Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	185.0	9471.0	51.0	-0.04	0.815	1000.0	-1000.0	-0.089	-1000.0
Glypican 2 network	132.0	530.0	4.0	0.085	0.137	1000.0	-1000.0	0.017	-1000.0
Angiopoietin receptor Tie2-mediated signaling	107.0	9439.0	88.0	-0.533	0.103	1000.0	-1000.0	-0.049	-1000.0
Aurora B signaling	100.0	6738.0	67.0	-0.154	0.291	1000.0	-1000.0	-0.028	-1000.0
HIF-1-alpha transcription factor network	95.0	7280.0	76.0	-0.052	0.438	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by the Hedgehog family	85.0	4465.0	52.0	-0.221	0.105	1000.0	-1000.0	-0.03	-1000.0
Endothelins	64.0	6219.0	96.0	-0.296	0.2	1000.0	-1000.0	-0.029	-1000.0
PLK1 signaling events	63.0	5373.0	85.0	-0.053	0.204	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	55.0	387.0	7.0	-0.0	0.173	1000.0	-1000.0	-0.005	-1000.0
Signaling mediated by p38-alpha and p38-beta	50.0	2203.0	44.0	-0.098	0.021	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Cones	48.0	1844.0	38.0	-0.088	0.12	1000.0	-1000.0	-0.015	-1000.0
Signaling events regulated by Ret tyrosine kinase	48.0	3939.0	82.0	-0.081	0.063	1000.0	-1000.0	-0.043	-1000.0
FOXA2 and FOXA3 transcription factor networks	47.0	2206.0	46.0	-0.204	0.154	1000.0	-1000.0	-0.063	-1000.0
IL4-mediated signaling events	44.0	4092.0	91.0	-0.647	0.356	1000.0	-1000.0	-0.088	-1000.0
Osteopontin-mediated events	43.0	1647.0	38.0	-0.004	0.251	1000.0	-1000.0	-0.033	-1000.0
Fc-epsilon receptor I signaling in mast cells	42.0	4166.0	97.0	-0.102	0.021	1000.0	-1000.0	-0.041	-1000.0
BMP receptor signaling	40.0	3278.0	81.0	-0.179	0.232	1000.0	-1000.0	-0.022	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	40.0	2127.0	52.0	-0.138	0.045	1000.0	-1000.0	-0.024	-1000.0
Syndecan-1-mediated signaling events	39.0	1331.0	34.0	-0.0	0.219	1000.0	-1000.0	-0.019	-1000.0
amb2 Integrin signaling	39.0	3277.0	82.0	-0.297	0.076	1000.0	-1000.0	-0.024	-1000.0
Ephrin B reverse signaling	39.0	1887.0	48.0	-0.079	0.079	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Rods	37.0	1946.0	52.0	-0.088	0.101	1000.0	-1000.0	-0.03	-1000.0
p75(NTR)-mediated signaling	32.0	4005.0	125.0	-0.139	0.14	1000.0	-1000.0	-0.043	-1000.0
IL23-mediated signaling events	30.0	1835.0	60.0	-0.191	0.027	1000.0	-1000.0	-0.09	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	29.0	2017.0	68.0	-0.149	0.065	1000.0	-1000.0	-0.048	-1000.0
Glucocorticoid receptor regulatory network	28.0	3198.0	114.0	-0.27	0.177	1000.0	-1000.0	-0.037	-1000.0
LPA4-mediated signaling events	27.0	325.0	12.0	-0.072	-0.0	1000.0	-1000.0	-0.016	-1000.0
Integrins in angiogenesis	27.0	2278.0	84.0	-0.084	0.247	1000.0	-1000.0	-0.041	-1000.0
Arf6 signaling events	26.0	1666.0	62.0	-0.106	0.074	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	26.0	1138.0	43.0	-0.135	0.148	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	26.0	1359.0	51.0	-0.205	0.094	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	26.0	215.0	8.0	-0.022	0.1	1000.0	-1000.0	-0.005	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	26.0	3130.0	120.0	-0.165	0.143	1000.0	-1000.0	-0.04	-1000.0
EGFR-dependent Endothelin signaling events	25.0	525.0	21.0	-0.024	0.074	1000.0	-1000.0	-0.028	-1000.0
Thromboxane A2 receptor signaling	24.0	2617.0	105.0	-0.102	0.074	1000.0	-1000.0	-0.036	-1000.0
Presenilin action in Notch and Wnt signaling	24.0	1479.0	61.0	-0.206	0.094	1000.0	-1000.0	-0.029	-1000.0
Aurora A signaling	24.0	1469.0	60.0	-0.029	0.192	1000.0	-1000.0	-0.018	-1000.0
Reelin signaling pathway	24.0	1376.0	56.0	-0.038	0.047	1000.0	-1000.0	-0.023	-1000.0
TCGA08_p53	24.0	172.0	7.0	-0.021	0.019	1000.0	-1000.0	-0.008	-1000.0
IL6-mediated signaling events	24.0	1802.0	75.0	-0.149	0.053	1000.0	-1000.0	-0.039	-1000.0
Wnt signaling	23.0	161.0	7.0	-0.026	0.038	1000.0	-1000.0	-0.006	-1000.0
Noncanonical Wnt signaling pathway	21.0	564.0	26.0	-0.047	0.038	1000.0	-1000.0	-0.023	-1000.0
