Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.185 0.194 -9999.0 0.0 -0.586 31.0 31.0 IHH -0.084 0.198 -9999.0 0.0 -0.693 42.0 42.0 SHH Np/Cholesterol/GAS1 0.003 0.1 -9999.0 0.0 -0.375 28.0 28.0 LRPAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.099 0.373 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.089 0.151 -9999.0 0.0 -0.519 25.0 25.0 SMO -0.1 0.15 -9999.0 0.0 -0.541 24.0 24.0 AKT1 -0.034 0.108 -9999.0 0.0 -0.551 10.0 10.0 ARRB2 0.027 0.034 -9999.0 0.0 -0.707 1.0 1.0 BOC 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.099 0.148 -9999.0 0.0 -0.533 24.0 24.0 STIL -0.074 0.134 -9999.0 0.0 -0.525 6.0 6.0 DHH N/PTCH2 0.007 0.125 -9999.0 0.0 -0.444 33.0 33.0 DHH N/PTCH1 -0.108 0.153 -9999.0 0.0 -0.494 33.0 33.0 PIK3CA 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.014 0.096 -9999.0 0.0 -0.639 10.0 10.0 PTHLH -0.287 0.273 -9999.0 0.0 -0.796 38.0 38.0 determination of left/right symmetry -0.099 0.148 -9999.0 0.0 -0.533 24.0 24.0 PIK3R1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.285 0.27 -9999.0 0.0 -0.787 38.0 38.0 IHH N/Hhip -0.164 0.254 -9999.0 0.0 -0.538 142.0 142.0 DHH N/Hhip -0.092 0.228 -9999.0 0.0 -0.479 119.0 119.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.099 0.148 -9999.0 0.0 -0.533 24.0 24.0 pancreas development -0.134 0.282 -9999.0 0.0 -0.626 116.0 116.0 HHAT 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.009 0.15 -9999.0 0.0 -0.584 29.0 29.0 somite specification -0.099 0.148 -9999.0 0.0 -0.533 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.085 0.13 -9999.0 0.0 -0.445 26.0 26.0 SHH Np/Cholesterol/PTCH2 0.006 0.092 -9999.0 0.0 -0.344 29.0 29.0 SHH Np/Cholesterol/Megalin -0.004 0.117 -9999.0 0.0 -0.416 31.0 31.0 SHH 0.011 0.068 -9999.0 0.0 -0.472 9.0 9.0 catabolic process -0.126 0.158 -9999.0 0.0 -0.522 31.0 31.0 SMO/Vitamin D3 -0.087 0.141 -9999.0 0.0 -0.491 25.0 25.0 SHH Np/Cholesterol/Hhip -0.068 0.175 -9999.0 0.0 -0.383 104.0 104.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.599 38.0 38.0 receptor-mediated endocytosis -0.1 0.165 -9999.0 0.0 -0.651 17.0 17.0 SHH Np/Cholesterol/BOC 0.022 0.056 -9999.0 0.0 -0.366 9.0 9.0 SHH Np/Cholesterol/CDO -0.017 0.122 -9999.0 0.0 -0.341 57.0 57.0 mesenchymal cell differentiation 0.068 0.173 0.38 104.0 -9999.0 0.0 104.0 mol:Vitamin D3 -0.079 0.139 -9999.0 0.0 -0.449 26.0 26.0 IHH N/PTCH2 -0.061 0.167 -9999.0 0.0 -0.468 64.0 64.0 CDON -0.043 0.198 -9999.0 0.0 -0.589 55.0 55.0 IHH N/PTCH1 -0.126 0.16 -9999.0 0.0 -0.529 31.0 31.0 Megalin/LRPAP1 0.004 0.131 -9999.0 0.0 -0.474 31.0 31.0 PTCH2 -0.003 0.136 -9999.0 0.0 -0.589 24.0 24.0 SHH Np/Cholesterol 0.011 0.054 -9999.0 0.0 -0.371 9.0 9.0 PTCH1 -0.126 0.158 -9999.0 0.0 -0.524 31.0 31.0 HHIP -0.134 0.282 -9999.0 0.0 -0.627 116.0 116.0