E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.004 0.066 -9999.0 0.0 -0.309 16.0 16.0 KLHL20 -0.0 0.051 0.157 1.0 -0.211 8.0 9.0 CYFIP2 0.015 0.043 -9999.0 0.0 -0.328 6.0 6.0 Rac1/GDP -0.01 0.061 0.319 3.0 -0.257 7.0 10.0 ENAH -0.004 0.066 -9999.0 0.0 -0.318 15.0 15.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.025 -9999.0 0.0 -0.14 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.028 -9999.0 0.0 -0.184 3.0 3.0 RAPGEF1 -0.008 0.057 0.203 2.0 -0.279 11.0 13.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.006 0.07 -9999.0 0.0 -0.316 17.0 17.0 CRK -0.011 0.056 -9999.0 0.0 -0.308 12.0 12.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.021 -9999.0 0.0 -0.198 2.0 2.0 alphaE/beta7 Integrin 0.027 0.017 -9999.0 0.0 -0.231 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.002 0.062 -9999.0 0.0 -0.32 13.0 13.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.026 0.016 -9999.0 0.0 -0.132 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.051 0.059 0.216 38.0 -0.173 4.0 42.0 PI3K -0.032 0.02 -9999.0 0.0 -0.166 2.0 2.0 ARF6 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.02 -9999.0 0.0 -0.231 2.0 2.0 TIAM1 0.016 0.039 -9999.0 0.0 -0.328 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.045 0.021 -9999.0 0.0 -0.171 2.0 2.0 AKT1 -0.017 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.025 -9999.0 0.0 -0.328 2.0 2.0 RhoA/GDP -0.01 0.065 0.289 4.0 -0.247 7.0 11.0 actin cytoskeleton organization 0.003 0.044 0.153 7.0 -0.154 8.0 15.0 CDC42/GDP -0.011 0.064 0.32 3.0 -0.255 7.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.008 0.019 -9999.0 0.0 -0.179 4.0 4.0 ITGB7 0.02 0.018 -9999.0 0.0 -0.328 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.023 -9999.0 0.0 -0.183 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.018 -9999.0 0.0 -0.166 2.0 2.0 mol:GDP -0.01 0.07 0.3 4.0 -0.282 8.0 12.0 CDC42/GTP/IQGAP1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.011 0.058 0.202 1.0 -0.248 5.0 6.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.005 0.038 0.137 10.0 -0.147 5.0 15.0 NME1 0.055 0.097 0.331 43.0 -9999.0 0.0 43.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.0 0.056 -9999.0 0.0 -0.311 11.0 11.0 regulation of cell-cell adhesion -0.026 0.018 -9999.0 0.0 -0.15 2.0 2.0 WASF2 -0.003 0.024 -9999.0 0.0 -0.089 1.0 1.0 Rap1/GTP -0.024 0.031 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.033 -9999.0 0.0 -0.177 3.0 3.0 CCND1 0.004 0.044 0.148 9.0 -0.171 6.0 15.0 VAV2 -0.005 0.119 -9999.0 0.0 -0.58 12.0 12.0 RAP1/GDP -0.019 0.046 0.193 1.0 -0.216 5.0 6.0 adherens junction assembly -0.002 0.059 -9999.0 0.0 -0.305 13.0 13.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.034 0.028 -9999.0 0.0 -0.175 3.0 3.0 E-cadherin/beta catenin 0.004 0.022 -9999.0 0.0 -0.278 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.068 -9999.0 0.0 -0.312 17.0 17.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.004 0.063 -9999.0 0.0 -0.319 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.039 0.021 -9999.0 0.0 -0.198 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.07 -9999.0 0.0 -0.322 17.0 17.0