Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	145.0	580.0	4.0	-0.201	-0.117	1000.0	-1000.0	-0.035	-1000.0
Angiopoietin receptor Tie2-mediated signaling	106.0	9384.0	88.0	-0.564	0.053	1000.0	-1000.0	-0.107	-1000.0
FOXM1 transcription factor network	106.0	5440.0	51.0	-0.603	0.01	1000.0	-1000.0	-0.19	-1000.0
Aurora B signaling	101.0	6816.0	67.0	-0.428	0.01	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by the Hedgehog family	79.0	4129.0	52.0	-0.369	0.177	1000.0	-1000.0	-0.069	-1000.0
Aurora C signaling	60.0	425.0	7.0	-0.271	0.005	1000.0	-1000.0	-0.031	-1000.0
Endothelins	58.0	5603.0	96.0	-0.291	0.031	1000.0	-1000.0	-0.067	-1000.0
PLK1 signaling events	57.0	4880.0	85.0	-0.309	0.064	1000.0	-1000.0	-0.049	-1000.0
HIF-1-alpha transcription factor network	55.0	4205.0	76.0	-0.498	0.016	1000.0	-1000.0	-0.156	-1000.0
Visual signal transduction: Cones	47.0	1796.0	38.0	-0.165	0.01	1000.0	-1000.0	-0.051	-1000.0
Osteopontin-mediated events	46.0	1767.0	38.0	-0.381	0.011	1000.0	-1000.0	-0.088	-1000.0
IL4-mediated signaling events	46.0	4264.0	91.0	-0.812	0.536	1000.0	-1000.0	-0.171	-1000.0
amb2 Integrin signaling	41.0	3414.0	82.0	-0.472	0.01	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	40.0	3261.0	81.0	-0.368	0.027	1000.0	-1000.0	-0.076	-1000.0
Fc-epsilon receptor I signaling in mast cells	38.0	3722.0	97.0	-0.151	0.028	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-alpha and p38-beta	38.0	1674.0	44.0	-0.11	0.01	1000.0	-1000.0	-0.048	-1000.0
Signaling events regulated by Ret tyrosine kinase	36.0	3033.0	82.0	-0.168	0.01	1000.0	-1000.0	-0.079	-1000.0
FOXA2 and FOXA3 transcription factor networks	35.0	1634.0	46.0	-0.486	0.016	1000.0	-1000.0	-0.09	-1000.0
TCGA08_retinoblastoma	35.0	280.0	8.0	-0.151	0.047	1000.0	-1000.0	-0.019	-1000.0
TCGA08_p53	33.0	234.0	7.0	-0.104	0.052	1000.0	-1000.0	-0.017	-1000.0
Visual signal transduction: Rods	31.0	1623.0	52.0	-0.158	0.01	1000.0	-1000.0	-0.074	-1000.0
LPA4-mediated signaling events	30.0	360.0	12.0	-0.12	0.013	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	30.0	3525.0	114.0	-0.395	0.243	1000.0	-1000.0	-0.072	-1000.0
p75(NTR)-mediated signaling	29.0	3648.0	125.0	-0.291	0.019	1000.0	-1000.0	-0.084	-1000.0
Arf6 signaling events	28.0	1762.0	62.0	-0.187	0.011	1000.0	-1000.0	-0.056	-1000.0
Canonical Wnt signaling pathway	27.0	1404.0	51.0	-0.34	0.146	1000.0	-1000.0	-0.057	-1000.0
Ephrin B reverse signaling	26.0	1275.0	48.0	-0.103	0.061	1000.0	-1000.0	-0.062	-1000.0
Integrins in angiogenesis	26.0	2193.0	84.0	-0.384	0.025	1000.0	-1000.0	-0.071	-1000.0
Effects of Botulinum toxin	25.0	652.0	26.0	-0.081	0.01	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	25.0	525.0	21.0	-0.095	0.01	1000.0	-1000.0	-0.054	-1000.0
Syndecan-1-mediated signaling events	24.0	817.0	34.0	-0.353	0.01	1000.0	-1000.0	-0.055	-1000.0
Glypican 1 network	24.0	1199.0	48.0	-0.103	0.019	1000.0	-1000.0	-0.043	-1000.0
Thromboxane A2 receptor signaling	23.0	2465.0	105.0	-0.095	0.03	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	23.0	1627.0	68.0	-0.14	0.032	1000.0	-1000.0	-0.123	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	23.0	2855.0	120.0	-0.236	0.197	1000.0	-1000.0	-0.06	-1000.0
ErbB4 signaling events	22.0	1528.0	69.0	-0.192	0.202	1000.0	-1000.0	-0.083	-1000.0
Aurora A signaling	22.0	1358.0	60.0	-0.304	0.016	1000.0	-1000.0	-0.053	-1000.0
Presenilin action in Notch and Wnt signaling	20.0	1240.0	61.0	-0.34	0.02	1000.0	-1000.0	-0.063	-1000.0
IL6-mediated signaling events	20.0	1573.0	75.0	-0.334	0.042	1000.0	-1000.0	-0.091	-1000.0
IL23-mediated signaling events	20.0	1234.0	60.0	-0.28	0.015	1000.0	-1000.0	-0.185	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	20.0	670.0	33.0	-0.145	0.024	1000.0	-1000.0	-0.053	-1000.0
