Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.041 0.201 -9999.0 0.0 -0.611 22.0 22.0 IHH 0.013 0.053 -9999.0 0.0 -0.183 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.02 0.103 0.174 4.0 -0.278 27.0 31.0 LRPAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.103 0.276 27.0 -0.172 4.0 31.0 SMO/beta Arrestin2 -0.005 0.12 -9999.0 0.0 -0.485 7.0 7.0 SMO -0.018 0.117 -9999.0 0.0 -0.507 7.0 7.0 AKT1 -0.001 0.1 -9999.0 0.0 -0.447 7.0 7.0 ARRB2 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.05 -9999.0 0.0 -0.479 2.0 2.0 ADRBK1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.116 -9999.0 0.0 -0.499 7.0 7.0 STIL -0.017 0.147 0.199 5.0 -0.33 22.0 27.0 DHH N/PTCH2 0.003 0.089 -9999.0 0.0 -0.343 12.0 12.0 DHH N/PTCH1 -0.018 0.136 -9999.0 0.0 -0.325 31.0 31.0 PIK3CA 0.022 0.034 -9999.0 0.0 -0.479 1.0 1.0 DHH -0.012 0.118 -9999.0 0.0 -0.479 12.0 12.0 PTHLH -0.064 0.279 -9999.0 0.0 -0.878 21.0 21.0 determination of left/right symmetry -0.017 0.116 -9999.0 0.0 -0.499 7.0 7.0 PIK3R1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.063 0.275 -9999.0 0.0 -0.847 22.0 22.0 IHH N/Hhip -0.056 0.156 -9999.0 0.0 -0.381 37.0 37.0 DHH N/Hhip -0.066 0.162 -9999.0 0.0 -0.352 48.0 48.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.116 -9999.0 0.0 -0.499 7.0 7.0 pancreas development -0.076 0.185 -9999.0 0.0 -0.478 36.0 36.0 HHAT 0.013 0.075 -9999.0 0.0 -0.479 5.0 5.0 PI3K 0.034 0.026 -9999.0 0.0 -0.345 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.011 0.059 -9999.0 0.0 -0.18 14.0 14.0 somite specification -0.017 0.116 -9999.0 0.0 -0.499 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.038 0.133 -9999.0 0.0 -0.292 41.0 41.0 SHH Np/Cholesterol/PTCH2 -0.025 0.1 -9999.0 0.0 -0.282 27.0 27.0 SHH Np/Cholesterol/Megalin -0.063 0.146 0.174 4.0 -0.324 44.0 48.0 SHH -0.038 0.122 -9999.0 0.0 -0.361 26.0 26.0 catabolic process -0.015 0.123 -9999.0 0.0 -0.367 21.0 21.0 SMO/Vitamin D3 -0.032 0.139 0.27 3.0 -0.402 14.0 17.0 SHH Np/Cholesterol/Hhip -0.066 0.148 0.176 3.0 -0.318 48.0 51.0 LRP2 -0.08 0.183 -9999.0 0.0 -0.479 35.0 35.0 receptor-mediated endocytosis -0.064 0.162 -9999.0 0.0 -0.472 19.0 19.0 SHH Np/Cholesterol/BOC -0.023 0.102 -9999.0 0.0 -0.279 28.0 28.0 SHH Np/Cholesterol/CDO -0.029 0.11 -9999.0 0.0 -0.288 30.0 30.0 mesenchymal cell differentiation 0.065 0.147 0.316 48.0 -0.174 3.0 51.0 mol:Vitamin D3 -0.009 0.158 0.198 23.0 -0.292 41.0 64.0 IHH N/PTCH2 0.022 0.047 -9999.0 0.0 -0.22 4.0 4.0 CDON 0.001 0.101 -9999.0 0.0 -0.416 11.0 11.0 IHH N/PTCH1 -0.009 0.127 -9999.0 0.0 -0.369 21.0 21.0 Megalin/LRPAP1 -0.044 0.138 -9999.0 0.0 -0.344 35.0 35.0 PTCH2 0.018 0.036 -9999.0 0.0 -0.479 1.0 1.0 SHH Np/Cholesterol -0.026 0.095 -9999.0 0.0 -0.277 26.0 26.0 PTCH1 -0.015 0.124 -9999.0 0.0 -0.368 21.0 21.0 HHIP -0.076 0.185 -9999.0 0.0 -0.479 36.0 36.0