E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.071 0.183 -9999.0 0.0 -0.427 31.0 31.0 KLHL20 -0.022 0.098 0.168 1.0 -0.211 23.0 24.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.337 2.0 2.0 Rac1/GDP -0.04 0.116 -9999.0 0.0 -0.247 29.0 29.0 ENAH -0.063 0.173 -9999.0 0.0 -0.401 31.0 31.0 AP1M1 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.094 -9999.0 0.0 -0.19 28.0 28.0 ABI1/Sra1/Nap1 -0.038 0.06 -9999.0 0.0 -0.161 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.096 -9999.0 0.0 -0.177 28.0 28.0 RAPGEF1 -0.065 0.147 -9999.0 0.0 -0.344 31.0 31.0 CTNND1 0.024 0.049 -9999.0 0.0 -0.337 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.052 0.169 -9999.0 0.0 -0.387 31.0 31.0 CRK -0.064 0.156 -9999.0 0.0 -0.374 29.0 29.0 E-cadherin/gamma catenin/alpha catenin -0.014 0.123 -9999.0 0.0 -0.222 40.0 40.0 alphaE/beta7 Integrin 0.036 0.044 -9999.0 0.0 -0.228 4.0 4.0 IQGAP1 0.029 0.029 -9999.0 0.0 -0.337 1.0 1.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.337 13.0 13.0 Rap1/GTP/I-afadin 0.044 0.055 -9999.0 0.0 -0.178 9.0 9.0 DLG1 -0.053 0.16 -9999.0 0.0 -0.386 29.0 29.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.063 -9999.0 0.0 -0.145 28.0 28.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.337 9.0 9.0 ARF6/GTP/NME1/Tiam1 0.038 0.061 -9999.0 0.0 -0.178 11.0 11.0 PI3K -0.032 0.082 -9999.0 0.0 -0.184 28.0 28.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.028 0.131 -9999.0 0.0 -0.267 36.0 36.0 TIAM1 0.003 0.091 -9999.0 0.0 -0.337 11.0 11.0 E-cadherin(dimer)/Ca2+ 0.018 0.096 -9999.0 0.0 -0.175 31.0 31.0 AKT1 -0.026 0.049 -9999.0 0.0 -0.147 9.0 9.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.033 0.132 -9999.0 0.0 -0.337 26.0 26.0 RhoA/GDP -0.041 0.118 -9999.0 0.0 -0.244 31.0 31.0 actin cytoskeleton organization -0.013 0.076 0.145 4.0 -0.156 22.0 26.0 CDC42/GDP -0.042 0.119 0.269 1.0 -0.243 32.0 33.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.04 0.109 -9999.0 0.0 -0.213 43.0 43.0 ITGB7 0.023 0.057 -9999.0 0.0 -0.337 4.0 4.0 RAC1 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.02 0.103 -9999.0 0.0 -0.187 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.01 0.085 -9999.0 0.0 -0.172 28.0 28.0 mol:GDP -0.06 0.125 -9999.0 0.0 -0.277 32.0 32.0 CDC42/GTP/IQGAP1 0.04 0.021 -9999.0 0.0 -0.195 1.0 1.0 JUP -0.008 0.111 -9999.0 0.0 -0.337 17.0 17.0 p120 catenin/RhoA/GDP -0.037 0.123 -9999.0 0.0 -0.253 30.0 30.0 RAC1/GTP/IQGAP1 0.036 0.022 -9999.0 0.0 -0.169 1.0 1.0 PIP5K1C/AP1M1 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.337 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.013 0.052 -9999.0 0.0 -0.136 14.0 14.0 NME1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.063 0.166 -9999.0 0.0 -0.389 31.0 31.0 regulation of cell-cell adhesion -0.024 0.079 -9999.0 0.0 -0.169 28.0 28.0 WASF2 -0.01 0.042 0.082 1.0 -0.094 18.0 19.0 Rap1/GTP -0.023 0.104 0.175 2.0 -0.209 28.0 30.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.01 0.123 -9999.0 0.0 -0.191 41.0 41.0 CCND1 -0.016 0.063 -9999.0 0.0 -0.167 14.0 14.0 VAV2 -0.092 0.218 -9999.0 0.0 -0.55 21.0 21.0 RAP1/GDP -0.028 0.11 -9999.0 0.0 -0.226 24.0 24.0 adherens junction assembly -0.062 0.161 -9999.0 0.0 -0.377 31.0 31.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.002 0.11 -9999.0 0.0 -0.188 39.0 39.0 E-cadherin/beta catenin -0.027 0.102 -9999.0 0.0 -0.274 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.07 0.167 -9999.0 0.0 -0.387 32.0 32.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.063 0.131 -9999.0 0.0 -0.333 24.0 24.0 E-cadherin/beta catenin/alpha catenin 0.01 0.1 -9999.0 0.0 -0.205 28.0 28.0 ITGAE 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.053 0.172 -9999.0 0.0 -0.395 31.0 31.0