Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	38.0	1301.0	34.0	-0.777	0.011	1000.0	-1000.0	-0.078	-1000.0
EGFR-dependent Endothelin signaling events	26.0	563.0	21.0	-0.762	0.011	1000.0	-1000.0	-0.079	-1000.0
FOXA2 and FOXA3 transcription factor networks	24.0	1128.0	46.0	-1.399	0.018	1000.0	-1000.0	-0.084	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1491.0	88.0	-0.852	0.049	1000.0	-1000.0	-0.12	-1000.0
Glypican 1 network	12.0	577.0	48.0	-0.527	0.031	1000.0	-1000.0	-0.053	-1000.0
Glypican 2 network	12.0	49.0	4.0	-0.121	-1000.0	1000.0	-1000.0	-0.037	-1000.0
PDGFR-alpha signaling pathway	10.0	468.0	44.0	-0.313	0.025	1000.0	-1000.0	-0.073	-1000.0
TCGA08_retinoblastoma	10.0	84.0	8.0	-0.247	0.062	1000.0	-1000.0	-0.018	-1000.0
Thromboxane A2 receptor signaling	9.0	1023.0	105.0	-0.762	0.057	1000.0	-1000.0	-0.083	-1000.0
Arf6 signaling events	9.0	579.0	62.0	-0.762	0.017	1000.0	-1000.0	-0.067	-1000.0
amb2 Integrin signaling	8.0	726.0	82.0	-0.726	0.011	1000.0	-1000.0	-0.105	-1000.0
Signaling events mediated by the Hedgehog family	7.0	366.0	52.0	-0.159	0.049	1000.0	-1000.0	-0.075	-1000.0
IL4-mediated signaling events	7.0	705.0	91.0	-0.988	0.499	1000.0	-1000.0	-0.158	-1000.0
BMP receptor signaling	7.0	640.0	81.0	-0.606	0.011	1000.0	-1000.0	-0.096	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	321.0	44.0	-0.14	0.011	1000.0	-1000.0	-0.051	-1000.0
FOXM1 transcription factor network	7.0	389.0	51.0	-0.313	0.019	1000.0	-1000.0	-0.186	-1000.0
Endothelins	6.0	596.0	96.0	-0.56	0.011	1000.0	-1000.0	-0.091	-1000.0
Integrins in angiogenesis	6.0	521.0	84.0	-0.651	0.027	1000.0	-1000.0	-0.106	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	760.0	120.0	-0.296	0.179	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	478.0	78.0	-0.317	0.038	1000.0	-1000.0	-0.092	-1000.0
Noncanonical Wnt signaling pathway	5.0	137.0	26.0	-0.335	0.011	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by PTP1B	5.0	392.0	76.0	-0.766	0.109	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	679.0	125.0	-0.135	0.013	1000.0	-1000.0	-0.102	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	364.0	68.0	-0.586	0.048	1000.0	-1000.0	-0.131	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	384.0	74.0	-0.762	0.047	1000.0	-1000.0	-0.089	-1000.0
Syndecan-1-mediated signaling events	4.0	136.0	34.0	-0.106	0.011	1000.0	-1000.0	-0.081	-1000.0
p75(NTR)-mediated signaling	4.0	502.0	125.0	-0.677	0.021	1000.0	-1000.0	-0.109	-1000.0
S1P1 pathway	4.0	148.0	36.0	-0.115	0.011	1000.0	-1000.0	-0.062	-1000.0
FoxO family signaling	4.0	307.0	64.0	-1.129	0.075	1000.0	-1000.0	-0.084	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	433.0	93.0	-0.575	0.253	1000.0	-1000.0	-0.092	-1000.0
Effects of Botulinum toxin	4.0	118.0	26.0	-0.263	0.014	1000.0	-1000.0	-0.071	-1000.0
Wnt signaling	4.0	29.0	7.0	-0.056	0.011	1000.0	-1000.0	-0.027	-1000.0
Syndecan-4-mediated signaling events	4.0	330.0	67.0	-0.667	0.096	1000.0	-1000.0	-0.107	-1000.0
