Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.005 0.113 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.038 0.213 -9999.0 0.0 -0.653 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.107 0.184 -9999.0 0.0 -0.375 21.0 21.0 LRPAP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.106 0.182 0.373 21.0 -9999.0 0.0 21.0 SMO/beta Arrestin2 -0.044 0.173 -9999.0 0.0 -0.515 6.0 6.0 SMO -0.06 0.175 -9999.0 0.0 -0.517 7.0 7.0 AKT1 -0.014 0.086 -9999.0 0.0 -0.318 1.0 1.0 ARRB2 0.029 0.026 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.021 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.059 0.172 -9999.0 0.0 -0.508 7.0 7.0 STIL -0.095 0.179 -9999.0 0.0 -0.38 14.0 14.0 DHH N/PTCH2 -0.014 0.144 -9999.0 0.0 -0.47 6.0 6.0 DHH N/PTCH1 -0.038 0.156 -9999.0 0.0 -0.349 13.0 13.0 PIK3CA 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.037 0.187 -9999.0 0.0 -0.628 6.0 6.0 PTHLH -0.017 0.138 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.059 0.172 -9999.0 0.0 -0.508 7.0 7.0 PIK3R1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.017 0.137 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.013 0.14 -9999.0 0.0 -0.416 7.0 7.0 DHH N/Hhip -0.016 0.145 -9999.0 0.0 -0.473 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.059 0.172 -9999.0 0.0 -0.508 7.0 7.0 pancreas development 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.173 -9999.0 0.0 -0.628 5.0 5.0 somite specification -0.059 0.172 -9999.0 0.0 -0.508 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.095 0.189 -9999.0 0.0 -0.372 19.0 19.0 SHH Np/Cholesterol/PTCH2 -0.077 0.168 -9999.0 0.0 -0.373 16.0 16.0 SHH Np/Cholesterol/Megalin -0.346 0.229 -9999.0 0.0 -0.448 51.0 51.0 SHH -0.124 0.197 -9999.0 0.0 -0.472 16.0 16.0 catabolic process -0.013 0.125 -9999.0 0.0 -0.37 7.0 7.0 SMO/Vitamin D3 -0.107 0.204 -9999.0 0.0 -0.556 6.0 6.0 SHH Np/Cholesterol/Hhip -0.078 0.163 -9999.0 0.0 -0.363 16.0 16.0 LRP2 -0.45 0.284 -9999.0 0.0 -0.622 48.0 48.0 receptor-mediated endocytosis -0.29 0.243 -9999.0 0.0 -0.635 17.0 17.0 SHH Np/Cholesterol/BOC -0.077 0.168 -9999.0 0.0 -0.374 16.0 16.0 SHH Np/Cholesterol/CDO -0.077 0.169 -9999.0 0.0 -0.374 16.0 16.0 mesenchymal cell differentiation 0.078 0.162 0.361 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.092 0.191 -9999.0 0.0 -0.381 17.0 17.0 IHH N/PTCH2 -0.009 0.14 -9999.0 0.0 -0.412 7.0 7.0 CDON 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.004 0.13 -9999.0 0.0 -0.374 7.0 7.0 Megalin/LRPAP1 -0.322 0.222 -9999.0 0.0 -0.454 48.0 48.0 PTCH2 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.088 0.161 -9999.0 0.0 -0.371 16.0 16.0 PTCH1 -0.013 0.126 -9999.0 0.0 -0.371 7.0 7.0 HHIP 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0