Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.035 0.056 0.242 4.0 -0.237 19.0 23.0 KIRREL 0.017 0.038 -9999.0 0.0 -0.337 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.035 0.056 0.237 19.0 -0.242 4.0 23.0 PLCG1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.051 0.053 0.223 19.0 -0.183 4.0 23.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.013 0.036 -9999.0 0.0 -0.197 4.0 4.0 FYN 0.017 0.086 0.214 53.0 -0.175 4.0 57.0 mol:Ca2+ 0.048 0.052 0.215 19.0 -0.182 4.0 23.0 mol:DAG 0.049 0.053 0.219 19.0 -0.182 4.0 23.0 NPHS2 -0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.049 0.053 0.219 19.0 -0.182 4.0 23.0 regulation of endocytosis 0.034 0.045 0.2 16.0 -0.17 4.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.041 0.05 0.209 19.0 -0.177 4.0 23.0 establishment of cell polarity 0.035 0.056 0.237 19.0 -0.242 4.0 23.0 Nephrin/NEPH1/podocin/NCK1-2 0.059 0.054 0.283 1.0 -0.171 4.0 5.0 Nephrin/NEPH1/beta Arrestin2 0.036 0.047 0.208 16.0 -0.171 4.0 20.0 NPHS1 0.038 0.078 0.339 23.0 -9999.0 0.0 23.0 Nephrin/NEPH1/podocin 0.038 0.048 0.207 19.0 -0.166 5.0 24.0 TJP1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.05 0.053 0.223 19.0 -0.183 4.0 23.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.053 0.223 18.0 -0.183 4.0 22.0 GRB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.093 0.22 47.0 -0.178 22.0 69.0 cytoskeleton organization -0.004 0.052 0.222 10.0 -0.21 4.0 14.0 Nephrin/NEPH1 0.03 0.044 0.194 19.0 -0.161 4.0 23.0 Nephrin/NEPH1/ZO-1 0.041 0.049 0.219 17.0 -0.193 4.0 21.0