Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0 epithelial cell differentiation 0.005 0.107 -9999.0 0.0 -0.207 3.0 3.0 CYFIP2 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.05 0.204 0.695 1.0 -9999.0 0.0 1.0 EGFR -0.037 0.129 -9999.0 0.0 -0.366 2.0 2.0 EPHA2 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.047 0.128 0.332 1.0 -9999.0 0.0 1.0 CTNNB1 -0.045 0.154 -9999.0 0.0 -0.366 3.0 3.0 ABI1/Sra1/Nap1 0.057 0.023 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.045 0.072 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.047 0.128 0.329 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.127 0.329 1.0 -9999.0 0.0 1.0 EGF -0.023 0.104 -9999.0 0.0 -0.176 4.0 4.0 NCKAP1 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.08 0.154 -9999.0 0.0 -0.466 2.0 2.0 cortical microtubule organization 0.005 0.107 -9999.0 0.0 -0.207 3.0 3.0 GO:0000145 -0.046 0.12 0.311 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.009 0.11 -9999.0 0.0 -0.209 3.0 3.0 MLLT4 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.097 0.068 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.04 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.051 0.088 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.055 0.091 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.069 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.016 0.102 -9999.0 0.0 -0.366 1.0 1.0 EGFR/EGFR/EGF/EGF -0.098 0.121 -9999.0 0.0 -0.257 5.0 5.0 RhoA/GDP -0.016 0.12 -9999.0 0.0 -0.215 4.0 4.0 actin cytoskeleton organization -0.053 0.122 0.306 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.02 0.035 -9999.0 0.0 -0.113 1.0 1.0 DIAPH1 0.013 0.146 -9999.0 0.0 -0.546 1.0 1.0 Wnt receptor signaling pathway -0.005 0.107 0.207 3.0 -9999.0 0.0 3.0 RHOA 0.004 0.096 -9999.0 0.0 -0.366 1.0 1.0 RhoA/GTP -0.107 0.079 -9999.0 0.0 -0.239 2.0 2.0 CTNNA1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.055 0.124 0.308 1.0 -9999.0 0.0 1.0 EFNA1 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.074 0.08 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.021 0.105 -9999.0 0.0 -0.213 3.0 3.0 SEC6/SEC8 -0.077 0.078 -9999.0 0.0 -0.219 2.0 2.0 MGAT3 -0.047 0.128 0.332 1.0 -9999.0 0.0 1.0 HGF/MET -0.028 0.084 -9999.0 0.0 -0.212 2.0 2.0 HGF 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.054 0.092 -9999.0 0.0 -0.206 4.0 4.0 actin cable formation -0.004 0.227 0.767 1.0 -0.277 1.0 2.0 KIAA1543 -0.041 0.121 0.313 1.0 -9999.0 0.0 1.0 KIFC3 -0.088 0.073 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.128 0.332 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.005 0.107 -9999.0 0.0 -0.207 3.0 3.0 EXOC4 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.076 0.068 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.048 0.129 0.332 1.0 -9999.0 0.0 1.0 LIMA1 0.004 0.096 -9999.0 0.0 -0.366 1.0 1.0 ABI1 0.029 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.045 0.221 0.735 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.042 0.168 0.44 1.0 -0.301 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.025 0.107 -9999.0 0.0 -0.219 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.042 0.129 0.332 1.0 -9999.0 0.0 1.0 mol:GTP 0.059 0.039 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.049 0.114 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.053 0.092 -9999.0 0.0 -0.205 4.0 4.0 regulation of cell-cell adhesion -0.053 0.122 0.306 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.054 0.092 -9999.0 0.0 -0.206 4.0 4.0