Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	5.0	289.0	51.0	-0.667	0.038	1000.0	-1000.0	-0.065	-1000.0
E-cadherin signaling events	5.0	25.0	5.0	-0.087	0.038	1000.0	-1000.0	0.025	-1000.0
Ephrin A  reverse signaling	4.0	31.0	7.0	-0.059	0.007	1000.0	-1000.0	-0.0	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	277.0	68.0	-0.458	0.282	1000.0	-1000.0	-0.074	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	307.0	74.0	-0.087	0.077	1000.0	-1000.0	-0.047	-1000.0
IL23-mediated signaling events	4.0	262.0	60.0	-0.592	0.041	1000.0	-1000.0	-0.073	-1000.0
IL12-mediated signaling events	3.0	266.0	87.0	-0.368	0.082	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by the Hedgehog family	3.0	173.0	52.0	-0.11	0.053	1000.0	-1000.0	-0.019	-1000.0
Thromboxane A2 receptor signaling	3.0	374.0	105.0	-0.206	0.044	1000.0	-1000.0	-0.038	-1000.0
Ephrin B reverse signaling	3.0	154.0	48.0	-0.098	0.045	1000.0	-1000.0	-0.042	-1000.0
Endothelins	3.0	360.0	96.0	-0.303	0.039	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	268.0	76.0	-0.136	0.061	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	3.0	24.0	8.0	-0.045	0.055	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in keratinocytes	3.0	141.0	43.0	-0.086	0.042	1000.0	-1000.0	-0.013	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	279.0	136.0	-0.411	0.098	1000.0	-1000.0	-0.051	-1000.0
PLK2 and PLK4 events	2.0	7.0	3.0	-0.028	-1000.0	1000.0	-1000.0	0.003	-1000.0
Osteopontin-mediated events	2.0	113.0	38.0	-0.073	0.038	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	2.0	189.0	76.0	-0.192	0.081	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	2.0	151.0	62.0	-0.042	0.084	1000.0	-1000.0	-0.016	-1000.0
PLK1 signaling events	2.0	190.0	85.0	-0.136	0.056	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	2.0	95.0	44.0	-0.217	0.054	1000.0	-1000.0	-0.027	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	170.0	82.0	-0.043	0.057	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	2.0	102.0	35.0	-0.112	0.081	1000.0	-1000.0	-0.019	-1000.0
Nongenotropic Androgen signaling	2.0	126.0	52.0	-0.189	0.092	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	328.0	125.0	-0.083	0.094	1000.0	-1000.0	-0.032	-1000.0
IL6-mediated signaling events	2.0	154.0	75.0	-0.152	0.057	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	1.0	121.0	74.0	-0.108	0.048	1000.0	-1000.0	-0.037	-1000.0
ErbB4 signaling events	1.0	70.0	69.0	-0.099	0.057	1000.0	-1000.0	-0.021	-1000.0
Syndecan-1-mediated signaling events	1.0	65.0	34.0	-0.138	0.049	1000.0	-1000.0	-0.021	-1000.0
Visual signal transduction: Cones	1.0	74.0	38.0	-0.057	0.044	1000.0	-1000.0	-0.0	-1000.0
Noncanonical Wnt signaling pathway	1.0	44.0	26.0	-0.021	0.037	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	1.0	80.0	69.0	-0.045	0.054	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	1.0	62.0	39.0	-0.169	0.04	1000.0	-1000.0	-0.022	-1000.0
p75(NTR)-mediated signaling	1.0	134.0	125.0	-0.138	0.081	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	1.0	159.0	91.0	-0.472	0.23	1000.0	-1000.0	-0.093	-1000.0
BMP receptor signaling	1.0	103.0	81.0	-0.034	0.074	1000.0	-1000.0	-0.031	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	121.0	97.0	-0.073	0.072	1000.0	-1000.0	-0.06	-1000.0
amb2 Integrin signaling	1.0	90.0	82.0	-0.048	0.059	1000.0	-1000.0	-0.02	-1000.0
Glucocorticoid receptor regulatory network	1.0	116.0	114.0	-0.245	0.084	1000.0	-1000.0	-0.057	-1000.0
Ceramide signaling pathway	1.0	115.0	76.0	-0.078	0.064	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	44.0	37.0	-0.049	0.073	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by HDAC Class III	1.0	54.0	40.0	-0.12	0.087	1000.0	-1000.0	-0.042	-1000.0
TRAIL signaling pathway	1.0	54.0	48.0	-0.002	0.066	1000.0	-1000.0	-0.028	-1000.0
