rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3) 2546874 17 11 17 4 4 5 1 5 2 0 0.245 0.00235 1.000 2 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 3275210 19 10 19 2 4 4 3 6 2 0 0.0588 0.00459 1.000 3 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(1), FMOD(1), KERA(2), LUM(2) 1171353 8 7 8 3 1 1 2 4 0 0 0.701 0.0228 1.000 4 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CDKN1B(1), CUL1(1), E2F1(1), RB1(4), SKP2(2), UBE2M(1) 2767786 11 8 11 1 1 1 4 1 4 0 0.172 0.0256 1.000 5 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CSF1R(3), EGF(3), MET(6), PDGFRA(8), PRKCA(3), SH3GLB1(3), SH3KBP1(3) 5420381 29 13 28 8 9 5 4 6 4 1 0.209 0.0262 1.000 6 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPS(2), ENPP2(2), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(4), PPAP2A(2), PPAP2C(1) 7485397 32 16 32 7 5 6 6 12 3 0 0.159 0.0273 1.000 7 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDC34(1), CDK2(1), CUL1(1), E2F1(1), RB1(4), SKP2(2) 2759061 11 8 11 1 1 1 4 1 4 0 0.191 0.0293 1.000 8 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(2), PLCG1(6), PRKCA(3), VAV1(4) 2922753 16 11 15 3 4 3 2 5 1 1 0.241 0.0417 1.000 9 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), NAT1(1), NAT2(2), XDH(7) 2572389 12 7 12 0 4 1 0 5 2 0 0.0358 0.0645 1.000 10 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(4), GLS(1), GLUD1(3), GOT1(2) 2521536 12 6 12 2 1 2 0 5 4 0 0.440 0.0688 1.000 11 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), TYR(4) 3128061 10 7 10 1 2 1 1 4 2 0 0.236 0.0859 1.000 12 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), LPO(5), MPO(2), PRDX1(1), TPO(4), TYR(4) 3115761 18 10 18 4 7 5 0 5 1 0 0.110 0.0934 1.000 13 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(2), ITGA4(2), ITGAL(2), ITGB1(2), ITGB2(1), SELE(4) 3915038 15 11 14 4 7 5 2 1 0 0 0.223 0.0952 1.000 14 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(3) 720054 6 3 6 1 2 0 0 1 3 0 0.417 0.0960 1.000 15 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(1), PC(1), PDHA1(2), SLC25A1(1) 2996746 8 7 8 0 1 2 0 3 2 0 0.0677 0.100 1.000 16 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(1), ELK1(3), INSR(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(1), SRF(2) 7014697 27 15 26 7 6 7 1 8 4 1 0.222 0.120 1.000 17 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CFL1(1), LIMK1(2), MAP3K1(2), MYL2(1), MYLK(3), NCF2(3), PAK1(2), PDGFRA(8), PLD1(4), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(4), VAV1(4), WASF1(1) 10067465 38 20 37 8 8 8 6 6 10 0 0.0532 0.124 1.000 18 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(3), CSNK1E(1), PER1(4) 2757941 10 6 10 1 2 3 1 2 2 0 0.215 0.125 1.000 19 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CDK2(1), CUL1(1), E2F1(1), FBXW7(1), RB1(4) 2665150 9 6 9 1 1 1 2 1 4 0 0.326 0.158 1.000 20 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(3), PFKL(3), PGAM1(1), PKLR(1), TPI1(1) 2997749 14 7 14 0 6 5 0 2 1 0 0.00219 0.160 1.000 21 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP19(2), SRP68(2), SRP72(3), SRPR(3) 2439245 10 5 9 1 3 0 3 2 2 0 0.225 0.162 1.000 22 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), PTGS1(2), PTGS2(2) 1726413 6 5 6 0 3 0 0 2 1 0 0.263 0.164 1.000 23 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1) 4700036 17 8 17 0 1 6 3 5 2 0 0.00418 0.174 1.000 24 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(4), CDC25A(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(3), RB1(4), WEE1(1), YWHAH(1) 5416177 19 9 19 7 3 2 3 2 9 0 0.766 0.183 1.000 25 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 1 CYP2C9(1) 326827 1 1 1 0 0 0 0 1 0 0 0.847 0.184 1.000 26 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2) 4287321 24 11 24 7 9 1 3 9 2 0 0.321 0.196 1.000 27 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2) 1825247 10 5 10 4 1 0 2 7 0 0 0.747 0.197 1.000 28 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(1), TYR(4) 4853521 14 8 14 2 2 3 1 5 3 0 0.238 0.206 1.000 29 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(4) 1522383 8 5 8 3 3 0 1 4 0 0 0.754 0.208 1.000 30 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(2) 766698 4 3 4 1 1 0 0 3 0 0 0.634 0.216 1.000 31 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(2), GAD2(1), GGT1(2) 1858698 5 4 5 0 2 1 1 1 0 0 0.162 0.230 1.000 32 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL4(2) 2319950 11 6 11 2 4 0 2 3 2 0 0.280 0.230 1.000 33 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(2), FUT5(2), FUT6(2) 1633390 7 4 7 2 3 1 1 1 1 0 0.573 0.236 1.000 34 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(1), CD3D(1), CTLA4(1), HLA-DRA(2), ITK(1), PTPN11(6) 2915323 12 9 11 4 3 1 1 7 0 0 0.628 0.240 1.000 35 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), LPO(5), MPO(2), TPO(4) 2700355 13 8 13 4 6 5 0 2 0 0 0.236 0.250 1.000 36 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(3), PDHA1(2), PDHA2(4) 2248485 11 6 11 2 2 5 1 1 2 0 0.137 0.259 1.000 37 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(2), ITGAL(2), ITGAM(1), ITGB2(1), SELE(4) 3356078 12 9 11 4 6 5 1 0 0 0 0.316 0.263 1.000 38 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), COQ5(1), COQ6(1), NDUFB11(1) 1297311 4 3 4 0 0 2 0 2 0 0 0.310 0.271 1.000 39 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(4), RXRA(1) 1756224 5 4 4 1 2 1 2 0 0 0 0.372 0.273 1.000 40 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(4), SP3(2) 2150383 6 4 6 0 1 0 1 1 3 0 0.248 0.273 1.000 41 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), OXCT1(1), PDHA1(2), PDHA2(4) 8339501 30 15 30 8 11 7 2 5 5 0 0.123 0.274 1.000 42 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD1(3), GLUD2(1) 1468655 5 4 5 2 0 2 0 2 1 0 0.734 0.276 1.000 43 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), JAK2(3), MAPK3(1), MPL(2), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), STAT1(2), STAT3(1), STAT5B(2) 8459261 28 15 27 4 6 3 2 8 6 3 0.0708 0.288 1.000 44 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3), ERBB3(2), NRG1(2) 2475288 7 5 7 1 5 0 0 1 1 0 0.411 0.290 1.000 45 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(2) 1238207 4 3 4 1 0 1 2 0 1 0 0.624 0.292 1.000 46 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(8), DFFA(1), HMGB2(1), PRF1(1), SET(1) 3412916 13 6 13 3 4 1 2 4 2 0 0.369 0.294 1.000 47 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(2), ITGA4(2), ITGAL(2), ITGAM(1), ITGB1(2), ITGB2(1), SELE(4), SELP(2) 5156494 18 12 17 6 7 5 3 3 0 0 0.387 0.294 1.000 48 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CYP2C9(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3) 9643755 40 15 38 9 15 6 3 7 9 0 0.144 0.300 1.000 49 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(2), P2RY1(1), P2RY2(3), P2RY6(2) 1927163 10 4 10 4 5 2 1 2 0 0 0.525 0.307 1.000 50 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(1), ATM(4), BAX(1), CCND1(1), CDK2(1), CDK4(1), E2F1(1), MDM2(2), RB1(4), TIMP3(2) 5581803 18 8 18 4 3 2 5 4 4 0 0.283 0.308 1.000 51 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 11959032 39 20 38 7 11 10 4 9 5 0 0.0269 0.311 1.000 52 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 852041 3 2 3 1 1 0 1 1 0 0 0.728 0.317 1.000 53 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(1), ACADS(1), ECHS1(2) 1745659 5 3 5 2 1 2 0 1 1 0 0.657 0.321 1.000 54 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), IDI1(1), SQLE(1) 1020417 3 2 3 0 0 0 3 0 0 0 0.337 0.339 1.000 55 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(3) 1597740 6 3 6 1 2 0 1 2 0 1 0.394 0.350 1.000 56 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), GRM1(5), PLCB1(2), PPP2CA(3), PPP3CA(1), PRKAR1A(1) 5180963 13 8 13 3 2 1 0 8 2 0 0.636 0.355 1.000 57 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4) 2584447 12 7 12 4 6 2 1 1 2 0 0.384 0.361 1.000 58 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4) 2584447 12 7 12 4 6 2 1 1 2 0 0.384 0.361 1.000 59 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(1), EGF(3), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 10035619 32 16 31 7 9 6 2 7 5 3 0.143 0.370 1.000 60 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(3), FDFT1(1), HMGCS1(1), IDI1(1), MVD(2), NSDHL(2), SC4MOL(1), SQLE(1) 4261561 13 6 13 4 5 1 4 3 0 0 0.402 0.371 1.000 61 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(1), ADCY4(4), CACNA1A(1), CACNA1B(7), GNAS(3), GRM4(2), ITPR3(6), KCNB1(3), PDE1A(1), PLCB2(2), SCNN1B(2), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(2), TAS2R13(1), TAS2R16(2), TAS2R3(1), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R9(4), TRPM5(2) 18333193 57 30 57 10 20 10 3 15 9 0 0.0132 0.377 1.000 62 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(5), ACAT2(1), ACSS1(1), ACSS2(3), ACYP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1) 15137114 48 24 47 10 16 11 5 10 6 0 0.0300 0.378 1.000 63 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), PANK2(1), PANK4(3) 4495741 12 7 12 3 2 2 0 5 3 0 0.636 0.385 1.000 64 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(1), CCND1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), E2F1(1), RB1(4), RBL1(2) 5189495 19 9 19 4 4 3 5 3 4 0 0.225 0.386 1.000 65 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(4), SP3(2), WT1(1) 2012076 7 4 6 0 3 1 0 3 0 0 0.0990 0.392 1.000 66 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(2), SHMT1(1) 1343926 4 3 4 1 2 1 1 0 0 0 0.431 0.394 1.000 67 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3) 682759 3 2 3 0 1 1 0 1 0 0 0.365 0.405 1.000 68 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), UGDH(1) 2757942 14 7 14 3 8 2 1 1 2 0 0.161 0.405 1.000 69 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(1), LEPR(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1) 4680350 19 7 18 2 4 2 2 9 2 0 0.0922 0.408 1.000 70 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(1), HLA-DRA(2) 983662 4 2 4 1 0 0 0 3 1 0 0.674 0.409 1.000 71 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 9 ACLY(3), ACO1(2), ACO2(2), ACSS1(1), ACSS2(3), FH(1) 3768263 12 6 12 0 5 2 0 3 2 0 0.0115 0.412 1.000 72 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(3), PRKAR1A(1), PRKCA(3) 3080513 9 6 9 2 2 0 1 4 1 1 0.621 0.416 1.000 73 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT3(1), AGPS(2), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GNPAT(1), LGALS13(2), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(2), PLCG1(6), PLCG2(6), PPAP2A(2), PPAP2C(1) 16131996 59 29 58 14 22 12 6 12 7 0 0.0601 0.417 1.000 74 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 1094396 2 2 2 0 0 1 0 1 0 0 0.592 0.420 1.000 75 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(2) 1578105 5 3 5 1 0 1 2 1 1 0 0.552 0.422 1.000 76 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 AKR1B10(2), ALOX15(1), CYP1A2(2), CYP2C8(1), CYP2C9(1), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 7387961 20 14 20 5 5 4 3 5 3 0 0.376 0.423 1.000 77 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3) 8065561 35 12 33 8 7 4 3 15 6 0 0.359 0.427 1.000 78 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRB2(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), DRD3(1), DRD5(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1) 8262333 31 15 31 9 9 5 4 6 7 0 0.166 0.430 1.000 79 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), E2F1(1), MAPK1(1), MAPK3(1), NFKB1(1), PAK1(2), RAC1(1), RAF1(1), RB1(4), RELA(1) 5309863 18 7 18 6 4 2 3 1 7 1 0.551 0.431 1.000 80 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), HTR2C(1), PLCB1(2), TUB(2) 2310706 6 4 6 2 2 1 0 2 1 0 0.574 0.441 1.000 81 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1) 5645997 29 12 29 9 8 3 3 10 5 0 0.388 0.442 1.000 82 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(2), INSR(3), IRS1(2), JAK2(3), MAPK1(1), MAPK3(1), PLCG1(6), PRKCA(3), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(1), SRF(2), STAT5B(2) 9458396 32 15 31 7 5 8 3 9 5 2 0.119 0.450 1.000 83 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CDC25A(1), CHEK1(3), MYT1(3), WEE1(1), YWHAH(1) 4448818 13 6 13 7 2 2 1 2 6 0 0.920 0.455 1.000 84 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT2(1), ACSM1(3), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), ILVBL(3), OXCT1(1), PDHA1(2), PDHA2(4), PLA1A(2) 13107506 48 20 48 11 17 9 4 11 7 0 0.0548 0.455 1.000 85 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), PON1(2), PON3(1) 2901622 9 5 8 2 5 0 0 1 3 0 0.457 0.457 1.000 86 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2) 5682954 15 9 15 4 3 1 4 6 1 0 0.357 0.462 1.000 87 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), HLA-DRA(2), IFNB1(1), IL12B(2), IL15(2), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1) 4245161 13 8 13 2 3 0 3 6 1 0 0.292 0.467 1.000 88 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(1), ELK1(3), IL6(1), IL6ST(2), JAK2(3), JAK3(1), MAPK3(1), PTPN11(6), RAF1(1), SHC1(1), SOS1(1), SRF(2), STAT3(1) 7716870 25 15 24 7 3 6 1 10 4 1 0.340 0.473 1.000 89 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), CAT(2), GH1(1), GHR(2), IGF1R(3), SHC1(1), SOD2(1) 3081306 11 5 11 1 2 3 2 3 1 0 0.0833 0.474 1.000 90 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), IDI1(1), SQLE(1) 1369511 3 2 3 0 0 0 3 0 0 0 0.329 0.474 1.000 91 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(8), DAXX(2), PAX3(1), PML(3), RB1(4), SP100(3), TNFRSF1B(2) 5865203 23 9 23 4 5 2 2 9 5 0 0.194 0.482 1.000 92 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(4), CDKN2A(2), E2F1(1), MDM2(2), POLR1A(4), POLR1B(2), RAC1(1), RB1(4), TBX2(1) 5061167 21 8 21 6 5 2 3 5 6 0 0.414 0.483 1.000 93 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(3), ST3GAL1(1), ST3GAL4(2) 2534693 6 5 6 2 2 2 0 1 1 0 0.578 0.484 1.000 94 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK2(3), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5) 3803994 12 5 12 3 3 1 0 5 2 1 0.506 0.489 1.000 95 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK2(3), JAK3(1), STAT1(2), STAT3(1), STAT5B(2), TYK2(5) 5950948 15 7 15 4 3 0 0 9 2 1 0.564 0.492 1.000 96 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), LPO(5), MPO(2), MTHFR(6), SHMT1(1), TPO(4) 3749710 23 9 23 5 9 7 1 5 1 0 0.0634 0.498 1.000 97 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(3), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), GCDH(1), ITGB1BP3(1), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3) 8373193 30 10 28 7 8 6 2 7 7 0 0.291 0.507 1.000 98 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(2), PLCB2(2) 3594474 11 9 11 4 4 3 0 2 2 0 0.557 0.507 1.000 99 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 3393741 9 5 9 2 3 0 1 3 2 0 0.486 0.509 1.000 100 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), JAK2(3), TYK2(5) 3393741 9 5 9 2 3 0 1 3 2 0 0.486 0.509 1.000 101 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(2), EPX(2), LPO(5), MPO(2), PRDX1(1), SHMT1(1), TPO(4) 3812704 19 8 19 5 8 7 0 3 1 0 0.104 0.514 1.000 102 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(1), GLUD1(3), OAT(1) 1781758 7 4 7 3 1 1 0 4 1 0 0.766 0.514 1.000 103 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(2), PRKAA1(3), PRKAA2(2), ULK2(5) 6816390 25 8 25 2 5 3 5 8 4 0 0.0156 0.518 1.000 104 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), PLCG1(6), PRKCA(3), SHC1(1), SOS1(1) 3807108 12 8 11 3 3 2 2 2 2 1 0.431 0.519 1.000 105 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 1253934 2 2 2 0 0 0 0 1 1 0 0.516 0.523 1.000 106 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(1) 3468022 8 6 8 2 2 1 2 1 2 0 0.466 0.523 1.000 107 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), ABAT(1), ADSL(3), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), ASS1(1), CAD(4), CRAT(1), DARS2(2), GAD1(2), GAD2(1), GOT1(2), NARS2(1), PC(1), PDHA1(2), PDHA2(4) 12223071 35 16 35 4 11 9 2 8 5 0 0.00575 0.524 1.000 108 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2), SHMT1(1) 1779297 3 3 3 1 1 1 1 0 0 0 0.568 0.526 1.000 109 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(2), AGTR2(1), KNG1(1), NOS3(5), REN(1) 3203948 12 7 12 4 6 1 1 2 2 0 0.581 0.529 1.000 110 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 587607 2 2 2 0 2 0 0 0 0 0 0.524 0.532 1.000 111 