PDGFR-alpha signaling pathway	18.0	812.0	44.0	-0.304	0.026	1000.0	-1000.0	-0.051	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	18.0	951.0	52.0	-0.245	0.042	1000.0	-1000.0	-0.048	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.014	-1000.0	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	17.0	924.0	52.0	-0.056	0.01	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	17.0	124.0	7.0	-0.062	0.009	1000.0	-1000.0	-0.028	-1000.0
PLK2 and PLK4 events	16.0	48.0	3.0	-0.021	-0.005	1000.0	-1000.0	-0.014	-1000.0
HIF-2-alpha transcription factor network	16.0	696.0	43.0	-0.136	0.069	1000.0	-1000.0	-0.088	-1000.0
Syndecan-3-mediated signaling events	16.0	593.0	35.0	-0.195	0.01	1000.0	-1000.0	-0.054	-1000.0
Regulation of Androgen receptor activity	15.0	1077.0	70.0	-0.247	0.028	1000.0	-1000.0	-0.059	-1000.0
Syndecan-2-mediated signaling events	14.0	996.0	69.0	-0.097	0.032	1000.0	-1000.0	-0.047	-1000.0
Syndecan-4-mediated signaling events	14.0	967.0	67.0	-0.187	0.014	1000.0	-1000.0	-0.073	-1000.0
Coregulation of Androgen receptor activity	13.0	990.0	76.0	-0.145	0.018	1000.0	-1000.0	-0.053	-1000.0
Reelin signaling pathway	13.0	760.0	56.0	-0.097	0.01	1000.0	-1000.0	-0.072	-1000.0
Noncanonical Wnt signaling pathway	12.0	334.0	26.0	-0.062	0.01	1000.0	-1000.0	-0.07	-1000.0
IL12-mediated signaling events	11.0	1023.0	87.0	-0.095	0.04	1000.0	-1000.0	-0.123	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	599.0	54.0	-0.143	0.021	1000.0	-1000.0	-0.082	-1000.0
Nectin adhesion pathway	11.0	728.0	63.0	-0.035	0.018	1000.0	-1000.0	-0.064	-1000.0
LPA receptor mediated events	11.0	1131.0	102.0	-0.109	0.03	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	11.0	892.0	78.0	-0.041	0.037	1000.0	-1000.0	-0.078	-1000.0
Caspase cascade in apoptosis	10.0	766.0	74.0	-0.052	0.029	1000.0	-1000.0	-0.044	-1000.0
Ephrin A  reverse signaling	10.0	72.0	7.0	-0.012	0.006	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PTP1B	10.0	824.0	76.0	-0.094	0.016	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class III	10.0	424.0	40.0	-0.114	0.018	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	10.0	483.0	47.0	-0.239	0.013	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PRL	10.0	341.0	34.0	-0.181	0.02	1000.0	-1000.0	-0.037	-1000.0
BARD1 signaling events	9.0	513.0	57.0	-0.181	0.031	1000.0	-1000.0	-0.055	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	9.0	849.0	85.0	-0.046	0.032	1000.0	-1000.0	-0.064	-1000.0
IL1-mediated signaling events	9.0	600.0	62.0	-0.139	0.049	1000.0	-1000.0	-0.078	-1000.0
S1P1 pathway	9.0	354.0	36.0	-0.06	0.012	1000.0	-1000.0	-0.052	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	284.0	31.0	-0.103	0.011	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1215.0	125.0	-0.304	0.039	1000.0	-1000.0	-0.086	-1000.0
BCR signaling pathway	9.0	982.0	99.0	-0.132	0.027	1000.0	-1000.0	-0.074	-1000.0
ErbB2/ErbB3 signaling events	8.0	528.0	65.0	-0.089	0.02	1000.0	-1000.0	-0.06	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	304.0	34.0	-0.031	0.013	1000.0	-1000.0	-0.054	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	781.0	93.0	-0.07	0.042	1000.0	-1000.0	-0.073	-1000.0
IL2 signaling events mediated by STAT5	8.0	178.0	22.0	-0.129	0.055	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	8.0	577.0	71.0	-0.084	0.034	1000.0	-1000.0	-0.056	-1000.0
EPHB forward signaling	7.0	656.0	85.0	-0.067	0.05	1000.0	-1000.0	-0.078	-1000.0
Regulation of p38-alpha and p38-beta	7.0	386.0	54.0	-0.066	0.02	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	7.0	622.0	86.0	-0.036	0.03	1000.0	-1000.0	-0.074	-1000.0
S1P4 pathway	7.0	188.0	25.0	-0.036	0.01	1000.0	-1000.0	-0.049	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	921.0	136.0	-0.107	0.051	1000.0	-1000.0	-0.064	-1000.0
S1P5 pathway	6.0	113.0	17.0	-0.036	0.03	1000.0	-1000.0	-0.049	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	159.0	28.0	-0.036	0.02	1000.0	-1000.0	-0.051	-1000.0
Cellular roles of Anthrax toxin	5.0	207.0	39.0	-0.043	0.016	1000.0	-1000.0	-0.025	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	80.0	15.0	-0.0	0.02	1000.0	-1000.0	-0.029	-1000.0
