Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.003 0.108 -9999.0 0.0 -0.371 6.0 6.0 epithelial cell differentiation -0.044 0.15 -9999.0 0.0 -0.558 6.0 6.0 CYFIP2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.031 0.104 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.007 0.036 -9999.0 0.0 -0.303 1.0 1.0 MYO6 -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.13 0.26 -9999.0 0.0 -0.618 16.0 16.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.009 0.15 -9999.0 0.0 -0.521 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.059 0.24 -9999.0 0.0 -0.615 11.0 11.0 EGF -0.762 0.366 -9999.0 0.0 -0.936 62.0 62.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.206 0.323 -9999.0 0.0 -0.679 23.0 23.0 cortical microtubule organization -0.044 0.15 -9999.0 0.0 -0.558 6.0 6.0 GO:0000145 -0.007 0.143 -9999.0 0.0 -0.497 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.045 0.152 -9999.0 0.0 -0.565 6.0 6.0 MLLT4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.119 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.002 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.144 -9999.0 0.0 -0.489 6.0 6.0 PVRL2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 ARF6/GTP -0.001 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.064 0.255 -9999.0 0.0 -0.936 6.0 6.0 EGFR/EGFR/EGF/EGF -0.462 0.229 -9999.0 0.0 -0.549 64.0 64.0 RhoA/GDP -0.041 0.141 -9999.0 0.0 -0.524 6.0 6.0 actin cytoskeleton organization -0.001 0.146 -9999.0 0.0 -0.499 6.0 6.0 IGF-1R heterotetramer 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.001 0.108 -9999.0 0.0 -0.936 1.0 1.0 DIAPH1 -0.002 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.044 0.15 0.558 6.0 -9999.0 0.0 6.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.036 0.12 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.002 0.15 -9999.0 0.0 -0.513 6.0 6.0 EFNA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.001 0.146 -9999.0 0.0 -0.5 6.0 6.0 Ephrin A1/EPHA2 -0.042 0.138 -9999.0 0.0 -0.51 6.0 6.0 SEC6/SEC8 -0.037 0.127 -9999.0 0.0 -0.469 6.0 6.0 MGAT3 -0.061 0.247 -9999.0 0.0 -0.632 11.0 11.0 HGF/MET -0.075 0.177 -9999.0 0.0 -0.526 10.0 10.0 HGF -0.039 0.211 -9999.0 0.0 -0.936 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.003 0.108 -9999.0 0.0 -0.374 6.0 6.0 actin cable formation 0.047 0.099 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.001 0.146 -9999.0 0.0 -0.5 6.0 6.0 KIFC3 -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 NCK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.044 0.15 -9999.0 0.0 -0.558 6.0 6.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 PIP5K1C -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 LIMA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.104 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.017 0.138 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.047 0.148 -9999.0 0.0 -0.511 7.0 7.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.014 0.085 -9999.0 0.0 -0.303 6.0 6.0 PLEKHA7 -0.009 0.153 -9999.0 0.0 -0.532 6.0 6.0 mol:GTP -0.002 0.014 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.019 0.136 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.003 0.108 -9999.0 0.0 -0.371 6.0 6.0 regulation of cell-cell adhesion -0.001 0.146 -9999.0 0.0 -0.499 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.003 0.108 -9999.0 0.0 -0.374 6.0 6.0