Glypican 1 network	21.0	1018.0	48.0	-0.053	0.037	1000.0	-1000.0	-0.021	-1000.0
Effects of Botulinum toxin	21.0	563.0	26.0	-0.0	0.042	1000.0	-1000.0	-0.01	-1000.0
Nongenotropic Androgen signaling	20.0	1063.0	52.0	-0.069	0.049	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19.0	647.0	33.0	-0.077	0.098	1000.0	-1000.0	-0.022	-1000.0
S1P4 pathway	19.0	492.0	25.0	-0.028	0.027	1000.0	-1000.0	-0.014	-1000.0
FoxO family signaling	18.0	1200.0	64.0	0.0	0.211	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	18.0	1257.0	67.0	-0.046	0.135	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	17.0	1209.0	69.0	-0.112	0.141	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	17.0	778.0	44.0	-0.184	0.037	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	17.0	1095.0	62.0	-0.076	0.042	1000.0	-1000.0	-0.04	-1000.0
LPA receptor mediated events	17.0	1776.0	102.0	-0.056	0.072	1000.0	-1000.0	-0.061	-1000.0
Regulation of Androgen receptor activity	17.0	1205.0	70.0	-0.137	0.123	1000.0	-1000.0	-0.027	-1000.0
Syndecan-2-mediated signaling events	16.0	1147.0	69.0	-0.046	0.057	1000.0	-1000.0	-0.032	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	513.0	34.0	-0.035	0.059	1000.0	-1000.0	-0.022	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	15.0	816.0	54.0	-0.033	0.109	1000.0	-1000.0	-0.031	-1000.0
S1P5 pathway	15.0	262.0	17.0	-0.02	0.021	1000.0	-1000.0	-0.002	-1000.0
FAS signaling pathway (CD95)	15.0	736.0	47.0	-0.231	0.034	1000.0	-1000.0	-0.026	-1000.0
EPHB forward signaling	15.0	1295.0	85.0	-0.032	0.088	1000.0	-1000.0	-0.044	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	493.0	31.0	-0.037	0.034	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.019	-1000.0
IL12-mediated signaling events	14.0	1291.0	87.0	-0.133	0.059	1000.0	-1000.0	-0.054	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.007	0.038	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PTP1B	14.0	1083.0	76.0	-0.053	0.075	1000.0	-1000.0	-0.029	-1000.0
Ceramide signaling pathway	14.0	1126.0	76.0	-0.02	0.074	1000.0	-1000.0	-0.025	-1000.0
BCR signaling pathway	14.0	1418.0	99.0	-0.046	0.081	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1268.0	86.0	-0.063	0.06	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	13.0	1020.0	76.0	-0.06	0.097	1000.0	-1000.0	-0.014	-1000.0
Nectin adhesion pathway	13.0	873.0	63.0	-0.041	0.05	1000.0	-1000.0	-0.045	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1218.0	93.0	-0.031	0.033	1000.0	-1000.0	-0.037	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	12.0	1070.0	85.0	-0.066	0.036	1000.0	-1000.0	-0.035	-1000.0
S1P1 pathway	12.0	434.0	36.0	-0.086	0.021	1000.0	-1000.0	-0.026	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	12.0	928.0	74.0	-0.093	0.074	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	948.0	78.0	-0.041	0.022	1000.0	-1000.0	-0.036	-1000.0
ErbB2/ErbB3 signaling events	11.0	772.0	65.0	-0.05	0.03	1000.0	-1000.0	-0.049	-1000.0
Caspase cascade in apoptosis	11.0	845.0	74.0	-0.03	0.078	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	11.0	683.0	57.0	-0.046	0.117	1000.0	-1000.0	-0.04	-1000.0
Regulation of p38-alpha and p38-beta	11.0	596.0	54.0	-0.038	0.058	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	10.0	432.0	40.0	-0.061	0.065	1000.0	-1000.0	-0.029	-1000.0
Syndecan-3-mediated signaling events	10.0	384.0	35.0	-0.114	0.046	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	9.0	1167.0	125.0	-0.184	0.041	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PRL	9.0	307.0	34.0	-0.023	0.089	1000.0	-1000.0	-0.03	-1000.0
IL27-mediated signaling events	8.0	444.0	51.0	-0.044	0.036	1000.0	-1000.0	-0.036	-1000.0
IL2 signaling events mediated by STAT5	8.0	192.0	22.0	-0.028	0.1	1000.0	-1000.0	-0.029	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	957.0	136.0	-0.17	0.074	1000.0	-1000.0	-0.029	-1000.0