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2B(2), ENPP1(1), ENPP3(2), G6PC(4), GAA(5), GANAB(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), MGAM(4), PYGB(1), PYGL(3), PYGM(1), SI(6), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(2) 18403976 63 32 63 14 20 11 10 15 7 0 0.0283 0.536 1.000 112 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CHEK1(3), WEE1(1) 2220504 5 3 5 3 1 1 1 0 2 0 0.951 0.536 1.000 113 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(2) 967753 3 2 3 1 0 1 1 1 0 0 0.687 0.537 1.000 114 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2) 1546595 4 4 4 2 2 0 0 1 1 0 0.865 0.538 1.000 115 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), F2(2), F5(7), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), PROS1(1), SERPING1(1) 14360896 48 23 48 11 12 12 9 8 6 1 0.0483 0.539 1.000 116 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(1), MST1(4), MST1R(1) 2117527 6 3 6 2 1 2 0 3 0 0 0.555 0.542 1.000 117 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(2), DDIT3(1), ELK1(3), MAP3K1(2), MAP3K5(2), MAP3K9(2), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), PLA2G4A(4), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1) 11825811 37 19 36 7 9 6 7 12 2 1 0.0773 0.545 1.000 118 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 369191 1 1 1 1 0 1 0 0 0 0 0.899 0.549 1.000 119 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(8), EP300(3), NCOA3(2), PRKAR1A(1), RXRA(1) 6675219 16 8 16 4 3 3 0 7 3 0 0.437 0.550 1.000 120 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(1), GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GCNT4(2), OGT(6), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 10432366 36 15 36 9 10 9 1 12 4 0 0.223 0.556 1.000 121 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(1), UGP2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 8822548 29 16 29 8 7 2 8 11 1 0 0.287 0.557 1.000 122 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GAPDHS(1), GCK(1), GOT1(2), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PFKL(3), PGAM1(1), PGAM2(1), PKLR(1), TNFAIP1(2), TPI1(1) 13733944 44 19 44 3 17 14 3 8 2 0 2.32e-05 0.558 1.000 123 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PFKL(3), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2), TKTL2(1) 7844683 24 12 24 7 13 7 0 3 1 0 0.124 0.559 1.000 124 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(7), F7(2), FGA(4), FGB(1), PROS1(1) 5294363 17 12 17 5 6 2 4 4 1 0 0.382 0.562 1.000 125 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(3), PDXK(1) 1568290 4 2 4 2 0 2 0 2 0 0 0.818 0.565 1.000 126 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK2(3), STAT1(2) 2647755 6 3 6 3 1 0 0 2 2 1 0.842 0.566 1.000 127 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(2) 1721526 3 3 3 0 0 0 0 3 0 0 0.585 0.580 1.000 128 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(1), IGF1R(3), POLR2A(3), PPP2CA(3), PRKCA(3), RB1(4), TEP1(7), TERF1(1), XRCC5(1) 7984539 26 11 26 4 8 2 5 6 4 1 0.0576 0.583 1.000 129 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), PAK1(2), PDGFRA(8), RAC1(1), WASL(1) 3113462 16 9 15 6 0 6 1 5 4 0 0.692 0.587 1.000 130 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), CCL5(1), CSK(1), F11R(1), GIT1(1), JAM2(3), JAM3(2), MAP3K14(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(1), MAPK9(1), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(6), PTPN11(6), PTPRZ1(7), RAC1(1), RELA(1), TCIRG1(1), TJP1(4) 21858308 72 31 70 17 21 13 9 15 13 1 0.0443 0.588 1.000 131 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3) 5342140 20 6 18 2 5 3 1 5 6 0 0.126 0.592 1.000 132 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(1) 2826621 7 5 7 3 4 3 0 0 0 0 0.492 0.593 1.000 133 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 MARCKS(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), SP3(2) 6760537 24 11 23 6 9 3 3 5 3 1 0.234 0.593 1.000 134 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(2), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(3), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(1), SYK(1), VAV1(4), VAV2(1), VAV3(2) 10357979 32 13 32 8 6 8 2 12 3 1 0.174 0.594 1.000 135 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(3), PANK2(1), PANK4(3), VNN1(1) 5579072 16 9 16 3 3 3 0 7 3 0 0.370 0.600 1.000 136 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GLS(1), GLUD1(3), GLUL(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 10711068 32 13 32 7 8 6 3 10 5 0 0.144 0.604 1.000 137 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), LARS(3), PDHA1(2), PDHA2(4) 3246509 10 5 10 3 2 2 2 2 2 0 0.538 0.608 1.000 138 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), NAGLU(3), SPAM1(1) 6624276 20 9 20 5 7 1 4 4 4 0 0.392 0.610 1.000 139 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 15792495 56 24 56 13 20 12 6 14 4 0 0.0259 0.611 1.000 140 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1) 15792495 56 24 56 13 20 12 6 14 4 0 0.0259 0.611 1.000 141 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(1), BTK(1), FYN(1), GAB2(1), INPP5D(2), KRAS(1), LAT(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PRKCA(3), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4), VAV2(1), VAV3(2) 22092035 74 33 73 18 23 16 11 15 7 2 0.0311 0.611 1.000 142 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(10), ACADL(1), ACADM(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ECHS1(2), EHHADH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 10696990 39 14 38 10 11 12 2 10 4 0 0.160 0.614 1.000 143 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RXRA(1) 1875389 7 6 7 4 1 1 1 4 0 0 0.814 0.621 1.000 144 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), STAT4(2), TYK2(5) 4758226 16 6 16 5 6 2 1 5 2 0 0.483 0.627 1.000 145 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(2), GALNT4(1), GALNT6(2), GALNT8(1), GALNT9(2), ST3GAL1(1), ST3GAL4(2), WBSCR17(4) 4667958 16 7 16 4 7 4 0 4 1 0 0.260 0.631 1.000 146 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(10), ACACB(5), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ALDH7A1(2), ECHS1(2), EHHADH(1), HIBCH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1) 12828543 49 18 48 13 16 13 4 11 5 0 0.116 0.634 1.000 147 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(3), HLA-DRA(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4) 4910342 17 11 17 5 7 5 0 4 1 0 0.320 0.639 1.000 148 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(1), ELK1(3), IGF1R(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2) 6790776 26 17 25 8 4 7 2 7 5 1 0.348 0.641 1.000 149 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(2), CDC25A(1), SHH(1), XPO1(1) 2805205 6 4 6 3 1 5 0 0 0 0 0.659 0.656 1.000 150 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(1), GGH(1), SPR(1) 2100770 3 3 3 1 1 1 0 0 1 0 0.756 0.657 1.000 151 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(3), PRKCA(3) 2907243 6 3 6 0 1 1 2 1 0 1 0.118 0.662 1.000 152 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(2), EGF(3), HGS(3), TF(1), TFRC(1) 3288427 10 6 10 2 4 2 1 2 1 0 0.303 0.666 1.000 153 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(4), ATR(4), CHEK1(3), CHEK2(3), YWHAH(1) 4908299 15 5 15 4 4 4 1 3 3 0 0.594 0.668 1.000 154 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(1), GFPT1(1), GNE(1), GNPDA1(2), HEXA(1), HK1(3), HK2(2), HK3(1), RENBP(1) 5484746 14 7 14 4 3 4 3 3 1 0 0.389 0.674 1.000 155 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 2114719 3 3 3 0 0 1 0 2 0 0 0.357 0.674 1.000 156 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(1) 2114719 3 3 3 0 0 1 0 2 0 0 0.357 0.674 1.000 157 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(2), PTPRC(4), ZAP70(3) 2921662 12 6 12 2 4 3 0 5 0 0 0.232 0.680 1.000 158 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(3), C9orf95(1), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT3(1), NNMT(1), NNT(3), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1) 6948691 20 8 20 3 1 8 4 5 2 0 0.0776 0.680 1.000 159 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), GAD1(2), GAD2(1), GOT1(2), PC(1) 8417973 24 10 24 2 8 6 0 7 3 0 0.0115 0.680 1.000 160 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CFLAR(1), DAXX(2), DFFA(1), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(8), PTPN13(1), RB1(4), SPTAN1(2) 13098788 32 14 32 6 6 6 4 8 7 1 0.127 0.685 1.000 161 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(3), EPRS(2), GUSB(2), HCCS(3), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2), UROS(1) 8848315 26 14 26 5 7 1 8 9 1 0 0.110 0.686 1.000 162 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(3), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), G6PC2(1), GALM(1), GAPDHS(1), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PFKL(3), PGAM1(1), PGAM2(1), PKLR(1), TPI1(1) 18811322 69 28 69 12 26 13 7 18 5 0 0.00133 0.687 1.000 163 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(2) 1050958 3 3 3 2 1 0 0 1 1 0 0.802 0.688 1.000 164 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD4(1) 1039182 3 2 3 2 1 1 0 1 0 0 0.811 0.688 1.000 165 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CSK(1), PRKCA(3), PTPRA(4) 2978712 10 3 10 3 3 3 2 1 0 1 0.403 0.689 1.000 166 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCA(1), SNCAIP(1) 2080004 4 3 4 2 3 0 0 1 0 0 0.719 0.693 1.000 167 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1) 4936244 15 7 15 4 4 0 0 8 3 0 0.608 0.698 1.000 168 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CFL1(1), E2F1(1), MDM2(2), PRB1(2) 2445355 13 8 13 5 3 2 3 3 2 0 0.587 0.703 1.000 169 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), RECK(2), TIMP3(2), TIMP4(1) 2432250 6 3 6 1 1 2 2 0 1 0 0.336 0.705 1.000 170 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(2) 1213959 3 2 3 0 1 0 0 2 0 0 0.423 0.709 1.000 171 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 7 ACO1(2), ACO2(2), FH(1) 2348396 5 3 5 0 3 1 0 1 0 0 0.163 0.713 1.000 172 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(2), CES1(1), CES7(1), ESCO2(2), LIPA(2), MYST3(1), MYST4(9), PLA1A(2), PNPLA3(1), SH3GLB1(3) 8182583 24 8 23 6 3 4 3 6 8 0 0.435 0.714 1.000 173 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(3), IFNGR2(1), JAK2(3), NFKB1(1), RB1(4), RELA(1), TNFRSF1B(2), WT1(1) 5600880 16 6 16 8 4 1 1 4 6 0 0.874 0.714 1.000 174 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EARS2(1), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GFPT2(3), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), GNPNAT1(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1) 12751310 40 17 40 10 8 8 4 13 7 0 0.189 0.725 1.000 175 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKAR1A(1), PTPRC(4), ZAP70(3) 7399880 25 12 25 6 7 4 0 11 3 0 0.323 0.725 1.000 176 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKAR1A(1), PTPRC(4), ZAP70(3) 7399880 25 12 25 6 7 4 0 11 3 0 0.323 0.725 1.000 177 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), LPA(5), PLAT(1), PLAU(1), PLG(3), SERPINE1(1), SERPINF2(1), VWF(5) 11400787 46 17 46 10 13 7 6 14 6 0 0.0604 0.728 1.000 178 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1) 1260201 1 1 1 1 0 1 0 0 0 0 0.875 0.728 1.000 179 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB3A(1), RAB9A(1) 1367216 3 2 3 0 2 1 0 0 0 0 0.267 0.729 1.000 180 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(2), ARSE(2), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(1), UGCG(2) 7818589 29 12 28 5 10 3 1 10 5 0 0.114 0.733 1.000 181 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), PRKAR1A(1) 2112413 5 5 5 2 1 0 0 2 2 0 0.797 0.736 1.000 182 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(1), NFS1(3), THTPA(2) 2074775 9 2 9 2 1 3 0 4 1 0 0.514 0.745 1.000 183 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(1), BRAF(3), CREB1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(1) 3606975 9 4 9 2 1 1 2 2 3 0 0.412 0.748 1.000 184 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACPP(1), ALPP(1), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), PON1(2), PON3(1) 5804831 10 7 9 1 5 0 0 1 4 0 0.139 0.748 1.000 185 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), PRB1(2) 2882957 11 7 11 3 3 1 4 2 1 0 0.372 0.753 1.000 186 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(4) 12685108 39 18 38 10 11 7 5 11 4 1 0.170 0.754 1.000 187 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(1), GUSB(2), HEXA(1), IDS(1), LCT(5), NAGLU(3) 4648962 13 6 13 4 6 1 2 2 2 0 0.517 0.768 1.000 188 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(3), DDC(1), GAD1(2), GAD2(1), HDC(2), PAH(1), TH(1), TPH1(2) 4641992 16 7 16 6 7 5 0 2 2 0 0.417 0.769 1.000 189 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C3AR1(2), C4BPA(2), C4BPB(1), C5(4), C6(2), C7(4), C8A(1), C8B(3), CD46(2), CD55(1), CFD(1), CFH(6), CPB2(1), CR1(3), CR2(3), F13A1(2), F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), KNG1(1), MBL2(2), PLAT(1), PLAU(1), PLG(3), PROS1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), VWF(5) 29221147 110 44 110 29 31 19 14 32 14 0 0.0308 0.771 1.000 190 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(3), LPL(2), NCOA1(1), PPARG(1), RXRA(1) 5965841 16 8 16 5 3 3 0 9 1 0 0.592 0.774 1.000 191 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1) 2250630 8 3 8 3 0 0 1 4 3 0 0.791 0.775 1.000 192 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CD3D(1), ELK1(3), FYN(1), LAT(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(1), VAV1(4), ZAP70(3) 14225955 49 19 48 13 19 8 3 11 6 2 0.130 0.775 1.000 193 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(6), PRKCA(3) 2174871 12 8 11 7 5 2 2 1 1 1 0.838 0.778 1.000 194 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(2), G6PC(4), GAA(5), GANAB(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4) 10533733 32 15 32 9 19 4 2 6 1 0 0.189 0.779 1.000 195 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(4) 2721745 5 3 5 0 2 1 1 1 0 0 0.168 0.780 1.000 196 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), CRADD(1), DFFA(1), LMNA(2), LMNB2(2), MADD(1), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(8), RB1(4), RIPK1(1), SPTAN1(2), TRADD(1) 12472362 29 16 29 6 8 4 4 5 7 1 0.162 0.780 1.000 197 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(1), KDR(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NOS3(5), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(1), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2) 22026601 85 36 84 23 30 14 15 15 9 2 0.0446 0.780 1.000 198 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), STAT1(2), TYK2(5) 3500853 9 4 9 3 2 0 1 4 1 1 0.670 0.781 1.000 199 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(3), EPOR(1), JAK2(3), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 6938242 21 11 20 6 3 6 1 6 4 1 0.325 0.784 1.000 200 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(1) 532411 3 1 3 0 0 3 0 0 0 0 0.291 0.784 1.000 201 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), GH1(1), GHR(2), NFKB1(1), PPP2CA(3), RELA(1), YWHAH(1) 3325546 10 4 10 4 3 1 1 4 1 0 0.763 0.785 1.000 202 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAX(1), BCL2L11(1), CASP8AP2(2), CES1(1) 3483797 6 3 6 0 1 2 0 1 2 0 0.181 0.786 1.000 203 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), AXIN1(1), BTRC(1), CCND1(1), CREBBP(8), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTBP1(3), FZD1(1), NLK(1), PPP2CA(3), WIF1(2) 9483112 27 9 27 5 6 4 2 11 4 0 0.127 0.788 1.000 204 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(2), OXCT1(1) 2317044 7 2 7 0 1 3 0 3 0 0 0.118 0.789 1.000 205 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1) 5333208 15 10 15 5 4 2 2 5 2 0 0.666 0.790 1.000 206 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), ECHS1(2), HSD17B4(2), MECR(1), PPT2(2) 2736878 9 5 9 4 3 2 0 2 2 0 0.783 0.791 1.000 207 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CEL(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GLA(1), GLB1(1), LCT(5), LIPC(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(3), PPAP2A(2), PPAP2C(1) 15575151 56 20 56 16 21 6 9 15 5 0 0.124 0.792 1.000 208 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(3) 995205 3 1 3 2 0 1 0 1 1 0 0.838 0.792 1.000 209 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(3), PLCE1(6), PRKAR1A(1), RAP2B(1) 