Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	8.0	409.0	51.0	-0.628	0.038	1000.0	-1000.0	-0.097	-1000.0
HIF-1-alpha transcription factor network	5.0	422.0	76.0	-0.455	0.052	1000.0	-1000.0	-0.059	-1000.0
TCGA08_retinoblastoma	5.0	42.0	8.0	-0.104	0.05	1000.0	-1000.0	-0.006	-1000.0
Osteopontin-mediated events	4.0	170.0	38.0	-0.309	0.041	1000.0	-1000.0	-0.041	-1000.0
Endothelins	4.0	391.0	96.0	-0.263	0.049	1000.0	-1000.0	-0.058	-1000.0
IL23-mediated signaling events	4.0	278.0	60.0	-0.563	0.038	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by the Hedgehog family	3.0	202.0	52.0	-0.278	0.114	1000.0	-1000.0	-0.04	-1000.0
IL4-mediated signaling events	3.0	362.0	91.0	-0.712	0.571	1000.0	-1000.0	-0.075	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	333.0	97.0	-0.157	0.039	1000.0	-1000.0	-0.079	-1000.0
TCGA08_p53	3.0	26.0	7.0	-0.085	0.053	1000.0	-1000.0	-0.014	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	142.0	44.0	-0.136	0.039	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	388.0	125.0	-0.123	0.052	1000.0	-1000.0	-0.052	-1000.0
IL27-mediated signaling events	3.0	184.0	51.0	-0.214	0.155	1000.0	-1000.0	-0.063	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	259.0	68.0	-0.465	0.165	1000.0	-1000.0	-0.075	-1000.0
EGFR-dependent Endothelin signaling events	3.0	76.0	21.0	-0.104	0.054	1000.0	-1000.0	-0.044	-1000.0
Caspase cascade in apoptosis	2.0	158.0	74.0	-0.065	0.052	1000.0	-1000.0	-0.046	-1000.0
IL12-mediated signaling events	2.0	237.0	87.0	-0.284	0.039	1000.0	-1000.0	-0.065	-1000.0
Syndecan-1-mediated signaling events	2.0	89.0	34.0	-0.163	0.039	1000.0	-1000.0	-0.049	-1000.0
Visual signal transduction: Cones	2.0	102.0	38.0	-0.156	0.044	1000.0	-1000.0	-0.006	-1000.0
Syndecan-2-mediated signaling events	2.0	144.0	69.0	-0.185	0.063	1000.0	-1000.0	-0.039	-1000.0
Arf6 signaling events	2.0	136.0	62.0	-0.104	0.039	1000.0	-1000.0	-0.019	-1000.0
BMP receptor signaling	2.0	182.0	81.0	-0.201	0.077	1000.0	-1000.0	-0.06	-1000.0
amb2 Integrin signaling	2.0	227.0	82.0	-0.149	0.049	1000.0	-1000.0	-0.037	-1000.0
Nectin adhesion pathway	2.0	151.0	63.0	-0.105	0.058	1000.0	-1000.0	-0.056	-1000.0
Glucocorticoid receptor regulatory network	2.0	245.0	114.0	-0.4	0.086	1000.0	-1000.0	-0.062	-1000.0
IL1-mediated signaling events	2.0	147.0	62.0	-0.142	0.065	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	2.0	134.0	48.0	-0.118	0.039	1000.0	-1000.0	-0.036	-1000.0
Syndecan-3-mediated signaling events	2.0	84.0	35.0	-0.185	0.05	1000.0	-1000.0	-0.023	-1000.0
Integrins in angiogenesis	2.0	192.0	84.0	-0.157	0.045	1000.0	-1000.0	-0.057	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	187.0	93.0	-0.051	0.054	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	2.0	9.0	4.0	-0.024	0.0	1000.0	-1000.0	0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	72.0	31.0	-0.237	0.04	1000.0	-1000.0	-0.052	-1000.0
Wnt signaling	2.0	20.0	7.0	-0.091	0.038	1000.0	-1000.0	-0.026	-1000.0
IL6-mediated signaling events	2.0	178.0	75.0	-0.447	0.05	1000.0	-1000.0	-0.048	-1000.0
BCR signaling pathway	2.0	268.0	99.0	-0.195	0.067	1000.0	-1000.0	-0.061	-1000.0
Syndecan-4-mediated signaling events	2.0	164.0	67.0	-0.109	0.042	1000.0	-1000.0	-0.046	-1000.0
Insulin Pathway	2.0	151.0	74.0	-0.126	0.062	1000.0	-1000.0	-0.036	-1000.0
Plasma membrane estrogen receptor signaling	2.0	232.0	86.0	-0.195	0.184	1000.0	-1000.0	-0.061	-1000.0
Visual signal transduction: Rods	2.0	139.0	52.0	-0.207	0.051	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	189.0	78.0	-0.113	0.044	1000.0	-1000.0	-0.073	-1000.0
Coregulation of Androgen receptor activity	1.0	80.0	76.0	-0.215	0.052	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	1.0	75.0	69.0	-0.3	0.072	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	-0.011	0.038	1000.0	-1000.0	-0.004	-1000.0