IL1-mediated signaling events	1.0	113.0	62.0	-0.075	0.063	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	57.0	52.0	-0.232	0.111	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	1.0	53.0	36.0	-0.096	0.038	1000.0	-1000.0	-0.036	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.029	0.037	1000.0	-1000.0	-0.006	-1000.0
FAS signaling pathway (CD95)	1.0	51.0	47.0	-0.037	0.052	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	76.0	44.0	-0.045	0.039	1000.0	-1000.0	-0.016	-1000.0
Integrins in angiogenesis	1.0	115.0	84.0	-0.041	0.091	1000.0	-1000.0	-0.027	-1000.0
EPHB forward signaling	1.0	130.0	85.0	-0.027	0.086	1000.0	-1000.0	-0.035	-1000.0
Effects of Botulinum toxin	1.0	44.0	26.0	-0.104	0.061	1000.0	-1000.0	-0.001	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	56.0	31.0	-0.076	0.044	1000.0	-1000.0	-0.053	-1000.0
Wnt signaling	1.0	10.0	7.0	-0.02	0.037	1000.0	-1000.0	-0.001	-1000.0
Class I PI3K signaling events	1.0	95.0	73.0	-0.069	0.072	1000.0	-1000.0	-0.031	-1000.0
BCR signaling pathway	1.0	185.0	99.0	-0.087	0.057	1000.0	-1000.0	-0.05	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.024	0.07	1000.0	-1000.0	-0.029	-1000.0
Syndecan-4-mediated signaling events	1.0	68.0	67.0	-0.073	0.051	1000.0	-1000.0	-0.034	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	120.0	88.0	-0.111	0.051	1000.0	-1000.0	-0.072	-1000.0
Visual signal transduction: Rods	1.0	77.0	52.0	-0.057	0.06	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PRL	1.0	57.0	34.0	-0.164	0.051	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	143.0	78.0	-0.07	0.051	1000.0	-1000.0	-0.052	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.033	0.039	1000.0	-1000.0	-0.027	-1000.0
Aurora B signaling	1.0	115.0	67.0	-0.156	0.064	1000.0	-1000.0	-0.049	-1000.0
LPA4-mediated signaling events	0.0	8.0	12.0	-0.049	0.01	1000.0	-1000.0	-0.017	-1000.0
ErbB2/ErbB3 signaling events	0.0	57.0	65.0	-0.052	0.055	1000.0	-1000.0	-0.067	-1000.0
Coregulation of Androgen receptor activity	0.0	72.0	76.0	-0.045	0.067	1000.0	-1000.0	-0.036	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	1.0	23.0	-0.011	0.066	1000.0	-1000.0	-0.019	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	7.0	34.0	-0.042	0.079	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	0.0	11.0	39.0	-0.0	0.081	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	0.0	19.0	75.0	-0.051	0.099	1000.0	-1000.0	-0.017	-1000.0
BARD1 signaling events	0.0	40.0	57.0	-0.07	0.079	1000.0	-1000.0	-0.049	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	26.0	28.0	-0.037	0.051	1000.0	-1000.0	-0.008	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.041	0.064	1000.0	-1000.0	-0.033	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	33.0	54.0	-0.028	0.099	1000.0	-1000.0	-0.012	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	5.0	17.0	0.0	0.063	1000.0	-1000.0	-0.023	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	3.0	5.0	0.022	0.041	1000.0	-1000.0	0.025	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	52.0	85.0	-0.287	0.106	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by PTP1B	0.0	71.0	76.0	-0.033	0.061	1000.0	-1000.0	-0.036	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	45.0	65.0	-0.046	0.073	1000.0	-1000.0	-0.042	-1000.0
Presenilin action in Notch and Wnt signaling	0.0	60.0	61.0	-0.104	0.081	1000.0	-1000.0	-0.049	-1000.0
Aurora A signaling	0.0	57.0	60.0	-0.056	0.096	1000.0	-1000.0	-0.01	-1000.0
Arf6 downstream pathway	0.0	20.0	43.0	-0.055	0.072	1000.0	-1000.0	-0.031	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.056	1000.0	-1000.0	-0.01	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	21.0	46.0	-0.031	0.062	1000.0	-1000.0	-0.069	-1000.0
Glypican 1 network	0.0	30.0	48.0	-0.038	0.075	1000.0	-1000.0	-0.026	-1000.0
EPO signaling pathway	0.0	26.0	55.0	-0.0	0.099	1000.0	-1000.0	-0.02	-1000.0