Ephrin A  reverse signaling	7.0	55.0	7.0	-0.014	0.029	1000.0	-1000.0	-0.011	-1000.0
Class I PI3K signaling events	7.0	537.0	73.0	-0.038	0.053	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	7.0	539.0	74.0	-0.099	0.051	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	7.0	418.0	56.0	-0.184	0.049	1000.0	-1000.0	-0.028	-1000.0
PDGFR-beta signaling pathway	7.0	753.0	97.0	-0.035	0.052	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	169.0	28.0	-0.019	0.032	1000.0	-1000.0	-0.018	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	118.0	17.0	-0.008	0.046	1000.0	-1000.0	-0.026	-1000.0
Cellular roles of Anthrax toxin	6.0	261.0	39.0	-0.031	0.028	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	449.0	65.0	-0.133	0.047	1000.0	-1000.0	-0.038	-1000.0
EPO signaling pathway	6.0	380.0	55.0	-0.026	0.045	1000.0	-1000.0	-0.025	-1000.0
mTOR signaling pathway	6.0	335.0	53.0	-0.057	0.025	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	6.0	428.0	68.0	-0.029	0.061	1000.0	-1000.0	-0.039	-1000.0
Retinoic acid receptors-mediated signaling	6.0	363.0	58.0	-0.091	0.04	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	273.0	45.0	-0.023	0.049	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	6.0	496.0	71.0	-0.037	0.038	1000.0	-1000.0	-0.032	-1000.0
S1P3 pathway	6.0	267.0	42.0	-0.025	0.034	1000.0	-1000.0	-0.02	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	104.0	17.0	-0.005	0.031	1000.0	-1000.0	-0.019	-1000.0
ceramide signaling pathway	5.0	286.0	49.0	-0.01	0.026	1000.0	-1000.0	-0.024	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	455.0	83.0	-0.058	0.041	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	5.0	537.0	104.0	-0.034	0.047	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	78.0	15.0	-0.018	0.022	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	420.0	76.0	-0.032	0.055	1000.0	-1000.0	-0.041	-1000.0
Regulation of Telomerase	5.0	555.0	102.0	-0.021	0.096	1000.0	-1000.0	-0.044	-1000.0
p38 MAPK signaling pathway	5.0	223.0	44.0	-0.008	0.061	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	4.0	194.0	43.0	-0.05	0.054	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	4.0	267.0	58.0	-0.014	0.07	1000.0	-1000.0	-0.026	-1000.0
TCGA08_rtk_signaling	4.0	110.0	26.0	-0.009	0.047	1000.0	-1000.0	-0.009	-1000.0
IGF1 pathway	4.0	242.0	57.0	-0.032	0.047	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in keratinocytes	4.0	182.0	43.0	-0.014	0.039	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	3.0	286.0	75.0	-0.02	0.056	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	3.0	75.0	22.0	-0.004	0.046	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	268.0	68.0	-0.027	0.045	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	2.0	96.0	39.0	-0.017	0.042	1000.0	-1000.0	-0.02	-1000.0
Insulin-mediated glucose transport	2.0	65.0	32.0	-0.016	0.038	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	82.0	37.0	-0.026	0.05	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.019	0.03	1000.0	-1000.0	0.019	-1000.0
TRAIL signaling pathway	1.0	89.0	48.0	-0.018	0.045	1000.0	-1000.0	-0.024	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	56.0	36.0	-0.036	0.039	1000.0	-1000.0	-0.03	-1000.0
Atypical NF-kappaB pathway	1.0	37.0	31.0	-0.018	0.029	1000.0	-1000.0	-0.021	-1000.0
Rapid glucocorticoid signaling	1.0	35.0	20.0	-0.008	0.026	1000.0	-1000.0	-0.009	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.018	-1000.0
Arf1 pathway	1.0	83.0	54.0	-0.008	0.033	1000.0	-1000.0	-0.014	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	22.0	23.0	-0.0	0.036	1000.0	-1000.0	-0.012	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	17.0	27.0	-0.019	0.045	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.055	1000.0	-1000.0	-0.0	-1000.0
Total	2760	163002	7203	-9.58915306886	10.8908829259	131000	-131000	-3.70391660662	-131000