Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.213 0.253 -9999.0 0.0 -0.657 70.0 70.0 IHH -0.306 0.272 -9999.0 0.0 -0.543 221.0 221.0 SHH Np/Cholesterol/GAS1 -0.041 0.101 -9999.0 0.0 -0.279 58.0 58.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.041 0.101 0.277 58.0 -9999.0 0.0 58.0 SMO/beta Arrestin2 -0.209 0.216 -9999.0 0.0 -0.507 79.0 79.0 SMO -0.225 0.228 -9999.0 0.0 -0.536 80.0 80.0 AKT1 -0.091 0.103 -9999.0 0.0 -0.301 8.0 8.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.037 -9999.0 0.0 -0.51 2.0 2.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.222 0.224 -9999.0 0.0 -0.527 80.0 80.0 STIL -0.197 0.219 -9999.0 0.0 -0.481 112.0 112.0 DHH N/PTCH2 -0.025 0.091 -9999.0 0.0 -0.354 28.0 28.0 DHH N/PTCH1 -0.19 0.193 -9999.0 0.0 -0.483 75.0 75.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.026 0.129 -9999.0 0.0 -0.502 27.0 27.0 PTHLH -0.277 0.293 -9999.0 0.0 -0.779 70.0 70.0 determination of left/right symmetry -0.222 0.224 -9999.0 0.0 -0.527 80.0 80.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.274 0.29 -9999.0 0.0 -0.77 70.0 70.0 IHH N/Hhip -0.369 0.255 -9999.0 0.0 -0.493 297.0 297.0 DHH N/Hhip -0.215 0.198 -9999.0 0.0 -0.379 223.0 223.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.222 0.224 -9999.0 0.0 -0.527 80.0 80.0 pancreas development -0.269 0.254 -9999.0 0.0 -0.501 214.0 214.0 HHAT 0.007 0.036 -9999.0 0.0 -0.502 2.0 2.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.004 0.084 -9999.0 0.0 -0.502 11.0 11.0 somite specification -0.222 0.224 -9999.0 0.0 -0.527 80.0 80.0 SHH Np/Cholesterol/PTCH1 -0.176 0.196 -9999.0 0.0 -0.463 88.0 88.0 SHH Np/Cholesterol/PTCH2 -0.034 0.089 -9999.0 0.0 -0.265 51.0 51.0 SHH Np/Cholesterol/Megalin -0.107 0.152 -9999.0 0.0 -0.297 141.0 141.0 SHH -0.03 0.124 -9999.0 0.0 -0.355 50.0 50.0 catabolic process -0.199 0.201 -9999.0 0.0 -0.519 62.0 62.0 SMO/Vitamin D3 -0.2 0.216 -9999.0 0.0 -0.512 85.0 85.0 SHH Np/Cholesterol/Hhip -0.178 0.164 -9999.0 0.0 -0.302 232.0 232.0 LRP2 -0.131 0.228 -9999.0 0.0 -0.502 108.0 108.0 receptor-mediated endocytosis -0.257 0.229 -9999.0 0.0 -0.53 131.0 131.0 SHH Np/Cholesterol/BOC -0.035 0.09 -9999.0 0.0 -0.265 52.0 52.0 SHH Np/Cholesterol/CDO -0.04 0.098 -9999.0 0.0 -0.274 57.0 57.0 mesenchymal cell differentiation 0.177 0.163 0.3 232.0 -9999.0 0.0 232.0 mol:Vitamin D3 -0.177 0.198 -9999.0 0.0 -0.466 88.0 88.0 IHH N/PTCH2 -0.175 0.167 -9999.0 0.0 -0.32 221.0 221.0 CDON -0.002 0.076 -9999.0 0.0 -0.502 9.0 9.0 IHH N/PTCH1 -0.201 0.203 -9999.0 0.0 -0.526 62.0 62.0 Megalin/LRPAP1 -0.097 0.158 -9999.0 0.0 -0.354 108.0 108.0 PTCH2 0.008 0.026 -9999.0 0.0 -0.502 1.0 1.0 SHH Np/Cholesterol -0.035 0.091 -9999.0 0.0 -0.272 50.0 50.0 PTCH1 -0.199 0.202 -9999.0 0.0 -0.521 62.0 62.0 HHIP -0.269 0.254 -9999.0 0.0 -0.502 214.0 214.0