Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.141 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.085 0.271 -9999.0 0.0 -0.679 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.002 0.084 -9999.0 0.0 -0.349 4.0 4.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.084 0.346 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 -0.033 0.186 -9999.0 0.0 -0.446 10.0 10.0 SMO -0.053 0.175 -9999.0 0.0 -0.454 11.0 11.0 AKT1 -0.034 0.158 -9999.0 0.0 -0.799 2.0 2.0 ARRB2 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.052 0.172 -9999.0 0.0 -0.447 11.0 11.0 STIL -0.034 0.134 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.023 0.087 -9999.0 0.0 -0.497 2.0 2.0 DHH N/PTCH1 -0.042 0.158 -9999.0 0.0 -0.358 15.0 15.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.002 0.109 -9999.0 0.0 -0.654 2.0 2.0 PTHLH -0.054 0.171 -9999.0 0.0 -0.441 10.0 10.0 determination of left/right symmetry -0.052 0.172 -9999.0 0.0 -0.447 11.0 11.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.054 0.17 -9999.0 0.0 -0.439 10.0 10.0 IHH N/Hhip -0.078 0.217 -9999.0 0.0 -0.466 18.0 18.0 DHH N/Hhip -0.014 0.154 -9999.0 0.0 -0.497 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.052 0.172 -9999.0 0.0 -0.447 11.0 11.0 pancreas development -0.02 0.168 -9999.0 0.0 -0.653 5.0 5.0 HHAT 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.002 0.132 -9999.0 0.0 -0.654 3.0 3.0 somite specification -0.052 0.172 -9999.0 0.0 -0.447 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.038 0.124 -9999.0 0.0 -0.321 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.013 0.049 -9999.0 0.0 -0.399 1.0 1.0 SHH Np/Cholesterol/Megalin -0.043 0.147 -9999.0 0.0 -0.399 11.0 11.0 SHH -0.02 0.056 -9999.0 0.0 -0.498 1.0 1.0 catabolic process -0.045 0.157 -9999.0 0.0 -0.389 13.0 13.0 SMO/Vitamin D3 -0.046 0.152 -9999.0 0.0 -0.399 10.0 10.0 SHH Np/Cholesterol/Hhip -0.014 0.106 -9999.0 0.0 -0.399 5.0 5.0 LRP2 -0.063 0.23 -9999.0 0.0 -0.654 10.0 10.0 receptor-mediated endocytosis -0.085 0.207 -9999.0 0.0 -0.655 6.0 6.0 SHH Np/Cholesterol/BOC 0.013 0.049 -9999.0 0.0 -0.399 1.0 1.0 SHH Np/Cholesterol/CDO 0.013 0.05 -9999.0 0.0 -0.399 1.0 1.0 mesenchymal cell differentiation 0.014 0.106 0.396 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 -0.009 0.154 0.359 1.0 -0.324 10.0 11.0 IHH N/PTCH2 -0.04 0.182 -9999.0 0.0 -0.438 13.0 13.0 CDON 0.029 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.038 0.162 -9999.0 0.0 -0.393 13.0 13.0 Megalin/LRPAP1 -0.032 0.181 -9999.0 0.0 -0.495 10.0 10.0 PTCH2 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.005 0.046 -9999.0 0.0 -0.394 1.0 1.0 PTCH1 -0.046 0.157 -9999.0 0.0 -0.39 13.0 13.0 HHIP -0.02 0.168 -9999.0 0.0 -0.654 5.0 5.0