Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.095 -9999.0 0.0 -0.233 34.0 34.0 epithelial cell differentiation 0.014 0.103 -9999.0 0.0 -0.248 28.0 28.0 CYFIP2 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.028 0.072 0.272 3.0 -9999.0 0.0 3.0 EGFR -0.005 0.11 -9999.0 0.0 -0.45 12.0 12.0 EPHA2 0.009 0.057 -9999.0 0.0 -0.479 2.0 2.0 MYO6 -0.023 0.091 -9999.0 0.0 -0.238 28.0 28.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.067 0.173 -9999.0 0.0 -0.46 28.0 28.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.021 0.089 -9999.0 0.0 -0.235 27.0 27.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.096 -9999.0 0.0 -0.242 30.0 30.0 EGF -0.005 0.108 -9999.0 0.0 -0.479 10.0 10.0 NCKAP1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.14 -9999.0 0.0 -0.522 12.0 12.0 cortical microtubule organization 0.014 0.103 -9999.0 0.0 -0.248 28.0 28.0 GO:0000145 -0.033 0.081 0.166 7.0 -0.225 27.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.105 -9999.0 0.0 -0.25 28.0 28.0 MLLT4 0.022 0.034 -9999.0 0.0 -0.479 1.0 1.0 ARF6/GDP -0.044 0.069 -9999.0 0.0 -0.258 1.0 1.0 ARF6 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.05 0.041 -9999.0 0.0 -0.267 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.035 0.099 -9999.0 0.0 -0.366 10.0 10.0 PVRL2 0.018 0.035 -9999.0 0.0 -0.479 1.0 1.0 ZYX -0.02 0.083 -9999.0 0.0 -0.238 24.0 24.0 ARF6/GTP 0.055 0.042 -9999.0 0.0 -0.249 2.0 2.0 CDH1 -0.066 0.176 -9999.0 0.0 -0.479 31.0 31.0 EGFR/EGFR/EGF/EGF -0.024 0.123 -9999.0 0.0 -0.261 42.0 42.0 RhoA/GDP 0.016 0.099 -9999.0 0.0 -0.235 28.0 28.0 actin cytoskeleton organization -0.027 0.087 -9999.0 0.0 -0.234 28.0 28.0 IGF-1R heterotetramer 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.005 0.091 -9999.0 0.0 -0.479 7.0 7.0 DIAPH1 0.025 0.101 -9999.0 0.0 -0.563 1.0 1.0 Wnt receptor signaling pathway -0.014 0.103 0.248 28.0 -9999.0 0.0 28.0 RHOA 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.044 0.07 -9999.0 0.0 -0.26 1.0 1.0 CTNNA1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.027 0.088 -9999.0 0.0 -0.239 28.0 28.0 EFNA1 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.041 0.086 0.172 6.0 -0.231 31.0 37.0 Ephrin A1/EPHA2 0.003 0.096 -9999.0 0.0 -0.228 30.0 30.0 SEC6/SEC8 -0.024 0.076 -9999.0 0.0 -0.226 24.0 24.0 MGAT3 -0.026 0.097 -9999.0 0.0 -0.246 30.0 30.0 HGF/MET -0.035 0.135 -9999.0 0.0 -0.278 44.0 44.0 HGF -0.004 0.079 -9999.0 0.0 -0.479 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.02 0.095 -9999.0 0.0 -0.235 34.0 34.0 actin cable formation -0.006 0.094 0.299 6.0 -0.253 3.0 9.0 KIAA1543 -0.038 0.085 0.167 4.0 -0.237 29.0 33.0 KIFC3 -0.024 0.095 -9999.0 0.0 -0.247 28.0 28.0 NCK1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.027 0.092 -9999.0 0.0 -0.24 29.0 29.0 NCK1/GIT1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.014 0.103 -9999.0 0.0 -0.248 28.0 28.0 EXOC4 0.02 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.022 0.092 -9999.0 0.0 -0.238 28.0 28.0 PIP5K1C -0.021 0.091 -9999.0 0.0 -0.238 27.0 27.0 LIMA1 0.011 0.082 -9999.0 0.0 -0.479 6.0 6.0 ABI1 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.028 0.085 0.292 4.0 -9999.0 0.0 4.0 adherens junction assembly -0.017 0.094 0.293 1.0 -0.48 2.0 3.0 IGF-1R heterotetramer/IGF1 0.002 0.107 -9999.0 0.0 -0.244 33.0 33.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.026 0.039 -9999.0 0.0 -0.345 2.0 2.0 MET -0.057 0.154 -9999.0 0.0 -0.479 23.0 23.0 PLEKHA7 -0.026 0.095 0.21 1.0 -0.248 29.0 30.0 mol:GTP 0.049 0.04 -9999.0 0.0 -0.265 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.009 0.121 0.306 9.0 -0.33 2.0 11.0 cortical actin cytoskeleton stabilization -0.019 0.095 -9999.0 0.0 -0.233 34.0 34.0 regulation of cell-cell adhesion -0.027 0.087 -9999.0 0.0 -0.234 28.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.02 0.095 -9999.0 0.0 -0.235 34.0 34.0