 -0.07 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 24.0 36.0 -0.151 0.015 1000.0 -1000.0 -0.069 -1000.0 Atypical NF-kappaB pathway 0.0 20.0 31.0 -0.032 0.018 1000.0 -1000.0 -0.063 -1000.0 IL2 signaling events mediated by PI3K 0.0 23.0 58.0 -0.029 0.034 1000.0 -1000.0 -0.093 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0 8.0 45.0 -0.016 0.046 1000.0 -1000.0 -0.085 -1000.0 Canonical Wnt signaling pathway 0.0 30.0 51.0 -0.138 0.069 1000.0 -1000.0 -0.068 -1000.0 EPHB forward signaling 0.0 39.0 85.0 -0.032 0.042 1000.0 -1000.0 -0.091 -1000.0 Regulation of p38-alpha and p38-beta 0.0 5.0 54.0 -0.032 0.031 1000.0 -1000.0 -0.062 -1000.0 Glypican 2 network 0.0 0.0 4.0 -0.01 -1000.0 1000.0 -1000.0 -0.037 -1000.0 Calcium signaling in the CD4+ TCR pathway 0.0 4.0 31.0 -0.03 0.041 1000.0 -1000.0 -0.091 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 21.0 125.0 -0.034 0.061 1000.0 -1000.0 -0.1 -1000.0 IL27-mediated signaling events 0.0 40.0 51.0 -0.184 0.04 1000.0 -1000.0 -0.084 -1000.0 Wnt signaling 0.0 4.0 7.0 -0.021 0.008 1000.0 -1000.0 -0.044 -1000.0 E-cadherin signaling in the nascent adherens junction 0.0 58.0 76.0 -0.02 0.029 1000.0 -1000.0 -0.079 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 0.0 27.0 -0.0 0.019 1000.0 -1000.0 -0.053 -1000.0 IL2 signaling events mediated by STAT5 0.0 7.0 22.0 -0.031 0.025 1000.0 -1000.0 -0.065 -1000.0 Class I PI3K signaling events 0.0 13.0 73.0 -0.098 0.029 1000.0 -1000.0 -0.075 -1000.0 Arf6 trafficking events 0.0 11.0 71.0 -0.115 0.029 1000.0 -1000.0 -0.073 -1000.0 TCGA08_retinoblastoma 0.0 0.0 8.0 -0.124 0.028 1000.0 -1000.0 -0.023 -1000.0 Regulation of Telomerase 0.0 62.0 102.0 -0.368 0.031 1000.0 -1000.0 -0.098 -1000.0 BCR signaling pathway 0.0 38.0 99.0 -0.098 0.025 1000.0 -1000.0 -0.078 -1000.0 IGF1 pathway 0.0 1.0 57.0 -0.06 0.023 1000.0 -1000.0 -0.087 -1000.0 Insulin Pathway 0.0 17.0 74.0 -0.032 0.026 1000.0 -1000.0 -0.091 -1000.0 VEGFR1 specific signals 0.0 6.0 56.0 -0.018 0.046 1000.0 -1000.0 -0.064 -1000.0 S1P3 pathway 0.0 14.0 42.0 -0.009 0.03 1000.0 -1000.0 -0.06 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 14.0 33.0 -0.121 0.024 1000.0 -1000.0 -0.058 -1000.0 Rapid glucocorticoid signaling 0.0 0.0 20.0 -0.052 0.008 1000.0 -1000.0 -0.036 -1000.0 PDGFR-beta signaling pathway 0.0 12.0 97.0 -0.031 0.042 1000.0 -1000.0 -0.079 -1000.0 S1P4 pathway 0.0 3.0 25.0 -0.005 0.023 1000.0 -1000.0 -0.048 -1000.0 p38 MAPK signaling pathway 0.0 0.0 44.0 -0.079 0.018 1000.0 -1000.0 -0.062 -1000.0 Arf1 pathway 0.0 0.0 54.0 -0.001 0.023 1000.0 -1000.0 -0.042 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 0.0 0.008 1000.0 -1000.0 -0.057 -1000.0 Regulation of Androgen receptor activity 0.0 45.0 70.0 -0.116 0.022 1000.0 -1000.0 -0.073 -1000.0 Aurora B signaling 0.0 36.0 67.0 -0.318 0.019 1000.0 -1000.0 -0.074 -1000.0 Total 224 15569 7203 -25.0559937513 -1995.68574625 131000 -131000 -9.38988900229 -131000