4746756 13 8 13 4 4 3 1 2 3 0 0.502 0.794 1.000 210 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(9), C5(4), C6(2), C7(4), ICAM1(2), IL6(1), ITGA4(2), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(1) 8014280 33 18 33 11 9 6 5 8 5 0 0.325 0.795 1.000 211 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(3), CBS(3), CTH(1), MUT(1) 1585906 8 2 8 0 2 5 0 1 0 0 0.0468 0.796 1.000 212 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(3), HK2(2), HK3(1), ISYNA1(2), TGDS(1) 3774191 10 5 10 2 3 4 2 1 0 0 0.183 0.799 1.000 213 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), OAT(1), ODC1(2), SMS(1) 5667340 18 6 18 5 3 4 0 6 5 0 0.476 0.799 1.000 214 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NQO2(1), SQLE(1) 3572052 9 3 9 4 3 1 3 1 1 0 0.586 0.802 1.000 215 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E1(3), GTF2F1(2), GTF2H1(1), GTF2IRD1(2), TAF1(7), TAF1L(1), TAF2(1), TAF4(3), TAF4B(3), TAF5L(2), TAF6L(1), TAF7L(1), TAF9(2), TAF9B(1), TBPL1(1) 11633193 31 12 31 5 6 9 3 10 3 0 0.0446 0.802 1.000 216 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AGK(1), AGPAT3(1), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CEL(1), DAK(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK2(3), GLA(1), GLB1(1), GPAM(1), LCT(5), LIPA(2), LIPC(1), LIPG(2), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(2), PPAP2C(1) 18967004 68 23 68 17 25 6 12 19 6 0 0.0522 0.803 1.000 217 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(1), GGT1(2), MARS(4), MARS2(1), SCLY(1) 4000845 12 4 12 1 3 5 1 3 0 0 0.0459 0.803 1.000 218 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(1), NOX1(1), RELA(1), XDH(7) 3208676 10 3 10 4 2 2 0 5 1 0 0.673 0.806 1.000 219 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(9), C5(4), C6(2), C7(4), C8A(1) 4056869 20 10 20 7 5 2 3 5 5 0 0.487 0.808 1.000 220 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(3), ESR1(1), MAPK1(1), MAPK3(1), PELP1(1) 4765601 15 4 15 4 5 2 0 6 1 1 0.443 0.809 1.000 221 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1) 1528404 1 1 1 0 0 0 0 0 1 0 0.719 0.810 1.000 222 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1), RB1(4), RELA(1) 5055638 15 6 15 6 6 2 1 1 4 1 0.700 0.810 1.000 223 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(4) 12343198 40 16 39 10 13 7 4 9 5 2 0.117 0.818 1.000 224 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK2(3), PTPRU(2), REG1A(1), STAT1(2) 3694252 9 5 9 4 2 1 0 2 3 1 0.690 0.820 1.000 225 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), ELK1(3), MAPK3(1), MAPK8(1), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1) 4945505 16 9 15 5 2 6 1 3 3 1 0.377 0.822 1.000 226 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(1), CHST13(1), SULT2A1(2), SULT2B1(1), SUOX(1) 2958947 7 3 7 3 0 1 0 5 1 0 0.814 0.827 1.000 227 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(1) 2628282 7 2 7 1 0 2 1 4 0 0 0.365 0.828 1.000 228 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(3), ABCB11(1), ABCB4(4), ABCC1(4), ABCC3(6) 4633699 18 6 18 4 4 2 3 7 2 0 0.263 0.834 1.000 229 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CD4(1), HLA-DRA(2), IL1B(1), IL5RA(1), IL6(1) 1726053 7 3 7 2 0 0 0 7 0 0 0.710 0.835 1.000 230 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(1), HMGB2(1), TOP2A(4), TOP2B(1) 2841465 7 2 7 3 3 1 2 0 1 0 0.682 0.841 1.000 231 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(1), ITPR1(2), ITPR2(11), ITPR3(6), PDK1(2), PHF11(1), PITX2(3), PLCG2(6), PPP1R13B(1), PREX1(5), PTPRC(4), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(1), SYK(1), TEC(1), VAV1(4) 16883485 62 24 62 16 20 11 9 21 1 0 0.0934 0.843 1.000 232 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FHL5(1), FSHR(2), GNAS(3), XPO1(1) 3073342 8 7 8 3 1 1 1 3 2 0 0.771 0.846 1.000 233 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 RIPK1(1), TNFRSF1B(2), TRADD(1) 2705368 4 3 4 2 2 0 0 0 2 0 0.775 0.848 1.000 234 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHSY1(1), DSE(1), XYLT1(1), XYLT2(1) 4499934 10 6 10 2 3 1 0 6 0 0 0.349 0.849 1.000 235 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(3), HK2(2), HK3(1), TGDS(1) 3307949 8 4 8 2 3 3 2 0 0 0 0.296 0.854 1.000 236 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(5), PYGL(3), PYGM(1), TPI1(1), TREH(1) 4334642 14 6 14 5 4 4 2 2 2 0 0.467 0.855 1.000 237 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(2), DAG1(1), DLG4(3), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RYR1(10) 14787823 47 17 47 11 14 9 9 12 3 0 0.0756 0.856 1.000 238 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP4B(2), INPP5B(2), INPPL1(4), IPMK(1), ISYNA1(2), ITGB1BP3(1), ITPK1(2), MINPP1(1), OCRL(4), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), SYNJ1(4), SYNJ2(5) 23046686 79 31 78 19 20 16 8 24 11 0 0.0634 0.856 1.000 239 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), CPO(1), HBA2(1), UROS(1) 2546634 6 2 6 1 3 0 1 2 0 0 0.392 0.857 1.000 240 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 AGT(2), AKT1(1), CALR(2), CAMK1G(1), CAMK4(1), CREBBP(8), CSNK1A1(2), F2(2), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(8), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RAF1(1), RPS6KB1(1) 15166254 45 18 45 13 16 8 2 14 4 1 0.159 0.860 1.000 241 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(1), RALBP1(1), RALGDS(2), RELA(1) 4933051 14 6 14 7 3 2 1 3 4 1 0.794 0.862 1.000 242 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(2), HDC(2), TH(1), TPH1(2) 1950402 7 3 7 2 4 2 0 1 0 0 0.349 0.864 1.000 243 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3RA(2), JAK2(3), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2) 5709695 12 6 12 4 2 0 0 5 4 1 0.655 0.865 1.000 244 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF4E(1), IGF1R(3), INPPL1(4), PPP2CA(3), RPS6KB1(1) 4876109 13 4 13 4 2 3 2 4 2 0 0.446 0.865 1.000 245 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(1), GNAS(3), PRKAR1A(1), SLC9A3R1(1) 4203884 8 7 8 3 3 1 0 2 2 0 0.681 0.866 1.000 246 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2651777 6 2 6 3 1 3 0 0 1 1 0.520 0.870 1.000 247 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), CFL1(1), FLNA(8), FLNC(7), FSCN1(2), FSCN2(1), GDI1(3), LIMK1(2), MYH2(8), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), ROCK1(2), ROCK2(2), RPS4X(2), WASF1(1), WASL(1) 15462312 57 19 57 15 20 9 7 16 5 0 0.0657 0.871 1.000 248 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), MAPK1(1), MAPK8(1), PRKCA(3) 2854422 6 2 6 1 1 2 1 0 1 1 0.221 0.871 1.000 249 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(2), FGA(4), FGB(1), PLAT(1), PLAU(1), PLG(3), SERPINE1(1) 4331976 16 8 16 5 8 3 1 2 2 0 0.334 0.872 1.000 250 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(5) 4038715 11 6 11 4 2 1 1 3 3 1 0.643 0.875 1.000 251 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CYCS(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), SMPD1(1), TRADD(1) 6630949 15 8 15 7 4 3 0 3 4 1 0.749 0.879 1.000 252 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(3), PGM2(5), SORD(1), TPI1(1), TSTA3(1) 12028493 36 14 36 8 16 9 2 5 4 0 0.0504 0.879 1.000 253 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), IL6(1), IL9(1) 1925035 3 2 3 1 0 0 0 3 0 0 0.803 0.880 1.000 254 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BAX(1), BIRC2(1), CYCS(2), DFFA(1), DIABLO(1) 4335087 7 3 7 1 1 2 0 3 1 0 0.323 0.880 1.000 255 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(4), PPP2CA(3), PRKAG1(1) 5871612 13 5 13 3 2 2 1 6 2 0 0.416 0.881 1.000 256 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1), IL6(1), KITLG(2) 1997771 5 2 5 1 0 1 1 3 0 0 0.522 0.882 1.000 257 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1) 2686257 10 3 10 3 5 1 1 2 1 0 0.548 0.883 1.000 258 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), G6PC(4), G6PC2(1), GAA(5), GANC(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4), PFKL(3), UGP2(1) 12492901 37 15 37 10 21 4 2 8 2 0 0.167 0.884 1.000 259 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(2), ARSE(2), B4GALT6(1), DEGS1(2), DEGS2(1), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SPTLC1(2), SPTLC2(1), UGCG(2) 11526070 39 14 38 7 13 4 2 15 5 0 0.0623 0.884 1.000 260 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(3), CPEB1(3), ERBB2(1), ERBB4(3), ETS1(3), ETV6(2), ETV7(1), FMN2(2), KRAS(1), MAPK1(1), MAPK3(1), NOTCH2(9), NOTCH3(4), NOTCH4(8), PIWIL2(3), PIWIL3(1), RAF1(1), SOS1(1), SOS2(4), SPIRE1(1), SPIRE2(2) 14744718 55 24 55 14 15 12 10 11 5 2 0.124 0.895 1.000 261 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1), MBL2(2) 6867942 31 14 31 10 8 3 4 10 6 0 0.427 0.898 1.000 262 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CYCS(2), PRF1(1) 4157413 7 4 7 3 1 4 0 2 0 0 0.653 0.899 1.000 263 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 18 ACO1(2), ACO2(2), FH(1), IDH3B(1), PC(1), PCK1(3), SUCLG2(1) 6124669 11 6 11 2 5 4 0 2 0 0 0.157 0.900 1.000 264 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCR(1), CRKL(1), JAK2(3), MAP3K1(2), MAPK3(1), MAPK8(1), RAF1(1), SOS1(1), STAT1(2), STAT5B(2) 7852936 16 6 16 4 4 3 0 4 3 2 0.259 0.900 1.000 265 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(2), AASDHPPT(1) 2251503 3 2 3 0 0 0 1 1 1 0 0.384 0.901 1.000 266 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(2), EHHADH(1) 1560559 5 2 5 3 2 1 1 0 1 0 0.762 0.906 1.000 267 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), JAK2(3), JAK3(1), PIAS3(1), PTPRU(2), REG1A(1), STAT3(1) 4929745 11 8 11 4 2 1 0 5 3 0 0.658 0.907 1.000 268 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(1), BRAF(3), DAG1(1), EPHB2(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT3(1) 18060242 50 17 50 10 13 6 11 16 4 0 0.0445 0.912 1.000 269 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 AKT1(1), APC(2), AR(2), BRAF(3), DAG1(1), GNA11(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(4), PIK3CD(1), PITX2(3), PTX3(1), RAF1(1) 15190995 45 15 45 12 11 6 11 13 4 0 0.178 0.914 1.000 270 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(2), ALG6(3), DAD1(1), DHDDS(2), DPAGT1(1), DPM1(2), FUT8(3), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(1), RPN2(1), ST6GAL1(1), STT3B(1) 13670920 44 17 44 11 9 10 7 7 11 0 0.188 0.915 1.000 271 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), BCAR1(1), CDKN1B(1), ITGB1(2), MAPK1(1), MAPK3(1), PTK2(1), SHC1(1), SOS1(1) 4753664 10 3 10 4 3 1 1 2 2 1 0.667 0.916 1.000 272 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(4), CES1(1), CES2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2) 7380990 14 7 14 4 4 2 3 4 1 0 0.354 0.917 1.000 273 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), IARS2(2), ILVBL(3), LARS(3), PDHA1(2), PDHA2(4), VARS(3), VARS2(1) 6008816 19 7 19 5 4 4 2 6 3 0 0.431 0.918 1.000 274 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TPI1(1) 5826742 12 5 12 2 5 2 1 3 1 0 0.213 0.919 1.000 275 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4872657 7 3 7 2 2 4 0 0 0 1 0.421 0.922 1.000 276 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4872657 7 3 7 2 2 4 0 0 0 1 0.421 0.922 1.000 277 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1) 4872657 7 3 7 2 2 4 0 0 0 1 0.421 0.922 1.000 278 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(3), MAP3K1(2), NCOR2(3), RXRA(1) 4728176 9 6 9 4 4 2 0 2 1 0 0.692 0.922 1.000 279 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(2), CASP1(1), INSR(3), MAGI1(2), MAGI2(4), RERE(5), WWP1(3) 7741494 23 9 23 6 10 6 1 4 2 0 0.228 0.923 1.000 280 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(2), CRY1(3), EIF4G2(1), ETV6(2), HERPUD1(1), HSPA8(1), IDI1(1), NCKAP1(2), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), TUBB3(3), UGP2(1), ZFR(1) 11801856 36 13 36 8 5 10 6 11 4 0 0.152 0.924 1.000 281 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 AGT(2), AGTR2(1), EDNRB(1), EGF(3), NFKB1(1), PLCG1(6), PRKCA(3), RELA(1) 5776517 18 9 17 7 6 3 2 5 1 1 0.611 0.924 1.000 282 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CCNB1(1), GNAI1(1), GNAS(3), MAPK1(1), MAPK3(1), MYT1(3), PRKAR1A(1), RPS6KA1(2) 6610830 14 10 14 8 1 2 0 4 6 1 0.893 0.925 1.000 283 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(4), ATR(4), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), RB1(4), SKP2(2), TGFB2(2), TGFB3(1) 9488294 30 10 30 6 8 4 5 7 6 0 0.122 0.925 1.000 284 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), CISH(1), IARS(1), IL13RA1(1), INPP5D(2), JAK2(3), JAK3(1), PI3(1), PPP1R13B(1), RPS6KB1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3), TYK2(5) 11223147 28 12 28 4 8 2 3 10 5 0 0.0792 0.925 1.000 285 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT3(1), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(1), MYST3(1), MYST4(9), PCYT1B(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(1), SH3GLB1(3) 21093852 61 20 60 15 17 14 6 13 11 0 0.0915 0.925 1.000 286 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(3), IRS1(2), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), YWHAH(1) 4908217 12 7 12 4 1 4 1 1 4 1 0.468 0.925 1.000 287 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 HSD11B1(1) 2234212 1 1 1 1 1 0 0 0 0 0 0.848 0.927 1.000 288 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(5), FYN(1), ITGA1(2), ITGB1(2), L1CAM(4), SELP(2) 5101359 16 5 16 6 5 3 2 6 0 0 0.564 0.927 1.000 289 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(1), CBR3(1), CYP4F3(4), EPX(2), GGT1(2), LPO(5), LTA4H(2), MPO(2), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TPO(4) 9016633 40 23 40 12 11 11 4 9 5 0 0.146 0.928 1.000 290 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPNS1(1), CAPNS2(1), EP300(3), HDAC2(4), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3) 7876165 24 8 24 8 7 3 3 5 5 1 0.565 0.930 1.000 291 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(1), AKT1(1), BAX(1), CSF2RB(1), IGF1R(3), IL3RA(2), KIT(3), KITLG(2), PRKAR1A(1), YWHAH(1) 5864869 16 8 16 5 2 2 2 5 5 0 0.478 0.930 1.000 292 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), GREB1(5), MTA3(2) 3526400 8 3 8 1 5 0 1 2 0 0 0.191 0.937 1.000 293 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(3), AGT(2), AGTR2(1), ANPEP(2), CMA1(2), CTSG(1), ENPEP(3), LNPEP(1), MME(2), REN(1), THOP1(3) 6846962 23 9 23 4 8 5 1 6 3 0 0.0807 0.937 1.000 294 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(4), ATR(4), BRCA1(1), BRCA2(4), CHEK1(3), CHEK2(3), FANCA(2), FANCC(1), FANCD2(2), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(2), RAD9A(1), TREX1(1) 14002862 37 11 37 8 9 10 4 9 5 0 0.175 0.940 1.000 295 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ECHS1(2), EHHADH(1) 3927954 15 8 15 7 7 3 1 1 3 0 0.586 0.942 1.000 296 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(2), AGTR2(1), CMA1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), REN(1) 8160096 23 9 23 8 6 9 1 3 3 1 0.474 0.942 1.000 297 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), FDXR(1), SHMT1(1) 5185119 8 3 8 2 3 4 0 0 0 1 0.341 0.942 1.000 298 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 HSD17B2(1), HSD17B4(2) 2620268 3 3 3 3 1 0 0 1 1 0 0.964 0.943 1.000 299 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), LMNA(2), LMNB2(2), PRF1(1) 6235175 13 5 13 3 3 5 1 3 1 0 0.274 0.946 1.000 300 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 FLT3(2), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1) 2626546 9 3 9 3 2 1 1 4 1 0 0.579 0.947 1.000 301 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(2), ACADM(1), ACADS(1), ACAT2(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ALDH7A1(2), AOX1(3), BCKDHA(1), DBT(2), ECHS1(2), EHHADH(1), HIBADH(1), HIBCH(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 13900413 47 17 46 13 17 12 3 8 7 0 0.179 0.948 1.000 302 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1) 4360447 10 5 10 4 4 2 1 3 0 0 0.623 0.949 1.000 303 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), FCGR3A(1), IL1B(1), SPN(1), TGFB2(2), TNFRSF1B(2), TNFRSF8(1), TNFSF8(1) 4226202 13 5 13 4 5 3 1 2 2 0 0.349 0.949 1.000 304 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK2(3), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1), SOAT1(1) 4432484 11 8 11 7 2 1 0 5 3 0 0.937 0.952 1.000 305 