Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	35.0	1215.0	34.0	-0.498	0.027	1000.0	-1000.0	-0.041	-1000.0
FOXA2 and FOXA3 transcription factor networks	29.0	1348.0	46.0	-1.185	0.028	1000.0	-1000.0	-0.069	-1000.0
EGFR-dependent Endothelin signaling events	21.0	442.0	21.0	-0.517	0.035	1000.0	-1000.0	-0.056	-1000.0
Angiopoietin receptor Tie2-mediated signaling	17.0	1531.0	88.0	-0.686	0.061	1000.0	-1000.0	-0.071	-1000.0
Glypican 1 network	11.0	533.0	48.0	-0.364	0.048	1000.0	-1000.0	-0.043	-1000.0
PDGFR-alpha signaling pathway	10.0	452.0	44.0	-0.243	0.033	1000.0	-1000.0	-0.058	-1000.0
Thromboxane A2 receptor signaling	9.0	1041.0	105.0	-0.517	0.077	1000.0	-1000.0	-0.05	-1000.0
BMP receptor signaling	8.0	661.0	81.0	-0.36	0.051	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	308.0	44.0	-0.107	0.026	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	6.0	406.0	62.0	-0.517	0.057	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PTP1B	6.0	473.0	76.0	-0.52	0.09	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	6.0	566.0	91.0	-0.831	0.359	1000.0	-1000.0	-0.105	-1000.0
amb2 Integrin signaling	6.0	530.0	82.0	-0.5	0.058	1000.0	-1000.0	-0.046	-1000.0
Endothelins	6.0	586.0	96.0	-0.542	0.049	1000.0	-1000.0	-0.069	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	779.0	120.0	-0.193	0.132	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	471.0	78.0	-0.219	0.049	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by the Hedgehog family	5.0	300.0	52.0	-0.085	0.038	1000.0	-1000.0	-0.043	-1000.0
FoxO family signaling	5.0	340.0	64.0	-1.017	0.069	1000.0	-1000.0	-0.055	-1000.0
Integrins in angiogenesis	5.0	496.0	84.0	-0.434	0.057	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	676.0	125.0	-0.101	0.055	1000.0	-1000.0	-0.079	-1000.0
FOXM1 transcription factor network	5.0	288.0	51.0	0.023	0.223	1000.0	-1000.0	-0.107	-1000.0
Ceramide signaling pathway	4.0	348.0	76.0	-0.517	0.185	1000.0	-1000.0	-0.047	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	440.0	93.0	-0.182	0.107	1000.0	-1000.0	-0.056	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	357.0	74.0	-0.517	0.059	1000.0	-1000.0	-0.078	-1000.0
Noncanonical Wnt signaling pathway	3.0	95.0	26.0	-0.219	0.04	1000.0	-1000.0	-0.051	-1000.0
p75(NTR)-mediated signaling	3.0	435.0	125.0	-0.465	0.07	1000.0	-1000.0	-0.087	-1000.0
Glucocorticoid receptor regulatory network	3.0	452.0	114.0	-0.444	0.141	1000.0	-1000.0	-0.061	-1000.0
ceramide signaling pathway	3.0	151.0	49.0	-0.022	0.038	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	3.0	109.0	36.0	-0.09	0.026	1000.0	-1000.0	-0.05	-1000.0
Nongenotropic Androgen signaling	3.0	168.0	52.0	-0.134	0.059	1000.0	-1000.0	-0.038	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	263.0	68.0	-0.391	0.077	1000.0	-1000.0	-0.08	-1000.0
IL23-mediated signaling events	3.0	187.0	60.0	-0.023	0.05	1000.0	-1000.0	-0.094	-1000.0
Plasma membrane estrogen receptor signaling	3.0	274.0	86.0	-0.081	0.047	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in keratinocytes	3.0	150.0	43.0	-0.206	0.029	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling events	3.0	15.0	5.0	-0.02	0.026	1000.0	-1000.0	0.003	-1000.0
LPA4-mediated signaling events	2.0	28.0	12.0	-0.094	0.007	1000.0	-1000.0	-0.032	-1000.0
ErbB2/ErbB3 signaling events	2.0	147.0	65.0	-0.035	0.065	1000.0	-1000.0	-0.064	-1000.0
Caspase cascade in apoptosis	2.0	201.0	74.0	-0.403	0.067	1000.0	-1000.0	-0.05	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	297.0	136.0	-0.387	0.086	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	2.0	201.0	76.0	-0.69	0.083	1000.0	-1000.0	-0.034	-1000.0
Osteopontin-mediated events	2.0	82.0	38.0	-0.087	0.049	1000.0	-1000.0	-0.054	-1000.0
