Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.073 0.117 0.224 61.0 -9999.0 0.0 61.0 KIRREL -0.108 0.165 -9999.0 0.0 -0.325 61.0 61.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.073 0.117 -9999.0 0.0 -0.224 61.0 61.0 PLCG1 -0.006 0.087 -9999.0 0.0 -0.322 12.0 12.0 ARRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.042 0.092 -9999.0 0.0 -0.199 32.0 32.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.029 0.086 -9999.0 0.0 -0.197 31.0 31.0 FYN -0.044 0.085 -9999.0 0.0 -0.189 34.0 34.0 mol:Ca2+ -0.054 0.099 -9999.0 0.0 -0.204 40.0 40.0 mol:DAG -0.054 0.099 -9999.0 0.0 -0.205 40.0 40.0 NPHS2 -0.013 0.04 -9999.0 0.0 -0.291 3.0 3.0 mol:IP3 -0.054 0.099 -9999.0 0.0 -0.205 40.0 40.0 regulation of endocytosis -0.032 0.082 -9999.0 0.0 -0.174 32.0 32.0 Nephrin/NEPH1/podocin/Cholesterol -0.051 0.087 -9999.0 0.0 -0.166 54.0 54.0 establishment of cell polarity -0.073 0.117 -9999.0 0.0 -0.224 61.0 61.0 Nephrin/NEPH1/podocin/NCK1-2 -0.027 0.083 -9999.0 0.0 -0.169 31.0 31.0 Nephrin/NEPH1/beta Arrestin2 -0.032 0.083 -9999.0 0.0 -0.176 32.0 32.0 NPHS1 -0.008 0.029 -9999.0 0.0 -0.316 1.0 1.0 Nephrin/NEPH1/podocin -0.046 0.084 -9999.0 0.0 -0.19 34.0 34.0 TJP1 -0.04 0.123 -9999.0 0.0 -0.313 28.0 28.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.054 0.1 -9999.0 0.0 -0.206 40.0 40.0 CD2AP 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 Nephrin/NEPH1/podocin/GRB2 -0.041 0.089 -9999.0 0.0 -0.193 32.0 32.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.055 0.085 -9999.0 0.0 -0.186 37.0 37.0 cytoskeleton organization -0.031 0.09 -9999.0 0.0 -0.201 31.0 31.0 Nephrin/NEPH1 -0.047 0.08 -9999.0 0.0 -0.185 32.0 32.0 Nephrin/NEPH1/ZO-1 -0.079 0.11 -9999.0 0.0 -0.21 60.0 60.0