Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.086 -9999.0 0.0 -0.189 31.0 31.0 epithelial cell differentiation 0.014 0.093 -9999.0 0.0 -0.173 31.0 31.0 CYFIP2 0.026 0.041 -9999.0 0.0 -0.337 2.0 2.0 ENAH -0.044 0.091 0.224 4.0 -0.25 12.0 16.0 EGFR 0.021 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 -0.006 0.101 -9999.0 0.0 -0.337 14.0 14.0 MYO6 -0.03 0.088 0.2 6.0 -0.178 32.0 38.0 CTNNB1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.035 0.078 -9999.0 0.0 -0.211 14.0 14.0 AQP5 -0.021 0.078 -9999.0 0.0 -0.332 3.0 3.0 CTNND1 0.024 0.05 -9999.0 0.0 -0.337 3.0 3.0 mol:PI-4-5-P2 -0.025 0.073 0.205 5.0 -0.162 26.0 31.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.097 0.198 4.0 -0.219 30.0 34.0 EGF -0.026 0.125 -9999.0 0.0 -0.337 23.0 23.0 NCKAP1 -0.001 0.099 -9999.0 0.0 -0.337 13.0 13.0 AQP3 -0.018 0.088 -9999.0 0.0 -0.427 3.0 3.0 cortical microtubule organization 0.014 0.093 -9999.0 0.0 -0.173 31.0 31.0 GO:0000145 -0.026 0.068 0.194 5.0 -0.154 27.0 32.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.096 -9999.0 0.0 -0.174 31.0 31.0 MLLT4 0.008 0.083 -9999.0 0.0 -0.337 9.0 9.0 ARF6/GDP -0.055 0.079 -9999.0 0.0 -0.181 40.0 40.0 ARF6 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.041 0.087 -9999.0 0.0 -0.194 18.0 18.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.072 0.183 2.0 -0.268 5.0 7.0 PVRL2 0.007 0.088 -9999.0 0.0 -0.337 10.0 10.0 ZYX -0.026 0.073 0.199 4.0 -0.169 27.0 31.0 ARF6/GTP 0.049 0.087 -9999.0 0.0 -0.183 18.0 18.0 CDH1 -0.033 0.132 -9999.0 0.0 -0.337 26.0 26.0 EGFR/EGFR/EGF/EGF -0.022 0.104 -9999.0 0.0 -0.177 48.0 48.0 RhoA/GDP 0.016 0.092 -9999.0 0.0 -0.167 31.0 31.0 actin cytoskeleton organization -0.033 0.087 0.193 6.0 -0.185 29.0 35.0 IGF-1R heterotetramer -0.001 0.102 -9999.0 0.0 -0.337 14.0 14.0 GIT1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.001 0.102 -9999.0 0.0 -0.337 14.0 14.0 IGF1 0.0 0.099 -9999.0 0.0 -0.337 13.0 13.0 DIAPH1 -0.014 0.204 -9999.0 0.0 -0.567 18.0 18.0 Wnt receptor signaling pathway -0.014 0.093 0.173 31.0 -9999.0 0.0 31.0 RHOA 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.079 -9999.0 0.0 -0.182 40.0 40.0 CTNNA1 0.021 0.057 -9999.0 0.0 -0.337 4.0 4.0 VCL -0.035 0.087 0.189 5.0 -0.188 29.0 34.0 EFNA1 0.014 0.069 -9999.0 0.0 -0.337 6.0 6.0 LPP -0.03 0.078 0.203 6.0 -0.164 31.0 37.0 Ephrin A1/EPHA2 -0.013 0.111 -9999.0 0.0 -0.19 43.0 43.0 SEC6/SEC8 -0.051 0.077 -9999.0 0.0 -0.185 34.0 34.0 MGAT3 -0.039 0.099 0.2 4.0 -0.222 30.0 34.0 HGF/MET -0.019 0.104 -9999.0 0.0 -0.174 47.0 47.0 HGF -0.024 0.123 -9999.0 0.0 -0.337 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.087 -9999.0 0.0 -0.191 31.0 31.0 actin cable formation -0.031 0.114 0.392 4.0 -0.241 15.0 19.0 KIAA1543 -0.034 0.07 0.192 2.0 -0.166 29.0 31.0 KIFC3 -0.034 0.086 0.203 4.0 -0.187 31.0 35.0 NCK1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.084 0.21 7.0 -0.168 31.0 38.0 NCK1/GIT1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.014 0.093 -9999.0 0.0 -0.173 31.0 31.0 EXOC4 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.078 0.192 5.0 -0.168 31.0 36.0 PIP5K1C -0.025 0.074 0.207 5.0 -0.164 26.0 31.0 LIMA1 0.03 0.029 -9999.0 0.0 -0.337 1.0 1.0 ABI1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.029 0.112 0.293 8.0 -0.267 7.0 15.0 adherens junction assembly -0.037 0.127 0.311 3.0 -0.399 10.0 13.0 IGF-1R heterotetramer/IGF1 -0.019 0.113 -9999.0 0.0 -0.184 49.0 49.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.086 -9999.0 0.0 -0.232 18.0 18.0 MET 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.033 0.075 0.205 2.0 -0.174 29.0 31.0 mol:GTP 0.039 0.086 -9999.0 0.0 -0.193 18.0 18.0 establishment of epithelial cell apical/basal polarity -0.026 0.119 0.317 8.0 -0.279 7.0 15.0 cortical actin cytoskeleton stabilization -0.015 0.086 -9999.0 0.0 -0.189 31.0 31.0 regulation of cell-cell adhesion -0.033 0.087 0.193 6.0 -0.185 29.0 35.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.087 -9999.0 0.0 -0.191 31.0 31.0