Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.022 0.071 -9999.0 0.0 -0.358 5.0 5.0 IHH 0.034 0.037 -9999.0 0.0 -0.148 5.0 5.0 SHH Np/Cholesterol/GAS1 0.004 0.058 -9999.0 0.0 -0.176 15.0 15.0 LRPAP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.058 0.175 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 -0.007 0.13 -9999.0 0.0 -0.423 7.0 7.0 SMO -0.015 0.121 -9999.0 0.0 -0.292 20.0 20.0 AKT1 0.017 0.068 -9999.0 0.0 -0.426 1.0 1.0 ARRB2 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.029 -9999.0 0.0 -0.337 1.0 1.0 ADRBK1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.12 -9999.0 0.0 -0.307 16.0 16.0 STIL 0.008 0.067 0.185 2.0 -0.314 5.0 7.0 DHH N/PTCH2 0.04 0.033 -9999.0 0.0 -0.237 2.0 2.0 DHH N/PTCH1 0.033 0.071 -9999.0 0.0 -0.362 5.0 5.0 PIK3CA 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.017 0.086 -9999.0 0.0 -0.447 5.0 5.0 determination of left/right symmetry -0.015 0.12 -9999.0 0.0 -0.307 16.0 16.0 PIK3R1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.018 0.085 -9999.0 0.0 -0.444 5.0 5.0 IHH N/Hhip 0.019 0.079 -9999.0 0.0 -0.26 11.0 11.0 DHH N/Hhip 0.02 0.07 -9999.0 0.0 -0.237 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.12 -9999.0 0.0 -0.307 16.0 16.0 pancreas development 0.0 0.091 -9999.0 0.0 -0.337 11.0 11.0 HHAT 0.025 0.049 -9999.0 0.0 -0.337 3.0 3.0 PI3K 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.0 0.095 -9999.0 0.0 -0.337 12.0 12.0 somite specification -0.015 0.12 -9999.0 0.0 -0.307 16.0 16.0 SHH Np/Cholesterol/PTCH1 0.014 0.064 -9999.0 0.0 -0.298 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.019 0.036 -9999.0 0.0 -0.175 5.0 5.0 SHH Np/Cholesterol/Megalin 0.019 0.027 -9999.0 0.0 -0.165 3.0 3.0 SHH -0.001 0.029 -9999.0 0.0 -0.237 2.0 2.0 catabolic process 0.013 0.075 -9999.0 0.0 -0.403 5.0 5.0 SMO/Vitamin D3 -0.007 0.089 -9999.0 0.0 -0.434 5.0 5.0 SHH Np/Cholesterol/Hhip 0.003 0.056 -9999.0 0.0 -0.176 14.0 14.0 LRP2 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.001 0.092 -9999.0 0.0 -0.475 5.0 5.0 SHH Np/Cholesterol/BOC 0.02 0.032 -9999.0 0.0 -0.168 4.0 4.0 SHH Np/Cholesterol/CDO 0.015 0.039 -9999.0 0.0 -0.175 6.0 6.0 mesenchymal cell differentiation -0.003 0.055 0.175 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.015 0.069 0.192 4.0 -0.327 5.0 9.0 IHH N/PTCH2 0.041 0.043 -9999.0 0.0 -0.261 2.0 2.0 CDON 0.02 0.05 -9999.0 0.0 -0.337 3.0 3.0 IHH N/PTCH1 0.023 0.078 -9999.0 0.0 -0.405 5.0 5.0 Megalin/LRPAP1 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.041 -9999.0 0.0 -0.337 2.0 2.0 SHH Np/Cholesterol 0.016 0.027 -9999.0 0.0 -0.168 3.0 3.0 PTCH1 0.013 0.075 -9999.0 0.0 -0.404 5.0 5.0 HHIP 0.0 0.091 -9999.0 0.0 -0.337 11.0 11.0