IL27-mediated signaling events	5.0	275.0	51.0	-0.105	0.011	1000.0	-1000.0	-0.068	-1000.0
Regulation of Telomerase	5.0	589.0	102.0	-0.097	0.032	1000.0	-1000.0	-0.096	-1000.0
Insulin Pathway	5.0	387.0	74.0	-0.147	0.03	1000.0	-1000.0	-0.08	-1000.0
VEGFR1 specific signals	5.0	297.0	56.0	-0.304	0.042	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class II	4.0	324.0	75.0	-0.046	0.027	1000.0	-1000.0	-0.051	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	324.0	65.0	-0.171	0.054	1000.0	-1000.0	-0.059	-1000.0
Ceramide signaling pathway	4.0	328.0	76.0	-0.095	0.032	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class I	4.0	456.0	104.0	-0.055	0.043	1000.0	-1000.0	-0.056	-1000.0
Retinoic acid receptors-mediated signaling	4.0	278.0	58.0	-0.159	0.033	1000.0	-1000.0	-0.065	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	316.0	74.0	-0.112	0.061	1000.0	-1000.0	-0.072	-1000.0
Class I PI3K signaling events	4.0	304.0	73.0	-0.06	0.025	1000.0	-1000.0	-0.054	-1000.0
p38 MAPK signaling pathway	4.0	218.0	44.0	-0.077	0.026	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	82.0	17.0	-0.013	0.02	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	3.0	84.0	22.0	-0.033	0.034	1000.0	-1000.0	-0.052	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	67.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.057	-1000.0
Arf6 downstream pathway	3.0	161.0	43.0	-0.052	0.027	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	3.0	241.0	68.0	-0.076	0.047	1000.0	-1000.0	-0.086	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	317.0	83.0	-0.064	0.04	1000.0	-1000.0	-0.078	-1000.0
FoxO family signaling	3.0	250.0	64.0	-0.136	0.055	1000.0	-1000.0	-0.09	-1000.0
IL2 signaling events mediated by PI3K	3.0	201.0	58.0	-0.135	0.066	1000.0	-1000.0	-0.078	-1000.0
S1P3 pathway	3.0	134.0	42.0	-0.035	0.021	1000.0	-1000.0	-0.052	-1000.0
TRAIL signaling pathway	2.0	108.0	48.0	-0.01	0.04	1000.0	-1000.0	-0.056	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	122.0	45.0	-0.02	0.061	1000.0	-1000.0	-0.084	-1000.0
TCGA08_rtk_signaling	2.0	75.0	26.0	-0.025	0.037	1000.0	-1000.0	-0.021	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	175.0	76.0	-0.053	0.05	1000.0	-1000.0	-0.072	-1000.0
IGF1 pathway	2.0	118.0	57.0	-0.039	0.042	1000.0	-1000.0	-0.081	-1000.0
Rapid glucocorticoid signaling	2.0	48.0	20.0	-0.006	0.01	1000.0	-1000.0	-0.035	-1000.0
PDGFR-beta signaling pathway	2.0	199.0	97.0	-0.041	0.049	1000.0	-1000.0	-0.07	-1000.0
Canonical NF-kappaB pathway	1.0	54.0	39.0	-0.021	0.066	1000.0	-1000.0	-0.073	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.003	0.009	1000.0	-1000.0	-0.035	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	47.0	37.0	-0.005	0.028	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	1.0	72.0	49.0	-0.02	0.036	1000.0	-1000.0	-0.046	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.038	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.003	0.036	1000.0	-1000.0	-0.061	-1000.0
EPO signaling pathway	0.0	44.0	55.0	-0.005	0.06	1000.0	-1000.0	-0.076	-1000.0
Insulin-mediated glucose transport	0.0	23.0	32.0	-0.004	0.035	1000.0	-1000.0	-0.058	-1000.0
mTOR signaling pathway	0.0	10.0	53.0	-0.001	0.027	1000.0	-1000.0	-0.052	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	22.0	68.0	-0.034	0.046	1000.0	-1000.0	-0.056	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	15.0	36.0	-0.004	0.018	1000.0	-1000.0	-0.063	-1000.0
Atypical NF-kappaB pathway	0.0	12.0	31.0	-0.002	0.038	1000.0	-1000.0	-0.058	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	14.0	27.0	-0.002	0.023	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	0.0	26.0	43.0	-0.008	0.038	1000.0	-1000.0	-0.057	-1000.0
Arf1 pathway	0.0	16.0	54.0	-0.006	0.024	1000.0	-1000.0	-0.038	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.01	1000.0	-1000.0	-0.047	-1000.0
Total	2309	134038	7203	-18.6445208074	-995.162095737	131000	-131000	-8.33904960142	-131000