Noncanonical Wnt signaling pathway	1.0	47.0	26.0	-0.091	0.038	1000.0	-1000.0	-0.049	-1000.0
Thromboxane A2 receptor signaling	1.0	201.0	105.0	-0.095	0.05	1000.0	-1000.0	-0.051	-1000.0
Cellular roles of Anthrax toxin	1.0	47.0	39.0	-0.059	0.036	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	136.0	85.0	-0.111	0.047	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by PTP1B	1.0	130.0	76.0	-0.139	0.091	1000.0	-1000.0	-0.044	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	65.0	65.0	-0.242	0.083	1000.0	-1000.0	-0.044	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	70.0	61.0	-0.158	0.046	1000.0	-1000.0	-0.057	-1000.0
FOXA2 and FOXA3 transcription factor networks	1.0	61.0	46.0	-0.249	0.044	1000.0	-1000.0	-0.084	-1000.0
Glypican 1 network	1.0	51.0	48.0	-0.009	0.053	1000.0	-1000.0	-0.023	-1000.0
PLK1 signaling events	1.0	94.0	85.0	-0.137	0.057	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	1.0	103.0	53.0	-0.067	0.039	1000.0	-1000.0	-0.048	-1000.0
IFN-gamma pathway	1.0	103.0	68.0	-0.105	0.04	1000.0	-1000.0	-0.053	-1000.0
Reelin signaling pathway	1.0	60.0	56.0	-0.036	0.061	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	1.0	79.0	48.0	-0.028	0.039	1000.0	-1000.0	-0.037	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	60.0	52.0	-0.088	0.071	1000.0	-1000.0	-0.044	-1000.0
HIF-2-alpha transcription factor network	1.0	52.0	43.0	-0.158	0.083	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	1.0	68.0	36.0	-0.129	0.038	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	1.0	83.0	47.0	-0.102	0.049	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	49.0	45.0	-0.049	0.052	1000.0	-1000.0	-0.055	-1000.0
Canonical Wnt signaling pathway	1.0	77.0	51.0	-0.158	0.098	1000.0	-1000.0	-0.063	-1000.0
EPHB forward signaling	1.0	118.0	85.0	-0.067	0.078	1000.0	-1000.0	-0.065	-1000.0
Nongenotropic Androgen signaling	1.0	61.0	52.0	-0.029	0.05	1000.0	-1000.0	-0.032	-1000.0
LPA receptor mediated events	1.0	158.0	102.0	-0.22	0.064	1000.0	-1000.0	-0.117	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	118.0	74.0	-0.107	0.056	1000.0	-1000.0	-0.069	-1000.0
IGF1 pathway	1.0	74.0	57.0	-0.059	0.062	1000.0	-1000.0	-0.045	-1000.0
VEGFR1 specific signals	1.0	65.0	56.0	-0.03	0.039	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	1.0	46.0	43.0	-0.082	0.041	1000.0	-1000.0	-0.041	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.03	0.03	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	-0.006	0.036	1000.0	-1000.0	0.012	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	22.0	17.0	-0.0	0.042	1000.0	-1000.0	-0.024	-1000.0
Aurora B signaling	1.0	118.0	67.0	-0.123	0.046	1000.0	-1000.0	-0.033	-1000.0
LPA4-mediated signaling events	0.0	4.0	12.0	-0.004	0.05	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	0.0	28.0	65.0	-0.021	0.078	1000.0	-1000.0	-0.081	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	93.0	136.0	-0.157	0.154	1000.0	-1000.0	-0.053	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.002	0.066	1000.0	-1000.0	-0.032	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	10.0	34.0	-0.042	0.081	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	0.0	15.0	39.0	-0.015	0.081	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	0.0	33.0	75.0	-0.11	0.074	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	0.0	16.0	57.0	-0.075	0.078	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	24.0	28.0	-0.035	0.042	1000.0	-1000.0	-0.017	-1000.0
Circadian rhythm pathway	0.0	10.0	22.0	-0.093	0.079	1000.0	-1000.0	-0.035	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	26.0	54.0	-0.039	0.052	1000.0	-1000.0	-0.051	-1000.0
