Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.049 0.132 -9999.0 0.0 -0.232 8.0 8.0 epithelial cell differentiation -0.015 0.139 -9999.0 0.0 -0.22 8.0 8.0 CYFIP2 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.059 0.081 -9999.0 0.0 -0.361 1.0 1.0 EGFR 0.003 0.112 -9999.0 0.0 -0.391 2.0 2.0 EPHA2 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.057 0.135 0.185 1.0 -0.234 8.0 9.0 CTNNB1 0.02 0.081 -9999.0 0.0 -0.391 1.0 1.0 ABI1/Sra1/Nap1 0.067 0.028 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.03 0.109 -9999.0 0.0 -0.35 1.0 1.0 CTNND1 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.048 0.115 0.183 1.0 -0.21 8.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.051 0.112 0.183 1.0 -0.208 8.0 9.0 EGF 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.04 0.117 -9999.0 0.0 -0.308 2.0 2.0 cortical microtubule organization -0.015 0.139 -9999.0 0.0 -0.22 8.0 8.0 GO:0000145 -0.06 0.101 0.165 1.0 -0.201 8.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.144 -9999.0 0.0 -0.222 8.0 8.0 MLLT4 0.02 0.081 -9999.0 0.0 -0.391 1.0 1.0 ARF6/GDP -0.069 0.085 -9999.0 0.0 -0.218 4.0 4.0 ARF6 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.074 0.044 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.059 0.105 -9999.0 0.0 -0.288 3.0 3.0 PVRL2 0.013 0.081 -9999.0 0.0 -0.391 1.0 1.0 ZYX -0.049 0.116 0.185 1.0 -0.213 8.0 9.0 ARF6/GTP 0.077 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.087 0.198 -9999.0 0.0 -0.391 8.0 8.0 EGFR/EGFR/EGF/EGF -0.048 0.129 -9999.0 0.0 -0.207 10.0 10.0 RhoA/GDP -0.017 0.155 -9999.0 0.0 -0.232 8.0 8.0 actin cytoskeleton organization -0.07 0.124 0.17 1.0 -0.232 8.0 9.0 IGF-1R heterotetramer 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.021 0.081 -9999.0 0.0 -0.391 1.0 1.0 DIAPH1 0.054 0.103 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.015 0.139 0.22 8.0 -9999.0 0.0 8.0 RHOA 0.02 0.081 -9999.0 0.0 -0.391 1.0 1.0 RhoA/GTP -0.074 0.106 -9999.0 0.0 -0.21 8.0 8.0 CTNNA1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.072 0.127 0.171 1.0 -0.237 8.0 9.0 EFNA1 0.039 0.002 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.057 0.09 0.173 1.0 -0.185 8.0 9.0 Ephrin A1/EPHA2 -0.02 0.127 -9999.0 0.0 -0.204 8.0 8.0 SEC6/SEC8 -0.064 0.119 -9999.0 0.0 -0.213 9.0 9.0 MGAT3 -0.051 0.113 0.185 1.0 -0.211 8.0 9.0 HGF/MET -0.028 0.126 -9999.0 0.0 -0.21 8.0 8.0 HGF 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.049 0.133 -9999.0 0.0 -0.233 8.0 8.0 actin cable formation -0.035 0.077 -9999.0 0.0 -0.229 1.0 1.0 KIAA1543 -0.069 0.092 -9999.0 0.0 -0.203 8.0 8.0 KIFC3 -0.051 0.115 0.185 1.0 -0.213 8.0 9.0 NCK1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.051 0.115 0.185 1.0 -0.213 8.0 9.0 NCK1/GIT1 0.055 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.015 0.139 -9999.0 0.0 -0.22 8.0 8.0 EXOC4 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.051 0.115 0.185 1.0 -0.213 8.0 9.0 PIP5K1C -0.049 0.116 0.185 1.0 -0.213 8.0 9.0 LIMA1 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.065 0.096 -9999.0 0.0 -0.427 1.0 1.0 adherens junction assembly -0.027 0.114 0.299 1.0 -0.312 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.022 0.15 -9999.0 0.0 -0.229 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.086 -9999.0 0.0 -0.276 2.0 2.0 MET 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.058 0.106 -9999.0 0.0 -0.213 8.0 8.0 mol:GTP 0.071 0.042 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.034 0.156 0.319 1.0 -0.465 1.0 2.0 cortical actin cytoskeleton stabilization -0.049 0.132 -9999.0 0.0 -0.232 8.0 8.0 regulation of cell-cell adhesion -0.07 0.124 0.17 1.0 -0.232 8.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.049 0.133 -9999.0 0.0 -0.233 8.0 8.0