Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.054 0.227 -9999.0 0.0 -0.525 14.0 14.0 IHH -0.159 0.378 -9999.0 0.0 -0.955 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.033 0.134 -9999.0 0.0 -0.6 4.0 4.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.033 0.133 0.595 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 -0.061 0.247 -9999.0 0.0 -0.566 14.0 14.0 SMO -0.072 0.26 -9999.0 0.0 -0.602 14.0 14.0 AKT1 -0.006 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.068 0.256 -9999.0 0.0 -0.591 14.0 14.0 STIL -0.048 0.201 -9999.0 0.0 -0.448 15.0 15.0 DHH N/PTCH2 -0.022 0.119 -9999.0 0.0 -0.736 2.0 2.0 DHH N/PTCH1 -0.111 0.218 -9999.0 0.0 -0.531 16.0 16.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.015 0.151 -9999.0 0.0 -0.936 2.0 2.0 PTHLH -0.066 0.258 -9999.0 0.0 -0.84 2.0 2.0 determination of left/right symmetry -0.068 0.256 -9999.0 0.0 -0.591 14.0 14.0 PIK3R1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.065 0.256 -9999.0 0.0 -0.83 2.0 2.0 IHH N/Hhip -0.157 0.309 -9999.0 0.0 -0.69 19.0 19.0 DHH N/Hhip -0.068 0.213 -9999.0 0.0 -0.736 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.068 0.256 -9999.0 0.0 -0.591 14.0 14.0 pancreas development -0.051 0.234 -9999.0 0.0 -0.934 5.0 5.0 HHAT 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.184 -9999.0 0.0 -0.936 3.0 3.0 somite specification -0.068 0.256 -9999.0 0.0 -0.591 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.057 0.205 -9999.0 0.0 -0.467 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.011 0.071 -9999.0 0.0 -0.599 1.0 1.0 SHH Np/Cholesterol/Megalin -0.097 0.219 -9999.0 0.0 -0.6 12.0 12.0 SHH 0.008 0.09 -9999.0 0.0 -0.738 1.0 1.0 catabolic process -0.071 0.244 -9999.0 0.0 -0.582 14.0 14.0 SMO/Vitamin D3 -0.062 0.231 -9999.0 0.0 -0.518 15.0 15.0 SHH Np/Cholesterol/Hhip -0.049 0.162 -9999.0 0.0 -0.6 6.0 6.0 LRP2 -0.126 0.333 -9999.0 0.0 -0.936 11.0 11.0 receptor-mediated endocytosis -0.146 0.275 -9999.0 0.0 -0.647 15.0 15.0 SHH Np/Cholesterol/BOC -0.01 0.07 -9999.0 0.0 -0.599 1.0 1.0 SHH Np/Cholesterol/CDO -0.015 0.074 -9999.0 0.0 -0.599 1.0 1.0 mesenchymal cell differentiation 0.049 0.161 0.595 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 -0.054 0.21 -9999.0 0.0 -0.473 15.0 15.0 IHH N/PTCH2 -0.106 0.262 -9999.0 0.0 -0.654 14.0 14.0 CDON -0.001 0.061 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.075 0.247 -9999.0 0.0 -0.591 14.0 14.0 Megalin/LRPAP1 -0.106 0.259 -9999.0 0.0 -0.736 11.0 11.0 PTCH2 0.007 0.036 -9999.0 0.0 -0.303 1.0 1.0 SHH Np/Cholesterol -0.01 0.071 -9999.0 0.0 -0.607 1.0 1.0 PTCH1 -0.072 0.245 -9999.0 0.0 -0.585 14.0 14.0 HHIP -0.052 0.235 -9999.0 0.0 -0.936 5.0 5.0