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TKTL2(1), TPI1(1) 6514736 13 6 13 2 5 2 1 4 1 0 0.183 0.953 1.000 306 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1) 2814325 6 3 6 3 2 1 1 1 1 0 0.833 0.953 1.000 307 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1) 2488542 6 2 6 3 1 2 0 2 1 0 0.837 0.953 1.000 308 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(2), PRKCA(3), RELA(1) 2661481 7 4 7 5 2 0 1 3 0 1 0.919 0.955 1.000 309 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GCK(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), PFKFB1(3), PFKFB3(2), SORD(1), TPI1(1) 7737991 21 8 21 5 8 8 1 3 1 0 0.0740 0.955 1.000 310 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(8), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1) 10062593 38 21 36 12 8 10 3 7 7 3 0.343 0.957 1.000 311 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(3), CREBBP(8), EP300(3), MAPK3(1), SKIL(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 8290939 25 7 25 4 5 4 1 13 1 1 0.142 0.957 1.000 312 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKAG1(1) 3254985 6 2 6 1 1 0 0 4 1 0 0.487 0.958 1.000 313 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK3(1), PABPC1(4), PRKCA(3), RPS6KB1(1) 7611421 26 12 26 8 5 7 3 3 6 2 0.463 0.960 1.000 314 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 EGF(3), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SPRY1(1), SPRY4(1) 7205669 19 10 19 5 6 1 2 4 5 1 0.432 0.961 1.000 315 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), MBTPS1(1), MBTPS2(2), SCAP(1), SREBF1(4), SREBF2(1) 3873194 10 3 10 3 0 2 3 5 0 0 0.513 0.961 1.000 316 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(4), AOX1(3), DDC(1), ECH1(1), ESCO2(2), FAH(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), MYST3(1), MYST4(9), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), SH3GLB1(3), TAT(1), TH(1), TPO(4), TYR(4), TYRP1(2) 19208972 73 25 72 23 19 9 8 25 12 0 0.337 0.962 1.000 317 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), PPP2CA(3), RPS6KB1(1), TSC1(2), TSC2(2) 7442362 21 11 21 6 4 5 4 5 3 0 0.369 0.963 1.000 318 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGAP4(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(3), INPPL1(4), ITPR1(2), ITPR2(11), ITPR3(6), LIMK1(2), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDK1(2), PIK3CD(1), PIK3CG(4), PITX2(3), PPP1R13B(1), ROCK1(2), ROCK2(2), RPS4X(2), SAG(1), WASF1(1), WASL(1) 21172938 70 23 70 16 17 14 14 21 4 0 0.0367 0.963 1.000 319 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(1), ANXA1(2), GNAS(3), NFKB1(1), NOS3(5), NR3C1(2), RELA(1) 4552192 16 10 16 7 9 0 2 3 2 0 0.765 0.964 1.000 320 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNB1(1), CHRNG(1), MUSK(4), PTK2(1), YWHAH(1) 4050442 9 4 9 6 2 0 1 4 2 0 0.948 0.965 1.000 321 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(2), DHRS3(1), DHRS7(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1) 4855894 15 3 14 3 6 2 1 5 1 0 0.177 0.965 1.000 322 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ARAF(1), ATF4(1), BRAF(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(8), EP300(3), GRIA1(3), GRIA2(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), GRM1(5), GRM5(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), RAF1(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2) 32152389 94 37 94 26 24 11 12 32 13 2 0.121 0.966 1.000 323 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), MAPK3(1), POLR2A(3), PRKAR1A(1) 4157559 6 3 6 2 1 0 0 3 1 1 0.652 0.967 1.000 324 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP7A(5), ATP7B(2), COX7A1(1), COX7B(1), NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1), SHMT1(1), UQCRC1(2), UQCRH(2) 12345356 31 9 31 5 5 6 2 12 5 1 0.0607 0.967 1.000 325 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL12B(2), IL15(2), IL16(6), IL6(1), IL9(1) 3208098 13 8 13 5 1 0 3 6 3 0 0.817 0.968 1.000 326 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(1), MAPK8(1), PLCG1(6), PRKCA(3) 4449543 11 8 10 6 2 3 3 1 1 1 0.736 0.969 1.000 327 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), SEC22B(1), SNAP29(1), STX11(1), TSNARE1(4), USE1(1), VAMP4(1), VAMP7(1), VAMP8(1), VTI1A(1) 5397916 13 8 13 7 5 3 1 1 3 0 0.792 0.970 1.000 328 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), GLB1(1), HEXA(1), LCT(5), SLC33A1(2), ST3GAL1(1), ST6GALNAC3(2), ST8SIA5(2) 5326097 16 7 16 7 8 1 1 2 4 0 0.843 0.970 1.000 329 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL29(1), RPL32(1), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(1), RPS3(1) 7278842 16 5 16 2 7 1 3 3 2 0 0.196 0.972 1.000 330 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(3), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(4), MARS2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SCLY(1) 8062953 23 5 23 4 5 7 2 8 1 0 0.0580 0.974 1.000 331 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUL(1), HAL(1) 6143797 15 9 15 6 2 5 1 4 3 0 0.660 0.975 1.000 332 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), DPAGT1(1), DPM1(2), FUT8(3), MAN1A1(2), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), RPN2(1), ST6GAL1(1) 6414678 20 8 20 6 4 5 3 3 5 0 0.391 0.976 1.000 333 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 ITGB1(2), KLRC1(1), KLRC2(1), LAT(1), MAPK3(1), PAK1(2), RAC1(1), SYK(1), VAV1(4) 4801019 14 5 14 7 2 2 3 2 4 1 0.774 0.977 1.000 334 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(1), GLA(1), HEXA(1), ST3GAL1(1), ST3GAL4(2) 3268794 8 5 8 5 4 0 0 3 1 0 0.942 0.978 1.000 335 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOB(1), TPI1(1) 1265958 4 1 4 0 0 4 0 0 0 0 0.151 0.978 1.000 336 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACSL1(1), ACSL3(2), ACSL4(1), CPT1A(1), CPT2(1), DCI(1), EHHADH(1), SCP2(1), SLC25A20(1) 5438873 14 4 14 6 1 4 1 4 4 0 0.762 0.979 1.000 337 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(2), FUT6(2), ST3GAL6(2) 5202736 16 9 16 8 5 1 3 5 2 0 0.847 0.979 1.000 338 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1) 4547375 12 2 12 3 3 2 1 5 1 0 0.353 0.980 1.000 339 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CTH(1), GOT1(2), LDHB(1), SULT1B1(2), SULT1C2(3) 4054664 9 2 9 1 1 3 0 3 2 0 0.262 0.980 1.000 340 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2M(1) 3402436 2 2 2 7 0 0 1 0 1 0 1.000 0.981 1.000 341 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT2(2), GBGT1(1), GLA(1), HEXA(1), ST3GAL1(1) 3469496 7 3 7 6 4 0 0 2 1 0 0.979 0.981 1.000 342 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TOB1(1), TOB2(1) 3410239 10 4 10 2 3 3 1 3 0 0 0.254 0.982 1.000 343 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), AR(2), ESR1(1), ESR2(3), ESRRA(2), HNF4A(1), NPM1(2), NR1D1(1), NR1D2(1), NR1H2(1), NR1H3(4), NR1I2(1), NR2C2(1), NR2E1(1), NR2F2(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A1(1), PGR(2), PPARA(2), PPARG(1), ROR1(2), RXRA(1), RXRG(3), VDR(1) 13568567 40 12 39 10 14 7 6 9 4 0 0.0999 0.982 1.000 344 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(2), EHHADH(1), HSD17B4(2), SIRT7(1) 3827223 8 4 8 4 2 1 1 2 2 0 0.827 0.983 1.000 345 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 4134428 8 3 8 3 3 4 0 1 0 0 0.527 0.984 1.000 346 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF1(4), SREBF2(1) 5901929 10 4 10 4 2 3 2 3 0 0 0.604 0.984 1.000 347 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(3), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(4), PER2(3), PER3(1) 5516815 17 7 17 7 2 5 1 7 2 0 0.775 0.985 1.000 348 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAPK1(1), MAPK3(1), NFKB1(1), PLCB1(2), PRKCA(3), RAF1(1), RELA(1) 5012579 10 5 10 6 2 1 1 3 1 2 0.814 0.985 1.000 349 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CFL1(1), GNAS(3), LIMK1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(1), PIK3C2G(1), PLCB1(2), PRKCA(3), PTK2(1), RAF1(1), ROCK2(2) 8099725 21 13 21 9 3 2 2 8 4 2 0.814 0.985 1.000 350 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(4), MARS(4), MARS2(1), MTR(2) 5628364 23 7 23 9 6 5 0 9 2 1 0.514 0.985 1.000 351 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(3), MEF2A(2), MEF2B(1), PLCG1(6), RPS6KA1(2), SHC1(1) 4896152 19 9 18 7 3 6 1 6 2 1 0.515 0.985 1.000 352 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3), GPHN(1), NSF(2) 3862122 20 11 20 8 4 8 1 5 2 0 0.569 0.986 1.000 353 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), APAF1(1), ATM(4), BAX(1), CYCS(2), PRKCA(3), PTK2(1), STAT1(2), TLN1(2) 8579711 17 6 17 5 4 2 1 7 1 2 0.440 0.986 1.000 354 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), ETV5(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), MAPK8(1), STAT4(2), TYK2(5) 6035563 17 7 17 8 6 3 2 4 2 0 0.782 0.986 1.000 355 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4) 3478779 11 8 11 5 5 5 0 1 0 0 0.540 0.987 1.000 356 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1) 4330441 8 3 8 3 3 4 0 1 0 0 0.520 0.987 1.000 357 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2) 8831099 22 13 22 8 9 1 5 6 1 0 0.411 0.987 1.000 358 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(2), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1) 4100216 8 6 8 6 2 1 1 3 1 0 0.946 0.987 1.000 359 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(2), CA1(1), CA13(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), HAL(1) 6868588 17 10 17 8 2 6 1 5 3 0 0.776 0.988 1.000 360 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4) 3648469 12 8 12 5 5 5 0 2 0 0 0.512 0.988 1.000 361 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPOR(1), JAK2(3), NFKB1(1), RELA(1), SOD2(1) 4093436 7 2 7 5 2 1 0 3 1 0 0.915 0.988 1.000 362 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(1), BRAF(3), CREB1(1), CREB3(1), CREBBP(8), CRKL(1), DAG1(1), EGR1(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(6), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), OPN1LW(1), PIK3C2G(1), PIK3CD(1), PTPN11(6), RPS6KA3(2), SHC1(1), TH(1) 15359879 52 23 51 17 13 8 6 19 5 1 0.325 0.989 1.000 363 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TLR4(1), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 16952308 52 19 52 16 18 6 12 12 3 1 0.189 0.989 1.000 364 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TLR4(1), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1) 16952308 52 19 52 16 18 6 12 12 3 1 0.189 0.989 1.000 365 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(1) 5173004 10 2 10 3 2 3 1 3 1 0 0.524 0.989 1.000 366 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RB(1), IL6(1), STAT1(2), STAT3(1) 3932485 7 3 7 4 2 0 0 4 0 1 0.865 0.990 1.000 367 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(4), AKT1(1), ARAF(1), AREG(2), BRAF(3), BTC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBLB(1), CBLC(1), CDKN1B(1), CRKL(1), EGF(3), ELK1(3), ERBB2(1), ERBB3(2), ERBB4(3), KRAS(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), NRG1(2), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PRKCG(1), PTK2(1), RAF1(1), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), STAT5B(2) 31182805 91 35 90 20 29 14 10 22 14 2 0.0148 0.990 1.000 368 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAX(1), BFAR(1), BTK(1), CAD(4), CASP8AP2(2), CD7(1), CSNK1A1(2), DAXX(2), DFFA(1), DIABLO(1), EPHB2(1), FAF1(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(6), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TPX2(2), TUFM(1) 22326973 57 17 57 14 17 9 7 10 14 0 0.138 0.990 1.000 369 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), MAF(2), MAP2K3(2), NFATC1(1), NFATC2(4), PRKAR1A(1) 3920545 11 5 11 6 6 1 0 4 0 0 0.752 0.991 1.000 370 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(3), MAPK1(1), MAPK3(1), PRKAR1A(1), PRKCA(3), RAC1(1), RPS6KA1(2), SOS1(1) 8166301 20 8 20 5 5 3 1 4 5 2 0.332 0.991 1.000 371 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(5), FASN(1), MCAT(1), OXSM(1) 5112048 18 10 17 9 4 4 2 6 2 0 0.767 0.991 1.000 372 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(1), JAK2(3), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(3), PLCG1(6), PRKCA(3), RAF1(1), SHC1(1), SOS1(1), STAT1(2), STAT3(1) 13460447 37 14 36 10 11 7 3 7 6 3 0.170 0.992 1.000 373 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IRS1(2), JAK3(1), RPS6KB1(1), SHC1(1), STAT6(3) 4783581 9 5 9 4 2 2 0 4 1 0 0.725 0.992 1.000 374 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGW(1), PIGZ(1) 7705650 19 4 19 4 9 3 3 4 0 0 0.110 0.992 1.000 375 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(1), DIAPH1(3), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), TLN1(2) 10839359 23 8 23 7 7 3 3 7 2 1 0.348 0.993 1.000 376 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), CHST1(1), CHST4(1), FUT8(3), ST3GAL1(1), ST3GAL4(2) 4015673 9 7 9 6 3 3 1 1 1 0 0.859 0.993 1.000 377 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD33(1), CD7(1), IFNB1(1), IL12B(2), TLR4(1), TLR7(3), TLR9(1) 6004076 12 6 11 9 2 2 2 4 2 0 0.964 0.994 1.000 378 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), AP2M1(1), BIN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5) 6936017 17 4 17 5 5 1 2 4 5 0 0.454 0.995 1.000 379 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), EPRS(2), FARS2(1), GARS(2), HARS(1), IARS(1), LARS(3), MARS(4), MARS2(1), QARS(1), RARS(2), WARS2(2), YARS(1) 10365161 22 6 22 6 5 6 1 8 2 0 0.421 0.995 1.000 380 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), SLC23A2(3), SLC2A1(1), SLC2A3(2) 8101504 20 8 20 8 6 7 1 2 3 1 0.522 0.995 1.000 381 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(2), PLCG1(6), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 9205214 25 12 24 8 7 7 2 2 5 2 0.293 0.995 1.000 382 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), CREB1(1), CREB3(1), DAG1(1), EPHB2(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1) 9239396 16 8 16 5 3 3 2 4 4 0 0.453 0.996 1.000 383 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(3), AKT1(1), ATM(4), BAX(1), CPB2(1), CSNK1A1(2), CSNK1D(1), IGFBP3(1), MAPK8(1), MDM2(2) 6438045 17 7 17 7 4 2 3 6 2 0 0.666 0.996 1.000 384 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 FURIN(1) 1678759 1 1 1 0 1 0 0 0 0 0 0.650 0.996 1.000 385 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 30 ACPP(1), ALPP(1), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP2C9(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), PON1(2) 9103023 13 11 13 7 4 0 1 4 4 0 0.905 0.996 1.000 386 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(2), APOA1(1), CD36(3), CITED2(1), CREBBP(8), EHHADH(1), EP300(3), HSD17B4(2), LPL(2), MAPK1(1), MAPK3(1), ME1(1), NCOA1(1), NCOR1(8), NCOR2(3), NR1H3(4), NRIP1(1), PDGFA(1), PPARA(2), PRKAR1A(1), PRKCA(3), PTGS2(2), RB1(4), RELA(1), RXRA(1), STAT5B(2) 19210365 60 24 59 19 11 11 6 19 10 3 0.458 0.996 1.000 387 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(2), PRKCA(3), PTGS1(2), PTK2(1), RAF1(1), SYK(1) 7874948 23 14 23 9 2 3 5 9 2 2 0.682 0.997 1.000 388 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(3), GTF2F1(2), HDAC3(1), NCOA1(1), NCOA3(2), NCOR2(3), POLR2A(3), RXRA(1) 8060769 17 9 17 8 3 5 0 6 3 0 0.757 0.997 1.000 389 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), BCR(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), CSK(1), DAG1(1), FLOT1(1), FLOT2(1), INPP5D(2), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(4), PDK1(2), PIK3CD(1), PLCG2(6), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(4), RAF1(1), SHC1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4) 22663068 70 27 70 21 22 12 10 20 5 1 0.162 0.998 1.000 390 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2) 6594319 20 9 20 9 10 7 0 2 1 0 0.417 0.998 1.000 391 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(1), CDK2(1), CDKN1B(1), CDKN2A(2), CREB1(1), CREB3(1), ERBB4(3), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), MET(6), NOLC1(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPP1R13B(1), PREX1(5), PTK2(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SOS1(1), SOS2(4), TSC1(2), TSC2(2), YWHAH(1), YWHAQ(1), YWHAZ(1) 23987567 74 22 73 21 14 12 12 23 13 0 0.203 0.998 1.000 392 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(2), LDHB(1) 2213391 4 1 4 1 1 2 0 1 0 0 0.530 0.998 1.000 393 