Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.006 0.078 -9999.0 0.0 -0.292 5.0 5.0 epithelial cell differentiation 0.021 0.108 -9999.0 0.0 -0.379 5.0 5.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.024 0.121 0.549 2.0 -9999.0 0.0 2.0 EGFR 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.024 0.119 0.341 2.0 -0.37 5.0 7.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.048 0.019 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.1 0.204 -9999.0 0.0 -0.585 10.0 10.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.022 0.119 0.338 2.0 -0.364 5.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.143 0.338 2.0 -0.411 7.0 9.0 EGF -0.517 0.263 -9999.0 0.0 -0.639 62.0 62.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.144 0.234 -9999.0 0.0 -0.562 16.0 16.0 cortical microtubule organization 0.021 0.108 -9999.0 0.0 -0.379 5.0 5.0 GO:0000145 -0.021 0.113 0.325 2.0 -0.347 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.111 -9999.0 0.0 -0.383 5.0 5.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.073 -9999.0 0.0 -0.344 4.0 4.0 ARF6 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.025 0.094 -9999.0 0.0 -0.341 5.0 5.0 PVRL2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.034 0.099 -9999.0 0.0 -0.37 5.0 5.0 ARF6/GTP 0.059 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.02 0.168 -9999.0 0.0 -0.654 5.0 5.0 EGFR/EGFR/EGF/EGF -0.261 0.179 -9999.0 0.0 -0.388 45.0 45.0 RhoA/GDP 0.023 0.106 -9999.0 0.0 -0.366 5.0 5.0 actin cytoskeleton organization -0.025 0.113 0.321 2.0 -0.36 5.0 7.0 IGF-1R heterotetramer 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.017 0.078 -9999.0 0.0 -0.654 1.0 1.0 DIAPH1 0.022 0.121 -9999.0 0.0 -0.568 1.0 1.0 Wnt receptor signaling pathway -0.021 0.108 0.379 5.0 -9999.0 0.0 5.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.074 -9999.0 0.0 -0.347 4.0 4.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.026 0.116 0.324 2.0 -0.369 5.0 7.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.03 0.108 0.33 1.0 -0.358 5.0 6.0 Ephrin A1/EPHA2 0.015 0.103 -9999.0 0.0 -0.364 5.0 5.0 SEC6/SEC8 -0.049 0.083 -9999.0 0.0 -0.354 5.0 5.0 MGAT3 -0.045 0.146 0.341 2.0 -0.418 7.0 9.0 HGF/MET 0.002 0.114 -9999.0 0.0 -0.365 6.0 6.0 HGF 0.004 0.109 -9999.0 0.0 -0.654 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.006 0.078 -9999.0 0.0 -0.294 5.0 5.0 actin cable formation 0.016 0.163 0.541 5.0 -9999.0 0.0 5.0 KIAA1543 -0.021 0.115 0.327 2.0 -0.353 5.0 7.0 KIFC3 -0.042 0.093 -9999.0 0.0 -0.37 5.0 5.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.021 0.121 0.341 2.0 -0.37 5.0 7.0 NCK1/GIT1 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.021 0.108 -9999.0 0.0 -0.379 5.0 5.0 EXOC4 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.043 0.09 -9999.0 0.0 -0.37 5.0 5.0 PIP5K1C -0.022 0.121 0.341 2.0 -0.37 5.0 7.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.153 0.458 5.0 -9999.0 0.0 5.0 adherens junction assembly -0.003 0.133 0.393 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer/IGF1 0.01 0.112 -9999.0 0.0 -0.365 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.022 0.121 0.341 2.0 -0.37 5.0 7.0 mol:GTP 0.055 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.028 0.11 0.311 1.0 -0.347 5.0 6.0 cortical actin cytoskeleton stabilization -0.006 0.078 -9999.0 0.0 -0.292 5.0 5.0 regulation of cell-cell adhesion -0.025 0.113 0.321 2.0 -0.36 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.006 0.078 -9999.0 0.0 -0.294 5.0 5.0