Insulin-mediated glucose transport	0.0	7.0	32.0	-0.0	0.078	1000.0	-1000.0	-0.014	-1000.0
mTOR signaling pathway	0.0	24.0	53.0	-0.048	0.063	1000.0	-1000.0	-0.03	-1000.0
IFN-gamma pathway	0.0	37.0	68.0	-0.069	0.061	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	41.0	68.0	-0.043	0.072	1000.0	-1000.0	-0.024	-1000.0
Nectin adhesion pathway	0.0	61.0	63.0	-0.087	0.077	1000.0	-1000.0	-0.051	-1000.0
Reelin signaling pathway	0.0	18.0	56.0	-0.029	0.086	1000.0	-1000.0	-0.016	-1000.0
S1P5 pathway	0.0	4.0	17.0	-0.004	0.038	1000.0	-1000.0	-0.007	-1000.0
ceramide signaling pathway	0.0	35.0	49.0	0.0	0.051	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	0.0	26.0	43.0	-0.125	0.128	1000.0	-1000.0	-0.05	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	32.0	83.0	-0.025	0.075	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class I	0.0	27.0	104.0	-0.071	0.073	1000.0	-1000.0	-0.042	-1000.0
FoxO family signaling	0.0	24.0	64.0	-0.122	0.066	1000.0	-1000.0	-0.044	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	12.0	15.0	-0.042	0.037	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	0.0	20.0	58.0	-0.008	0.072	1000.0	-1000.0	-0.041	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	22.0	36.0	-0.065	0.072	1000.0	-1000.0	-0.035	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	-0.0	0.053	1000.0	-1000.0	-0.008	-1000.0
IL2 signaling events mediated by PI3K	0.0	13.0	58.0	-0.015	0.065	1000.0	-1000.0	-0.041	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	79.0	93.0	-0.148	0.17	1000.0	-1000.0	-0.039	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	40.0	45.0	-0.004	0.066	1000.0	-1000.0	-0.05	-1000.0
Canonical Wnt signaling pathway	0.0	48.0	51.0	-0.103	0.083	1000.0	-1000.0	-0.033	-1000.0
Regulation of p38-alpha and p38-beta	0.0	32.0	54.0	-0.039	0.084	1000.0	-1000.0	-0.048	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.0	0.027	1000.0	-1000.0	-0.0	-1000.0
IL27-mediated signaling events	0.0	32.0	51.0	-0.074	0.065	1000.0	-1000.0	-0.053	-1000.0
TCGA08_rtk_signaling	0.0	19.0	26.0	-0.049	0.084	1000.0	-1000.0	-0.006	-1000.0
LPA receptor mediated events	0.0	101.0	102.0	-0.142	0.061	1000.0	-1000.0	-0.072	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.084	1000.0	-1000.0	-0.017	-1000.0
IL2 signaling events mediated by STAT5	0.0	12.0	22.0	-0.045	0.045	1000.0	-1000.0	-0.021	-1000.0
Arf6 trafficking events	0.0	19.0	71.0	-0.046	0.071	1000.0	-1000.0	-0.028	-1000.0
Regulation of Telomerase	0.0	69.0	102.0	-0.14	0.098	1000.0	-1000.0	-0.05	-1000.0
IGF1 pathway	0.0	17.0	57.0	-0.032	0.101	1000.0	-1000.0	-0.021	-1000.0
Insulin Pathway	0.0	37.0	74.0	-0.022	0.091	1000.0	-1000.0	-0.029	-1000.0
Plasma membrane estrogen receptor signaling	0.0	83.0	86.0	-0.052	0.055	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	0.0	6.0	56.0	-0.017	0.082	1000.0	-1000.0	-0.027	-1000.0
S1P3 pathway	0.0	18.0	42.0	-0.041	0.061	1000.0	-1000.0	-0.019	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	6.0	33.0	-0.014	0.094	1000.0	-1000.0	-0.033	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	-0.044	0.03	1000.0	-1000.0	-0.001	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	105.0	120.0	-0.105	0.111	1000.0	-1000.0	-0.045	-1000.0
PDGFR-beta signaling pathway	0.0	69.0	97.0	-0.055	0.106	1000.0	-1000.0	-0.03	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.036	0.036	1000.0	-1000.0	-0.025	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.005	0.051	1000.0	-1000.0	-0.013	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.029	0.066	1000.0	-1000.0	-0.018	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.002	0.051	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	0.0	0.069	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	37.0	70.0	-0.134	0.076	1000.0	-1000.0	-0.045	-1000.0
Total	112	9969	7203	-11.6894500211	-991.039796923	131000	-131000	-4.00638965856	-131000