Ephrin A  reverse signaling	2.0	15.0	7.0	-0.025	0.016	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	2.0	217.0	76.0	-0.086	0.157	1000.0	-1000.0	-0.065	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	230.0	85.0	-0.118	0.116	1000.0	-1000.0	-0.046	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	146.0	61.0	-0.094	0.07	1000.0	-1000.0	-0.048	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	198.0	97.0	-0.087	0.09	1000.0	-1000.0	-0.078	-1000.0
IFN-gamma pathway	2.0	165.0	68.0	-0.409	0.064	1000.0	-1000.0	-0.065	-1000.0
Reelin signaling pathway	2.0	112.0	56.0	-0.066	0.062	1000.0	-1000.0	-0.049	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	187.0	82.0	-0.056	0.031	1000.0	-1000.0	-0.065	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	129.0	52.0	-0.225	0.074	1000.0	-1000.0	-0.048	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	35.0	15.0	-0.017	0.027	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	2.0	82.0	35.0	-0.086	0.07	1000.0	-1000.0	-0.047	-1000.0
Effects of Botulinum toxin	2.0	72.0	26.0	-0.164	0.078	1000.0	-1000.0	-0.018	-1000.0
IL27-mediated signaling events	2.0	110.0	51.0	-0.837	0.311	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	183.0	76.0	-0.049	0.046	1000.0	-1000.0	-0.068	-1000.0
Regulation of Telomerase	2.0	224.0	102.0	-0.516	0.063	1000.0	-1000.0	-0.057	-1000.0
Regulation of Androgen receptor activity	2.0	141.0	70.0	-0.782	0.043	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	1.0	102.0	87.0	-0.184	0.066	1000.0	-1000.0	-0.08	-1000.0
ErbB4 signaling events	1.0	136.0	69.0	-0.218	0.096	1000.0	-1000.0	-0.057	-1000.0
Syndecan-1-mediated signaling events	1.0	44.0	34.0	-0.025	0.039	1000.0	-1000.0	-0.058	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	31.0	28.0	-0.078	0.049	1000.0	-1000.0	-0.034	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	69.0	54.0	-0.019	0.078	1000.0	-1000.0	-0.071	-1000.0
Syndecan-2-mediated signaling events	1.0	128.0	69.0	-0.5	0.059	1000.0	-1000.0	-0.047	-1000.0
Cellular roles of Anthrax toxin	1.0	62.0	39.0	-0.108	0.034	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	1.0	140.0	85.0	-0.009	0.063	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	1.0	74.0	43.0	-0.133	0.074	1000.0	-1000.0	-0.061	-1000.0
Ephrin B reverse signaling	1.0	80.0	48.0	-0.051	0.053	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	1.0	85.0	58.0	-0.032	0.064	1000.0	-1000.0	-0.056	-1000.0
Canonical Wnt signaling pathway	1.0	76.0	51.0	-0.094	0.071	1000.0	-1000.0	-0.061	-1000.0
EPHB forward signaling	1.0	152.0	85.0	-0.059	0.062	1000.0	-1000.0	-0.083	-1000.0
Regulation of p38-alpha and p38-beta	1.0	97.0	54.0	-0.063	0.06	1000.0	-1000.0	-0.053	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	43.0	31.0	-0.089	0.051	1000.0	-1000.0	-0.045	-1000.0
Wnt signaling	1.0	8.0	7.0	-0.007	0.04	1000.0	-1000.0	-0.027	-1000.0
TCGA08_rtk_signaling	1.0	50.0	26.0	-0.122	0.068	1000.0	-1000.0	-0.017	-1000.0
LPA receptor mediated events	1.0	139.0	102.0	-0.087	0.04	1000.0	-1000.0	-0.066	-1000.0
IL6-mediated signaling events	1.0	124.0	75.0	-0.272	0.039	1000.0	-1000.0	-0.053	-1000.0
Arf6 trafficking events	1.0	116.0	71.0	-0.249	0.042	1000.0	-1000.0	-0.037	-1000.0
BCR signaling pathway	1.0	189.0	99.0	-0.062	0.07	1000.0	-1000.0	-0.075	-1000.0
Syndecan-4-mediated signaling events	1.0	129.0	67.0	-0.458	0.151	1000.0	-1000.0	-0.057	-1000.0
S1P3 pathway	1.0	68.0	42.0	-0.078	0.039	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	1.0	190.0	97.0	-0.032	0.063	1000.0	-1000.0	-0.07	-1000.0
Visual signal transduction: Rods	1.0	101.0	52.0	-0.128	0.055	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PRL	1.0	40.0	34.0	-0.042	0.038	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.018	0.018	1000.0	-1000.0	-0.01	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	32.0	17.0	-0.022	0.038	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.019	0.043	1000.0	-1000.0	-0.034	-1000.0