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(2), SDHC(1), UQCRC1(2) 2135329 5 2 5 2 0 1 1 3 0 0 0.730 0.998 1.000 394 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ABL1(4), ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGEF6(3), BCAR1(1), BRAF(3), CDKN2A(2), DOCK1(1), EPHB2(1), FYN(1), GRB7(3), GRLF1(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PIK3CB(1), PKLR(1), PLCG1(6), PLCG2(6), PTK2(1), RAF1(1), RALA(1), ROCK1(2), ROCK2(2), SHC1(1), SOS1(1), SOS2(4), TLN1(2), TLN2(3), WAS(2) 38522009 107 37 106 23 31 15 14 32 15 0 0.0107 0.999 1.000 395 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATP6V0C(1), GART(3), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 5780564 18 3 18 8 5 6 2 3 1 1 0.586 0.999 1.000 396 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), BPNT1(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), RBL2(2), SHC1(1), SOS1(1) 5610173 11 4 11 7 1 3 0 5 1 1 0.897 0.999 1.000 397 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 MAP3K1(2), MAP3K5(2), MAP4K5(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF9(2) 6254463 10 6 10 5 4 2 2 1 1 0 0.753 0.999 1.000 398 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(1), ARHGEF1(1), F2(2), GNAI1(1), PLCB1(2), PRKCA(3), ROCK1(2) 7127924 12 7 12 8 3 2 2 2 2 1 0.873 0.999 1.000 399 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ADCY3(2), ADCY9(3), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ERO1L(1), GNAS(3), PLCG1(6), PLCG2(6), PRKCA(3), SEC61A1(1) 11931972 35 19 34 11 17 7 3 4 3 1 0.280 0.999 1.000 400 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CMAS(1), GFPT1(1), GFPT2(3), GNE(1), GNPDA1(2), GNPNAT1(1), HEXA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), RENBP(1) 9281667 23 11 23 8 4 7 3 5 4 0 0.519 0.999 1.000 401 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(3), IL2RB(1), JAK3(1), MAPK3(1), MAPK8(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1) 7538375 14 9 14 6 1 4 1 5 2 1 0.626 0.999 1.000 402 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(2), TRAF3(1) 7256398 12 5 12 7 6 1 1 1 3 0 0.828 0.999 1.000 403 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(1), ARHGAP4(1), ARHGAP5(1), ARHGEF1(1), ARHGEF11(2), ARPC1B(1), ARPC3(1), BAIAP2(2), CFL1(1), DIAPH1(3), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(2), ROCK1(2), TLN1(2), VCL(1) 14647812 29 12 29 9 8 4 3 12 2 0 0.392 0.999 1.000 404 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(1), GCDH(1) 2519009 6 3 6 4 1 2 0 2 1 0 0.871 0.999 1.000 405 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(2), ELK1(3), MAP2K2(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(3), PTK2(1), RAC1(1), RAF1(1), SHC1(1), SOS1(1) 9968678 24 7 24 9 5 6 1 6 4 2 0.514 0.999 1.000 406 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), UROS(1) 2456723 4 1 4 1 2 0 0 2 0 0 0.640 0.999 1.000 407 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CREB1(1), ELK1(3), GNAI1(1), GNAS(3), MAPK3(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), RAF1(1), RPS6KA3(2) 11255732 35 16 34 12 10 4 4 8 7 2 0.471 0.999 1.000 408 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 25 ACLY(3), ACO1(2), ACO2(2), FH(1), IDH3B(1), OGDHL(2), PC(1), PCK1(3), SDHC(1), SUCLG2(1) 9118253 17 9 17 7 7 4 1 4 1 0 0.511 0.999 1.000 409 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(1) 2698718 6 4 6 6 2 2 0 1 1 0 0.970 0.999 1.000 410 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), AOX1(3), BCKDHA(1), ECHS1(2), EHHADH(1), HIBADH(1), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2) 11635936 38 14 37 13 12 13 2 6 5 0 0.342 1.000 1.000 411 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CRADD(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRADD(1) 7797393 12 7 12 8 6 3 0 1 2 0 0.899 1.000 1.000 412 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), ARHGEF1(1), MYL2(1), MYLK(3), PLCB1(2), PRKCA(3), ROCK1(2) 6665505 13 5 13 6 5 1 3 2 1 1 0.670 1.000 1.000 413 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HIBCH(1), MLYCD(3), SMS(1), SRM(1) 8718433 35 13 35 13 14 7 3 7 4 0 0.405 1.000 1.000 414 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(8), EP300(3), FYN(1), JAK3(1), STAT5B(2) 7819255 15 6 15 8 4 1 0 9 1 0 0.916 1.000 1.000 415 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(2), PPP3CA(1), PPP3CC(1), SLC2A4(1), YWHAH(1) 6538740 18 4 18 6 5 6 0 3 4 0 0.456 1.000 1.000 416 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CDK4(1), CDKN1B(1), CEBPB(1), DMC1(2), EGR1(1), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(1), NCOR1(8), NR5A1(1), NRIP1(1), PGR(2), PRLR(1), SMPD1(1), VDR(1), ZP2(1) 11324495 37 13 37 12 9 7 2 12 6 1 0.532 1.000 1.000 417 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), BLVRA(2), COX15(1), CP(3), EARS2(1), EPRS(2), FTH1(2), GUSB(2), HCCS(3), MMAB(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1) 13644703 46 21 46 14 14 4 12 15 1 0 0.274 1.000 1.000 418 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 DNAJC3(2), MAP3K14(1), NFKB1(1), RELA(1) 2892012 5 1 5 4 1 2 0 1 1 0 0.918 1.000 1.000 419 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CFLAR(1), CYCS(2), DFFA(1), GAS2(1), LMNA(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(2), TRADD(1) 10782245 16 6 16 7 5 3 1 4 3 0 0.706 1.000 1.000 420 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), PFKL(3), PLCG1(6), RAC1(1), RPS6KB1(1), VAV2(1) 8043001 20 10 19 9 7 7 1 3 2 0 0.632 1.000 1.000 421 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(1), CAPN10(3), CAPN11(2), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(3), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(2), MAPK4(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PIK3R2(1), PTK2(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(2), ROCK2(2), SDCCAG8(1), SHC1(1), SORBS1(1), SOS1(1), TLN1(2), TNS1(2), VAV2(1), VAV3(2), VCL(1) 43281592 108 33 108 27 35 18 13 30 12 0 0.0248 1.000 1.000 422 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), SHC1(1), SOS1(1) 2854607 3 2 3 3 0 0 0 1 2 0 0.931 1.000 1.000 423 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1D(2), EEF2(1), EEF2K(1), EIF1AX(2), EIF2AK3(2), EIF2B4(1), EIF4A1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G3(4), GSPT2(4), KIAA0664(5), PABPC1(4), PABPC3(1), PAIP1(1) 14158673 35 23 35 11 9 6 4 9 7 0 0.483 1.000 1.000 424 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMB8(1) 2824261 7 1 7 1 2 1 1 3 0 0 0.328 1.000 1.000 425 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(1), EIF4E(1), FBL(1), LDHB(1), NCL(1) 2880412 7 1 7 2 2 2 1 1 1 0 0.402 1.000 1.000 426 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1) 8772495 15 4 15 8 9 1 1 1 3 0 0.825 1.000 1.000 427 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(4), ASH2L(1), CTCFL(2), DOT1L(2), EHMT1(4), EHMT2(2), EZH1(3), EZH2(1), HCFC1(2), HSF4(1), JMJD6(2), KDM6A(2), MEN1(1), MLL(7), MLL2(12), MLL3(12), MLL4(7), MLL5(2), NSD1(2), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(2), PRDM7(2), PRMT5(1), PRMT6(1), SATB1(2), SETD1A(1), SETD2(6), SETD7(3), SETD8(1), SETDB1(1), SETDB2(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(2), WHSC1L1(3) 37683223 107 37 107 29 30 18 14 32 13 0 0.120 1.000 1.000 428 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), BRD4(1), CDKN2A(2), FLOT1(1), FLOT2(1), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), LNPEP(1), MAPK1(1), MAPK3(1), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPYR1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(4), YWHAH(1), YWHAQ(1), YWHAZ(1) 17745046 50 17 49 15 8 10 6 17 8 1 0.364 1.000 1.000 429 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(2), AXIN1(1), BMP10(1), BMP4(2), BMP5(3), CHRD(1), FZD1(1), MYL2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2) 11733811 21 6 21 4 8 4 2 6 1 0 0.112 1.000 1.000 430 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN2(6), ACTN3(1), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(1), RAC1(1), SPTAN1(2), TLN1(2) 9213738 21 6 21 9 6 3 4 6 2 0 0.674 1.000 1.000 431 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT2(1), B3GALT5(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(2), FUT6(2), GBGT1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL4(2), ST3GAL6(2), ST6GALNAC3(2), ST8SIA5(2), UGCG(2) 15665817 47 17 47 15 18 6 5 13 5 0 0.316 1.000 1.000 432 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFAT5(3), PDE6B(3), PDE6C(5), SLC6A13(2), TF(1) 11571861 38 16 38 14 13 8 7 7 3 0 0.370 1.000 1.000 433 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SRD5A1(1), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 16229980 48 22 48 16 15 4 10 16 3 0 0.305 1.000 1.000 434 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(2), CNGA3(2), CNGA4(1), CNGB1(1), GNAL(1), PDE1C(5), PRKG1(1), PRKG2(1) 9850175 25 6 25 9 14 4 1 3 3 0 0.334 1.000 1.000 435 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR3(1), MAP3K1(2), NFATC1(1), NFATC2(4), NFKB1(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RELA(1) 9031743 19 10 18 9 7 2 1 7 2 0 0.828 1.000 1.000 436 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(1), GPR161(1), GPR171(1), GPR34(1), GPR75(1), GPR81(1) 3170561 7 2 7 9 0 1 2 2 2 0 0.991 1.000 1.000 437 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(3), ATP5B(1), ATP5G2(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), COX15(1), COX17(1), COX7A1(1), COX7B(1), COX7B2(1), NDUFA10(3), NDUFA9(3), NDUFB11(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHC(1), TCIRG1(1), UQCRC1(2), UQCRH(2) 18012426 44 13 44 14 10 10 3 14 6 1 0.391 1.000 1.000 438 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(2), CD1A(2), CD1B(3), CD1E(3), CD22(1), CD33(1), CD36(3), CD3D(1), CD4(1), CD44(2), CD55(1), CD7(1), CR1(3), CR2(3), CSF1R(3), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), GP5(1), GP9(1), HLA-DRA(2), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(2), IL5RA(1), IL6(1), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), MME(2), MS4A1(2), TFRC(1), TPO(4) 26293436 82 24 82 27 20 20 8 26 8 0 0.188 1.000 1.000 439 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), CFLAR(1), CRKL(1), E2F1(1), IL2RB(1), IRS1(2), JAK3(1), MAPK1(1), MAPK3(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1) 10456309 17 8 17 8 2 5 1 5 3 1 0.688 1.000 1.000 440 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(1), FBXW7(1), ITK(1), LAT(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PLCG1(6), PTPRC(4), RAF1(1), RASGRP2(2), RASGRP3(1), SOS1(1), SOS2(4), VAV1(4), ZAP70(3) 17978990 52 17 51 15 18 11 4 11 8 0 0.211 1.000 1.000 441 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), CYCS(2), DAXX(2), FAS(1), MAPKAPK2(1), MAPKAPK3(1) 3660511 8 2 8 4 0 2 2 4 0 0 0.834 1.000 1.000 442 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(5), CAMK4(1), CEBPB(1), CNR1(1), CREBBP(8), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(3), FCGR3A(1), GATA3(1), GRLF1(3), IFNB1(1), IL1B(1), IL6(1), ITK(1), KPNA5(2), MAPK8(1), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(4), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(2), TRPV6(3), VAV1(4), VAV2(1), VAV3(2) 29366269 86 24 86 27 21 24 4 25 12 0 0.173 1.000 1.000 443 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(1), CREB1(1) 3739229 9 2 9 3 4 3 0 0 2 0 0.412 1.000 1.000 444 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), BMP5(3), BMP6(1), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(1), GLI1(2), GLI2(1), GLI3(2), HHIP(2), LRP2(12), PTCH1(3), SHH(1), SMO(2), SUFU(1), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1), ZIC2(2) 19647341 55 21 55 18 21 11 8 11 4 0 0.197 1.000 1.000 445 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP4B(2), INPPL1(4), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6) 13770494 40 19 39 13 10 8 5 12 5 0 0.472 1.000 1.000 446 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), RPN2(1) 4171691 8 2 8 4 2 2 1 2 1 0 0.813 1.000 1.000 447 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 AKT1(1), BTK(1), CDKN2A(2), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SOS1(1), SOS2(4), TEC(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 10650499 29 11 29 10 5 4 4 12 4 0 0.630 1.000 1.000 448 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), IMPDH1(2), POLB(1), POLD1(1), POLG(1), PRPS2(3), RRM1(3), SRM(1) 4015447 15 5 15 7 5 4 2 3 1 0 0.666 1.000 1.000 449 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(5), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(3), MAPK7(3), MEF2A(2), MEF2B(1), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), YWHAH(1) 10010504 28 9 28 11 11 7 1 6 3 0 0.472 1.000 1.000 450 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AB1(1), IFI30(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), KIR2DL1(1), KLRC1(1), KLRC2(1), LGMN(1), RFX5(1), RFXANK(1) 14919197 32 13 32 12 6 5 5 11 5 0 0.564 1.000 1.000 451 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(1) 4696560 8 2 8 5 2 3 1 1 1 0 0.813 1.000 1.000 452 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(2), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ATP6V0C(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), PLOD1(2), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(1) 11962542 35 10 35 13 16 7 3 4 5 0 0.273 1.000 1.000 453 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), ELK1(3), MAP2K2(1), NGFR(1), PIK3CD(1), SHC1(1), SOS1(1) 4504042 9 3 9 5 3 2 0 3 1 0 0.793 1.000 1.000 454 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12B(2), ALOX15(1), CBR3(1), CYP2B6(1), CYP2C8(1), CYP2C9(1), CYP2U1(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX4(1), LTA4H(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS1(2), PTGS2(2) 12245903 37 23 37 13 8 7 6 12 4 0 0.490 1.000 1.000 455 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(2), COPA(2), GBF1(2), GPLD1(1) 5241404 8 3 8 5 2 2 1 2 1 0 0.867 1.000 1.000 456 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), ALOX5AP(1), GGT1(2), LTA4H(2), PLA2G6(2), PTGS1(2), PTGS2(2) 4872346 12 5 12 6 2 5 2 2 1 0 0.706 1.000 1.000 457 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CHRM1(1), CHRNA1(2), FLT1(3), FLT4(3), KDR(6), NOS3(5), PDE3A(2), PRKAR1A(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1) 13067595 38 20 38 15 11 6 7 10 4 0 0.497 1.000 1.000 458 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), CREB1(1), EP300(3), NOS3(5) 5493214 10 3 10 6 5 0 2 2 1 0 0.849 1.000 1.000 459 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), DUSP4(1), GCK(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK7(3), MAPK8(1), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(1), ZAK(1) 15986569 36 13 36 12 12 5 8 9 2 0 0.442 1.000 1.000 460 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), TNFAIP3(1), TRAF3(1) 5864594 8 3 8 8 5 0 1 1 1 0 0.976 1.000 1.000 461 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(2), AXIN1(1), BTRC(1), FZD1(1) 5595688 5 2 5 3 1 1 0 2 1 0 0.897 1.000 1.000 462 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(3), CELSR1(8), CELSR2(9), CELSR3(10), CHRM3(2), EMR2(2), EMR3(1), FSHR(2), GHRHR(2), GNRHR(2), GPR116(5), GPR132(3), GPR133(1), GPR143(3), GPR61(2), GPR77(1), GPR84(2), GRM1(5), GRPR(2), HRH4(1), LPHN2(5), LPHN3(3), LTB4R2(1), NTSR1(2), OR8G2(1), P2RY13(1), PTGFR(5), SMO(2), SSTR2(1), TAAR5(1), TSHR(4) 21512059 97 37 97 30 32 20 11 23 11 0 0.0706 1.000 1.000 463 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(1), BRAF(3), CAB39(1), EIF4B(1), MAPK1(1), MAPK3(1), PGF(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), TSC1(2), TSC2(2), ULK2(5), VEGFA(2), VEGFB(1), VEGFC(2) 15954112 46 16 46 16 15 6 8 12 4 1 0.404 1.000 1.000 464 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(4), CANT1(4), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(3), TK2(3), TXNRD2(2), UCK1(2), UMPS(1), UPP1(1), UPP2(2), UPRT(2) 26135191 83 33 83 27 19 13 10 30 11 0 0.377 1.000 1.000 465 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(1), GSN(1), LMNA(2), LMNB2(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(2), NFKB1(1), NUMA1(6), PRKDC(8), PTK2(1), RASA1(4), RB1(4), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF1B(2), TRADD(1) 22292663 54 23 54 17 15 8 8 14 8 1 0.367 1.000 1.000 466 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(4), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), NT5C(2), NT5E(1), NT5M(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), RRM1(3), TK2(3), UCK1(2), UMPS(1), UPP1(1) 