E-cadherin signaling in keratinocytes	4.0	172.0	43.0	-0.319	0.029	1000.0	-1000.0	-0.073	-1000.0
Coregulation of Androgen receptor activity	3.0	263.0	76.0	-0.846	0.023	1000.0	-1000.0	-0.061	-1000.0
HIF-1-alpha transcription factor network	3.0	268.0	76.0	-0.189	0.049	1000.0	-1000.0	-0.172	-1000.0
Glucocorticoid receptor regulatory network	3.0	413.0	114.0	-0.584	0.177	1000.0	-1000.0	-0.081	-1000.0
Nongenotropic Androgen signaling	3.0	175.0	52.0	-0.104	0.028	1000.0	-1000.0	-0.069	-1000.0
E-cadherin signaling events	3.0	18.0	5.0	-0.064	0.011	1000.0	-1000.0	-0.043	-1000.0
Aurora B signaling	3.0	226.0	67.0	-0.271	0.011	1000.0	-1000.0	-0.078	-1000.0
LPA4-mediated signaling events	2.0	33.0	12.0	-0.167	0.019	1000.0	-1000.0	-0.03	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	313.0	136.0	-0.583	0.07	1000.0	-1000.0	-0.094	-1000.0
ErbB4 signaling events	2.0	203.0	69.0	-0.338	0.125	1000.0	-1000.0	-0.092	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	67.0	28.0	-0.138	0.011	1000.0	-1000.0	-0.068	-1000.0
Osteopontin-mediated events	2.0	83.0	38.0	-0.15	0.037	1000.0	-1000.0	-0.112	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	130.0	54.0	-0.203	0.023	1000.0	-1000.0	-0.111	-1000.0
Ephrin A  reverse signaling	2.0	20.0	7.0	-0.039	0.0	1000.0	-1000.0	-0.03	-1000.0
Syndecan-2-mediated signaling events	2.0	173.0	69.0	-0.726	0.034	1000.0	-1000.0	-0.069	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	158.0	61.0	-0.177	0.078	1000.0	-1000.0	-0.079	-1000.0
Reelin signaling pathway	2.0	143.0	56.0	-0.178	0.011	1000.0	-1000.0	-0.097	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	211.0	82.0	-0.124	0.011	1000.0	-1000.0	-0.091	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	126.0	52.0	-0.35	0.046	1000.0	-1000.0	-0.077	-1000.0
IL27-mediated signaling events	2.0	109.0	51.0	-0.917	0.209	1000.0	-1000.0	-0.098	-1000.0
IL6-mediated signaling events	2.0	169.0	75.0	-0.332	0.053	1000.0	-1000.0	-0.106	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	169.0	76.0	-0.064	0.025	1000.0	-1000.0	-0.086	-1000.0
Regulation of Telomerase	2.0	236.0	102.0	-0.763	0.037	1000.0	-1000.0	-0.111	-1000.0
BCR signaling pathway	2.0	217.0	99.0	-0.107	0.027	1000.0	-1000.0	-0.095	-1000.0
Plasma membrane estrogen receptor signaling	2.0	255.0	86.0	-0.138	0.025	1000.0	-1000.0	-0.093	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	74.0	33.0	-0.245	0.034	1000.0	-1000.0	-0.07	-1000.0
Visual signal transduction: Rods	2.0	111.0	52.0	-0.214	0.011	1000.0	-1000.0	-0.102	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.017	-1000.0
Regulation of Androgen receptor activity	2.0	172.0	70.0	-0.914	0.027	1000.0	-1000.0	-0.066	-1000.0
ErbB2/ErbB3 signaling events	1.0	72.0	65.0	-0.121	0.027	1000.0	-1000.0	-0.079	-1000.0
