Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.028 0.091 -9999.0 0.0 -0.191 35.0 35.0 epithelial cell differentiation -0.03 0.091 -9999.0 0.0 -0.177 34.0 34.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 ENAH -0.054 0.1 -9999.0 0.0 -0.223 30.0 30.0 EGFR 0.001 0.046 -9999.0 0.0 -0.262 5.0 5.0 EPHA2 -0.058 0.136 -9999.0 0.0 -0.309 38.0 38.0 MYO6 -0.037 0.098 -9999.0 0.0 -0.179 40.0 40.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.085 -9999.0 0.0 -0.221 15.0 15.0 AQP5 -0.026 0.081 -9999.0 0.0 -0.284 3.0 3.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 mol:PI-4-5-P2 -0.026 0.083 -9999.0 0.0 -0.161 34.0 34.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.114 -9999.0 0.0 -0.214 41.0 41.0 EGF -0.087 0.157 -9999.0 0.0 -0.318 53.0 53.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 AQP3 -0.03 0.105 -9999.0 0.0 -0.35 8.0 8.0 cortical microtubule organization -0.03 0.091 -9999.0 0.0 -0.177 34.0 34.0 GO:0000145 -0.026 0.078 -9999.0 0.0 -0.154 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GDP -0.073 0.083 -9999.0 0.0 -0.279 14.0 14.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.024 0.101 -9999.0 0.0 -0.215 26.0 26.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.079 -9999.0 0.0 -0.3 2.0 2.0 PVRL2 -0.006 0.093 -9999.0 0.0 -0.381 10.0 10.0 ZYX -0.026 0.084 -9999.0 0.0 -0.163 34.0 34.0 ARF6/GTP -0.015 0.094 -9999.0 0.0 -0.193 26.0 26.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 EGFR/EGFR/EGF/EGF -0.087 0.093 -9999.0 0.0 -0.196 52.0 52.0 RhoA/GDP -0.024 0.085 -9999.0 0.0 -0.162 34.0 34.0 actin cytoskeleton organization -0.033 0.096 -9999.0 0.0 -0.174 41.0 41.0 IGF-1R heterotetramer -0.026 0.121 -9999.0 0.0 -0.357 20.0 20.0 GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.026 0.121 -9999.0 0.0 -0.357 20.0 20.0 IGF1 -0.034 0.125 -9999.0 0.0 -0.334 25.0 25.0 DIAPH1 -0.043 0.177 -9999.0 0.0 -0.604 15.0 15.0 Wnt receptor signaling pathway 0.03 0.091 0.177 34.0 -9999.0 0.0 34.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.073 0.083 -9999.0 0.0 -0.279 14.0 14.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 VCL -0.034 0.098 -9999.0 0.0 -0.177 41.0 41.0 EFNA1 -0.034 0.115 -9999.0 0.0 -0.287 29.0 29.0 LPP -0.02 0.08 -9999.0 0.0 -0.15 34.0 34.0 Ephrin A1/EPHA2 -0.089 0.098 -9999.0 0.0 -0.253 30.0 30.0 SEC6/SEC8 -0.064 0.085 -9999.0 0.0 -0.257 19.0 19.0 MGAT3 -0.047 0.115 -9999.0 0.0 -0.217 41.0 41.0 HGF/MET -0.082 0.09 -9999.0 0.0 -0.225 27.0 27.0 HGF -0.073 0.156 -9999.0 0.0 -0.331 45.0 45.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.029 0.091 -9999.0 0.0 -0.192 35.0 35.0 actin cable formation -0.032 0.093 -9999.0 0.0 -0.219 15.0 15.0 KIAA1543 -0.035 0.095 -9999.0 0.0 -0.217 19.0 19.0 KIFC3 -0.04 0.098 -9999.0 0.0 -0.188 39.0 39.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.026 0.084 -9999.0 0.0 -0.163 34.0 34.0 NCK1/GIT1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.03 0.091 -9999.0 0.0 -0.177 34.0 34.0 EXOC4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.084 -9999.0 0.0 -0.163 34.0 34.0 PIP5K1C -0.026 0.084 -9999.0 0.0 -0.163 34.0 34.0 LIMA1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.041 0.094 -9999.0 0.0 -0.245 14.0 14.0 adherens junction assembly -0.036 0.113 -9999.0 0.0 -0.301 15.0 15.0 IGF-1R heterotetramer/IGF1 -0.081 0.095 -9999.0 0.0 -0.23 33.0 33.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.028 0.106 -9999.0 0.0 -0.22 38.0 38.0 MET 0.003 0.055 -9999.0 0.0 -0.262 7.0 7.0 PLEKHA7 -0.037 0.095 -9999.0 0.0 -0.18 40.0 40.0 mol:GTP -0.024 0.1 -9999.0 0.0 -0.214 26.0 26.0 establishment of epithelial cell apical/basal polarity -0.032 0.102 -9999.0 0.0 -0.243 19.0 19.0 cortical actin cytoskeleton stabilization -0.028 0.091 -9999.0 0.0 -0.191 35.0 35.0 regulation of cell-cell adhesion -0.033 0.096 -9999.0 0.0 -0.174 41.0 41.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.029 0.091 -9999.0 0.0 -0.192 35.0 35.0