18497555 55 19 55 19 15 12 5 19 4 0 0.435 1.000 1.000 467 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), DARS2(2), EARS2(1), EPRS(2), FARS2(1), GARS(2), HARS(1), HARS2(1), IARS(1), IARS2(2), LARS(3), MARS(4), MARS2(1), MTFMT(1), NARS2(1), PARS2(1), QARS(1), RARS(2), RARS2(4), SARS2(1), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1) 17532786 41 9 41 12 7 10 4 15 5 0 0.392 1.000 1.000 468 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(1), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), EP400(2), ERCC2(1), ERCC3(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(4), SKIV2L2(2), SMARCA2(1), SMARCA5(1), SPR(1) 20259273 45 14 45 15 14 9 6 10 6 0 0.428 1.000 1.000 469 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(4), CCNA1(1), CCNB1(1), CCND1(1), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CREB3(1), CREB3L1(1), E2F1(1), E2F3(1), E2F5(1), GBA2(1), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MYT1(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLE(7), PRIM1(1), RB1(4), RBL1(2), RPA1(2), TNXB(9), WEE1(1) 24638987 70 24 70 24 16 9 10 19 16 0 0.453 1.000 1.000 470 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 ACO2(2), FH(1), IDH3B(1), PC(1), PDHA1(2), PDHA2(4), PDK1(2), PDK3(3), PDK4(1), PDP2(1), SDHC(1), SUCLG2(1) 8910981 20 9 20 9 4 4 3 8 1 0 0.694 1.000 1.000 471 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK3(3), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF3(3), DDIT3(1), DHX16(2), DHX38(3), DHX8(7), DHX9(2), DICER1(1), FUS(2), LOC440563(2), METTL3(2), NCBP1(1), NONO(1), PAPOLA(5), POLR2A(3), PRPF18(1), PRPF4(1), PRPF4B(2), PRPF8(6), PSKH1(1), PTBP1(1), RNGTT(2), SF3A3(1), SF3B1(5), SF3B2(1), SF4(1), SFRS14(1), SFRS2(1), SFRS4(1), SFRS5(2), SFRS7(1), SFRS8(3), SFRS9(1), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNURF(1), SPOP(2), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), U2AF1(2), U2AF2(1), XRN2(2) 34148182 100 35 99 27 33 19 7 24 17 0 0.244 1.000 1.000 472 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2B(2), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), ENPP1(1), ENPP3(2), EP400(2), ERCC2(1), ERCC3(1), G6PC(4), G6PC2(1), GAA(5), GANC(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), IFIH1(1), LYZL1(1), MGAM(4), MOV10L1(1), PYGB(1), PYGL(3), PYGM(1), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(4), SI(6), SKIV2L2(2), SMARCA2(1), SMARCA5(1), TREH(1), UGDH(1), UGP2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UXS1(2) 39968690 120 44 120 31 36 20 21 32 11 0 0.0329 1.000 1.000 473 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), ARHGAP5(1), BCAR1(1), BIRC2(1), BRAF(3), CCND1(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), CRKL(1), DIAPH1(3), DOCK1(1), EGF(3), ELK1(3), ERBB2(1), FARP2(1), FLNA(8), FLNB(7), FLNC(7), FLT1(3), FN1(2), FYN(1), GRLF1(3), HGF(3), IBSP(1), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KDR(6), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), MET(6), MYL2(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PARVA(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PGF(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PRKCA(3), PRKCG(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(6), ROCK1(2), ROCK2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TLN1(2), TLN2(3), TNC(3), TNN(7), TNR(4), TNXB(9), VAV1(4), VAV2(1), VAV3(2), VCL(1), VEGFA(2), VEGFB(1), VEGFC(2), VWF(5) 117568737 350 99 349 113 104 77 42 85 39 3 0.0137 1.000 1.000 474 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY7(2), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), AVPR1A(2), AVPR1B(1), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM5(4), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), ERBB2(1), ERBB3(2), ERBB4(3), GNA11(1), GNA14(1), GNAL(1), GNAS(3), GRIN2A(1), GRIN2C(2), GRIN2D(4), GRM1(5), GRM5(2), GRPR(2), HRH1(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), ITPR1(2), ITPR2(11), ITPR3(6), LTB4R2(1), MYLK(3), MYLK2(1), NOS1(2), NOS3(5), NTSR1(2), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(8), PHKA1(2), PHKA2(4), PHKG1(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), PPID(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGER3(1), PTGFR(5), RYR1(10), RYR2(10), RYR3(6), SLC25A5(1), SLC25A6(1), SLC8A2(3), SLC8A3(1), TACR2(1), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(2) 86014816 283 96 281 100 96 53 35 58 40 1 0.0971 1.000 1.000 475 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(3), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CALCR(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CNR1(1), CNR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD3(1), DRD5(2), EDNRB(1), F2(2), FPR1(1), FSHR(2), GABBR1(2), GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3), GABRB1(4), GABRB2(2), GABRB3(2), GABRD(2), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(2), GALR1(1), GH1(1), GHR(2), GHRHR(2), GIPR(2), GLP2R(1), GLRA1(1), GLRB(2), GNRHR(2), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(3), GRIA2(2), GRIA3(5), GRIA4(2), GRID1(1), GRID2(3), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(4), GRIK5(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), GRIN3A(2), GRM1(5), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM6(2), GRM7(3), GRM8(1), GRPR(2), HCRTR2(2), HRH1(1), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LEPR(1), LTB4R(2), LTB4R2(1), MC3R(1), MC4R(3), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(1), NPY1R(3), NR3C1(2), NTSR1(2), OPRL1(1), OPRM1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(3), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(1), PPYR1(2), PRLR(1), PRSS1(1), PRSS3(1), PTGER3(1), PTGER4(1), PTGFR(5), PTH2R(1), RXFP1(2), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(4), TAAR5(1), TAAR6(1), TACR2(1), TBXA2R(1), TRHR(2), TSHR(4), UTS2R(1), VIPR1(1) 71529312 279 88 279 90 85 57 33 77 27 0 0.0118 1.000 1.000 476 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(2), ACVR1C(1), AKT1(1), ARRB1(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D3(1), CACNA2D4(2), CACNB2(3), CACNB3(1), CACNG1(3), CACNG2(1), CACNG3(2), CACNG7(3), CACNG8(1), CRKL(1), DAXX(2), DDIT3(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP7(1), DUSP9(2), EGF(3), ELK1(3), FAS(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(3), FLNA(8), FLNB(7), FLNC(7), IL1B(1), IL1R1(1), IL1R2(2), KRAS(1), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K8(2), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MRAS(1), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(1), PAK1(2), PDGFA(1), PDGFRA(8), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(3), RASA1(4), RASA2(2), RASGRF1(2), RASGRF2(2), RASGRP2(2), RASGRP3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RRAS(1), SOS1(1), SOS2(4), SRF(2), STK3(2), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), ZAK(1) 89267334 271 86 269 111 86 55 32 61 34 3 0.488 1.000 1.000 477 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(2), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), DSC1(2), DSC2(1), DSC3(4), DSG1(2), DSG2(2), DSG3(2), DSG4(1), FN1(2), GJA1(4), GJA10(1), GJA3(1), GJA4(1), GJA8(2), GJB2(1), GJB6(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(2), KRT1(1), KRT12(1), KRT14(1), KRT15(1), KRT16(3), KRT17(2), KRT2(1), KRT20(3), KRT24(1), KRT25(1), KRT27(1), KRT28(2), KRT3(3), KRT31(1), KRT33A(4), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT39(2), KRT5(4), KRT6B(2), KRT6C(3), KRT7(1), KRT71(2), KRT73(1), KRT75(2), KRT76(1), KRT77(1), KRT78(1), KRT8(3), KRT83(2), KRT84(1), KRT86(2), KRT9(1), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), LMNA(2), LMNB2(2), NES(3), PRPH(1), RELN(6), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VIM(2), VWF(5) 80400410 255 84 254 86 93 61 22 59 19 1 0.0541 1.000 1.000 478 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 ABI2(2), ACTN2(6), ACTN3(1), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(1), ARHGEF4(3), ARHGEF6(3), ARPC1B(1), ARPC3(1), BAIAP2(2), BCAR1(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(5), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(3), EZR(1), F2(2), FGD3(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(3), FN1(2), GIT1(1), GRLF1(3), GSN(1), IQGAP1(9), IQGAP2(3), IQGAP3(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KRAS(1), LIMK1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MRAS(1), MYH10(4), MYH14(3), MYL2(1), MYLK(3), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDGFA(1), PDGFRA(8), PFN4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(2), RRAS(1), SCIN(2), SOS1(1), SOS2(4), SSH2(1), SSH3(1), TIAM1(3), TIAM2(3), TMSL3(1), VAV1(4), VAV2(1), VAV3(2), VCL(1), WAS(2), WASF1(1), WASL(1) 87182345 243 82 242 84 61 48 34 66 32 2 0.176 1.000 1.000 479 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), AMOTL1(1), ASH1L(4), CASK(1), CDK4(1), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), HCLS1(1), INADL(4), JAM2(3), JAM3(2), KRAS(1), LLGL1(3), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(5), MLLT4(4), MPDZ(6), MRAS(1), MYH1(5), MYH10(4), MYH11(3), MYH13(4), MYH14(3), MYH15(5), MYH2(8), MYH3(6), MYH4(5), MYH6(2), MYH7(5), MYH7B(6), MYH8(7), MYL2(1), NRAS(1), OCLN(1), PARD3(1), PARD6A(1), PPM1J(2), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PPP2R3A(2), PPP2R4(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RAB3B(1), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(1), TJP1(4), TJP2(1), TJP3(1), YES1(2), ZAK(1) 62286358 189 69 189 71 63 30 26 50 19 1 0.372 1.000 1.000 480 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(3), CD44(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), DAG1(1), FN1(2), FNDC1(2), FNDC3A(3), FNDC5(1), GP5(1), GP9(1), HSPG2(8), IBSP(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), RELN(6), SDC1(1), SDC3(1), SPP1(1), SV2A(2), SV2B(2), SV2C(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VWF(5) 72351113 216 63 216 64 67 56 24 52 16 1 0.0100 1.000 1.000 481 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(5), EFNA1(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(1), EPHA2(2), EPHA3(3), EPHA4(5), EPHA5(2), EPHA6(1), EPHA7(4), EPHA8(2), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(3), FES(2), FYN(1), GNAI1(1), ITGB1(2), KRAS(1), L1CAM(4), LIMK1(2), LRRC4C(4), MAPK1(1), MAPK3(1), MET(6), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NGEF(3), NRAS(1), NRP1(3), NTN4(1), NTNG1(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PLXNA1(7), PLXNA2(4), PLXNA3(4), PLXNB1(4), PLXNB2(5), PLXNB3(3), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC2(1), RASA1(4), RGS3(5), RHOD(1), RND1(1), ROBO1(3), ROBO2(5), ROBO3(1), ROCK1(2), ROCK2(2), SEMA3A(4), SEMA3C(1), SEMA3D(2), SEMA3E(4), SEMA3F(2), SEMA4B(2), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA6A(2), SEMA6B(3), SEMA6C(2), SEMA6D(2), SEMA7A(2), SLIT1(4), SLIT2(3), SLIT3(1), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(1) 63799219 209 62 209 68 62 41 28 58 19 1 0.0631 1.000 1.000 482 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 248 ACVR1(3), ACVR1B(2), ACVR2A(1), AMHR2(1), CCL11(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CSF1R(3), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(4), EGF(3), EPOR(1), FAS(1), FLT1(3), FLT3(2), FLT4(3), GDF5(1), GH1(1), GHR(2), HGF(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(1), IL17RA(1), IL18RAP(1), IL1B(1), IL1R1(1), IL1R2(2), IL1RAP(1), IL20RA(2), IL22RA1(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), INHBA(1), INHBB(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEPR(1), LTBR(2), MET(6), MPL(2), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(8), PRLR(1), RELT(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(2), TNFSF14(1), TNFSF15(3), TNFSF8(1), TPO(4), VEGFA(2), VEGFB(1), VEGFC(2), XCL1(1) 56284199 183 59 182 76 47 43 29 40 24 0 0.497 1.000 1.000 483 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(2), ARRB1(2), ATP1B2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1S(6), CACNB3(1), CALR(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), GJA1(4), GJA4(1), GJB2(1), GJB6(1), GNA11(1), GNAO1(2), GNB5(1), GRK4(4), GRK5(4), ITPR1(2), ITPR2(11), ITPR3(6), KCNB1(3), KCNJ3(1), KCNJ5(2), MIB1(1), PLCB3(3), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(2), RYR1(10), RYR2(10), RYR3(6), SFN(2), SLC8A3(1), YWHAH(1), YWHAQ(1) 60541758 187 58 187 67 65 35 21 43 22 1 0.180 1.000 1.000 484 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADK(1), ADSL(3), ADSSL1(1), AK5(1), AK7(4), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), CANT1(4), ENPP1(1), ENPP3(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(3), GMPR(1), GMPR2(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), PAICS(1), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE7A(1), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(2), PRPS1L1(1), PRPS2(3), RRM1(3), XDH(7) 52732559 159 56 158 54 53 29 19 42 16 0 0.147 1.000 1.000 485 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(4), CD22(1), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CDH1(3), CDH15(1), CDH2(2), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(1), CNTN2(1), CNTNAP1(4), CNTNAP2(3), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(3), JAM3(2), L1CAM(4), MPZ(1), NCAM1(2), NEGR1(2), NEO1(4), NFASC(1), NLGN1(2), NLGN2(3), NLGN3(2), NRCAM(3), NRXN1(5), NRXN3(3), OCLN(1), PDCD1LG2(1), PTPRC(4), PTPRF(3), PTPRM(4), PVR(2), PVRL1(1), SDC1(1), SDC3(1), SELE(4), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(5) 47706524 155 54 154 54 47 41 12 40 15 0 0.0988 1.000 1.000 486 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CSNK1D(1), EGF(3), GJA1(4), GNA11(1), GNAI1(1), GNAS(3), GRM1(5), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(3), NPR1(1), NPR2(2), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), SOS1(1), SOS2(4), TJP1(4), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1) 41845975 133 53 132 48 46 21 18 25 21 2 0.284 1.000 1.000 487 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCBP2(1), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHML(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD3(1), DRD5(2), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GPR174(1), GPR35(1), GPR37(1), GPR4(1), GPR50(2), GPR6(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), GPR87(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LTB4R(2), MC3R(1), MC4R(3), MC5R(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPY1R(3), NTSR1(2), OPN1SW(1), OPN3(1), OPRL1(1), OPRM1(1), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(2), OR7C1(1), P2RY1(1), P2RY12(1), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(2), PTGER4(1), PTGFR(5), SSTR2(1), SSTR3(2), SSTR4(4), SUCNR1(1), TBXA2R(1), TRHR(2) 39203052 148 52 148 53 48 24 18 43 15 0 0.117 1.000 1.000 488 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ARRB1(2), ATF4(1), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), CREB3(1), GABPA(2), GABPB2(1), GBA2(1), GJA1(4), GNB5(1), GRK4(4), GRK5(4), GUCY1A3(1), IGFBP2(2), IGFBP3(1), IL1B(1), IL6(1), ITPR1(2), ITPR2(11), ITPR3(6), MIB1(1), MYL2(1), MYLK2(1), NFKB1(1), NOS1(2), NOS3(5), PDE4D(3), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(6), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(2), RLN1(1), RYR1(10), RYR2(10), RYR3(6), SFN(2), TNXB(9), YWHAH(1), YWHAQ(1) 55873772 170 52 169 65 60 26 22 42 19 1 0.389 1.000 1.000 489 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(3), C7orf16(1), CACNA1A(1), GNA11(1), GNAI1(1), GNAO1(2), GNAS(3), GRIA1(3), GRIA2(2), GRIA3(5), GRID2(3), GRM1(5), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IGF1R(3), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(2), NOS3(5), NPR1(1), NPR2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), RYR1(10) 35600821 123 50 123 37 33 21 21 29 17 2 0.125 1.000 1.000 490 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ATF4(1), CACNA1D(5), CACNA1F(4), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(3), GNRHR(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAP3K3(2), MAP3K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLD1(4), PRKCA(3), RAF1(1), SOS1(1), SOS2(4) 