Caspase cascade in apoptosis	1.0	113.0	74.0	-0.388	0.035	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	1.0	170.0	87.0	-0.193	0.041	1000.0	-1000.0	-0.125	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	19.0	17.0	-0.056	0.019	1000.0	-1000.0	-0.079	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	112.0	85.0	-0.151	0.039	1000.0	-1000.0	-0.086	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	176.0	97.0	-0.151	0.029	1000.0	-1000.0	-0.092	-1000.0
IFN-gamma pathway	1.0	122.0	68.0	-0.601	0.059	1000.0	-1000.0	-0.099	-1000.0
Ceramide signaling pathway	1.0	145.0	76.0	-0.762	0.241	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	1.0	78.0	62.0	-0.137	0.058	1000.0	-1000.0	-0.113	-1000.0
S1P5 pathway	1.0	19.0	17.0	-0.059	0.028	1000.0	-1000.0	-0.068	-1000.0
Syndecan-3-mediated signaling events	1.0	64.0	35.0	-0.188	0.011	1000.0	-1000.0	-0.074	-1000.0
IL2 signaling events mediated by PI3K	1.0	78.0	58.0	-0.065	0.061	1000.0	-1000.0	-0.091	-1000.0
Canonical Wnt signaling pathway	1.0	57.0	51.0	-0.176	0.081	1000.0	-1000.0	-0.063	-1000.0
EPHB forward signaling	1.0	109.0	85.0	-0.126	0.05	1000.0	-1000.0	-0.108	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	57.0	31.0	-0.151	0.017	1000.0	-1000.0	-0.093	-1000.0
LPA receptor mediated events	1.0	121.0	102.0	-0.151	0.031	1000.0	-1000.0	-0.103	-1000.0
IL2 signaling events mediated by STAT5	1.0	27.0	22.0	-0.1	0.047	1000.0	-1000.0	-0.044	-1000.0
Arf6 trafficking events	1.0	77.0	71.0	-0.413	0.04	1000.0	-1000.0	-0.071	-1000.0
IL23-mediated signaling events	1.0	95.0	60.0	-0.13	0.025	1000.0	-1000.0	-0.171	-1000.0
S1P3 pathway	1.0	61.0	42.0	-0.138	0.024	1000.0	-1000.0	-0.073	-1000.0
PDGFR-beta signaling pathway	1.0	117.0	97.0	-0.091	0.049	1000.0	-1000.0	-0.096	-1000.0
Signaling events mediated by PRL	1.0	36.0	34.0	-0.051	0.021	1000.0	-1000.0	-0.063	-1000.0
S1P4 pathway	1.0	26.0	25.0	-0.059	0.024	1000.0	-1000.0	-0.061	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	30.0	17.0	-0.024	0.025	1000.0	-1000.0	-0.05	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.043	1000.0	-1000.0	-0.076	-1000.0
Canonical NF-kappaB pathway	0.0	4.0	39.0	-0.03	0.076	1000.0	-1000.0	-0.101	-1000.0
Signaling events mediated by HDAC Class II	0.0	44.0	75.0	-0.113	0.033	1000.0	-1000.0	-0.081	-1000.0
BARD1 signaling events	0.0	55.0	57.0	-0.121	0.028	1000.0	-1000.0	-0.08	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	-0.018	0.007	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	0.0	29.0	38.0	-0.027	0.011	1000.0	-1000.0	-0.067	-1000.0
Circadian rhythm pathway	0.0	0.0	22.0	-0.011	0.044	1000.0	-1000.0	-0.072	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.011	1000.0	-1000.0	-0.034	-1000.0
Cellular roles of Anthrax toxin	0.0	30.0	39.0	-0.169	0.019	1000.0	-1000.0	-0.031	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	31.0	65.0	-0.06	0.06	1000.0	-1000.0	-0.071	-1000.0
Aurora A signaling	0.0	55.0	60.0	-0.162	0.034	1000.0	-1000.0	-0.07	-1000.0
Arf6 downstream pathway	0.0	1.0	43.0	-0.025	0.026	1000.0	-1000.0	-0.049	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.166	0.011	1000.0	-1000.0	-0.047	-1000.0