Canonical NF-kappaB pathway	0.0	5.0	39.0	-0.016	0.053	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class II	0.0	37.0	75.0	-0.063	0.061	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	0.0	33.0	57.0	-0.051	0.066	1000.0	-1000.0	-0.058	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.009	-1000.0	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	0.0	21.0	38.0	-0.02	0.048	1000.0	-1000.0	-0.033	-1000.0
Circadian rhythm pathway	0.0	0.0	22.0	-0.013	0.057	1000.0	-1000.0	-0.043	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	6.0	17.0	0.014	0.063	1000.0	-1000.0	-0.041	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.026	0.038	1000.0	-1000.0	0.003	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	44.0	65.0	-0.004	0.063	1000.0	-1000.0	-0.046	-1000.0
Aurora A signaling	0.0	4.0	60.0	-0.008	0.064	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	0.0	30.0	43.0	-0.041	0.042	1000.0	-1000.0	-0.036	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.069	1000.0	-1000.0	-0.022	-1000.0
EPO signaling pathway	0.0	43.0	55.0	-0.011	0.052	1000.0	-1000.0	-0.053	-1000.0
Insulin-mediated glucose transport	0.0	20.0	32.0	-0.017	0.056	1000.0	-1000.0	-0.036	-1000.0
mTOR signaling pathway	0.0	52.0	53.0	-0.023	0.046	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.026	0.056	1000.0	-1000.0	-0.041	-1000.0
Nectin adhesion pathway	0.0	45.0	63.0	-0.02	0.071	1000.0	-1000.0	-0.058	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	0.0	37.0	-0.014	0.069	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	0.0	5.0	40.0	-0.046	0.047	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	0.0	4.0	48.0	-0.016	0.063	1000.0	-1000.0	-0.047	-1000.0
IL1-mediated signaling events	0.0	59.0	62.0	-0.073	0.078	1000.0	-1000.0	-0.083	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.011	0.026	1000.0	-1000.0	-0.022	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	79.0	83.0	-0.22	0.056	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class I	0.0	43.0	104.0	-0.063	0.064	1000.0	-1000.0	-0.043	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.033	0.025	1000.0	-1000.0	-0.016	-1000.0
FAS signaling pathway (CD95)	0.0	38.0	47.0	-0.09	0.038	1000.0	-1000.0	-0.04	-1000.0
Retinoic acid receptors-mediated signaling	0.0	44.0	58.0	-0.01	0.06	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.047	0.055	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	0.0	4.0	31.0	-0.017	0.038	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	33.0	45.0	-0.01	0.067	1000.0	-1000.0	-0.057	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.04	0.051	1000.0	-1000.0	0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.021	0.059	1000.0	-1000.0	-0.046	-1000.0
IL2 signaling events mediated by STAT5	0.0	4.0	22.0	-0.007	0.06	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	0.0	59.0	73.0	-0.031	0.042	1000.0	-1000.0	-0.054	-1000.0
TCGA08_retinoblastoma	0.0	6.0	8.0	-0.021	0.085	1000.0	-1000.0	-0.006	-1000.0
IGF1 pathway	0.0	35.0	57.0	-0.035	0.061	1000.0	-1000.0	-0.073	-1000.0
Insulin Pathway	0.0	39.0	74.0	-0.057	0.063	1000.0	-1000.0	-0.065	-1000.0
VEGFR1 specific signals	0.0	10.0	56.0	-0.021	0.064	1000.0	-1000.0	-0.068	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	26.0	33.0	-0.016	0.082	1000.0	-1000.0	-0.039	-1000.0
Rapid glucocorticoid signaling	0.0	1.0	20.0	-0.01	0.033	1000.0	-1000.0	-0.015	-1000.0
S1P4 pathway	0.0	9.0	25.0	-0.001	0.039	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	0.0	14.0	44.0	-0.0	0.043	1000.0	-1000.0	-0.035	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.009	0.054	1000.0	-1000.0	-0.027	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.065	1000.0	-1000.0	0.0	-1000.0
Aurora B signaling	0.0	43.0	67.0	-0.146	0.122	1000.0	-1000.0	-0.044	-1000.0
Total	331	23574	7203	-22.5587378779	-991.567227985	131000	-131000	-6.37768912515	-131000