40256300 120 48 120 38 46 20 15 22 15 2 0.0746 1.000 1.000 491 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), BRAF(3), CD244(1), FAS(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(1), KLRC1(1), KLRC2(1), KRAS(1), LAT(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(3), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NRAS(1), PAK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(3), PRKCG(1), PTPN11(6), RAC1(1), RAC2(1), RAF1(1), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SYK(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(4), VAV2(1), VAV3(2), ZAP70(3) 35398052 114 47 112 39 32 18 17 28 17 2 0.249 1.000 1.000 492 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(10), ACACB(5), AKT1(1), ARAF(1), BRAF(3), CBLB(1), CBLC(1), CRKL(1), ELK1(3), EXOC7(1), FASN(1), FBP1(1), FBP2(2), FLOT1(1), FLOT2(1), G6PC(4), G6PC2(1), GCK(1), GYS1(1), INPP5D(2), INSR(3), IRS1(2), IRS2(1), IRS4(6), KRAS(1), LIPE(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PCK1(3), PDE3A(2), PFKL(3), PHKA1(2), PHKA2(4), PHKG1(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(1), PPP1CB(1), PPP1R3A(2), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKCI(1), PTPRF(3), PYGB(1), PYGL(3), PYGM(1), RAF1(1), RAPGEF1(3), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(4), SREBF1(4), TSC1(2), TSC2(2) 50539591 136 46 134 53 36 25 13 43 17 2 0.532 1.000 1.000 493 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(2), ACTN2(6), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(3), MYH3(6), MYH6(2), MYH7(5), MYH8(7), MYL1(1), MYL2(1), MYOM1(1), NEB(16), TNNI1(1), TNNT1(1), TNNT3(1), TPM1(5), TPM3(2), TPM4(1), TTN(75), VIM(2) 43911699 150 45 150 48 42 30 17 48 12 1 0.184 1.000 1.000 494 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(2), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(1), CHD8(1), CREBBP(8), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CTBP1(3), CUL1(1), CXXC4(1), DAAM1(1), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), LRP5(4), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NKD2(1), NLK(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PORCN(4), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(3), PRKCA(3), PRKCG(1), RAC1(1), RAC2(1), ROCK1(2), ROCK2(2), RUVBL1(1), SENP2(2), SFRP1(1), SFRP2(1), SFRP4(1), SIAH1(1), SMAD2(3), SMAD3(1), SOX17(2), TBL1XR1(1), TCF7L2(2), VANGL1(1), VANGL2(1), WIF1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 51945249 145 43 145 44 47 25 15 41 16 1 0.0755 1.000 1.000 495 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(1), BCAR1(1), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(2), CTNNA3(1), CXCR4(1), CYBB(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GRLF1(3), ICAM1(2), ITGA4(2), ITGAL(2), ITGAM(1), ITGB1(2), ITGB2(1), ITK(1), JAM2(3), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(4), MMP9(1), MYL2(1), NCF1(1), NCF2(3), NOX1(1), NOX3(1), OCLN(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PRKCG(1), PTK2(1), PTPN11(6), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(2), SIPA1(2), TXK(1), VAV1(4), VAV2(1), VAV3(2), VCAM1(1), VCL(1) 38911384 120 43 118 50 41 23 12 32 11 1 0.534 1.000 1.000 496 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CDS2(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(2), INPP5B(2), INPP5D(2), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPR1(2), ITPR2(11), ITPR3(6), OCRL(4), PI4KA(5), PI4KB(1), PIK3C2A(3), PIK3C2G(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), PRKCA(3), PRKCG(1), SYNJ1(4), SYNJ2(5) 38778592 120 42 119 35 37 22 15 30 15 1 0.112 1.000 1.000 497 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(2), CDH1(3), CREBBP(8), CSNK2A1(1), CTNNA2(2), CTNNA3(1), EP300(3), ERBB2(1), FARP2(1), FER(1), FGFR1(1), FYN(1), IGF1R(3), INSR(3), IQGAP1(9), LMO7(4), MAPK1(1), MAPK3(1), MET(6), MLLT4(4), NLK(1), PARD3(1), PTPRB(5), PTPRF(3), PTPRJ(2), PTPRM(4), PVRL1(1), PVRL4(2), RAC1(1), RAC2(1), SMAD2(3), SMAD3(1), SORBS1(1), SSX2IP(1), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(4), VCL(1), WAS(2), WASF1(1), WASF3(2), WASL(1), YES1(2) 37848622 114 41 114 36 35 18 11 33 16 1 0.154 1.000 1.000 498 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT1(1), CBLB(1), CBLC(1), CCND1(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(8), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(3), EPOR(1), GH1(1), GHR(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL20RA(2), IL22RA1(1), IL23A(1), IL23R(4), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), IRF9(2), JAK2(3), JAK3(1), LEPR(1), MPL(2), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRLR(1), PTPN11(6), SOCS4(1), SOS1(1), SOS2(4), SPRED1(1), SPRED2(2), SPRY1(1), SPRY4(1), STAM2(1), STAT1(2), STAT3(1), STAT4(2), STAT5B(2), STAT6(3), TPO(4), TYK2(5) 45678408 127 40 126 48 29 19 18 48 12 1 0.627 1.000 1.000 499 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADK(1), ADSL(3), AK5(1), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), ATP5B(1), ATP5G2(1), CANT1(4), ENPP1(1), ENPP3(2), ENTPD1(1), GART(3), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE6B(3), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), PPAT(2), PRPS1L1(1), PRPS2(3), RRM1(3) 41397427 120 40 120 52 44 26 14 28 8 0 0.636 1.000 1.000 500 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(4), ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(4), ATR(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB1(1), CCNB3(3), CCND1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(2), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC27(3), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CHEK1(3), CHEK2(3), CREBBP(8), CUL1(1), DBF4(4), E2F1(1), E2F3(1), EP300(3), ESPL1(5), FZR1(2), HDAC2(4), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PKMYT1(1), PLK1(1), PRKDC(8), RB1(4), RBL1(2), RBL2(2), SFN(2), SKP2(2), SMAD2(3), SMAD3(1), SMC1A(1), SMC1B(4), TGFB2(2), TGFB3(1), WEE1(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 43575727 142 39 141 44 23 31 22 39 25 2 0.297 1.000 1.000 501 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3(1), CREB3L1(1), CREB3L2(1), CREBBP(8), DVL2(1), DVL3(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAO1(2), GNAS(3), KIT(3), KITLG(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PRKCA(3), PRKCG(1), RAF1(1), TCF7L2(2), TYR(4), TYRP1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1) 35147589 96 39 96 35 36 10 7 27 14 2 0.344 1.000 1.000 502 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(3), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHST3(2), CHST4(1), CHSY1(1), DAD1(1), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL3(1), FUT8(3), GALNT1(1), GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GANAB(3), GCNT4(2), HS6ST2(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(1), NDST1(2), NDST2(2), NDST3(2), NDST4(1), OGT(6), RPN2(1), ST3GAL1(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(4), XYLT1(1), XYLT2(1) 35536693 104 38 104 33 32 19 11 28 14 0 0.261 1.000 1.000 503 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), AKAP11(1), AKAP12(1), AKAP3(1), AKAP4(4), AKAP5(2), AKAP6(8), AKAP7(1), AKAP8(2), AKAP9(5), ARHGEF1(1), GNA11(1), GNA14(1), GNAL(1), GNAO1(2), GNB5(1), ITPR1(2), KCNJ3(1), KRAS(1), NRAS(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE7A(1), PDE7B(2), PDE8A(4), PLCB3(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RRAS(1) 37791831 90 36 90 47 30 14 8 23 14 1 0.923 1.000 1.000 504 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(3), ACVR1B(2), ACVRL1(3), AKT1(1), BUB1(3), CDS2(2), CLK1(2), CLK4(1), CSNK2A1(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(2), INPPL1(4), NEK3(1), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PIM2(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6), PLK3(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), TGFBR1(1), VRK1(3) 35715501 94 36 93 37 27 17 11 23 14 2 0.627 1.000 1.000 505 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 81 ABL1(4), ATM(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB1(1), CCNB3(3), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(2), CDC20(1), CDC25A(1), CDH1(3), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(3), DTX4(1), E2F1(1), E2F3(1), E2F5(1), EP300(3), ESPL1(5), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MPEG1(2), MPL(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PLK1(1), PRKDC(8), PTPRA(4), RB1(4), RBL1(2), SKP2(2), TBC1D8(1), WEE1(1) 35178997 111 31 111 40 20 26 17 29 17 2 0.546 1.000 1.000 506 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), ALDH1A3(3), ALDH3A1(4), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C8(1), CYP2C9(1), CYP2S1(1), CYP3A7(1), EPHX1(3), GSTA4(1), GSTA5(3), GSTZ1(2), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1) 18188255 62 29 62 23 17 6 12 22 5 0 0.555 1.000 1.000 507 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(5), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOR1(2), ADIPOR2(3), AKT1(1), CAMKK1(1), CAMKK2(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), G6PC(4), G6PC2(1), IRS1(2), IRS2(1), IRS4(6), JAK2(3), JAK3(1), LEPR(1), MAPK10(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIE(1), NPY(1), PCK1(3), PPARA(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(6), RELA(1), RXRA(1), RXRG(3), SLC2A1(1), SLC2A4(1), STAT3(1), TNFRSF1B(2), TRADD(1), TYK2(5) 26804589 86 29 84 37 24 17 5 29 11 0 0.753 1.000 1.000 508 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(8), CTBP1(3), DTX2(1), DTX3L(1), DTX4(1), DVL2(1), DVL3(1), EP300(3), HDAC2(4), JAG1(2), LFNG(1), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NCOR2(3), NCSTN(3), NOTCH2(9), NOTCH3(4), NOTCH4(8), NUMBL(2), RBPJ(2), RBPJL(1), SNW1(1) 21028888 65 28 65 27 19 10 4 17 14 1 0.754 1.000 1.000 509 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(1), CBLB(1), CBLC(1), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FYN(1), ITK(1), KRAS(1), LAT(1), MAP3K14(1), MAP3K8(2), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(4), SOS1(1), SOS2(4), TEC(1), VAV1(4), VAV2(1), VAV3(2), ZAP70(3) 31548182 85 28 84 33 27 16 7 22 13 0 0.543 1.000 1.000 510 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), CREB1(1), DAXX(2), ELK1(3), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K8(2), MAP3K9(2), MAP4K3(1), MAP4K4(2), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), NFKB1(1), PAK1(2), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1) 30685412 82 28 81 32 24 12 13 22 9 2 0.568 1.000 1.000 511 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(3), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVRL1(3), AMHR2(1), BMP4(2), BMP5(3), BMP6(1), CHRD(1), CREBBP(8), CUL1(1), DCN(1), E2F5(1), EP300(3), GDF5(1), GDF6(1), INHBA(1), INHBB(1), INHBE(1), LTBP1(4), MAPK1(1), MAPK3(1), NODAL(1), PITX2(3), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), RBL1(2), RBL2(2), ROCK1(2), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(3), SMAD2(3), SMAD3(1), SMAD5(1), SMAD7(2), SMAD9(2), SMURF1(1), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(1), THBS2(4), THBS3(2), THBS4(3) 31925093 98 27 98 31 31 15 13 31 7 1 0.157 1.000 1.000 512 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(1), CCL5(1), CD40(1), CXCL9(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IKBKE(4), IL12B(2), IL1B(1), IL6(1), IRAK4(1), IRF7(2), LBP(1), MAP2K2(1), MAP2K3(2), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(1), SPP1(1), STAT1(2), TBK1(2), TICAM1(1), TLR1(2), TLR3(5), TLR4(1), TLR6(2), TLR7(3), TLR9(1), TRAF3(1) 27753498 71 27 70 33 21 16 11 16 5 2 0.707 1.000 1.000 513 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(2), MC3R(1), MC4R(3), MC5R(1), NMBR(3), NPY1R(3), NTSR1(2), OPRL1(1), OPRM1(1), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR2(1), TRHR(2), TSHR(4) 16894569 60 26 60 27 20 10 10 17 3 0 0.553 1.000 1.000 514 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(3), ABCA12(3), ABCA13(9), ABCA2(3), ABCA3(3), ABCA4(4), ABCA5(2), ABCA6(5), ABCA7(2), ABCA8(3), ABCA9(2), ABCB1(3), ABCB11(1), ABCB4(4), ABCB5(3), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(4), ABCC10(7), ABCC11(3), ABCC12(4), ABCC3(6), ABCC4(2), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(4), ABCD1(2), ABCG1(1), ABCG4(2), ABCG5(3), ABCG8(3), CFTR(1) 38104499 104 25 104 43 30 18 15 30 10 1 0.617 1.000 1.000 515 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(1), ATM(4), ATR(4), BAI1(2), BAX(1), CCNB1(1), CCNB3(3), CCND1(1), CCNE2(1), CCNG2(1), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(3), CYCS(2), DDB2(1), EI24(2), FAS(1), GTSE1(4), IGFBP3(1), LRDD(1), MDM2(2), MDM4(1), PPM1D(1), RFWD2(3), SERPINE1(1), SESN1(1), SESN3(1), SFN(2), SIAH1(1), STEAP3(1), THBS1(1), TSC2(2), ZMAT3(3) 20539907 61 24 61 24 14 10 11 19 7 0 0.576 1.000 1.000 516 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), AOX1(3), CAT(2), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2), KMO(2), LCMT1(2), LCMT2(1), LNX1(3), METTL2B(3), METTL6(1), NFX1(1), OGDHL(2), PRMT2(2), PRMT5(1), PRMT6(1), TDO2(1), TPH1(2), TPH2(1), WARS2(2) 19576881 58 21 58 25 22 11 4 13 8 0 0.644 1.000 1.000 517 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ANGPTL4(1), APOA1(1), AQP7(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP7A1(1), EHHADH(1), FABP7(1), FADS2(2), GK2(3), HMGCS2(2), LPL(2), ME1(1), NR1H3(4), PCK1(3), PPARA(2), PPARG(1), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A5(3), SORBS1(1), UBC(3) 21137211 62 21 61 25 14 15 9 20 4 0 0.574 1.000 1.000 518 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), IFITM1(1), INPP5D(2), KRAS(1), LILRB3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(1), SYK(1), VAV1(4), VAV2(1), VAV3(2) 22792446 60 21 60 27 24 11 4 14 7 0 0.665 1.000 1.000 519 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 ELK1(3), GNAS(3), IGF1R(3), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), PDGFRA(8), PPP2CA(3), PTPRR(3), RAF1(1), RPS6KA1(2), SHC1(1), SOS1(1), STAT3(1) 9816917 35 20 34 16 6 8 4 9 7 1 0.820 1.000 1.000 520 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), DCI(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2) 15825533 51 20 51 23 15 8 5 15 8 0 0.808 1.000 1.000 521 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), AOX1(3), CAT(2), CYP1A2(2), CYP2B6(1), CYP2C8(1), CYP2C9(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), KMO(2), TDO2(1), TPH1(2), WARS2(2) 17444680 43 20 43 21 15 9 3 10 6 0 0.845 1.000 1.000 522 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), GOT1(2), NOS1(2), NOS3(5), OAT(1), ODC1(2), P4HA1(1), RARS(2), SMS(1) 14293713 45 19 45 23 16 9 4 10 6 0 0.850 1.000 1.000 523 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH1A3(3), ALDH3A1(4), DDC(1), EPX(2), ESCO2(2), GOT1(2), HPD(1), LPO(5), MPO(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(4) 11047347 43 19 42 16 14 9 4 8 8 0 0.527 1.000 1.000 524 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(4), AOX1(3), DDC(1), FAH(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), TAT(1), TH(1), TPO(4), TYR(4) 10247796 42 19 42 17 15 3 5 14 5 0 0.590 1.000 1.000 525 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 CRKL(1), DOCK1(1), ELK1(3), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(6), PAK1(2), PTK2(1), PTPN11(6), RAF1(1), RASA1(4), SOS1(1), STAT3(1) 12752205 38 18 37 16 10 5 4 11 7 1 0.662 1.000 1.000 526 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(2), ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(2), SLC27A5(3), SOAT1(1), SOAT2(2), SRD5A1(1) 10211068 45 17 45 18 15 5 4 17 4 0 0.690 1.000 1.000 527 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(1), FTCD(1), HAL(1), HARS(1), HARS2(1), HDC(2), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRPS2(3), UROC1(1) 12810338 42 17 42 19 19 8 3 9 3 0 0.573 1.000 1.000 528 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(1), BCR(1), BLNK(2), BTK(1), CSK(1), DAG1(1), EPHB2(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PI3(1), PIK3CD(1), PLCG2(6), PPP1R13B(1), RAF1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4) 15785017 39 17 39 16 16 6 4 9 4 0 0.560 1.000 1.000 529 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(4), ATR(4), BRCA1(1), CCNB1(1), CDC25A(1), CDC34(1), CHEK1(3), CHEK2(3), EP300(3), MDM2(2), MYT1(3), PRKDC(8), RPS6KA1(2), WEE1(1), YWHAH(1), YWHAQ(1) 