EPO signaling pathway	0.0	24.0	55.0	-0.064	0.073	1000.0	-1000.0	-0.104	-1000.0
PLK1 signaling events	0.0	10.0	85.0	-0.125	0.013	1000.0	-1000.0	-0.057	-1000.0
Insulin-mediated glucose transport	0.0	20.0	32.0	-0.117	0.056	1000.0	-1000.0	-0.07	-1000.0
mTOR signaling pathway	0.0	0.0	53.0	0.0	0.031	1000.0	-1000.0	-0.066	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	2.0	68.0	-0.117	0.046	1000.0	-1000.0	-0.072	-1000.0
Nectin adhesion pathway	0.0	54.0	63.0	-0.1	0.052	1000.0	-1000.0	-0.083	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	6.0	37.0	-0.04	0.028	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by HDAC Class III	0.0	9.0	40.0	-0.019	0.021	1000.0	-1000.0	-0.054	-1000.0
TRAIL signaling pathway	0.0	20.0	48.0	-0.034	0.044	1000.0	-1000.0	-0.082	-1000.0
ceramide signaling pathway	0.0	9.0	49.0	-0.03	0.042	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	0.0	36.0	43.0	-0.158	0.133	1000.0	-1000.0	-0.104	-1000.0
Ephrin B reverse signaling	0.0	27.0	48.0	-0.067	0.047	1000.0	-1000.0	-0.089	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	37.0	83.0	-0.269	0.045	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class I	0.0	34.0	104.0	-0.113	0.044	1000.0	-1000.0	-0.082	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.165	0.099	1000.0	-1000.0	-0.022	-1000.0
FAS signaling pathway (CD95)	0.0	38.0	47.0	-0.084	0.028	1000.0	-1000.0	-0.052	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	10.0	15.0	-0.014	0.029	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	0.0	28.0	58.0	-0.055	0.034	1000.0	-1000.0	-0.086	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	5.0	36.0	-0.01	0.021	1000.0	-1000.0	-0.078	-1000.0
Atypical NF-kappaB pathway	0.0	4.0	31.0	-0.002	0.041	1000.0	-1000.0	-0.069	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	9.0	45.0	-0.03	0.066	1000.0	-1000.0	-0.095	-1000.0
Regulation of p38-alpha and p38-beta	0.0	43.0	54.0	-0.113	0.063	1000.0	-1000.0	-0.061	-1000.0
TCGA08_rtk_signaling	0.0	25.0	26.0	-0.201	0.034	1000.0	-1000.0	-0.024	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.007	0.027	1000.0	-1000.0	-0.06	-1000.0
Class I PI3K signaling events	0.0	66.0	73.0	-0.064	0.031	1000.0	-1000.0	-0.083	-1000.0
IGF1 pathway	0.0	27.0	57.0	-0.045	0.049	1000.0	-1000.0	-0.099	-1000.0
Insulin Pathway	0.0	27.0	74.0	-0.064	0.033	1000.0	-1000.0	-0.104	-1000.0
VEGFR1 specific signals	0.0	0.0	56.0	-0.004	0.052	1000.0	-1000.0	-0.087	-1000.0
Rapid glucocorticoid signaling	0.0	3.0	20.0	-0.004	0.011	1000.0	-1000.0	-0.053	-1000.0
p38 MAPK signaling pathway	0.0	7.0	44.0	-0.018	0.042	1000.0	-1000.0	-0.072	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.006	0.03	1000.0	-1000.0	-0.051	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.011	1000.0	-1000.0	-0.081	-1000.0
Total	380	24251	7203	-34.2220200576	-1994.04021408	131000	-131000	-10.379781638	-131000