Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.025 -9999.0 0.0 -0.176 7.0 7.0 epithelial cell differentiation 0.041 0.02 -9999.0 0.0 -0.17 2.0 2.0 CYFIP2 0.015 0.043 -9999.0 0.0 -0.328 6.0 6.0 ENAH -0.02 0.059 0.404 2.0 -0.232 1.0 3.0 EGFR 0.015 0.043 0.331 1.0 -0.328 5.0 6.0 EPHA2 0.014 0.046 -9999.0 0.0 -0.328 7.0 7.0 MYO6 -0.018 0.043 0.23 8.0 -9999.0 0.0 8.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.024 -9999.0 0.0 -0.198 3.0 3.0 AQP5 -0.058 0.165 0.441 3.0 -0.376 70.0 73.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.019 0.043 0.221 9.0 -0.166 2.0 11.0 regulation of calcium-dependent cell-cell adhesion -0.092 0.076 0.162 3.0 -0.168 185.0 188.0 EGF 0.074 0.127 0.331 72.0 -0.328 4.0 76.0 NCKAP1 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.023 0.076 0.238 1.0 -0.319 19.0 20.0 cortical microtubule organization 0.041 0.02 -9999.0 0.0 -0.17 2.0 2.0 GO:0000145 -0.018 0.041 0.21 9.0 -0.158 2.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.021 -9999.0 0.0 -0.171 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.025 -9999.0 0.0 -0.168 5.0 5.0 ARF6 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.039 0.036 -9999.0 0.0 -0.183 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.011 0.042 0.423 2.0 -9999.0 0.0 2.0 PVRL2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.044 0.223 9.0 -9999.0 0.0 9.0 ARF6/GTP 0.042 0.037 -9999.0 0.0 -0.175 5.0 5.0 CDH1 0.019 0.025 -9999.0 0.0 -0.328 2.0 2.0 EGFR/EGFR/EGF/EGF 0.042 0.057 0.245 1.0 -0.185 8.0 9.0 RhoA/GDP 0.042 0.021 -9999.0 0.0 -0.166 2.0 2.0 actin cytoskeleton organization -0.02 0.041 0.215 8.0 -0.172 2.0 10.0 IGF-1R heterotetramer 0.02 0.018 -9999.0 0.0 -0.327 1.0 1.0 GIT1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.018 -9999.0 0.0 -0.328 1.0 1.0 IGF1 0.017 0.042 0.331 1.0 -0.328 5.0 6.0 DIAPH1 0.015 0.122 -9999.0 0.0 -0.561 10.0 10.0 Wnt receptor signaling pathway -0.041 0.02 0.17 2.0 -9999.0 0.0 2.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.028 -9999.0 0.0 -0.188 6.0 6.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.041 0.216 8.0 -0.175 2.0 10.0 EFNA1 0.017 0.019 -9999.0 0.0 -0.328 1.0 1.0 LPP -0.022 0.042 0.213 9.0 -9999.0 0.0 9.0 Ephrin A1/EPHA2 0.026 0.036 -9999.0 0.0 -0.183 8.0 8.0 SEC6/SEC8 -0.025 0.019 -9999.0 0.0 -0.168 1.0 1.0 MGAT3 -0.093 0.077 0.163 3.0 -0.17 185.0 188.0 HGF/MET 0.022 0.056 -9999.0 0.0 -0.172 25.0 25.0 HGF 0.008 0.075 0.331 3.0 -0.328 16.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.025 -9999.0 0.0 -0.177 7.0 7.0 actin cable formation 0.01 0.089 0.313 14.0 -0.25 3.0 17.0 KIAA1543 -0.021 0.03 0.177 7.0 -0.16 2.0 9.0 KIFC3 -0.024 0.024 0.163 4.0 -9999.0 0.0 4.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.043 0.223 9.0 -9999.0 0.0 9.0 NCK1/GIT1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.02 -9999.0 0.0 -0.17 2.0 2.0 EXOC4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.032 0.188 7.0 -9999.0 0.0 7.0 PIP5K1C -0.019 0.043 0.223 9.0 -0.168 2.0 11.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.007 0.081 0.346 7.0 -0.263 1.0 8.0 adherens junction assembly -0.026 0.095 0.358 6.0 -0.455 8.0 14.0 IGF-1R heterotetramer/IGF1 0.031 0.033 -9999.0 0.0 -0.164 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.027 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.012 0.072 0.331 5.0 -0.328 13.0 18.0 PLEKHA7 -0.022 0.032 0.188 7.0 -9999.0 0.0 7.0 mol:GTP 0.038 0.035 -9999.0 0.0 -0.182 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.022 0.098 0.299 15.0 -9999.0 0.0 15.0 cortical actin cytoskeleton stabilization 0.009 0.025 -9999.0 0.0 -0.176 7.0 7.0 regulation of cell-cell adhesion -0.02 0.041 0.215 8.0 -0.172 2.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.025 -9999.0 0.0 -0.177 7.0 7.0