Ephrin A  reverse signaling	0.0	5.0	7.0	0.0	0.029	1000.0	-1000.0	-0.002	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	9.0	17.0	-0.003	0.08	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.036	0.056	1000.0	-1000.0	0.013	-1000.0
Aurora A signaling	0.0	27.0	60.0	-0.042	0.083	1000.0	-1000.0	-0.029	-1000.0
p75(NTR)-mediated signaling	0.0	106.0	125.0	-0.17	0.09	1000.0	-1000.0	-0.052	-1000.0
Arf6 downstream pathway	0.0	20.0	43.0	-0.048	0.053	1000.0	-1000.0	-0.026	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.026	0.042	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	0.0	31.0	55.0	0.0	0.076	1000.0	-1000.0	-0.041	-1000.0
Insulin-mediated glucose transport	0.0	6.0	32.0	-0.024	0.059	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	0.0	34.0	44.0	-0.065	0.062	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	61.0	68.0	-0.024	0.066	1000.0	-1000.0	-0.037	-1000.0
Ceramide signaling pathway	0.0	75.0	76.0	-0.061	0.054	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	14.0	37.0	-0.004	0.09	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.087	0.069	1000.0	-1000.0	-0.026	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	78.0	82.0	-0.053	0.051	1000.0	-1000.0	-0.073	-1000.0
S1P5 pathway	0.0	8.0	17.0	-0.025	0.039	1000.0	-1000.0	-0.009	-1000.0
ceramide signaling pathway	0.0	29.0	49.0	-0.061	0.045	1000.0	-1000.0	-0.041	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	20.0	83.0	-0.038	0.071	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class I	0.0	13.0	104.0	-0.053	0.081	1000.0	-1000.0	-0.039	-1000.0
FoxO family signaling	0.0	54.0	64.0	-0.248	0.054	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.041	0.038	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	0.0	42.0	58.0	-0.022	0.075	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	12.0	36.0	-0.073	0.079	1000.0	-1000.0	-0.045	-1000.0
Atypical NF-kappaB pathway	0.0	7.0	31.0	0.0	0.056	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	0.0	25.0	58.0	-0.03	0.073	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	0.0	29.0	54.0	-0.047	0.072	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	0.0	25.0	26.0	-0.027	0.033	1000.0	-1000.0	-0.015	-1000.0
TCGA08_rtk_signaling	0.0	25.0	26.0	-0.082	0.054	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	55.0	76.0	-0.042	0.062	1000.0	-1000.0	-0.073	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.066	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	0.0	13.0	22.0	-0.063	0.045	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events	0.0	53.0	73.0	-0.038	0.039	1000.0	-1000.0	-0.043	-1000.0
Arf6 trafficking events	0.0	4.0	71.0	-0.051	0.067	1000.0	-1000.0	-0.029	-1000.0
Regulation of Telomerase	0.0	76.0	102.0	-0.11	0.073	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	0.0	26.0	42.0	-0.033	0.042	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	49.0	88.0	-0.108	0.088	1000.0	-1000.0	-0.071	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	27.0	33.0	-0.137	0.101	1000.0	-1000.0	-0.038	-1000.0
Rapid glucocorticoid signaling	0.0	6.0	20.0	-0.0	0.034	1000.0	-1000.0	-0.007	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	0.0	83.0	120.0	-0.109	0.085	1000.0	-1000.0	-0.055	-1000.0
PDGFR-beta signaling pathway	0.0	41.0	97.0	-0.041	0.091	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PRL	0.0	33.0	34.0	-0.105	0.056	1000.0	-1000.0	-0.052	-1000.0
S1P4 pathway	0.0	12.0	25.0	-0.0	0.042	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	0.0	33.0	44.0	-0.074	0.063	1000.0	-1000.0	-0.027	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.0	0.046	1000.0	-1000.0	-0.022	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.095	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	49.0	70.0	-0.215	0.05	1000.0	-1000.0	-0.052	-1000.0
Total	141	11731	7203	-15.3339348392	8.41550143125	131000	-131000	-5.36507692821	-131000