13216021 39 16 39 14 5 7 4 14 8 1 0.720 1.000 1.000 530 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT(2), AGXT2(1), ALAS1(1), ATP6V0C(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PLCB2(2), PLCG1(6), PLCG2(6), SARDH(1), SHMT1(1) 13599866 33 16 32 16 15 11 2 4 1 0 0.653 1.000 1.000 531 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), EPRS(2), GLUD1(3), GLUD2(1), GOT1(2), LAP3(1), NOS1(2), NOS3(5), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4) 11613838 38 16 38 16 11 8 3 12 4 0 0.697 1.000 1.000 532 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NAGLU(3), NEU1(1), NEU2(2), NEU3(1), SPAM1(1) 11131660 31 16 31 15 9 3 5 9 5 0 0.886 1.000 1.000 533 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(2), AXIN1(1), CCND1(1), CSNK1E(1), DVL2(1), DVL3(1), FZD1(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), MAPK10(1), MAPK9(1), PAFAH1B1(4), PLAU(1), PPP2R5C(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT2(2), WNT2B(1), WNT5B(1), WNT7A(1) 19376916 42 16 42 18 14 4 8 10 5 1 0.611 1.000 1.000 534 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ADC(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(2), SMS(1), SRM(1) 9528850 30 15 30 13 10 4 3 6 7 0 0.712 1.000 1.000 535 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), HSD17B4(2), NSD1(2), OGDHL(2), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(3), SETDB1(1), SHMT1(1), SUV39H1(1), TMLHE(1) 18763915 48 15 48 22 22 7 2 8 9 0 0.712 1.000 1.000 536 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(2), AKT1(1), APAF1(1), ATM(4), BAX(1), BIRC2(1), CFLAR(1), CSF2RB(1), CYCS(2), DFFA(1), FAS(1), IL1B(1), IL1R1(1), IL1RAP(1), IL3RA(2), IRAK2(1), IRAK3(4), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKAR1A(1), RELA(1), RIPK1(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1) 25495133 48 15 48 28 11 8 6 15 8 0 0.985 1.000 1.000 537 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH1A3(3), ALDH3A1(4), DDC(1), EPX(2), GOT1(2), HPD(1), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(4) 7103039 28 15 28 14 13 6 3 3 3 0 0.613 1.000 1.000 538 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), DLG4(3), LPA(5), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(4), PLD3(1), PTK2(1), RDX(5), ROCK1(2), ROCK2(2), SERPINA4(1), SRF(2), TBXA2R(1) 15832845 47 15 47 18 13 8 6 15 5 0 0.620 1.000 1.000 539 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 EIF2B4(1), FLT1(3), FLT4(3), KDR(6), NOS3(5), PLCG1(6), PRKCA(3), PTK2(1), SHC1(1) 9769161 29 15 28 16 9 5 6 5 3 1 0.873 1.000 1.000 540 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CEL(1), CYP27A1(1), CYP7A1(1), SOAT2(2), SRD5A1(1) 7501490 31 14 31 13 11 4 3 11 2 0 0.634 1.000 1.000 541 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CCND1(1), CREBBP(8), EP300(3), ERCC3(1), ESR1(1), GRIP1(1), GTF2E1(3), GTF2F1(2), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), NCOR2(3), NRIP1(1), PELP1(1), POLR2A(3) 14916144 40 14 40 16 11 5 2 14 8 0 0.769 1.000 1.000 542 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(1), ELK1(3), FPR1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1) 12360821 37 14 37 18 15 6 1 8 6 1 0.787 1.000 1.000 543 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5D(1), GRM1(5), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM7(3), GRM8(1) 6783130 26 14 26 13 9 4 2 8 3 0 0.859 1.000 1.000 544 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ASPA(1), CNDP1(2), DDC(1), HAL(1), HARS(1), HDC(2), PRPS2(3) 7898599 25 14 25 14 13 5 2 3 2 0 0.787 1.000 1.000 545 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 DAXX(2), EGF(3), ETS1(3), HOXA7(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), PPP2CA(3), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), RAF1(1), RELA(1), RIPK1(1), TNFRSF1B(2) 14998340 37 14 37 15 12 7 4 7 5 2 0.471 1.000 1.000 546 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(2), AKT1(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(2), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(4), PLD3(1) 14479365 42 14 42 19 13 7 8 12 2 0 0.693 1.000 1.000 547 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(2), AXIN1(1), CSNK1A1(2), DACT1(2), DKK1(1), DKK2(2), DKK4(2), LRP1(15), NKD2(1), PTPRA(4), SENP2(2), SFRP1(1), WIF1(2) 13021838 40 14 40 15 12 8 3 13 4 0 0.615 1.000 1.000 548 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), MLYCD(3), SMS(1) 9385429 33 13 33 14 12 8 2 7 4 0 0.563 1.000 1.000 549 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1), C8B(3) 6711054 32 13 32 13 8 5 3 11 5 0 0.619 1.000 1.000 550 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 20 ADCY1(1), AKT1(1), GNAI1(1), ITGAV(2), ITGB3(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(8), PLCB1(2), PRKCA(3), PTK2(1), RAC1(1), SMPD1(1), SMPD2(1) 7650435 27 13 26 11 4 7 3 5 6 2 0.584 1.000 1.000 551 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3) 8248254 22 13 22 10 7 3 3 6 2 1 0.650 1.000 1.000 552 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(6), FAU(1), IL6ST(2), MRPL19(2), RPL10(3), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL29(1), RPL32(1), RPL36(1), RPL5(1), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPS4X(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SLC36A2(1), TBC1D10C(1), UBC(3) 16908600 46 13 46 16 13 7 6 14 6 0 0.618 1.000 1.000 553 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(2), PI3(1), PIK3C2G(1), PIK3CD(1), RPS4X(2), SGCB(1) 14513295 36 13 36 17 7 4 8 13 3 1 0.883 1.000 1.000 554 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(1), ELTD1(1), EMR1(2), EMR2(2), GHRHR(2), GIPR(2), GLP2R(1), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(3), VIPR1(1) 8626311 26 12 26 13 5 5 6 10 0 0 0.861 1.000 1.000 555 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), CREB3(1), EEF2K(1), EIF4E(1), ELK1(3), IL1R1(1), MAP2K3(2), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MYEF2(2), NFKB1(1), NR2C2(1), SRF(2) 10748098 28 12 28 14 8 4 6 7 3 0 0.848 1.000 1.000 556 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(3), APOA1(1), APOA4(2), APOE(1), CETP(1), CYP7A1(1), LIPC(1), LPL(2), LRP1(15), SOAT1(1) 8838605 28 12 28 12 10 6 1 9 2 0 0.663 1.000 1.000 557 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(1), CXCR4(1), GNAI1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(3), PTK2(1), RAF1(1), RELA(1) 7704031 19 11 18 15 5 3 3 3 3 2 0.983 1.000 1.000 558 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1) 6576644 18 11 18 13 6 2 2 6 2 0 0.983 1.000 1.000 559 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(3), CUL1(1), CUL2(3), CUL3(1), FBXW7(1), FZR1(2), SKP2(2), SMURF1(1), SMURF2(2), UBE2D4(2), WWP1(3) 12995559 33 11 32 18 6 5 6 11 5 0 0.967 1.000 1.000 560 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(1), ANXA3(1), ANXA6(2), EDNRB(1), HSD11B1(1), PLA2G4A(4), PTGER4(1), PTGFR(5), PTGS1(2), PTGS2(2), SCGB1A1(2) 6665309 24 11 24 10 7 3 3 8 3 0 0.726 1.000 1.000 561 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(1), F2(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), MYEF2(2), PLD1(4), PLD3(1), PTK2(1), RAF1(1), RASAL1(2), TEC(1), VAV1(4) 8857628 29 11 29 10 7 8 1 11 2 0 0.445 1.000 1.000 562 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 ELK1(3), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), PPARA(2), RELA(1), TLR10(4), TLR3(5), TLR4(1), TLR6(2), TLR7(3), TLR9(1) 11792859 29 11 28 15 9 6 5 7 2 0 0.844 1.000 1.000 563 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BAX(1), BIRC2(1), CYCS(2), FAS(1), MAP3K1(2), MAP3K14(1), MAPK10(1), MDM2(2), NFKB1(1), PARP1(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1) 11803447 20 10 20 10 6 2 2 6 4 0 0.829 1.000 1.000 564 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAX(1), CASP1(1), CASP4(1), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(1), FAS(1), IKBKE(4), NFKB1(1), NGFR(1), NR3C1(2), PTPN13(1), RIPK1(1), SFRS2IP(2), TFG(1), TNFRSF1B(2), TRADD(1), TRAF3(1) 14024116 31 10 31 17 11 5 1 8 6 0 0.901 1.000 1.000 565 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), IRS1(2), IRS2(1), JAK3(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3) 10553541 21 10 21 10 4 4 2 8 2 1 0.789 1.000 1.000 566 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(1), BAX(1), BCL2L11(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), FAS(1), HELLS(2), IRF1(4), IRF2(1), IRF4(1), IRF6(1), IRF7(2), MAP3K1(2), MAPK10(1), MDM2(2), NFKB1(1), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TNFRSF21(2), TRADD(1), TRAF3(1) 18202369 38 9 38 16 16 6 2 8 6 0 0.646 1.000 1.000 567 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(3), E2F1(1), ETS1(3), ETV3(1), HDAC2(4), HDAC5(1), NCOR2(3), RBL1(2), RBL2(2), SIN3A(2), SIN3B(1) 8395269 23 9 23 10 5 4 1 6 7 0 0.767 1.000 1.000 568 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(2), EXTL1(2), EXTL3(1), HS6ST2(3), NDST1(2), NDST2(2), NDST3(2), NDST4(1) 6678595 17 9 17 8 9 1 2 5 0 0 0.764 1.000 1.000 569 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1) 7586129 23 9 23 10 7 2 3 9 2 0 0.718 1.000 1.000 570 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), AXIN1(1), CREBBP(8), EP300(3), FZD1(1), LDB1(2), PITX2(3), TRRAP(5) 10708128 25 9 25 12 8 4 1 11 1 0 0.797 1.000 1.000 571 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(1), GTF2E1(3), GTF2H1(1), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3K(1), TAF9(2) 11322716 27 9 27 16 9 4 2 10 2 0 0.926 1.000 1.000 572 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(4), MARS(4), MARS2(1), MTFMT(1), MTR(2), SRM(1), TAT(1) 6703499 26 8 26 11 6 5 1 11 2 1 0.626 1.000 1.000 573 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLB(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(2), POLQ(1), PRIM1(1), PRIM2(2), REV1(2), REV3L(2) 13060086 32 8 32 13 6 5 4 12 5 0 0.827 1.000 1.000 574 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IL1B(1), IL1R1(1), IL1RAP(1), IL6(1), IRAK2(1), IRAK3(4), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1) 9570724 21 8 21 10 6 4 4 5 2 0 0.771 1.000 1.000 575 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN2(6), ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), SOS1(1), TLN1(2), VCL(1) 15221061 31 8 31 14 10 6 4 8 2 1 0.694 1.000 1.000 576 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(1), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1), TGFB2(2), TGFB3(1) 6457092 13 8 13 10 4 2 3 3 1 0 0.946 1.000 1.000 577 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PIK3CD(1), TRAF3(1), TRAF5(1) 9617582 23 8 23 10 9 4 2 5 2 1 0.583 1.000 1.000 578 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(3), CREB1(1), CREB3(1), DUSP4(1), DUSP9(2), EEF2K(1), EIF4E(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(1), SOS2(4), TRAF3(1) 9534233 29 8 29 12 8 3 5 9 3 1 0.664 1.000 1.000 579 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(4), ATM(4), BRCA1(1), CHEK1(3), CHEK2(3), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(1), RAD50(2), RBBP8(2), RELA(1) 9363030 26 7 26 11 6 7 3 7 3 0 0.764 1.000 1.000 580 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(2), AXIN1(1), CCND1(1), FZD1(1), GJA1(4), GNAI1(1), LBP(1), NFKB1(1), PPP2CA(3), RELA(1), TLR4(1) 8704979 18 7 18 10 6 3 1 6 2 0 0.887 1.000 1.000 581 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPNS1(1), CAPNS2(1), EGF(3), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKAR1A(1), PTK2(1), TLN1(2) 9699140 19 7 19 12 6 1 4 6 1 1 0.943 1.000 1.000 582 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(8), EP300(3), IL1B(1), MAP2K3(2), MAP3K14(1), NFKB1(1), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(2) 9591922 22 7 22 12 5 3 2 10 2 0 0.923 1.000 1.000 583 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDK2(1), CDT1(1), DIAPH2(1), GMNN(1), MCM10(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), PRIM1(1), RFC4(2), RPA1(2), UBC(3) 16361207 42 6 42 20 9 6 6 15 6 0 0.857 1.000 1.000 584 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR24(2), DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NSDHL(2), SC4MOL(1), SQLE(1) 6224796 15 6 15 9 6 1 5 3 0 0 0.891 1.000 1.000 585 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PHGDH(1), PIPOX(1), SARDH(1), SARS2(1), SHMT1(1), TARS2(1) 13804739 24 6 24 15 9 9 2 3 1 0 0.882 1.000 1.000 586 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IL1R1(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1) 7864709 12 6 12 12 7 0 1 1 3 0 0.993 1.000 1.000 587 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(8), EP300(3), HDAC3(1), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1) 7222668 18 6 18 11 6 1 0 8 3 0 0.958 1.000 1.000 588 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(2), G6PD(2), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTZ1(2) 5306649 11 5 11 10 5 3 2 1 0 0 0.952 1.000 1.000 589 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 ANPEP(2), G6PD(2), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTA5(3), GSTZ1(2), OPLAH(2) 6560408 16 5 16 11 7 5 2 2 0 0 0.849 1.000 1.000 590 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(3), FADS2(2), FASN(1), SCD(1) 4628942 9 5 9 11 2 1 0 4 2 0 0.996 1.000 1.000 591 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN2(6), ACTN3(1), BCAR1(1), CSK(1), CTNNA2(2), PTK2(1), VCL(1) 6191959 13 4 13 6 6 3 0 4 0 0 0.642 1.000 1.000 592 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), FTCD(1), GART(3), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1) 6119790 19 4 19 10 5 6 2 4 1 1 0.747 1.000 1.000 593 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(3), DNMT1(3), MTNR1A(1), PTGER4(1), PTGFR(5), TBXA2R(1) 3605223 15 4 15 10 4 2 0 8 1 0 0.937 1.000 1.000 594 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), NCKAP1(2), RAC1(1), WASF1(1), WASF3(2), WASL(1) 4938808 11 3 11 5 2 3 1 5 0 0 0.737 1.000 1.000 595 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), CES1(1) 1951690 3 3 3 3 1 1 1 0 0 0 0.904 1.000 1.000 596 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(2) 1284645 4 3 4 3 1 0 0 3 0 0 0.915 1.000 1.000 597 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2) 3728598 4 3 4 4 1 1 1 1 0 0 0.954 1.000 1.000 598 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST3GAL4(2) 1828757 3 3 3 3 2 0 0 1 0 0 0.946 1.000 1.000 599 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(2), APOBEC3F(1), APOBEC3G(1), APOBEC4(1) 2367857 5 3 5 5 2 0 0 3 0 0 0.980 1.000 1.000 600 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), RELN(6), VLDLR(1) 4529648 8 3 8 9 2 4 0 2 0 0 0.988 1.000 1.000 601 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(1), GLI2(1), GLI3(2), PRKAR1A(1), SHH(1), SMO(2), SUFU(1) 5373568 9 3 9 5 1 5 0 3 0 0 0.722 1.000 1.000 602 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(2) 1972451 3 2 3 3 1 0 1 1 0 0 0.969 1.000 1.000 603 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(1), HSD11B1(1) 2979467 3 2 3 3 1 0 1 1 0 0 0.922 1.000 1.000 604 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1) 5370493 14 2 14 9 3 2 2 7 0 0 0.938 1.000 1.000 605 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11B1(1), HSD11B1(1) 2979467 3 2 3 3 1 0 1 1 0 0 0.922 1.000 1.000 606 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(3) 2996496 9 2 9 5 2 0 3 4 0 0 0.871 1.000 1.000 607 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF11A(2) 3581656 7 2 7 7 1 1 1 4 0 0 0.978 1.000 1.000 608 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2) 2033818 2 2 2 3 1 0 1 0 0 0 0.979 1.000 1.000 609 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(3), FYN(1), THBS1(1) 2388173 5 2 5 4 2 2 1 0 0 0 0.840 1.000 1.000 610 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 ACO2(2), FH(1) 2784013 3 1 3 5 2 0 0 1 0 0 0.986 1.000 1.000 611 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(1) 1966210 1 1 1 2 0 0 1 0 0 0 0.971 1.000 1.000 612 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT2A1(2), SUOX(1) 1975657 4 1 4 3 0 1 0 3 0 0 0.935 1.000 1.000 613 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 233896 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 164465 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 494927 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 553302 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000