Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.089 0.298 -9999.0 0.0 -0.734 28.0 28.0 IHH -0.008 0.072 -9999.0 0.0 -0.511 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.101 0.176 -9999.0 0.0 -0.435 38.0 38.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.1 0.174 0.432 38.0 -9999.0 0.0 38.0 SMO/beta Arrestin2 -0.029 0.178 -9999.0 0.0 -0.69 7.0 7.0 SMO -0.039 0.189 -9999.0 0.0 -0.698 8.0 8.0 AKT1 0.005 0.093 -9999.0 0.0 -0.425 3.0 3.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.081 -9999.0 0.0 -0.584 4.0 4.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.038 0.185 -9999.0 0.0 -0.682 8.0 8.0 STIL -0.089 0.237 -9999.0 0.0 -0.61 25.0 25.0 DHH N/PTCH2 -0.064 0.158 -9999.0 0.0 -0.44 32.0 32.0 DHH N/PTCH1 -0.064 0.202 -9999.0 0.0 -0.495 26.0 26.0 PIK3CA 0.011 0.046 -9999.0 0.0 -0.673 1.0 1.0 DHH -0.052 0.191 -9999.0 0.0 -0.591 24.0 24.0 PTHLH -0.108 0.365 -9999.0 0.0 -0.983 27.0 27.0 determination of left/right symmetry -0.038 0.185 -9999.0 0.0 -0.682 8.0 8.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.106 0.358 -9999.0 0.0 -0.966 27.0 27.0 IHH N/Hhip -0.137 0.238 -9999.0 0.0 -0.491 66.0 66.0 DHH N/Hhip -0.174 0.238 -9999.0 0.0 -0.468 82.0 82.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.038 0.185 -9999.0 0.0 -0.682 8.0 8.0 pancreas development -0.168 0.286 -9999.0 0.0 -0.604 65.0 65.0 HHAT -0.004 0.108 -9999.0 0.0 -0.643 6.0 6.0 PI3K -0.002 0.033 -9999.0 0.0 -0.497 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.022 0.135 -9999.0 0.0 -0.519 15.0 15.0 somite specification -0.038 0.185 -9999.0 0.0 -0.682 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.092 0.238 -9999.0 0.0 -0.59 27.0 27.0 SHH Np/Cholesterol/PTCH2 -0.095 0.176 -9999.0 0.0 -0.426 39.0 39.0 SHH Np/Cholesterol/Megalin -0.185 0.238 -9999.0 0.0 -0.496 63.0 63.0 SHH -0.087 0.214 -9999.0 0.0 -0.469 50.0 50.0 catabolic process -0.037 0.181 -9999.0 0.0 -0.583 11.0 11.0 SMO/Vitamin D3 -0.083 0.239 -9999.0 0.0 -0.627 22.0 22.0 SHH Np/Cholesterol/Hhip -0.18 0.236 -9999.0 0.0 -0.478 67.0 67.0 LRP2 -0.179 0.285 -9999.0 0.0 -0.585 71.0 71.0 receptor-mediated endocytosis -0.177 0.237 -9999.0 0.0 -0.63 36.0 36.0 SHH Np/Cholesterol/BOC -0.088 0.164 -9999.0 0.0 -0.416 36.0 36.0 SHH Np/Cholesterol/CDO -0.1 0.179 -9999.0 0.0 -0.431 41.0 41.0 mesenchymal cell differentiation 0.179 0.234 0.474 67.0 -9999.0 0.0 67.0 mol:Vitamin D3 -0.09 0.239 -9999.0 0.0 -0.589 27.0 27.0 IHH N/PTCH2 -0.008 0.113 -9999.0 0.0 -0.526 9.0 9.0 CDON -0.019 0.144 -9999.0 0.0 -0.641 11.0 11.0 IHH N/PTCH1 -0.037 0.182 -9999.0 0.0 -0.587 11.0 11.0 Megalin/LRPAP1 -0.136 0.202 -9999.0 0.0 -0.422 71.0 71.0 PTCH2 -0.01 0.125 -9999.0 0.0 -0.651 8.0 8.0 SHH Np/Cholesterol -0.084 0.162 -9999.0 0.0 -0.37 50.0 50.0 PTCH1 -0.037 0.182 -9999.0 0.0 -0.585 11.0 11.0 HHIP -0.169 0.286 -9999.0 0.0 -0.605 65.0 65.0